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| 1 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 2 | Variations in paleoproductivity and the environmental implications over the past six decades in the Changjiang Estuary显示文摘Total organic carbon and organic carbon stable isotope, biogenic silica, chlorin were measured from a high resolution sediment core to indicate the variation in paleoproductivity and the environmental implications over the past decades (1942 to 1997) in the Changjiang Estuary. Based on these biomarkers, the shift in the phytoplankton community structure in the past decades was discussed in response to the long-term variations in nutrient concentrations and nutrient ratios. The results showed that the δ 13 C values varied from –26.15‰ to –19.5‰, suggesting the combined organic carbon sources of riverine and marine organisms. Based on the biogenic proxies, paleoproductivity changes were categorized into three stages: low production before 1950; an increase in production with the dominance of diatoms during 1950 to 1980, consistent with increasing of nutrient concentrations; a decrease in production after 1980 when the diatom production decreased while the production of non-silicious phytoplankton increased due to high nutrient inputs, and high N/P and P/Si ratios in the Changjiang Estuary. The sedimentation records also indicated that the riverine organic carbon increased since 1980. | JIN Haiyan CHEN Jianfang WENG Huanxin LI Hongliang ZHANG Weiyan XU Jie BAI Youcheng WANG Kui | 2010 | Acta Oceanologica Sinica2010，29，3： | 8 |
| 3 | Phytoplankton composition and its ecological effect in subsurface cold pool of the northern Bering Sea in summer as revealed by HPLC derived pigment signatures显示文摘CHEMTAX analysis of high-performance liquid chromatography(HPLC) pigment was conducted to study phytoplankton community structure in the northern Bering Sea shelf, where a seasonal subsurface cold pool emerges. The results showed that fucoxanthin(Fuco) and chlorophyll a(Chl a) were the most abundant diagnostic pigments, with the integrated water column values ranging from 141 to 2 160 μg/m2 and 477 to 5 535 μg/m2, respectively. Moreover, a diatom bloom was identified at Sta. BB06 with the standing stock of Fuco up to 9 214 μg/m3. The results of CHEMTAX suggested that the phytoplankton community in the northern Bering Sea shelf was dominated by diatoms and chrysophytes with an average relative contribution to Chl a of 80% and 12%, respectively, followed by chlorophytes, dinoflagellates, and cryptophytes. Diatoms were the absolutely dominant algae in the subsurface cold pool with a relative contribution exceeding 90%, while the contribution of chrysophytes was generally higher in oligotrophic upper water. Additionally, the presence of a cold pool would tend to favor accumulation of diatom biomass and a bloom that occurred beneath the halocline would be beneficial to organic matter sinks, which suggests that a large part of the phytoplankton biomass would settle to the seabed and support a rich benthic biomass. | ZHUANG Yanpei JIN Haiyan LI Hongliang CHEN Jianfang WANG Bin CHEN Fajin BAI Youcheng LU Yong TIAN Shichao | 2014 | Acta Oceanologica Sinica2014，33，6： | 7 |
| 4 | Composition of algal pigments in surface freshen layer after ice melt in the central Arctic显示文摘Seasonal meltwater input creates a thin freshen layer in surface seawater under ice,which largely shifts the algae assemblages.Our recent observation of photosynthetic pigments in the high Arctic showed that ice bottom and 5m of seawater under ice contained relatively high concentration of fucoxanthin,while chlorophyll b and lutein were the major diagnostic pigments in ice-water interface and 0 m of seawater under ice.Additionally,a notable change of dominant phytoplankton occurred in the top 5 m of seawater under ice,from chlorophytes-dominated at surface to diatoms-dominated at 5 m depth,which might attribute to the sharp salinity gradient(salinity from12.5 to 28.1) in the surface seawater under ice.Our results imply that phytoplankton community in surface layer under ice would become more chlorophytes in the future warming Arctic Ocean. | ZHUANG Yanpei JIN Haiyan GU Fan ZHANG Yang BAI Youcheng JI Zhongqiang LU Yong CHEN lianfang | 2017 | Acta Oceanologica Sinica2017，36，8： | 6 |
| 5 | Variations in organic carbon loading of surface sediments from the shelf to the slope of the Chukchi Sea,Arctic Ocean显示文摘The content of organic carbon(OC) normalized to the specific surface area(SSA) of sediment is widely used to trace variations in OC loading(OC/SSA).This study presents observations of OC/SSA of surface sediments collected in the Chukchi Sea,a typical Arctic marginal sea.Shelf sediments exhibit much higher OC/SSA values than slope sediments in the study area.Compared with OC/SSA values reported from the East Siberian Shelf and Mackenzie River,the slope sediments possess lower OC loading.This abrupt decrease in OC/SSA is mostly related to the lower primary production on slope as well as possible oxidization processes.The results of linear regression analysis between OC and SSA indicate a sedimentary source rock for the OC in the Chukchi Sea sediments.Moreover,shelf sediments with low SSA possess a larger rock OC fraction than slope sediments do.The dataset of the present study enables a more thorough understanding of regional OC cycling in the Chukchi Sea. | LI Zhongqiao WANG Xinyi JIN Haiyan JI Zhongqiang BAI Youcheng CHEN Jianfang | 2017 | Acta Oceanologica Sinica2017，36，8： | 6 |
| 6 | Locomotion Performance of the Amphibious Robot on Various Terrains and Underwater with Flexible Flipper Legs显示文摘 | Bin Zhong Youcheng Zhou Xiaoxiang Li Min Xu Shiwu Zhang | 2016 | Journal of Bionic Engineering2016，13，4： | 5 |
| 7 | Analysis of the Tunable Asymmetric Fiber F-P Cavity for Fiber Strain Sensor Edge-Filter Demodulation显示文摘不对称的纤维(Fabry-P | Haotao CHEN Youcheng LIANG | 2014 | Photonic Sensors2014，4，4： | 4 |
| 8 | TARGET AGGREGATION OF SECOND-ORDER MULTI-AGENT SYSTEMS WITH SWITCHING INTERCONNECTION显示文摘在这份报纸,目标聚集为由秒顺序代理人和多重领导人组成的一个多代理人系统被调查。足够的条件被建议让代理人接近这些动人的领导人跨越的目标集合。与交换互联拓扑学上的条件,所有活动代理人能 asymptotically 追踪多重动人的领导人与围住的错误指定的动态目标集合。而且,与静态的领导人一起的案例的讨论也被给。 | Youcheng LOU Yiguang HONG Guodong SHI | 2012 | Journal of Systems Science & Complexity2012，25，3： | 4 |
| 9 | Concave Cu-Pd bimetallic nanocrystals: Ligand-based Co-reduction and mechanistic study显示文摘The synthesis of highly uniform alloy nanocrystals with a concave feature is desirable for applications in catalysis but is an arduous task. This article proposes an initiative protocol for the fabrication of novel Cu-Pd alloy nanocrystals, wherein the volume of decylamine (DA) in the reaction system was found to greatly influence the formation of different morphologies, including the tetrahedron (TH), concave tetrahedron (CTH), rhombohedral-tetrapod (RTP), and tetrapod (TP). The alloy structure of the products arises from the coordination interaction between the DA and metal ions, which affects the reduction potential of Cu and Pd species, and thus yields co-reduction. Other reaction parameters, such as the type of ligand, amount of reductant, and temperature, were also altered to study the growth mechanism, yielding consistent conclusions in the diffusion-controlled regime. As a catalyst, 48-nm Cu-Pd concave tetrahedral nanocrystals were highly active for the hydrogenation of 3-nitrostyrene and exhibited 〉99.9% chemoselectivity to C=C instead of-NO2. | Lan Zhang Hongyang Su Mei Sun Youcheng Wang Wenlong Wu Taekyung Yu Jie Zeng | 2015 | Nano Research2015，8，7： | 4 |
| 10 | A potential-driven switch of activity promotion mode for the oxygen evolution reaction at Co_(3)O_(4)/NiO_(x)H_(y) interface显示文摘Co_(3)O_(4)spinel oxides have manifested promising activity toward the oxygen evolution reaction(OER)through effective modifications.For them to become top electrocatalysts,however,accurate accounts of the catalytic kinetics are essential to gain a deep understanding of the activity promotion mechanisms.Herein,we use a newly proposed kinetic model based on energetic span as the rate-determining term for the electrocatalytic reaction to throw light on the promotion mechanism of Co_(3)O_(4)interfaced with nickel hydroxides(NiO_(x)H_(y))for the OER.We find that depending on the electrode potential,the OER kinetics at the designed interface between Co_(3)O_(4)and NiO_(x)H_(y)are boosted in entirely different ways.As a result,the OER can occur at a lower onset potential as well as a low Tafel slope.This work emphasizes the benefit of using rational theoretical models for electrocatalyst design. | Wang Wang Zixu Wang Youcheng Hu Yucheng Liu Shengli Chen | 2022 | eScience2022，2，4： | 2 |
| 11 | Periurethral Injection of Autologous Adipose-Derived Stem Cells with Controlled-Release Nerve Growth Factor for the Treatment of Stress Urinary Incontinence in a Rat Model显示文摘 | Weiming Zhao Cheng Zhang Chengjun Jin Zijian Zhang Deling Kong Wanhai Xu Youcheng Xiu | 2010 | European Urology2010，，1： | 2 |
| 12 | Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axis显示文摘Ginsenoside Rh2,which is extracted from ginseng,exerts antitumor activity.Recent studies suggest that Rh2 may suppress the growth of colon cancer(CC)in vitro.However,the underlying mechanism remains unclear.In this study,we identified the relative levels of miR-150-3p in CC tissues and cells by a comprehensive strategy of data mining,computational biology,and real-time reverse transcription PCR(qRT-PCR)experiments.The regulatory effects of miR-150-3p/SRCIN1 on the proliferative and invasive abilities of CC cells are evaluated by CCK-8,EdU,wound healing,and transwell assays.Cell cycle-and apoptosis-related protein levels are assessed by western blot analysis.An in vivo tumor formation assay was conducted to explore the effects of miR-150-3p on tumor growth.Furthermore,bioinformatics and dual luciferase reporter assays are applied to determine the functional binding of miRNA to mRNA of the target gene.Finally,the relationship between Rh2 and miR-150-3p was further verified in SW620 and HCT-116 cells.miR-150-3p is downregulated in CC tissues and cell lines.Functional assays indicate that the upregulation of miR-150-3p inhibits tumor growth both in vivo and in vitro.In addition,SRCIN1 is upregulated in CC and predicts a poor prognosis,and it is the direct target for miR-150-3p.Moreover,the miR-150-3p mimic decreases Topflash/Fopflash-dependent luciferase activity,resulting in the inhibition of Wnt pathway activity.Rh2 can suppress the growth of CC by increasing miR-150-3p expression.Rh2 alleviates the accelerating effect on Wnt pathway activity,cell proliferation/migration,and colony formation caused by miR-150-3p inhibition.Rh2 inhibits the miR-150-3p/SRCIN1/Wnt axis to suppress colon cancer growth. | Shipeng Li Wenfeng Han Qichen He Yang Wang Gang Jin Youcheng Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 2 |
| 13 | Formalin-induced astrocyte glutamate-glutamine cycle involved in rat spinal cord central sensitization显示文摘BACKGROUND:Central sensitization,a state of increased excitability of nociceptive neurons in the spinal dorsal horn following peripheral tissue injury and/or inflammation,is an important mechanism underlying hyperalgesia and neuropathic pain.Participation of the glutamate-glutamine cycle in central sensitization of the spinal cord remains poorly understood. OBJECTIVE:To determine whether the astrocyte-neuronal glutamate-glutamine cycle is involved in formalin-induced central sensitization in the spinal cord. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Institute of Orthopedics,Second Hospital,Lanzhou University,China from September 2007 to August 2008. MATERIALS:Methionine sulfoximine(MSO,0.1 mmol/L),glutamine(0.25 mmol/L),and formalin were used for this study. METHODS:A total of 43 male,Sprague Dawley rats,aged 4 months,were randomly assigned to a sham operation group(n = 6) and a model group(n = 37).Rats in the model group received intrathecal infusion in the spinal cord.7 days later,37 model rats were randomly divided into PBS, MSO,glutamine,MSO + glutamine and formalin subcutaneous injection alone groups.The PBS, MSO,glutamine,MSO + glutamine groups were respectively intrathecally injected with PBS,MSO, glutamine,MSO + glutamine(50μL each),and then infused with 10μL of saline.Rats from the sham operation group were not subjected to intrathecal infusion in the spinal cord.At 15 minutes after intrathecal injection,a rat model of formalin-induced inflammatory pain was established by subcutaneous injection of 5%formalin(50μL) in the left hindpaw. MAIN OUTCOME MEASURES:Changes in spontaneous nociceptive behavior(licking/biting or flinching) were observed following formalin injection into the rat hindpaw. RESULTS:Compared with the PBS group,duration of licking/biting was significantly shortened,and flinching frequency was significantly diminished in the MSO group(P<0.05).Compared with the MSO group,duration of licking/biting was significantly prolonged,and flinching frequency was significantly increased in the MSO + glutamine group(P<0.05).There was no significant difference in inflammatory pain behaviors among the sham operation,PBS,glutamine,MSO + glutamine,and formalin subcutaneous injection alone groups(P>0.05). CONCLUSION:The astrocyte-neuronal glutamate-glutamine cycle in the spinal cord was shown to be involved in central sensitization induced by formalin subcutaneous injection into the hindpaw. | Haili Shen Yufeng XieO Hua Han Yayi Xia Youcheng Zhang Cuifang Wang Jing Wang | 2009 | Neural Regeneration Research2009，4，11： | 2 |
| 14 | Association of Heart Rate Variability in Taxi Drivers with Marked Changes in Particulate Air Pollution in Beijing in 2008显示文摘 | Wu Shaowei Deng Furong Niu Jie Huang Qinsheng Liu Youcheng Guo Xinbiao | 2010 | Environmental Health Perspectives2010，，1： | 1 |
| 15 | Electron transfer reactions of piperidine aminoxyl radicals显示文摘This review article summarizes the electron transfer reactions of piperidine aminoxyl radicals. Electrochemical studies revealed the single electron transfer nature of piperidine aminoxyl radicals. In solution, piperidine aminoxyl radicals serve as single electron transfer oxidation reagent to react with various biologically interesting molecules such as glutathione, cysteine, ascorbic acid, and amines. The reaction product distribution, reaction kinetics, intermediates, and the reaction features in biological mimic environments including micelles and cyclodextrins were investigated. Oxoammonium salts, the one-electron transfer oxidation products of piperidine aminoxyl radicals, are agents of organic synthesis to selectively generate ketones or di-ketones from alcohols or ketones bearing α-methylene group under mild conditions. The new reactions of oxoammonium salts with aromatic amines, phenols, heterocycles including phenothiazines, papaverine, and bilirubin are also illustrated. | ZHANG Fa LIU YouCheng | 2010 | Chinese Science Bulletin2010，55，25： | 1 |
| 16 | Understanding the relationship of quality, value, equity, satisfaction, and behavioral intentions among golf travelers 显示文摘 | Hutchinson J Fujun L Youcheng W | 2009 | Tourism Management2009，30，2： | 1 |
| 17 | Measuring the effectiveness of US offi- cial state tourism websites 显示文摘 | Xu Li Youcheng Wang | 2011 | Journal of Vacation Marketing2011，17，4： | 1 |
| 18 | Controlling the lateral and vertical dimensions of Bi2Se3 nanoplates via seeded growth显示文摘nanostructures 的形态学的调整经常是一项令人满意却挑战性的任务。我们采用了播种生长方法并且导致了运动控制综合双性人 < 潜水艇 class= “ a-plus-plus ” > 2 Se < 潜水艇 class= “ a-plus-plus ” > 有可修改的形态学的 3 nanoplates。由操作先锋答案与注射泵在被注入种子答案的率,二个特殊生长模式能被认识到。与快注射,双性人的厚度<潜水艇class=“ a-plus-plus ”> 2 Se <潜水艇class=“ a-plus-plus ”>当边长度从 160 nm (种子)长大了到 12 m 时, 3 nanoplates 稍微从 7.5 nm (种子)增加了到 9.5 nm ,在播种生长的 6 个连续回合以后。与慢注射,厚度和边长度分别地在 6 轮生长以后同时增加了到 35 nm 和 6 m。这二个模式能被看作在原子免职和表面移植之间的一场比赛。产品出现了有趣,厚度依赖者拉曼性质。另外, NIR 透明,高度传导性、灵活的双性人<潜水艇class=“ a-plus-plus ”> 2 Se <潜水艇class=“ a-plus-plus ”> 3 有不同厚度的薄电影被同样综合的双性人的集会构造<潜水艇class=“ a-plus-plus ”> 2 Se <潜水艇class=“ a-plus-plus ”> 3 nanoplates 。这条途径能显著地与多样的形态学基于播种生长和运动控制支持万用的 nanostructures 的发展。 | Awei Zhuang Yuzhou Zhao Xianli Liu Mingrui Xu Youcheng Wang Unyong Jeong Xiaoping Wang Jie Zeng | 2015 | Nano Research2015，8，1： | 1 |
| 19 | Towards Understanding Members' General Participation in and Active Contribution to an Online Travel Community显示文摘 | Wang Youcheng Fesenmaier Daniel R | 2004 | Tourism Management2004，25，6： | 1 |
| 20 | Examining the Deter- minants of Hotel Chain Expansion Through International Franchising 显示文摘 | Ilan Alon Liqiang Ni Youcheng Wang | 2012 | International Journal of Hospitality Manage- ment2012，31，2： | 1 |
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