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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | QTL analysis of rice low temperature germinability显示文摘A double haploid population, derived from anther culture of F, hybrid between a typical indica and a japonica (ZYQ8/JX17), has been used to investigate the low temperature germinability (LTG) at 15℃. The low temperature germinability of two parents was significantly different. In 6-11 d, the germination percentage of ZYQ8 was higher than that of JX17. In 12-16 d, the germination percentage of JX17 was higher than that of ZYQ8. The quantitative trait loci (QTLs) of every day for low temperature germinabilityhave been mapped based on a molecular linkage map constructed from this population. In 8-11 d, qLTG-9 was identified in C397B-RZ617B on chromosome 9, the additive effect was positive, showing that, the allele from JX17 could increase low temperature germinability. In 12-16 d, qLTG-4 was mapped between RG908 and CT563 on chromosome 4, the additive effect was negative, showing that the allele from ZYQ8 could increase low temperature germinability. These two QTLs were detected at different stages, | TENG Sheng ZENG Dali QIAN Qian Kunihifo Yasufumi HUANG Danian Zhu Lihuang | 2001 | Chinese Science Bulletin2001，46，21： | 14 |
| 3 | Reduced hemoglobin and increased C-reactive protein are associated with upper gastrointestinal bleeding显示文摘AIM: To investigate the early upper gastrointestinal endoscopy(endoscopy) significantly reduces mortality resulting from upper gastrointestinal(GI) bleeding. METHODS: Upper GI bleeding was defined as 1a, 1b, 2a, and 2b according to the Forrest classification. The hemoglobin(Hb), and C-reactive protein(CRP) were examined at around the day of endoscopy and 3 mo prior to endoscopy. The rate of change was calculated as follows:(the result of blood examination on the day of endoscopy- the results of blood examination 3 mo prior to endoscopy)/(results of blood examination 3 mo prior to endoscopy). Receiver operating characteristic curves were created to determine threshold values. RESULTS: Seventy-nine men and 77 women were enrolled. There were 17 patients with upper GI bleeding: 12 with a gastric ulcer, 3 with a duodenal ulcer, 1 with an acute gastric mucosal lesion, and 1 with gastric cancer. The area under the curve(AUC), threshold, sensitivity, and specificity of Hb around the day of endoscopy were 0.902, 11.7 g/dL, 94.1%, and 77.1%, respectively, while those of CRP were 0.722, 0.5 mg/dL, 70.5%, and 73%, respectively. The AUC, threshold, sensitivity, and specificity of the rate of change of Hb were 0.851,-21.3%, 76.4%, and 82.6%, respectively, while those of CRP were 0.901, 100%, 100%, and 82.5%, respectively. CONCLUSION: Predictors for upper GI bleeding were Hb < 11.7 g/dL, reduction rate in the Hb > 21.3% and an increase in the CRP > 100%, 3 mo before endoscopy. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Akira Togawa Yoshinori Shirai Noboru Ichiki Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Makoto Sueishi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 4 | Patient characteristics with high or low blood urea nitrogen in upper gastrointestinal bleeding显示文摘AIM: To examine characteristics of patients with blood urea nitrogen(BUN) levels higher and lower than the normal limit.METHODS: Patient records between April 2011 and March 2014 were analyzed retrospectively. During this time, 3296 patients underwent upper endoscopy. In total, 50 male(69.2 ± 13.2 years) and 26 female(72.3 ± 10.2 years) patients were assessed. Patients were divided into two groups based on BUN levels: higher than the normal limit(21.0 mg/d L)(H) and lower thanthe normal limit(L). One-way analysis of variance was performed to reveal differences in the variables between the H and L groups. Fisher's exact test was used to compare the percentage of patients with gastric ulcer or gastric cancer in the H and L groups.RESULTS: White blood cell count was higher in the H group than in the L group(P = 0.0047). Hemoglobin level was lower in the H group than in the L group(P = 0.0307). Glycated hemoglobin was higher in the H group than in the L group(P = 0.0264). The percentage of patients with gastric ulcer was higher in the H group(P = 0.0002). The H group contained no patients with gastric cancer.CONCLUSION: Patients with BUN ≥ 21 mg/d L might have more severe upper gastrointestinal bleeding. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki Ishige | 2015 | World Journal of Gastroenterology2015，21，24： | 8 |
| 5 | Sonoporation:Gene transfer using ultrasound显示文摘Genes can be transferred using viral or non-viral vectors.Non-viral methods that use plasmid DNA and short interference RNA(si RNA)have advantages,such as low immunogenicity and low likelihood of genomic integration in the host,when compared to viral methods.Non-viral methods have potential merit,but their gene transfer efficiency is not satisfactory.Therefore,new methods should be developed.Low-frequency ultrasound irradiation causes mechanical perturbation of the cell membrane,allowing the uptake of large molecules in the vicinity of the cavitation bubbles.The collapse of these bubbles generates small transient holes in the cell membrane and induces transient membrane permeabi-lization.This formation of small pores in the cell membrane using ultrasound allows the transfer of DNA/RNA into the cell.This phenomenon is known as sonoporation and is a gene delivery method that shows great promise as a potential new approach in gene therapy.Microbubbles lower the threshold of cavity formation.Complexes of therapeutic genes and microbubbles improve the transfer efficiency of genes.Diagnostic ultrasound is potentially a suitable sonoporator because it allows the real-time monitoring of irradiated fields. | Minoru Tomizawa Fuminobu Shinozaki Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Makoto Sueishi | 2013 | World Journal of Methodology2013，3，4： | 4 |
| 6 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Tadashi Yoshino Shigeo Nakamura Shigeyuki Kawa Hideaki Hamano Terumi Kamisawa Toru Shimosegawa Akira Shimatsu Seiji Nakamura Tetsuhide Ito Kenji | 2012 | Modern Rheumatology2012，，1： | 4 |
| 7 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Takayuki Sumida Tsuneyo Mimori Yoshiya Tanaka Kazuo Tsubota Tadashi Yoshino Shigeyuki Kawa Ritsuro Suzuki Tsutomu Takegami Naohisa Tomosugi Nozo | 2012 | Modern Rheumatology2012，，1： | 4 |
| 8 | Periostin as a Novel Factor Responsible for Ventricular Dilation显示文摘 | Naruto Katsuragi Ryuichi Morishita Noriko Nakamura Tayehito Ochiai Yoshiaki Taniyama Yasuhiro Hasegawa Kayoko Kawashima Yasufumi Kaneda Toshio Ogihara Keijiro Sugimura | 2004 | Circulation2004，，13： | 2 |
| 9 | QTL analysis of leaf photosynthetic rate and related physiological traits in rice(Oryza sativa L.)显示文摘Photosynthesis is one of the most important factors that influence the biomass andyield.Recently,more attention has been paid to genetic study on rice photo-synthesis and rice breeding for the physiological traits related to high efficientphotosynthesis.Chlorophyll content,stomatal resistance,and transpiration ratewere very important physiological traits related to photosynthesis.But until now,no genetic study on these traits has been reported.A DH population derived fromanther culture of ZYQ8/JX17,a typical indica/japonica hybrid was developed, | TENG Sheng, QIAN Qian, ZENG Dali, Yasufumi Kunihiro, Hiroshi Fujimoto, HUANG Daman, and ZHU Lihuang, Key Lab for Rice Biology, CNRRI, Hangzhou 310006 Inst of Genetics and Development Biology, the Chinese Academy of Sciences, Beijing 100101 College of Life Sci, Zhejiang Univ, Hangzhou 310029, China Japan International Res Center for Agri Sci, Tsukuba, Japan | 2002 | Chinese Rice Research Newsletter2002，10，3： | 2 |
| 10 | Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding显示文摘AIM: To distinguish upper from lower gastrointestinal(GI) bleeding. METHODS: Patient records between April 2011 and March 2014 were analyzed retrospectively(3296 upper endoscopy, and 1520 colonoscopy). Seventysix patients had upper GI bleeding(Upper group) and 65 had lower GI bleeding(Lower group). Variables were compared between the groups using one-way analysis of variance. Logistic regression was performed to identify variables significantly associated with the diagnosis of upper vs lower GI bleeding. Receiveroperator characteristic(ROC) analysis was performed to determine the threshold value that could distinguish upper from lower GI bleeding. RESULTS: Hemoglobin(P = 0.023), total protein(P = 0.0002), and lactate dehydrogenase(P = 0.009) were significantly lower in the Upper group than in the Lower group. Blood urea nitrogen(BUN) was higher in the Upper group than in the Lower group(P = 0.0065). Logistic regression analysis revealed that BUN was most strongly associated with the diagnosis of upper vslower GI bleeding. ROC analysis revealed a threshold BUN value of 21.0 mg/d L, with a specificity of 93.0%.CONCLUSION: The threshold BUN value for distinguishing upper from lower GI bleeding was 21.0 mg/d L. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki Ishige | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 11 | LDL Cholesterol and the Development of Stroke Subtypes and Coronary Heart Disease in a General Japanese Population The Hisayama Study显示文摘 | Tsuyoshi Imamura Yasufumi Doi Hisatomi Arima | 2009 | Stroke February2009，40，2： | 1 |
| 12 | Novel ferroelectric liquid crystal mode for active matrix liquid crystal display using cholesteric chiral smectic phase transition material显示文摘 | YASUFUMI A TAKESHI T MASAHIRO T | 1999 | Jpn J Appl Phys1999，38，10： | 1 |
| 13 | Involvement of gap junctions in tumor suppression:analysis of genetically-manipulated mice显示文摘 | YASUFUMI O MARIA L KOHJI Y | 2001 | Mutation Research2001，477，2： | 1 |
| 14 | Synthesis of wholly alicyclic polyimides from N-silylated alicyclic diamines and alicyclic dianhydrides显示文摘 | Yasufumi Watanabe Yoshimasa Sakai Yuji Shibaski | | 0，，： | 1 |
| 15 | X-ray Debye temperature and Grüneisen constant of NpO 2显示文摘 | Hiroyuki Serizawa Yasuo Arai Masahide Takano Yasufumi Suzuki | 1999 | Journal of Alloys and Compounds1999，，1： | 1 |
| 16 | Development of wire harness modules 显示文摘 | Osada Yasufumi Nakano Hiroyuki | 1999 | Furukawa Review1999，18，： | 1 |
| 17 | Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment显示文摘 | Yusuke Sato Yasufumi Goto Norihiko Narita Dave S.B. Hoon | 2009 | Cancer Microenvironment2009，，1： | 1 |
| 18 | QTL analysis of rice low temperature germinability显示文摘 | Teng S Zeng D L Qian Q Yasufumi K Huang D L Zhu L H | 2001 | Chinese Sci Bull2001，46，21： | 1 |
| 19 | Expression analyses of vasohibin as a novel angiogenesis inhibitor in cervical cancer显示文摘 | Kousuke Yoshinaga Kiyoshi Ito Yasufumi Sato | 2009 | Cancer Res May 12009，69，： | 1 |
| 20 | Poster Presentations Vasohibin,a novel endothelium-derived angiogenesis inhibitor:its expression on ovarian carcinoma in relation to tumor vascularity显示文摘 | Kousuke Yoshinaga Yasufumi Sato | 2007 | Cancer Res May2007，67，： | 1 |
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