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| 1 | Numerical simulation of powder transport behavior in laser cladding with coaxial powder feeding显示文摘Laser cladding with coaxial powder feeding is one of the new processes applied to produce well bonding coating on the component to improve performance of its surface. In the process, the clad material is transported by the carrying gas through the coaxial nozzle, generating gas-powder flow. The powder feeding process in the coaxial laser cladding has important influence on the clad qualities. A 3D numerical model was developed to study the powder stream structure of a coaxial feeding nozzle. The predicted powder stream structure was well agreed with the experimental one. The validated model was used to explore the collision behavior of particles in the coaxial nozzle, as well as powder concentration distribution. It was found that the particle diameter and restitution coefficient greatly affect the velocity vector at outlet of nozzle due to the collisions, as well as the powder stream convergence characteristics below the nozzle. The results indicated a practical approach to optimize the powder stream for the coaxial laser cladding. | LIU Hao HE XiuLi YU Gang WANG Zhong Bin LI ShaoXia ZHENG CaiYun NING WeiJian | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，10： | 17 |
| 2 | Numerical study of thermal history in laser aided direct metal deposition process显示文摘Temperature evolution in the laser aided direct metal deposition (LADMD) process has considerable influence on the micro-structure and properties of the final part. A 3D transient finite element model was developed to study the temperature evolution during the multilayer LADMD process. To make the property analysis from thermal history easier, a critical temperature specific to thermal history was defined and the distribution of it in the part was also discussed. The simulation results indicated that the critical temperature can make the property analysis from thermal history easier. Thermal history of all the deposited materials was similar. It was also concluded that process parameters needed to be time-varying according to the real-time temperature field during the process. | ZHANG YongJie YU Gang HE XiuLi | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，8： | 7 |
| 3 | Facile fabrication of integrated three-dimensional C- MoSe2/reduced graphene oxide composite with enhanced performance for sodium storage显示文摘先进电极材料的谨慎小心的设计和制造为开发高效的钠离子电池是重要的。此处,我们报导一出灵巧的一步舞为与高孔和大表面区域合成的 C-MoSe 2/rGO 的建设的热水的策略。MoSe 2 nanosheets 的两倍修正在这被认识到由介绍减少的 graphene 氧化物(rGO ) 合成骨骼和外部碳保护的层。MoSe 2 nanosheets 被碳层很好包并且强烈也在互连的 rGO 网络上抛锚了。作为在钠离子电池的阳极,设计 C-MoSe 2/rGO 合成交付显著地提高的钠离子存储,与 445 mAh 潨灳瑩的一个高特定的能力? | Dong Xie Wangjia Tang Yadong Wang Xinhui Xia Yu Zhong Ding Zhou DonghuangWang Xiuli Wang Jiangping Tu | 2016 | Nano Research2016，9，6： | 7 |
| 4 | Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides显示文摘Eight new 9,10-anthraquinones(1-8)including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones(68)were isolated from an ethanol extract of the roots of Knoxia valeriamoides.On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC-DAD-ESI-MS analysis of the extracts,the previously and newly isolated 2-methoxymethy-and 2-ethoxymethyl-9,10-anthraquinones(4,5,and 9-13),as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives(68),were shown to be solvolytic artifacts.In the in vitro assays,compound 4 was active to protect hepatocyte(WB-F344)damage. | Feng Zhao Sujuan Wang Sheng Lin Chenggen Zhu Zhenggang Yue Yang Yu Bo Liu Xiuli Wu Yongchun Yang Yan Li Jiangong Shi | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 7 |
| 5 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 6 | Namib desert beetle inspired special patterned fabric with programmable and gradient wettability for efficient fog harvesting显示文摘Efficient collection of water from fog provides a potential solution to solve the global freshwater shortage problem, particularly in the desert or arid regions. In this work, a flexible and highly efficient fog collector was prepared by mimicking the back exoskeleton structure of the Namib desert beetle. The improved fog collector was constructed by a superhydrophobic-superhydrophilic patterned fabric via a simple weaving method, followed by in-situ deposition of copper particles. Compared with the conventional fog collector with a plane structure, the fabric has shown a higher water-harvesting rate at 1432.7 mg/h/cm2,owing to the biomimetic three-dimensional structure, its enhanced condensation performance enabled by the copper coating and the rational distribution of wetting units. The device construction makes use of the widely available textile materials through mature manufacturing technology, which makes it highly suitable for large-scale industrial production. | Zhihua Yu Huimei Zhang Jianying Huang Shuhui Li Songnan Zhang Yan Cheng Jiajun Mao Xiuli Dong Shouwei Gao Shanchi Wang Zhong Chen Yaoxing Jiang Yuekun Lai | 2021 | Journal of Materials Science & Technology2021，，2： | 5 |
| 7 | Co-delivery of doxorubicin and paclitaxel with linear-dendritic block copolymer for enhanced anti-cancer efficacy显示文摘A series of well-defined amphiphilic linear-dendritic block copolymers(telodendrimers, MPEG-b-PAMAM-cholesterol) with 1,2,4 or 8 cholesteryl groups(named as P1, P2, P4, P8, respectively) were synthesized. Their chemical structures were characterized with 1H NMR and mass spectrum(MALDI-TOF MS). The telodendrimers could self-assemble into micelles in aqueous solution, and encapsulate chemotherapeutic drug doxorubicin(DOX) and paclitaxel(PTX) for combination therapy. All the telodendrimers could encapsulate DOX with similar capability. However, their drug-loading capability of PTX is increased with the increasing number of cholesteryl groups. P8 exhibited much higher PTX loading efficiency than its counterparts. Thus, P8 was selected for further application of drug delivery in the paper. The drug-loading micellar nanoparticles(NPs) of P8 were spherical in shape and their diameters were less than 150 nm which were determined by dynamic light scattering measurements(DLS) and transmission electron microscope(TEM). In vitro drug release experiment demonstrated that P8 exhibited a controlled release manner for both DOX and PTX, and the two drugs were released simultaneously. In vitro cytotoxicity experiment further demonstrated that the co-delivery of DOX and PTX in P8 exhibited better anti-cancer efficiency than the delivery systems encapsulated with single drug(DOX or PTX). This indicates a synergistic effect. The co-delivery system showed potential in future anti-cancer treatment. | ZHANG Yu XIAO ChunSheng LI MingQiang DING JianXun YANG ChenGuang ZHUANG XiuLi CHEN XueSi | 2014 | Science China Chemistry2014，57，4： | 4 |
| 8 | Directional construction of Cu2S branch arrays for advanced oxygen evolution reaction显示文摘Metal sulphide electrocatalyst is considered as one of the most promising low-cost candidates for oxygen evolution reaction(OER).In this work,we report a novel free-standing Cu2S branch array via a facile TiO2-induced electrodeposition-sulfurization method.Interestingly,cross-linked Cu2S nanoflake branch is strongly anchored on the TiO2 backbone forming high-quality Cu2S/TiO2/Cu2S core-branch arrays.The branch formation mechanism is also proposed.As compared to the pure Cu2S nanowire arrays,the asprepared Cu2S/TiO2/Cu2S core-branch arrays show much better alkaline OER performance with lower overpotential(284 mV at 10 mA cm^-2)and smaller Tafel slope(72 dec-1)as well as enhanced longterm durability mainly due to larger exposed area and more active electrocatalytic sites.Our work provides a new way for construction of advanced metal sulphide electrocatalysts for electrochemical energy conversion. | Shengjue Deng Yanbin Shen Dong Xie Yangfan Lu Xiaolong Yu Liang Yang Xiuli Wang Xinhui Xia Jiangping Tu | 2019 | Journal of Energy Chemistry2019，28，12： | 3 |
| 9 | Nodal Promotes mir206 Expression to Control Convergence and Extension Movements During Zebrafish Gastrulation显示文摘Nodal,a member of the transforming growth factor b(TGF-b)superfamily,has been shown to play a role in mesendoderm induction and gastrulation movements.The activity of Nodal signaling can be modulated by microRNAs(miRNAs)as previously reported,but little is known about which miRNAs are regulated by Nodal during gastrulation.In the present study,we found that the expression of mir206,one of the most abundant miRNAs during zebrafish early embryo development,is regulated by Nodal signaling.Abrogation of Nodal signal activity results in defective convergence and extension(CE)movements,and these cell migration defects can be rescued by supplying an excess of mir206,suggesting that mir206 acts downstream of Nodal signaling to regulate CE movements.Furthermore,in mir206 morphants,the expression of cell adhesion molecule E-cadherin is significantly increased,while the key transcriptional repressor of E-cadherin,snail1a,is depressed.Our study uncovers a novel mechanism by which Nodal-regulated mir206 modulates gastrulation movements in connection with the Snail/E-cadherin pathway. | Xiuli Liu Yuanqing Ma Congwei Zhang Shi Wei Yu Cao Qiang Wang | 2013 | Journal of Genetics and Genomics2013，40，10： | 2 |
| 10 | Diurnal Variation of Soil CO2 Efflux and Its Optimal Measuring Time-window of Temperate Meadow Steppes in Western Songnen Plain, China显示文摘In order to study the diurnal variation of soil CO_2 efflux from temperate meadow steppes in Northeast China, and determine the best time for observation, a field experiment was conducted with a LI-6400 soil CO_2 flux system under five typical plant communities(Suaeda glauca(Sg), Chloris virgata(Cv), Puccinellia distans(Pd), Leymus chinensis(Lc) and Phragmites australis(Pa)) and an alkali-spot land(As) at the meadow steppe of western Songnen Plain. The results showed that the diurnal variation of soil CO_2 efflux exhibited a single peak curve in the growing season. Diurnal maximum soil respiration(Rs) often appeared between 11:00 and 13:00, while the minimum occurred at 21:00–23:00 or before dawn. Air temperature near the soil surface(Ta) and soil temperature at 10 cm depth(T10) exerted dominant control on the diurnal variations of soil respiration. The time-windows 7:00–9:00 could be used as the optimal measuring time to represent the daily mean soil CO_2 efflux at the Cv, Pd, Lc and Pa sites. The daily mean soil CO_2 efflux was close to the soil CO_2 efflux from 15:00 to 17:00 and the mean of 2 individual soil CO_2 efflux from 15:00 to 19:00 at the As and Sg sites, respectively. During nocturnal hours, negative soil CO_2 fluxes(CO_2 downwards into the soil) were frequently observed at the As and Sg sites, the magnitude of the negative CO_2 fluxes were 0.10–1.55 μmol/(m^2·s) and 0.10–0.69 μmol/(m^2·s)at the two sites. The results implied that alkaline soils could absorb CO_2 under natural condition, which might have significant implications to the global carbon budget accounting. | YU Xiuli LI Xiujun XU Linshu WANG Ming ZHANG Jitao JIANG Ming WANG Guodong | 2016 | Chinese Geographical Science2016，26，4： | 2 |
| 11 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 12 | A 3D elastic-plastic-viscous constitutive model for soils considering the stress path dependency显示文摘In order to consider the stress path dependency of soils,this paper decomposes any arbitrary stress path into several infinitesimal stress paths.Then the infinitesimal stress path is further transformed into the superposition of two parts,i.e..a constant stress ratio part and a constant mean stress part,which arc sufficiently close to the real stress path.T he plastic strain increments under the transformed paths arc determined separately,and then the plastic strain under any path is obtained.Based on the instantaneous loading line of normally consolidated soil,a reference state line is proposed to determine the overconsolidation ratio and creep time of soil.The overconsolidation ratio is introduced into the viscous How rule to obtain the viscous strain increment.The strcss-strain-timc relationship for triaxial compression condition is extended to 3D stress condition by the transformed stress method.The proposed model adopts only seven material parameters and each of them has a clear physical meaning.Comparisons with test results demonstrate that the model can not only reasonably predict the plastic strain under typical stress paths of excavation,but adequately capture the time-dependent behaviours of soils,including creep,stress relaxation and strain rate effect. | LU DeChun MIAO JinBo DU XiuLi TIAN Yu YAO YangPing | 2020 | Science China(Technological Sciences)2020，63，5： | 2 |
| 13 | Cloning, identification, and expression analysis at the stage of gonadal sex differentiation of chicken miR-363 and 363显示文摘miRNAs (microRNAs ) 是小的,功能的、非编码的 RNA 并且被证明了在从房间区别到有机体开发的多样的生物过程的规定含有。以达到在鸡胚胎上探索 miRNAs 的角色性决心和 gonadal 区别,我们克隆并且识别茎环先锋结构( GenBank 同意没有 GU597370 )鸡肉, miR-363 和363*由在 E3.56.5 d 的阶段在鸡胚胎学习他们的时间、空间的表示模式列在后面(胚胎的天 3.56.5 )由半量的 RT-PCR 和愿望(在 situ 杂交整个山)在这研究。结果显示出那 miR-363 * 根据 miRNAs 的结构的特征在 miR-363 和 363* 的鸡染色体,和 flanking 顺序在未知片断的克隆的顺序定位了先锋。显著地微分的表示(P < 0.05 ) 在雌、雄的鸡肉之间的 gga-miR-363,胚胎的性腺被发现在 E4.5 和 6.5 d,而是 gga-miR-363 的微分表示 * 从 E3.5,到 6.5,在两性之间的 d 达不到重要水平。那个表达式 gga-miR-363 表明的显示的愿望的结果主要在 E6.5 出现在手足芽,脊索,外胚层,在 E4.5 d 鸡胚胎的大脑,和尿生殖的系统(UGS ) d,和 E6.5 d 的表达式水平在男性比那在女性是更高的。gga-miR-363 将在 gonadal 发展和 gga-miR-363 包含,这能被推测 * 可能在鸡胚胎开发的早阶段期间有短暂规章的功能。 | Pan Huang Yanzhang Gong Xiuli Peng ShijunLi Yu Yang Yanping Feng | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 2 |
| 14 | Driving mechanism of keyhole evolution during multi-pulse drilling with a millisecond laser显示文摘To better understand the physical processes of multi-pulse laser drilling,this study investigates the keyhole evolution and its driving mechanism in a time-resolved observation system.The evolution characteristics suggested a two-phase process of rapid penetration followed by moderate penetration.As revealed in the ejection and vaporization behavior,the keyhole evolution was dominated by ejection and vaporization during the rapid and moderate penetration stages,respectively.In a single laser-pulsed drilling experiment,the driving mechanism itself was found to be affected by the dimensionless laser power density.The effect of dimensionless laser power density on depth increment was then discussed by comparing the experimental observations with numerical simulation results.The results further confirmed the driving mechanism of the keyhole evolution.The results in this paper are useful for understanding the driving mechanism of the keyhole evolution during multi-pulse laser drilling. | Yue Zhang Gang Yu XiuLi He ShaoXia Li WeiJian Ning | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，10： | 2 |
| 15 | Dasatinib inhibits proliferation of liver cancer cells,but activation of Akt/mTOR compromises dasatinib as a cancer drug显示文摘Dasatinib is a multi-target protein tyrosine kinase inhibitor.Due to its potent inhibition of Src,Abl,the platelet-derived growth factor receptor(PDGFR)family kinases,and other oncogenic kinases,it has been investigated as a targeted therapy for a broad spectrum of cancer types.However,its efficacy has not been significantly extended beyond leukemia.The mechanism of resistance to dasatinib in a wide array of cancers is not clear.In the present study,we investigated the effect of dasatinib on hepatocellular carcinoma cell growth and explored the underlying mechanisms.Our results showed that dasatinib potently inhibited the proliferation of SNU-449 cells,but not that of other cell lines,such as SK-Hep-1,even though it inhibited the phosphorylation of Src on both negative and positive regulation sites in all these cells.Dasatinib activated the phosphoinositide-dependent protein kinase1(PDK1)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway in SK-Hep-1 cells,but not in SNU-449 cells.Blocking the Akt/mTOR signaling pathway strongly promoted the efficacy of dasatinib in SK-Hep-1 cells.In SNU-449 cells,dasatinib promoted apoptosis and the cleavage of caspase-3 and caspase-7,induced cell cycle arrest in the G1 phase,and inhibited the expression of Cyclin-dependent kinase(CDK4)/6/CyclinD1 complex.These findings demonstrate that dasatinib exerts its anti-proliferative effect on hepatocellular cell proliferation by blocking the Src family kinases;however,it causes Akt activation,which compromises dasatinib as an anti-cancer drug. | Chang Liu Xiaoxia Zhu Yuqi Jia Fenqing Chi Keru Qin Jinhong Pei Chan Zhang Xiuli Mu Hongwei Zhang Xiushan Dong Jun Xu Baofeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 16 | High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair显示文摘 | Bing Pan Baoqi Yu Hui Ren Belinda Willard Ling Pan Lingyun Zu Xiaoli Shen Yijing Ma Xiuli Li Chenguang Niu Jinge Kong Siyu Kang Y. Eugene Chen Subramaniam Pennathur Lemin Zheng | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 17 | Crystallization behavior of asymmetric PLLA/PDLA blends 显示文摘 | SUN Jingru YU Haiyang ZHUANG Xiuli | 2011 | J Phys Chem B2011，115，12： | 1 |
| 18 | An RBD virus-like particle vaccine for SARS-CoV-2 induces cross-variant antibody responses in mice and macaques显示文摘Dear Editor,Since early 2020,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread globally infecting over 500 million people and causing over 6 million deaths.The massive worldwide immunisation programmes and the arising clinical trial data present a unique opportunity to compare the vaccines and various delivery platforms(i.e.viral vector platform,mRNA platform and virus-like particle platform). | Yuanyuan Li Yanan Zhang Yu Zhou Yan Li Jiao Xu Yuanbao Ai Lei Xu Xiuli Xiao Bo Zhang Jing Jin | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 19 | Review of Ag/Al2O3-Reductant System in the Selective Catalytic Reduction of NO x显示文摘 | Hong He Xiuli Zhang Qiang Wu Changbin Zhang Yunbo Yu | 2008 | Catalysis Surveys from Asia2008，，1： | 1 |
| 20 | Synthesis,characterization,and tunable wettability of poly (ionic liquid) brushes via nitroxide-mediated radical polymerization (NMP)显示文摘Well-defined poly(ionic liquid) brushes with tunable wettability are successfully synthesized via nitroxide-mediated radical polymerization.X-ray photoelectron spectroscopy,attenuated total reflection infrared spectroscopy and static water contact angle measurements are used to monitor each step.Ellipsometry,nuclear magnetic resonance(1H and 13C) spectra and gel permeation chromatographic measurements reveal that there is a linear increase in polymer film thickness with polymerization time,indicating that chain growth from the surface is a controlled/'living' polymerization.The surface morphology was measured by atomic force microscopy.Moreover,the surfaces of the poly(ionic liquid) brushes with tunable wettability and reversible switching between hydrophilicity and hydrophobicity can be easily achieved by counteranion exchange. | YAG Wu HE XiaoJing GAO JinZhang GUO Hao HE XiaoYan WAN Fei ZHAO XiuLi YU Yan PEI Ben | 2010 | Chinese Science Bulletin2010，55，31： | 1 |
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