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| 1 | Multidisciplinary therapy for treatment of patients with peritoneal carcinomatosis from gastric cancer显示文摘There is no standard treatment for peritoneal carcinomatosis (PC) from gastric cancer.A novel multidisciplinary treatment combining bidirectional chemotherapy [neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS)],peritonectomy,hyperthermic intraperitoneal chemoperfusion (HIPEC) and early postoperative intraperitoneal chemotherapy has been developed.In this article,we assess the indications,safety and eff icacy of this treatment,review the relevant studies and introduce our experiences.The aims of NIPS are stage reduction,the eradication of peritoneal free cancer cells,and an increased incidence of complete cytoreduction (CC-0) for PC.A complete response after NIPS was ob-tained in 15 (50%) out of 30 patients with PC.Thus,a signif icantly high incidence of CC-0 can be obtained in patients with a peritoneal cancer index (PCI) ≤ 6.Using a multivariate analysis to examine the survival benef it,CC-0 and NIPS are identified as significant indicators of a good outcome.However,the high morbidity and mortality rates associated with peritonectomy and perioperative chemotherapy make stringent patient selection important.The best indications for multidisciplinary therapy are localized PC (PCI≤6) from resectable gastric cancer that can be completely removed during a peritonectomy.NIPS and complete cytoreduction are essential treatment modalities for improving the survival of patients with PC from gastric cancer. | Yutaka Yonemura Ayman Elnemr Yoshio Endou Mitsumasa Hirano Akiyoshi Mizumoto Nobuyuki Takao Masumi Ichinose Masahiro Miura | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 27 |
| 2 | Effects of Neoadjuvant Intraperitoneal/Systemic Chemotherapy (Bidirectional Chemotherapy) for the Treatment of Patients with Peritoneal Metastasis from Gastric Cancer显示文摘 | Yutaka Yonemura Ayman Elnemr Yoshio Endou Haruaki Ishibashi Akiyoshi Mizumoto Masahiro Miura Yan Li Lapo Bencini | 2012 | International Journal of Surgical Oncology2012，，： | 2 |
| 3 | Role of MMP-7 in the formation of peritoneal dissemination in gastric cancer显示文摘 | Yutaka Yonemura Yoshio Endou Hideto Fujita Sachio Fushida Etsurou Bandou Keizou Taniguchi Kouichi Miwa Kazuo Sugiyama Takuma Sasaki | 2000 | Gastric Cancer2000，，2： | 2 |
| 4 | Effects of intraoperative chemohyperthermia in patients with gastric cancer with peritoneal dissemination显示文摘 | Yutaka Yonemura Takashi Fujimura Genichi Nishimura Raul Falla Toshiharu Sawa Kanji Katayama Kouichirou Tsugawa Sachio Fushida Itsuo Miyazaki Motohiro Tanaka Yoshio Endou Takuma Sasaki | 1996 | Surgery1996，，4： | 1 |
| 5 | Peritoneal cancer treatment显示文摘 | Yutaka Yonemura Emel Canbay Yoshio Endou Haruaki Ishibashi Akiyoshi Mizumoto Masahiro Miura Yan Li Yan Liu Kazuyoshi Takeshita Masumi Ichinose Nobuyuki Takao Masamitsu Hirano Shouzou Sako Gorou Tsukiyama | 2014 | Expert Opinion on Pharmacotherapy2014，，5： | 1 |
| 6 | Comprehensive treatment for the peritoneal metastasis from gastric cancer显示文摘Recently, a novel comprehensive treatment consisting of cytoreductive surgery(CRS) and perioperative chemotherapy(POC) was developed for the treatment of peritoneal metastasis(PM) with a curative intent. In the treatment, the macroscopic disease is completely removed by the peritonectomy techniques in combination with POC. This article reviews the results of the comprehensive treatment for PM from gastric cancer, and verifies the effects of CRS and POC, including neoadjuvant chemotherapy(NAC) and hyperthermic intraoperative intraperitoneal chemotherapy(HIPEC). Completeness of cytoreduction, peritoneal carcinomatosis index(PCI) less than the threshold levels after NAC,absence of ascites, cytologic status, pathologic response after NAC are the independent prognostic factors. Among these prognostic factors, PCI threshold level is the most valuable independent prognostic factor. After staging laparoscopy, patients with PM from gastric cancer are recommended to treat with NAC before CRS. After NAC, indication for CRS is determined by laparoscopy. The indications of the comprehensive treatment are patients with PCI less than the threshold levels, negative cytology, and responders after NAC. Patients satisfy these factors are the candidates for the CRS and HIPEC. | Yutaka Yonemura Emel Canbay Yoshio Endou Haruaki Ishibashi Akiyosi Mizumoto Yan Li Yang Liu Kazuyoshi Takeshita Masumi Ichinose Nobuyuki Takao Takuya Saitou Kousuke Noguchi Masamitu Hirano Oliver Glehen Bjorn Br?cher Paul H Sugarbaker | 2015 | World Journal of Surgical Procedures2015，5，2： | 1 |
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