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| 1 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 2 | Flexible smart sensing skin for“Fly-by-Feel”morphing aircraft显示文摘Flexible smart sensing skin is a key enabling technology for the future'Fly-by-Feel'control of morphing aircraft.It represents the next-generation skin of aircraft that can exhibit a more powerful sensing function than a conventional one and could be mounted on arbitrary curvilinear surfaces,especially for advanced autonomic,morphing aircraft.Recent significant technical advances in flexible electronics have overcome many historic drawbacks of conventional smart skin,e.g.,only a limited number of discrete block sensors can be integrated due to the inevitable structural damage and heavy guidelines.Herein,we review the key developments in flexible sensors technology and highlight both the state-of-the-art devices and the potential applications for the measurement of aircraft.We begin with the importance of flexible smart skin for morphing aircraft and then expand to the latest progress in various types of flexible sensors.Then we highlight flexible sensors as smart skin to measure aerodynamic parameters and monitor the structural health,and further to achieve the Fly-by-Feel control.Finally,the challenges and opportunities on flexible smart sensing skin are discussed,from the functional design to practical applications. | HUANG YongAn ZHU Chen XIONG WenNan WANG Yu JIANG YongGang QIU Lei GUO DongLiang HOU Chao JIANG Shan YANG ZhaoXi WANG Bo WANG Lu YIN ZhouPing | 2022 | Science China(Technological Sciences)2022，65，1： | 6 |
| 3 | Smart Service System(SSS):A Novel Architecture Enabling Coordination of Heterogeneous Networking Technologies and Devices for Internet of Things显示文摘In Internet of Things(IoT), the devices or terminals are connected with each other, which can be very diverse over the wireless networks. Unfortunately, the current devices are not designed to communicate with the collocated devices which employ different communication technologies. Consequently, the communication between these devices will be realized only by using the gateway nodes. This will cause the inefficient use of wireless resources. Therefore, in this paper, a smart service system(SSS) architecture is proposed, which consists of smart service terminal(SST), and smart service network(SSN), to realize the Io T in a general environment with diverse communication networks, devices, and services. The proposed architecture has the following advantages: i) the devices in this architecture cover multiple types of terminals and sensor-actuator devices; ii) the communications network therein is a converged network, and will coordinate multiple kinds of existing and emerging networks. This converged network offers ubiquitous access for various sensors and terminals; iii) the architecture has services and applications covering all smart service areas. It also provides theadaptability to new services and applications. A SSS architecture-based smart campus system was developed and deployed. Evaluation experiments of the proposed smart campus system demonstrate the SSS's advantages over the existing counterparts, and verify the effectiveness of the proposed architecture. | yongan guo hongbo zhu longxiang yang | 2017 | China Communications2017，14，3： | 6 |
| 4 | Conformable,programmable and step-linear sensor array for large-range wind pressure measurement on curved surface显示文摘The wind pressure measurement,especially on curved surfaces is imperative in revealing flow characteristics.The flexible sensor with high linear sensitivity over large pressure range is still a significant challenge,especially for commutatively positive and negative pressure measurement.Here,we propose a conformable,range-programmable capacitive sensor that can extremely extend the measuring range but with high linear sensitivity.The key point is to precisely control the reference pressure of the flexible capacitive sensor array through microchannel network.The proposed sensor with reference pressure 0 kPa keeps stable at a highly-linear sensitivity of 0.28 kPa-1 in an initial measurement regime from 0 to 3 kPa,beyond which the linearity changes significantly.Via the tunable reference pressure,the linear ranges can be customized arbitrarily according to different flight conditions and measured positions,but without any deterioration of sensitivity.The theoretical model is built for the flexible capacitive sensor with tunable reference pressure,agreeing well with the experimental and finite element method results.Additionally,the bending effect is discovered when the flexible sensor is conformed on curved surfaces.This surface-mounted sensor skin is tested on a plate and is integrated with acquisition circuits on a standard airfoil NACA0012 in a wind tunnel and compares with the standard destructive method of pressure taps.It shows great potential applications in measuring wind pressure on curved surfaces,such as for'Fly-by-Feel'of unmanned aerial vehicles and wind tunnel test. | XIONG WenNan GUO DongLiang YANG ZhaoXi ZHU Chen HUANG YongAn | 2020 | Science China(Technological Sciences)2020，63，10： | 5 |
| 5 | The relationship between dietary methionine and growth,digestion,absorption,and antioxidant status in intestinal and hepatopancreatic tissues of sub-adult grass carp(Ctenopharyngodon idella)显示文摘Background: Methionine is an essential amino acid for fish. The present study was conducted to investigate the effects of dietary methionine on growth performance, digestive and absorptive ability, as well as antioxidant capacity in the intestine and hepatopancreas of sub-adult grass carp(Ctenopharyngodon idella).Results: Dietary methionine deficiency significantly decreased percentage weight gain(PWG), feed intake, feed efficiency and protein efficiency ratio, as well as activities of hepatopancreatic glutamate-oxaloacetate transaminase and muscle glutamate-pyruvate transaminase in sub-adult grass carp(P < 0.05). Furthermore, methionine deficiency significantly reduced activities of trypsin, lipase and amylase in the intestine, Na^+/K^+-ATPase, alkaline phosphatase and γ-glutamyl transpeptidase in three intestinal segments, and creatine kinase(CK) in the proximal intestine(P < 0.05). However, an unexplained and significant increase in CK activity in the mid intestine was associated with dietary methionine deficiency. Malondialdehyde and protein carbonyl contents in the intestine and hepatopancreas were significantly increased by methionine deficiency(P < 0.05), whereas anti-hydroxyl radical capacity in the hepatopancreas and intestine, and anti-superoxide anion capacity in the intestine, were significantly decreased by methionine deficiency(P < 0.05). Moreover, methionine deficiency significantly decreased superoxide dismutase and glutathione reductase activities, glutathione contents in the hepatopancreas and intestine, as well as glutathione peroxidase activity in the intestine(P < 0.05), whereas it significantly increased activities of catalase in the hepatopancreas and glutathione-S-transferase in the hepatopancreas and intestine(P < 0.05).(Continued on next page)(Continued from previous page)Conclusions: The present results demonstrated that dietary methionine deficiency induced poor growth, and decreased digestive and absorptive function and antioxidant capacity in the hepatopancreas and intestine of sub-adult grass carp. Methionine requirements for sub-adult grass carp(450-1, 170 g) based on PWG, intestinal trypsin, and hepatopancreatic anti-hydroxyl radical activities were estimated to be 6.12 g/kg diet(21.80 g/kg protein),6.99 g/kg diet(24.90 g/kg protein) and 5.42 g/kg diet(19.31 g/kg protein), respectively, in the presence of 1.50 g cysteine/kg(5.35 g/kg protein). | Pei Wu Ling Tang Weidan Jiang Kai Hu Yang Liu Jun Jiang Shengyao Kuang ling tang Wuneng Tang Yongan Zhang Xiaoqiu Zhou Lin Feng | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 4 |
| 6 | Service-Oriented Network Virtualization Architecture for Internet of Things显示文摘As a key technology to realize smart services of Internet of Things(Io T),network virtualization technology can support the network diversification and ubiquity,and improve the utilization rate of network resources.This paper studies the service-oriented network virtualization architecture for Io T services.Firstly the semantic description method for Io T services is proposed,then the resource representation model and resource management model in the environment of network virtualization are presented.Based on the above models,the service-oriented virtual network architecture for Io T is established.Finally,a smart campus system is designed and deployed based on the service-oriented virtual network architecture.Moreover,the proposed architecture and models are verified in experiments. | Yongan Guo Hongbo Zhu Longxiang Yang | 2016 | China Communications2016，13，9： | 4 |
| 7 | An Exact Virtual Network Embedding Algorithm Based on Integer Linear Programming for Virtual Network Request with Location Constraint显示文摘Network virtualization is known as a promising technology to tackle the ossification of current Internet and will play an important role in the future network area. Virtual network embedding(VNE) is a key issue in network virtualization. VNE is NP-hard and former VNE algorithms are mostly heuristic in the literature.VNE exact algorithms have been developed in recent years. However, the constraints of exact VNE are only node capacity and link bandwidth.Based on these, this paper presents an exact VNE algorithm, ILP-LC, which is based on Integer Linear Programming(ILP), for embedding virtual network request with location constraints. This novel algorithm is aiming at mapping virtual network request(VNR) successfully as many as possible and consuming less substrate resources.The topology of each VNR is randomly generated by Waxman model. Simulation results show that the proposed ILP-LC algorithm outperforms the typical heuristic algorithms in terms of the VNR acceptance ratio, at least 15%. | Zeheng Yang Yongan Guo | 2016 | China Communications2016，13，8： | 3 |
| 8 | Growth,digestive and absorptive capacity and antioxidant status in intestine and hepatopancreas of sub-adult grass carp Ctenopharyngodonidella fed graded levels of dietary threonine显示文摘Background:This study was carried out to investigate effects of threonine levels on growth,digestive and absorptive capacity and antioxidant status in intestine and hepatopancreas of sub-adult grass carp(Ctenopharyngodonidella).Results:Weight gain,specific growth rate,feed intake and feed efficiency were significantly improved by dietary threonine(P<0.05).Intestinal activities of trypsin,chymotrypsin,alpha-amylase,lipase,alkaline phosphatase,y-glutamyl transpeptidase and creatine kinase took the similar trends.Contents of malondialdehyde and protein carbonyl in intestine and hepatopancreas were significantly decreased by dietary optimal threonine supplementation(P<0.05).Anti-superoxide anion capacity,anti-hydroxyl radical capacity,glutathione content and activities of superoxide dismutase,catalase and glutathione-S-transferase in intestine and hepatopancreas were enhanced by dietary threonine(P< 0.05).Conclusions:Dietary threonine could improve growth,enhance digestive and absorptive capacity and antioxidant status in intestine and hepatopancreas of sub-adult grass carp.The dietary threonine requirement of sub-adult grass carp(441.9-1,013.4 g) based on weight gain was 11.6 g/kg diet or 41.5 g/kg of dietary protein by quadratic regression analysis. | Yang Hong Weidan Jiang Shengyao Kuang Kai Hu Ling Tang Yang Liu Jun Jiang Yongan Zhang Xiaoqiu Zhou Lin Feng | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 3 |
| 9 | Moderate sewage sludge biochar application on alkaline soil for corn growth:a field study显示文摘In view of the risks induced by the inhibitory effects of applying impracticably large amounts of sewage sludge biochar(SSB)to the alkaline soil,this field study investigated the influence of moderate biochar amendments(0,1500,4500,and 9000 kg/hm2)on corn growth,alkaline soil properties,and the uptake of potentially toxic elements(PTEs).The results showed that applying more SSB would decrease the ammonium nitrogen concentration and increase the available phosphorus and potassium concentrations,which inhibited corn plant growth because of high background nutrient levels of the alkaline soil.When the alkaline soil was amended with 1500 kg/hm2 SSB,the dry weight of 100 niblets increased from 32.11 g in the control to 35.07 g.There was no significant variation in the total concentration of PTEs in the soil.The concentrations of Mn,Ni,Cu,and Zn in niblets decreased from 5.54,0.83,2.26,and 27.15 mg/kg in the control to 4.47,0.62,1.30,and 23.45 mg/kg,respectively.Accordingly,the health risk from corn consumption was significantly reduced.Furthermore,the combination of SSB and fertilizer improved corn growth and reduced the risk of consumption of PTEs.Therefore,considering the increase in corn fruit yield and the decrease in consumption risk,applying 1500 kg/hm2 of biochar to alkaline soils is a realistically achievable rate,which can broaden the utilization of SSB for remediation of different types of soil. | Shengyu Xie Guangwei Yu Ruqing Jiang Jianli Ma Xiaofu Shang Gang Wang Yin Wang Yongan Yang Chunxing Li | 2021 | Biochar2021，3，2： | 2 |
| 10 | Ghosting theoretical model of single photon counting imagers with Vernier anode显示文摘In this paper, the distribution of the phase deviations for the ghosting of Vernier based imagers is provided. The equality of the phase errors is shown. The relationship between the charge noise amplitude of electrodes and the total charge noise amplitude is provided. The relationship between the phase error and the total charge noise amplitude is also provided, which reveals the magnitude of 10 4 electrons for the ghosting occurrence threshold for the 4-coarse-pixel anode imagers. | YANG Hao ZHAO BaoSheng YAN QiuRong LIU YongAn | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，8： | 2 |
| 11 | Decoding algorithms of single photon counting imager based on two-dimensional Vernier anodes显示文摘The decoding algorithms of two-dimensional Vernier anodes are deduced theoretically.The precision of decoding and uniqueness of encoding are proved.The influencing factors of detection sensitivity and spatial resolution are discussed.The single photon imaging system is constructed,and the two-dimensional Vernier collector is fabricated.The image of the ultra-weak emission source is reconstructed.The spatial resolution of the system is about 100μm. | YANG Hao ZHAO BaoSheng YAN QiuRong LIU YongAn HU HuiJun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 2 |
| 12 | A new method for measuring solvent diffusivity in heavy oil by dynamic pendant drop shape analysis (DPDSA) 显示文摘 | Chaodong Yang Yongan Gu | 2006 | SPE842022006，，： | 1 |
| 13 | Interracial interactions between crude oil and CO2 under reservoir conditions 显示文摘 | Yang Daoyong Gu Yongan | 2005 | Petroleum Science and Technology2005，23，910： | 1 |
| 14 | Interfacial Interactions Between Crude Oil and CO2Under Reservoir Conditions显示文摘 | Yang Daoyong and Gu Yongan | 2005 | Petroleum Science and Technology2005，23，910： | 1 |
| 15 | Identification of heat shock cognate protein 70 gene (Alhsc70) of Apolygus lucorum and its expression in response to different temperature and pesticide stresses显示文摘热吃惊血缘的蛋白质(Hsc70 ) 70 是对环境压力的昆虫的很重要的压力抵抗蛋白质。我们采用了荧光灯即时量的聚合酶链反应和西方污点的技术在 Apolygus 强调 lucorum 在极端温度(4 °C 和 40 °C ) 或 4 杀虫剂下面分析 transcriptional 和 AlHSC70 的翻译表示侧面。结果证明 AlHSC70 的表示被 cyhalothrin 或极其高的温度( 40 °C )显著地在 transcriptional 和翻译层次导致( P < 0.05 ),当 transcriptional 和 AlHSC70 的翻译水平在 chlorpyrifos 或极端冷温度( 4 °C )的处理显著地减少了时( P < 0.05 )。而且在 imidacloprid 或 emamectin 安息香酸盐对待的 Apolygus lucorum 以后, AlHSC70 的表示在 transcriptional 显著地仅仅是起来调整的,铺平(P < 0.05 ) ,尽管在 AlHSC70 的翻译水平显然起来调整。因此,这研究证实 Alhsc70 基因响应温度和杀虫剂压力起了重要作用,特别为 cyhalothrin 或极其高的温度(40 °C ) 。另外,在温度之间的重要多项式回归关联和 Alhsc70 表示水平在所有美女和成年阶段被显示出(P < 0.01 ) ,显示温度是一个重要因素影响 Alhsc70 的相对表示。 | Yang Sun Jing Zhao Yang Sheng Ying-Fang Xiao Yong-Jun Zhang Li-Xin Bai Yongan Tan Liu-Bin Xiao Guang-Chun Xu | 2016 | Insect Science2016，23，1： | 1 |
| 16 | Flexible electronics manufacturing technology and equipment显示文摘Flexible electronics such as mechanically compliant displays,sensors and solar cells,have important applications in the fields of energy,national defence and biomedicine,etc.Various types of flexible electronics have been proposed or developed by the improvements in structural designs,material properties and device integrations.However,the manufacturing of flexible electronics receives little attention,which limits its mass production and industrialization.The increasing demands on the size,functionality,resolution ratio and reliability of flexible electronics bring several significant challenges in their manufacturing processes.This work aims to report the state-of-art technologies and applications of flexible electronics manufacturing.Three key technologies including electrohydrodynamic direct-writing,flip chip and automatic optical inspection are highlighted.The mechanism and developments of these technologies are discussed in detail.Based on these technologies,the present work develops three kinds of manufacturing equipment,i.e.,inkjet printing manufacturing equipment,robotized additive manufacturing equipment,and roll-to-roll manufacturing equipment.The advanced manufacturing processes,equipment and systems for flexible electronics pave the way for applications of new displays,smart sensing skins and epidermal electronics,etc.By reviewing the developments of flexible electronics manufacturing technology and equipment,it can be found that the existing advances greatly promote the applications and commercialization of flexible electronics.Since flexible electronics manufacturing contains many multi-disciplinary problems,the current investigations are confronted with great challenges.Therefore,further developments of the reviewed manufacturing technology and equipment are necessary to break the current limitations of manufacturing resolution,efficiency and reliability. | YIN ZhouPing HUANG YongAn YANG Hua CHEN JianKui DUAN YongQing CHEN Wei | 2022 | Science China(Technological Sciences)2022，65，9： | 1 |
| 17 | Stress evolution with time and space during mining of a coal seam显示文摘 | YANG Wei L1N Baiquan QU Yongan | 2011 | International Journal of Rock Mechanics and Mining Sciences2011，48，： | 1 |
| 18 | Cornparison of three different interface mass transfer models used in the experimental measurement of solvent diffusivity in heavy oil显示文摘 | Tharanivasan AK Yang Chaodong Gu Yongan | 2004 | Journal of Petroleum Science and Engineering2004，44，4： | 1 |
| 19 | Real-time adaptive particle image velocimetry for accurate unsteady flow field measurements显示文摘Almost all conventional open-loop particle image velocimetry(PIV) methods employ fixed-interval-time optical imaging technology and the time-consuming cross-correlation-based PIV measurement algorithm to calculate the velocity field.In this study,a novel real-time adaptive particle image velocity(RTA-PIV) method is proposed to accurately measure the instantaneous velocity field of an unsteady flow field.In the proposed closed-loop RTA-PIV method,a new correlation-filter-based PIV measurement algorithm is introduced to calculate the velocity field in real time.Then,a Kalman predictor model is established to predict the velocity of the next time instant and a suitable interval time can be determined.To adaptively adjust the interval time for capturing two particle images,a new high-speed frame-straddling vision system is developed for the proposed RTA-PIV method.To fully analyze the performance of the RTA-PIV method,we conducted a series of numerical experiments on ground-truth image pairs and on real-world image sequences. | OUYANG ZhenXing YANG Hua LU Jin HUANG YongAn YIN ZhouPing | 2022 | Science China(Technological Sciences)2022，65，9： | 1 |
| 20 | Radial position-controlled doping in CdS/ZnS core/ shell nanocrystals 显示文摘 | YANG Yongan CHEN Ou ANGERHOFER A | 2006 | Journal of the American Chem- ical Society2006，128，12： | 1 |
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