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| 1 | Protective effect of Yiguanjian decoction against DNA damage on concanavalin A-induced liver injury mice model显示文摘OBJECTIVE:To investigate the inhibitory effect of Yiguanjian decoction(YD) on DNA damage in Concanavalin A(Con A)-induced liver injury mice model and to explain the possible mechanism.METHODS:Totally 120 male BALB/c mice were randomly divided into 6 groups,20 mice each:normal group,model group,Bifendate group,YD low dose group,YD middle dose group and YD high dose group.Except normal group,liver injury model induced by Con A was established.While modeling,each mouse in YD group was given YD(0.4 m L/20 g per day) by intragastric administration(0.13 g YD for YD low dose group;0.26 g for YD middle dose group;0.52 g for YD high dose group).Bifendate group was given Bifendate(0.2 gnd model·kg-1 grou·d-1) by gavage.Normal group ap were fed with same volume of physiological saline daily.After 8 weeks,the serum alanine transaminase(ALT)and aspartate transaminase(AST) were tested.The hematoxylin-eosin staining was used to evaluate the grade of liver inflammation and liver fibrosis stage.Hepatocellular DNA damage was detected by single cell gel electrophoresis technology.The protein expression of tumor necrosis factor-α(TNF-α),Bax and Mut T Homolog 1(MTH1) was detected by western blotting and enzyme linked immunosorbent assay.Bax m RNA and MTH1 m RNA were detected by Real-time Polymerase Chain Reaction(PCR).RESULTS:YD can improve the degree of liver inflammation and fibrosis in the liver of chronic hepatitis mice,the dose effect relationship is remarkable(P < 0.05).YD can reduce liver cell DNA damage.The difference between YD middle dose group and model group was statistically significant(P < 0.05).YD middle dose group had decreased the protein expression of TNF-α in the mice liver of immunological liver injury(P < 0.05).YD can increase the protein expression of Bax(P < 0.05).Compared with normal group,the protein expression of MTH1 was decreased(P < 0.05),but there was no statistical significance between YD group and model group(P >0.05).YD can increase the m RNA expression of Bax and MTH1(both P < 0.05).CONCLUSION:YD can effectively inhibit the DNA damage in immunological liver injury mice,the mechanism may be that it can decrease the TNF-αand increase the Bax and MTH1 expression. | Tian Mengxi Liu Wenlan You Hongjie Zhao Qingzhou Ouyang Luodan Gao Biane Zhang Xin Che Niancong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 7 |
| 2 | Changes in the activities of pro- and anti-oxidant enzymes in peach fruit inoculated with Cryptococcus laurentii or Penicillium expansum at 0 or 20 °C显示文摘 | You Sheng Wang Shi Ping Tian Yong Xu Guo Zheng Qin Hongjie Yao | 2004 | Postharvest Biology and Technology2004，，1： | 1 |
| 3 | Engineering porosity into trimetallic PtPdNi nanospheres for enhanced electrocatalytic oxygen reduction activity显示文摘Platinum(Pt)-based multi-metallic nanostructures show great promise as electrocatalysts for the oxygen reduction reaction(ORR) in fuel cell cathodes. Herein, we report a simple, one-step surfactant-directed synthetic strategy to directly synthesize tri-metallic PtPdNi mesoporous nanospheres(PtPdNi MNs) in a high yield. The synthesis could be accomplished in aqueous solution at mild reaction temperature(40C)without needing any organic solvent, yielding well-dispersed PtPdNi MNs with uniform shape and narrow size distribution. Benefitting from their unique mesoporous and highly open structure and tri-metallic composition, the as-synthesized PtPdNi MNs demonstrate superior catalytic activity and stability for ORR in acidic solution in comparison with PtPdNi nanodendrites(PtPdNi NDs), PtPd MNs and commercial Pt/C catalyst. The present approach may open a reliable path to the design of advanced electrocatalysts with desired performance. | Chunjie Li You Xu Yinghao Li Hongjie Yu Shuli Yin Hairong Xue Xiaonian Li Hongjing Wang Liang Wang | 2018 | Green Energy & Environment2018，3，4： | 1 |
| 4 | Low-content Pt-triggered the optimized d-band center of Rh metallene for energy-saving hydrogen production coupled with hydrazine degradation显示文摘Utilizing the hydrazine-assisted water electrolysis for energy-efficient hydrogen production shows a promising application, which relies on the development and design of efficient bifunctional electrocatalysts. Herein, we reported a low-content Pt-doped Rh metallene(Pt-Rhene) for hydrazine-assisted water electrolysis towards energy-saving hydrogen(H_(2)) production, where the ultrathin metallene is constructed to provide enough favorable active sites for catalysis and improve atom utilization.Additionally, the synergistic effect between Rh and Pt can optimize the electronic structure of Rh for improving the intrinsic activity. Therefore, the required overpotential of Pt-Rhene is only 37 mV to reach a current density of-10 mA cm^(-2) in the hydrogen evolution reaction(HER), and the Pt-Rhene exhibits a required overpotential of only 11 mV to reach a current density of 10 mA cm^(-2) in the hydrazine oxidation reaction(HzOR). With the constructed HER-HzOR two-electrode system, the Pt-Rhene electrodes exhibit an extremely low voltage(0.06/0.19/0.28 V) to achieve current densities of 10/50/100 mA cm^(-2) for energy-saving H_(2) production, which greatly reduces the electrolysis energy consumption. Moreover,DFT calculations further demonstrate that the introduction of Pt modulates the electronic structure of Rh and optimizes the d-band center, thus enhancing the adsorption and desorption of reactant/intermediates in the electrocatalytic reaction. | Qiqi Mao Wenxin Wang Kai Deng Hongjie Yu Ziqiang Wang You Xu Xiaonian Li Liang Wang Hongjing Wang | 2023 | Journal of Energy Chemistry2023，，10： | 1 |
| 5 | FOLR1-induced folate deficiency reduces viral replication via modulating APOBEC3 family expression显示文摘Folate receptor alpha(FOLR1)is vital for cells ingesting folate(FA).FA plays an indispensable role in cell pro-liferation and survival.However,it is not clear whether the axis of FOLR1/FA has a similar function in viral replication.In this study,we used vesicular stomatitis virus(VSV)to investigate the relationship between FOLR1-mediated FA deficiency and viral replication,as well as the underlying mechanisms.We discovered that FOLR1 upregulation led to the deficiency of FA in HeLa cells and mice.Meanwhile,VSV replication was notably sup-pressed by FOLR1 overexpression,and this antiviral activity was related to FA deficiency.Mechanistically,FA deficiency mainly upregulated apolipoprotein B mRNA editing enzyme catalytic subunit 3B(APOBEC3B)expression,which suppressed VSV replication in vitro and in vivo.In addition,methotrexate(MTX),an FA metabolism inhibitor,effectively inhibited VSV replication by enhancing the expression of APOBEC3B in vitro and in vivo.Overall,our present study provided a new perspective for the role of FA metabolism in viral infections and highlights the potential of MTX as a broad-spectrum antiviral agent against RNA viruses. | Jing Wu Yajing Han Ruining Lyu Fang Zhang Na Jiang Hongji Tao Qiao You Rui Zhang Meng Yuan Waqas Nawaz Deyan Chen Zhiwei Wu | 2023 | Virologica Sinica2023，38，3： | 0 |
| 6 | MAQMC:Multi-Agent Deep Q-Network for Multi-Zone Residential HVAC Control显示文摘The optimization of multi-zone residential heating,ventilation,and air conditioning(HVAC)control is not an easy task due to its complex dynamic thermal model and the uncertainty of occupant-driven cooling loads.Deep reinforcement learning(DRL)methods have recently been proposed to address the HVAC control problem.However,the application of single-agent DRL formulti-zone residential HVAC controlmay lead to non-convergence or slow convergence.In this paper,we propose MAQMC(Multi-Agent deep Q-network for multi-zone residential HVAC Control)to address this challenge with the goal of minimizing energy consumption while maintaining occupants’thermal comfort.MAQMC is divided into MAQMC2(MAQMC with two agents:one agent controls the temperature of each zone,and the other agent controls the humidity of each zone)and MAQMC3(MAQMC with three agents:three agents control the temperature and humidity of three zones,respectively).The experimental results showthatMAQMC3 can reduce energy consumption by 6.27%andMAQMC2 by 3.73%compared with the fixed point;compared with the rule-based,MAQMC3 andMAQMC2 respectively can reduce 61.89%and 59.07%comfort violation.In addition,experiments with different regional weather data demonstrate that the well-trained MAQMC RL agents have the robustness and adaptability to unknown environments. | Zhengkai Ding Qiming Fu Jianping Chen You Lu Hongjie Wu Nengwei Fang Bin Xing | 2023 | Computer Modeling in Engineering & Sciences2023，，9： | 0 |
| 7 | Estimating Changes in Contact Patterns in China Over the First Year of the COVID-19 Pandemic:Implications for SARS-CoV-2 Spread—Four Cities,China,2020显示文摘Introduction:Previous studies have demonstrated significant changes in social contacts during the firstwave coronavirus disease 2019(COVID-19)in Chinese mainland.The purpose of this study was to quantify the time-varying contact patterns by age in Chinese mainland in 2020 and evaluate their impact on the transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods:Diary-based contact surveys were performed for four periods:baseline(prior to 2020),outbreak(February 2020),post-lockdown(March–May 2020),and post-epidemic(September–November 2020).We built a Susceptible-Infected-Recovered(SIR)model to evaluate the effect of reducing contacts on transmission.Results:During the post-epidemic period,daily contacts resumed to 26.7%,14.8%,46.8%,and 44.2%of the pre-COVID levels in Wuhan,Shanghai,Shenzhen,and Changsha,respectively.This suggests a moderate risk of resurgence in Changsha,Shenzhen,and Wuhan,and a low risk in Shanghai.School closure alone was not enough to interrupt transmission of SARS-CoV-2 Omicron BA.5,but with the addition of a 75%reduction of contacts at the workplace,it could lead to a 16.8%reduction of the attack rate.To control an outbreak,concerted strategies that target schools,workplaces,and community contacts are needed.Discussion:Monitoring contact patterns by age is key to quantifying the risk of COVID-19 outbreaks and evaluating the impact of intervention strategies. | Yuxia Liang Cheng Peng Qian You Maria Litvinova Marco Ajelli Juanjuan Zhang Hongjie Yu | 2023 | China CDC weekly2023，5，5： | 0 |
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