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| 1 | Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: Case report and literature review显示文摘Acquired immune deficiency syndrome (AIDS)-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the highly active anti-retroviral therapy (HAART) era. Recently, rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma. Here, we report a rare case of gastrointestinal (GI)-ARL with MYC rearrangements and coinfected with Epstein-Barr virus (EBV) infection presenting with various endoscopic findings. A 38-yearold homosexual man who presented with anemia and was diagnosed with an human immunodeficiency virus infection for the first time. GI endoscopy revealed multiple dish-like lesions, ulcerations, bloody spots, nodular masses with active bleeding in the stomach, erythematous flat lesions in the duodenum, and multiple nodular masses in the colon and rectum. Magnified endoscopy with narrow band imaging showed a honeycomb-like pattern without irregular microvessels in the dish-like lesions of the stomach. Biopsy specimens from the stomach, duodenum, colon, and rectum revealed diffuse large B-cell lymphoma concomitant with EBV infection that was detected by high tissue EBV-polymerase chain reaction levels and Epstein-Barr virus small RNAs in situ hybridization. Fluorescence in situ hybridization analysis revealed a fusion between the immunoglobulin heavy chain (IgH) and c-MYC genes, but not between the IgH and BCL2 loci. After 1-mo of treatment with HAART and R-CHOP, endoscopic appearance improved remarkably, and the histological features of the biopsy specimens revealed no evidence of lymphoma. However, he died from multiple organ failure on the 139 th day after diagnosis. The cause of his poor outcome may be related to MYC rearrangement. The GI tract involvement in ARL is rarely reported, and its endoscopic findings are various and may be different from those in non-AIDS GI lymphoma; thus, we also conducted a literature review of GI-ARL cases. | Shohei Tanaka Naoyoshi Nagata Sohtaro Mine Toru Igari Taiichiro Kobayashi Jun Sugihara Haruhito Honda Katsuji Teruya Yoshimi Kikuchi Shinichi Oka Naomi Uemura | 2013 | World Journal of Gastroenterology2013，19，29： | 3 |
| 2 | Effects of high-molucular-weight sodium hyalumnate on experimental osteoarthrosis induced by resection of rabbit anterior cruciate ligament显示文摘 | Yoshimi T Kikuchi T Obara L | 1994 | Clin Orthop Relat Res1994，，298： | 1 |
| 3 | Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament 显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orthop Relat Res1994，29，8： | 1 |
| 4 | Effects of high-mo-lecular-weight sodium hyaluronate on experimental cruciate ligament显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orhtop Related Res1994，298，： | 1 |
| 5 | Myeloid/natural killer cell pre- cursor acute leukemia diagnosed by cell marker analysis 显示文摘 | Miura R Yoshimi M Kikuchi Y | 2013 | Rinsho Ketsueki2013，54，57： | 1 |
| 6 | Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orthop Relat Res1994，298，： | 1 |
| 7 | Temperature and humidity dependence of the electrode polarization in intermediate-temperature fuel cells employing CsH2PO4/SiP2O7-based composite electrolytes显示文摘 | Yoshimi S Matsui T Kikuchi R | 2008 | J Power Sources2008，179，2： | 1 |
| 8 | Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orthop Related Res1994，298，： | 1 |
| 9 | Effects of high-molecular weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament 显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orthop Relat Res1994，，298： | 1 |
| 10 | Characterization of a second ly-sine decarboxylase isolated from Escherichia coli 显示文摘 | Yoshimi kikuchi Hiroyuki kojim | 1997 | Jouranal ofbacteriology1997，179，14： | 1 |
| 11 | Comparison of neuropathic pain and neuronal apoptosis following nerve root or spinal nerve compression显示文摘 | Miho Sekiguchi Yasufumi Sekiguchi Shin-ichi Konno Hideo Kobayashi Yoshimi Homma Shin-ichi Kikuchi | 2009 | European Spine Journal2009，，12： | 1 |
| 12 | Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthritis induced by the resection of rabbit anterior cruciate ligament显示文摘 | YOSHIMI T KIKUCHI T OBARA T | 1994 | Clin Orthop1994，298，： | 1 |
| 13 | Production of Chryseobacterium proteolyticum protein-glutaminase using the twin-arginine translocation pathway in Corynebacterium glutamicum显示文摘 | Yoshimi Kikuchi Hiroshi Itaya Masayo Date Kazuhiko Matsui Long-Fei Wu | 2008 | Applied Microbiology and Biotechnology2008，，1： | 1 |
| 14 | Effects of high-molecularweight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament 显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orthop Relat Res1994，298，： | 1 |
| 15 | Effects of high molecular weight sodium hyaluronate on experimental osteoarthritis induced by the resection of rabbit anterior cruciate ligament显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orthop1994，298，： | 1 |
| 16 | Effects of high- molecular-weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orthop Relat Res1994，298，： | 1 |
| 17 | Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthrosis induced by the resec- tion of rabbit anterior cruciate ligament 显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orthop Relat Res1994，，298： | 1 |
| 18 | Effects of high-too-lecular- weight sodium hyaluronate on experimental osteoar-throsis induced by the resection of rabbit anterior cruciate lig-ament 显示文摘 | Yoshimi T Kikuchi T Obara T | 1994 | Clin Orthop Relat Res1994，298，： | 1 |
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