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| 1 | Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis显示文摘NF-κ 的受体使活跃之物; B (等级) 和 immunoreceptor 包含适配器的基于酷氨酸的激活主题(ITAM ) 是涉及调整改变的骨破折形成和骨头的必要因素。这里,我们识别早导致雌激素的基因(EEIG1 ) 1 作为一篇小说评价身体上与等级并且进一步交往的可诱导的蛋白质与 Gab2 联系的 ligand (RANKL ) , PLCγ 2 并且在 RANKL 刺激之上的 Tec/Btk kinases。EEIG1 断然调整导致 RANKL 的骨破折形成,由于它便于刺激 RANKL 的 PLCγ 的能力可能; 2 phosphorylation 和 NFATc1 正式就职。另外,设计堵住 RANK-EEIG1 相互作用的禁止的肽由减少骨破折形成禁止了导致 RANKL 的骨头破坏。一起,我们的结果作为一篇小说识别 EEIG1 评价控制调停等级的骨破折形成的发信号的部件,并且建议那指向的 EEIG1 可能为病理学的骨头再吞的处理代表新治疗学的策略。 | Han Kyoung Choi Hye Ri Kang Eutteum Jung Tae Eon Kim Jing Jing Lin Soo Young Lee | 2013 | Cell Research2013，23，4： | 4 |
| 2 | MRI of magnetically labeled mesenchymal stem cells in hepatic failure model显示文摘AIM:To track intravascularly transplanted mesenchymal stem cells (MSCs) labeled with superparamagnetic iron oxide (SPIO) by using magnetic resonance imaging (MRI) in an experimental rabbit model of hepatic failure.METHODS:Human MSCs labeled with FDA-approved SPIO particles (Feridex) were transplanted via the mes-enteric vein into rabbits (n=16) with carbon tetrachloride-induced hepatic failure.Magnetic resonance (MR) examinations were performed with a 3.0 T clinical scanner immediately before and 2 h and 1,3,and 7 d after transplantation.Signal intensity (SI) changes on T2weighted MRI were measured,and correlation between MR findings and histomorphologic findings was also investigated.RESULTS:SI on T2-weighted MRI decreased significantly in the liver 2 h after injection of human MSCs and returned gradually to the levels found before injection in 7 d.Changes in SI in the liver at 2 h,1,3,and 7 d were 41.87% ± 9.63%,10.42% ± 4.3%,5.12% ± 1.9%,3.75% ± 1.2%,respectively (P < 0.001).Histologic analyses confirmed the presence of MSCs in the liver,localized mainly in the sinusoids in early period (2 h and 1 d) and concentrated to the border zone in late period (3 and 7 d).The number of iron-positive cells in the liver at 2 h and on 1,3 and 7 d after transplantation was 29.2 ± 4.8,10.1 ± 3.7,6.7 ± 2.2,and 5.8 ± 2.1,respectively (P=0.013).CONCLUSION:Intravascularly injected SPIO-labeled MSCs in an experimental rabbit model of hepatic failure can be detected and followed with MRI. | Kyu Ri Son Se Young Chung Hyo-Cheol Kim Hoe Suk Kim Seung Hong Choi Jeong Min Lee Woo Kyung Moon | 2010 | World Journal of Gastroenterology2010，16，44： | 4 |
| 3 | Early Intrapulmonary Recurrence After Pulmonary Metastasectomy Related to Colorectal Cancer显示文摘 | Mi Ri Hwang Ji Won Park Dae Yong Kim Hee Jin Chang Sun Young Kim Hyo Seong Choi Moon Soo Kim Jae Ill Zo Jae Hwan Oh | 2010 | The Annals of Thoracic Surgery2010，，2： | 2 |
| 4 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 5 | Prognostic Impact of Circumferential Resection Margin in Rectal Cancer Treated with Preoperative Chemoradiotherapy显示文摘 | Mi Ri Hwang Ji Won Park Sohee Park Hyekyoung Yoon Dae Yong Kim Hee Jin Chang Sun Young Kim Sung Chan Park Hyo Seong Choi Jae Hwan Oh Seung-Yong Jeong | 2014 | Annals of Surgical Oncology2014，，4： | 2 |
| 6 | Comparison of Endoscopic Papillary Balloon Dilation and Sphincterotomy in Young Patients with CBD Stones and Gallstones显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Ji Su Ha Tae Hoon Lee Sang-Woo Cha Young Deok Cho Sang-Heum Park Sun-Joo Kim | 2014 | Digestive Diseases and Sciences2014，，5： | 2 |
| 7 | Papillary balloon dilation is not itself a cause of post‐endoscopic retrograde cholangiopancreatography pancreatitis; results of anterograde and retrograde papillary balloon dilation显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park Sun‐Joo Kim | 2013 | J Gastroenterol Hepatol2013，，8： | 2 |
| 8 | Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1(G93A)mice and SOD1(G17S and G86S)ALS patients显示文摘Background:MicroRNAs(miRNAs)are endogenous non-coding RNAS that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases.Overexpressed miRNAs play an important role in amyotrophic lateral sclerosis(ALS);however,the pathogenic mechanisms of deregulated miRNAS are still unclear.Methods:We aimed to assess the dysfunction of RNAS or miRNAs in fALS(SOD1 mutations).We compared the RNA-seq of subcellular fractions in NSC-34 WT(hSOD1)and MT(hSOD1(G93A))cells to find altered RNAs or miRNAs.We identified that Hif1a and Mef2c were upregulated,and Mctp1 and Rarb were downregulated in the cytoplasm of NSC-34 MT cells.Results:SOD1 mutations decreased the level of miR-18b-5p.Induced Hif1a which is the target for miR-18b increased Mef2c expression as a transcription factor.Mef2c upregulated miR-206 as a transcription factor.Inhibition of Mctp1 and Rarb,which are targets of miR-206,induced intracellular Ca^2+ levels and reduced cell differentiation,respectively.The miR-18b-5p pathway was also observed in G93A Tg mice,fALS(G86S)patient,and iPSC-derived motor neurons from fALS(G17S)patient.Conclusions:Our data indicate that SOD1 mutation decreases miR-18b-5p,which sequentially regulates Hif1a,Mef2c,miR-206,Mctp1 and Rarb in fALS-linked SOD1 mutation.These results provide new insights into the downregulation of miR-18b-5p-dependent pathogenic mechanisms of ALS. | Ki Yoon Kim Yu Ri Kim Kyung Won Choi Mijung Lee Somyung Lee Wooseok Im Je-Young Shin Jin Young Kim Yoon Ho Hong Manho Kim Jong-ll Kim Jung-Joon Sung | 2020 | Translational Neurodegeneration2020，9，3： | 2 |
| 9 | Chemical and functional components in different parts of rough rice ( Oryza sativa L.) before and after germination显示文摘 | Hyun Young Kim In Guk Hwang Tae Myoung Kim Koan Sik Woo Dong Sik Park Jae Hyun Kim Dae Joong Kim Junsoo Lee Youn Ri Lee Heon Sang Jeong | 2012 | Food Chemistry2012，，1： | 2 |
| 10 | New Hg2+-selective fluoroionophores derived from p-tert-butylcalix[4]areneazacrown ethers显示文摘 | Na Ri Cha Mi Yee Kim Young Hee Kim | | 0，，02： | 1 |
| 11 | Cytotoxicity of TNF-alpha is regulated by integrin-mediated matrix signaling显示文摘 | Chen CC Young JL Monzon RI | 2007 | EMBO J2007，26，5： | 1 |
| 12 | Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) study显示文摘 | Seong Hye Choi SangYun Kim Seol-Heui Han Duk L. Na Doh-Kwan Kim Hae-Kwan Cheong Jae-Hong Lee Seong Yoon Kim Chang Hyung Hong So Young Moon Jay C. Kwon Jung Eun Kim Jee H. Jeong Hae Ri Na Kyung Ryeol Cha Sang Won Seo Yong S. Shim Jun-Young Lee Kyung Won Pa | 2012 | Neurological Sciences2012，，4： | 1 |
| 13 | Dynamic adjust of container stacking policy in an automated container terminal 显示文摘 | Taejin Park Ri Choe Young Hun Kim Kwang Ryel Ryu | 2011 | Interuational Journal of Production Economics2011，133，： | 1 |
| 14 | Interactions of oral strains of Candida albicans and Lactobacilli显示文摘 | Krasner RI Young G Yudkofsky PL | 1956 | J Bacteriol1956，72，4： | 1 |
| 15 | Glyceol thizotomy for treatment of trigeminal 显示文摘 | Young RI | 1988 | Neurosurg1988，69，： | 1 |
| 16 | Hemorrhage and resuscitation induce delay inflammation and pulmonary dysfunction in mice 显示文摘 | Clandge JA Enelow RI Young JS | 2000 | J Surg Res2000，92，2： | 1 |
| 17 | Structural and functional characterization of HP0377, a thioredoxin‐fold protein from Helicobacter pylori显示文摘 | Ji Young Yoon Jieun Kim Doo Ri An Sang Jae Lee Hyoun Sook Kim Ha Na Im Hye‐Jin Yoon Jin Young Kim Soon‐Jong Kim Byung Woo Han Se Won Suh | 2013 | Acta Cryst D2013，，5： | 1 |
| 18 | Cancer incidence, survival, mortality for children younger than age 15 years 显示文摘 | Young JL Jr Ries LG Silverberg E | 1996 | Cancer1996，58，2： | 1 |
| 19 | Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling显示文摘 | Chen CC Young JL Monzon RI | 2007 | EMBO J2007，26，： | 1 |
| 20 | Tunable electrochemical preparation of cobalt micro/nanostructures and their morphology-dependent wettability property显示文摘 | Ri Qiu Dun Zhang Peng Wang Xiao Li Zhang Young Soo Kang | 2011 | Electrochimica Acta2011，，： | 1 |
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