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| 1 | Long-term antiviral efficacy of entecavir and liver histology improvement in Chinese patients with hepatitis B virus-related cirrhosis显示文摘AIM: To evaluate the clinical outcomes of 240-wk treatment with entecavir(0.5 mg) in Chinese nucleosidenaive patients with cirrhosis.METHODS: A total of 204 nucleoside-naive patients with compensated(n = 96) or decompensated(n = 108) hepatitis B virus(HBV)-induced cirrhosis at the Department of Gastroenterology of the China-Japan Union Hospital(Jilin University, Changchun, China) who were treated with entecavir(0.5 mg) for 240 wk were enrolled in this study. Liver biopsy samples obtained from 38 patients prior to treatment(baseline) and at week 240 were evaluated by different independent histopathologists. Efficacy assessments included the proportions of patients who achieved an HBV DNA level < 500 copies/m L, the association of interleukin-28 B genetic variation with antivirus therapy, clinical outcomes, and histologic improvement. Changes in liver disease severity were analyzed, and liver histologic evaluation was performed in 38 patients with paired biopsies. Student t tests were used to compare the means of continuous variables between the groups, and the proportions of patients who achieved the endpoints were compared using the χ2 test.RESULTS: At week 240, 87.5% of the patients with compensated cirrhosis and 92.6% of the patients with decompensated cirrhosis achieved a HBV DNA level < 500 copies/m L. Three patients had genotypic entecavir resistance within the 240-wk period. No significant association was observed between virologic response and interleukin-28 genotype(CT, 88.2% vs CC, 90.6%). The proportion of patients with Child-Pughclass A disease was significantly increased at week 240(68%) from the baseline(47%; P < 0.01). The proportion of patients with Child-Pugh class B disease was significantly decreased at week 240(25%) from the baseline(39%; P = 0.02). In the patients with paired liver biopsies, the mean reduction in the Knodell necroinflammatory score from the baseline was 3.58 ± 1.03 points(7.11 ± 1.80 vs 3.53 ± 1.35, P < 0.01). The mean reduction in Ishak fibrosis score from the baseline was 1.26 ± 0.64 points(5.58 ± 0.50 vs 4.32 ± 0.81, P < 0.01).CONCLUSION: Entecavir is an effective treatment option for patients with HBV-related compensated or decompensated cirrhosis that can result in sustained virologic suppression and histologic improvement. | Yan Xu Yong-Gui Zhang Xu Wang Wen-Qian Qi Shao-You Qin Zhen-Hua Liu Jian Jiao Jiang-Bin Wang | 2015 | World Journal of Gastroenterology2015，21，25： | 50 |
| 2 | Massive individual orbital angular momentum channels for multiplexing enabled by Dammann gratings显示文摘Data transmission rates in optical communication systems are approaching the limits of conventional multiplexing methods.Orbital angular momentum(OAM)in optical vortex beams offers a new degree of freedom and the potential to increase the capacity of free-space optical communication systems,with OAM beams acting as information carriers for OAM division multiplexing(OAM-DM).We demonstrate independent collinear OAM channel generation,transmission and simultaneous detection using Dammann optical vortex gratings(DOVGs).We achieve 80/160 Tbit s^(-1) capacity with uniform power distributions along all channels,with 1600 individually modulated quadrature phase-shift keying(QPSK)/16-QAM data channels multiplexed by 10 OAM states,80 wavelengths and two polarizations.DOVG-enabled OAM multiplexing technology removes the bottleneck of massive OAM state parallel detection and offers an opportunity to raise optical communication systems capacity to Pbit s^(-1) level. | Ting Lei Meng Zhang Yuru Li Ping Jia Gordon Ning Liu Xiaogeng Xu Zhaohui Li Changjun Min Jiao Lin Changyuan Yu Hanben Niu Xiaocong Yuan | 2015 | Light(Science & Applications)2015，4，1： | 47 |
| 3 | UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil显示文摘AIM:To evaluate effects of UDP-glucuronosyltransferase1A1(UGT1A1) and thymidylate synthetase(TS) gene polymorphisms on irinotecan in metastatic colorectal cancer(mCRC).METHODS:Two irinotecan-and fluorouracil-based regimens,FOLFIRI and IFL,were selected as second-line therapy for 138 Chinese mCRC patients.Genomic DNA was extracted from peripheral blood samples before treatment.UGT1A1 and TS gene polymorphisms were determined by direct sequencing and restriction fragment length polymorphism,respectively.Gene polymorphisms of UGT1A1*28,UGT1A1*6 and promoter enhancer region of TS were analyzed.The relationship between genetic polymorphisms and clinical outcome,that is,response,toxicity and survival were assessed.Pharmacokinetic analyses were performed in a subgroup patients based on different UGT1A1 genotypes.Plasma concentration of irinotecan and its active metabolite SN-38 and inactive metabolite SN-38G were determined by high performance liquid chromatography.Differences in irinotecan and its metabolites between UGT1A1 gene variants were compared.RESULTS:One hundred and eight patients received the FOLFIRI regimen,29 the IFL regimen,and one irinotecan monotherapy.One hundred and thirty patients were eligible for toxicity and 111 for efficacy evaluation.One hundred and thirty-six patients were tested for UGT1A1*28 and *6 genotypes and 125 for promoter enhancer region of TS.Patients showed a higher frequency of wild-type UGT1A1*28(TA6/6) compared with a Caucasian population(69.9% vs 45.2%).No significant difference was found between response rates and UGT1A1 genotype,although wild-type showed lower response rates compared with other variants(17.9% vs 24.2% for UGT1A1*28,15.7% vs 26.8% for UGT1A1*6).When TS was considered,the subgroup with homozygous UGT1A1*28(TA7/7) and non-3RG genotypes showed the highest response rate(33.3%),while wild-type UGT1A1*28(TA6/6) with non-3RG only had a 13.6% response rate,but no significant difference was found.Logistic regression showed treatment duration was closely linked to clinical response.In toxicity comparison,UGT1A1*28 TA6/6 was associated with lower incidence of grade 2-4 diarrhea(27.8% vs 100%),and significantly reduced the risk of grade 4 neutropenia compared with TA7/7(7.8% vs 37.5%).Wild-type UGT1A1*6(G/G) tended to have a lower incidence of grade 3/4 diarrhea vs homozygous mutant(A/A) genotype(13.0% vs 40.0%).Taking UGT1A1 and TS genotypes together,lower incidence of grade 2-4 diarrhea was found in patients with non-3RG TS genotypes,when TA6/6 was compared with TA7/7(35.3% vs 100.0%).No significant association with time to progression(TTP) and overall survival(OS) was observed with either UGT1A1 or TS gene polymorphisms,although slightly longer TTP and OS were found with UGT1A1*28(TA6/6).Irinotecan PK was investigated in 34 patients,which showed high area under concentration curve(AUC) of irinotecan and SN-38,but low AUC ratio(SN-38G /SN-38) in those patients with UGT1A1*28 TA7/7.CONCLUSION:A distinct distribution pattern of UGT1A1 genotypes in Chinese patients might contribute to relatively low toxicity associated with irinotecan and 5-fluorouracil in mCRC patients. | Yan Wang Lin Shen Nong Xu Jin-Wan Wang Shun-Chang Jiao Ze-Yuan Liu Jian-Ming Xu | 2012 | World Journal of Gastroenterology2012，18，45： | 34 |
| 4 | Modulatory effects of acupuncture on brain networks in mild cognitive impairment patients显示文摘Functional magnetic resonance imaging has been widely used to investigate the effects of acupuncture on neural activity. However, most functional magnetic resonance imaging studies have focused on acute changes in brain activation induced by acupuncture. Thus, the time course of the therapeutic effects of acupuncture remains unclear. In this study, 32 patients with amnestic mild cognitive impairment were randomly divided into two groups, where they received either Tiaoshen Yizhi acupuncture or sham acupoint acupuncture. The needles were either twirled at Tiaoshen Yizhi acupoints, including Sishencong(EX-HN1), Yintang(EX-HN3), Neiguan(PC6), Taixi(KI3), Fenglong(ST40), and Taichong(LR3), or at related sham acupoints at a depth of approximately 15 mm, an angle of ± 60°, and a rate of approximately 120 times per minute. Acupuncture was conducted for 4 consecutive weeks, five times per week, on weekdays. Resting-state functional magnetic resonance imaging indicated that connections between cognition-related regions such as the insula, dorsolateral prefrontal cortex, hippocampus, thalamus, inferior parietal lobule, and anterior cingulate cortex increased after acupuncture at Tiaoshen Yizhi acupoints. The insula, dorsolateral prefrontal cortex, and hippocampus acted as central brain hubs. Patients in the Tiaoshen Yizhi group exhibited improved cognitive performance after acupuncture. In the sham acupoint acupuncture group, connections between brain regions were dispersed, and we found no differences in cognitive function following the treatment. These results indicate that acupuncture at Tiaoshen Yizhi acupoints can regulate brain networks by increasing connectivity between cognition-related regions, thereby improving cognitive function in patients with mild cognitive impairment. | Ting-ting Tan Dan Wang Ju-ke Huang Xiao-mei Zhou Xu Yuan Jiu-ping Liang Liang Yin Hong-liang Xie Xin-yan Jia Jiao Shi Fang Wang Hao-bo Yang Shang-jie Chen | 2017 | Neural Regeneration Research2017，12，2： | 32 |
| 5 | Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes显示文摘 | Honghe Sun Shan WU Guoyu Zhang Chen Jiao Shaogui Guo Yi Ren Jie Zhang Haiying Zhang Guoyi Gong Zhangcai Jia Fan Zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li Zhangjun Fei Yong Xu | 2017 | Molecular Plant2017，10，10： | 33 |
| 6 | Blue carbon on the rise:challenges and opportunities显示文摘BLUE CARBON ON THE RISE Climate change is a global concem that requires urgent solutions.As a signatory to the Paris Agreement,China has committed to have its greenhouse gas emission reach a peak by the year 2030,which means that severe countermeasures for reducing emissions have to be put into practice.This is a hard mission given that development is still the top priority in the years to come for China.Under such circumstances,enhancing carbon sequestration becomes an effective approach to achieving the goal.While terrestrial green carbon sink is already in practice,the ocean carbon reservoir,containing 93%of global CO2,as 50 and 20 times the carbon inventories of atmosphere and land,respectively,has great potential to expand.Each year,at least 25% of the anthropogenic CO2 has been captured by marine ecosystems as blue carbon [1]. | Nianzhi Jiao Hong Wang Guanhua Xu Salvatore Aricò | 2018 | National Science Review2018，5，4： | 25 |
| 7 | FAT10 level in human gastric cancer and its relation with mutant p53 level,lymph node metastasis and TNM staging显示文摘AIM:To investigate the role of FAT10 and mutant p53 in the pathogenesis,severity and prognosis of gastric cancer.METHODS:FAT10,mutant p53 mRNA and protein levels were measured by reverse transcription(RT)-PCR and immunohistochemistry in gastric cancer tissue(n = 62),tumoradjacent tissue(n = 62) and normal gastric tissue(n = 62).Relation of FAT10 and mutant p53 expression with clinicopathological features and clinical outcomes of gastric cancer patients were analyzed.RESULTS:The FAT10,mutant p53 mRNA and protein levels were signif icantly higher in gastric cancer than in its adjacent and normal tissue.The FAT10 and mutant p53 levels in gastric cancer tissue were significantly correlated with lymph node metastasis and tumor,nodes,metastasis(TNM) staging.Moreover,the high FAT10 level was associated with the overall survival rate of patients.Multivariate Cox-proportional hazards model analysis showed that mRNA and protein levels of FAT10 and mutant p53,lymph node metastasis,distant metastasis and TNM stage were the independent prognostic factors for gastric cancer.CONCLUSION:FAT10 may be involved in gastric carcinogenesis,and is a potential marker for the prognosis of gastric cancer patients.FAT10 and mutant p53 may play a common role in the carcinogenesis of gastric cancer. | Feng Ji Xi Jin Chun-Hua Jiao Qin-Wei Xu Zi-Wei Wang Yue-Liang Chen | 2009 | World Journal of Gastroenterology2009，15，18： | 23 |
| 8 | Expert consensus on the use of human serum albumin in critically ill patients显示文摘Introduction Human serum albumin(HSA)is a non-glycosylated,negatively charged,single-chain polypeptide composed of 585 amino acid residues with a relative molecular mass of 66.438 kD.It is synthesized by the liver at a rate of approximately 200 mg·kg^(-1)·day^(-1),with a half-life of 21 days,and subjected to catabolism in the muscles,liver,and kidneys at a rate of 4%per day.[1]Albumin,accounting for 60%of the total plasma protein,has various physiological functions,[2]such as maintaining 70%to 80%of effective plasma colloid osmotic pressure,coordinating vascular endothelial integrity,anti-oxidant and anti-inflammatory activities,maintaining the acidbase balance,and participating in the transport,distribution,and metabolism of a variety of endogenous and exogenous substances. | Yue-Tian Yu Jiao Liu Bo Hu Rui-Lan Wang Xiang-Hong Yang Xiu-Ling Shang Gang Wang Chang-Song Wang Bai-Ling Li Ye Gong Sheng Zhang Xin Li Lu Wang Min Shao Mei Meng Feng Zhu You Shang Qiang-Hong Xu Zhi-Xiong Wu De-Chang Chen | 2021 | Chinese Medical Journal2021，，14： | 22 |
| 9 | A Facile One-Step Synthesis of TiOe/Graphene Composites for Photodegradation of Methyl Orange显示文摘 | Haijiao Zhang Panpan Xu Guidong Du Zhiwen Chen Kokyo Oh Dengyu Pan Zheng Jiao | 2011 | Nano Research2011，4，3： | 21 |
| 10 | Anthropogenic Impact on Surface Water Quality in Taihu Lake Region,China显示文摘Taihu Lake region is one of the most industrialized areas in China, and the surface water is progressively susceptible to anthropogenic pollution. The physicochemical parameters of surface water quality were determined at 20 sampling sites in Taihu Lake region, China in spring, summer, autumn, and winter seasons of 2005-2006 to assess the effect of human activities on the surface water quality. Principal component analysis (PCA) and cluster analysis (CA) were used to identify characteristics of the water quality in the studied water bodies. PCA extracted the first three principal components (PCs), explaining 80.84% of the total variance of the raw data. Especially, PC1 (38.91%) was associated with NH 4 -N, total N, soluble reactive phosphorus, and total P. PC2 (22.70%) was characterized by NO 3 -N and temperature. PC3 (19.23%) was mainly associated with pH and dissolved organic carbon. CA showed that streams were influenced by urban residential subsistence and livestock farming contributed significantly to PC1 throughout the year. The streams influenced by farmland runoff contributed most to PC2 in spring and winter compared with other streams. PC3 was affected mainly by aquiculture in spring, rural residential subsistence in summer, and livestock farming in fall and winter seasons. Further analyses showed that farmlands contributed significantly to nitrogen pollution of Taihu Lake, while urban residential subsistence and livestock farming also polluted water quality of Taihu Lake in rainy season. The results would be helpful for the authorities to take sound actions for an effective management of water quality in Taihu Lake region. | XU Ha YANG Lin-Zhang ZHAO Geng-Mao JIAO Jia-Guo YIN Shi-Xue LIU Zhao-Pu | 2009 | Pedosphere2009，19，6： | 20 |
| 11 | GRAIN INCOMPLETE FILLING 2 regulates grain filling and starch synthesis during rice caryopsis development显示文摘Rice grain filling determines grain weight,final yield and grain quality.Here,a rice defective grain filling mutant,gif2,was identified.Grains of gif2 showed a slower filling rate and a significant lower final grain weight and yield compared to wild-type.The starch content in gif2 was noticeably decreased and its physicochemical properties were also altered.Moreover,gif2 endosperm cells showed obvious defects in compound granule formation.Positional cloning identified GIF2 to encode an ADP-glucose pyrophosphorylase(AGP) large subunit,AGPL2;consequently,AGP enzyme activity in gif2 endosperms was remarkably decreased.GIF2 is mainly expressed in developing grains and the coded protein localizes in the cytosol.Yeast two hybrid assay showed that GIF2 interacted with AGP small subunits Os AGPS1,Os AGPS2a and Os AGPS2 b.Transcript levels for granule-bound starch synthase,starch synthase,starch branching enzyme and starch debranching enzyme were distinctly elevated in gif2 grains.In addition,the level of nucleotide diversity of the GIF2 locus was extremely low in both cultivated and wild rice.All of these results suggest that GIF2 plays important roles in the regulation of grain filling and starch biosynthesis during caryopsis development,and that it has been preserved during selection throughout domestication of modern rice. | Xiangjin Wei Guiai Jiao Haiyan Lin Zhonghua Sheng Gaoneng Shao Lihong Xie Shaoqing Tang Qingguo Xu Peisong Hu | 2017 | Journal of Integrative Plant Biology2017，59，2： | 20 |
| 12 | Lung transplantation as therapeutic option in acute respiratory distress syndrome for coronavirus disease 2019-related pulmonary fibrosis显示文摘Background:Critical patients with the coronavirus disease 2019(COVID-19),even those whose nucleic acid test results had turned negative and those receiving maximal medical support,have been noted to progress to irreversible fatal respiratory failure.Lung transplantation(LT)as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients.Methods:From February 10 to March 10,2020,three male patients were urgently assessed and listed for transplantation.After conducting a full ethical review and after obtaining assent from the family of the patients,we performed three LT procedures for COVID-19 patients with illness durations of more than one month and extremely high sequential organ failure assessment scores.Results:Two of the three recipients survived post-LT and started participating in a rehabilitation program.Pearls of the LT team collaboration and perioperative logistics were summarized and continually improved.The pathological results of the explanted lungs were concordant with the critical clinical manifestation,and provided insight towards better understanding of the disease.Government health affair systems,virology detection tools,and modern communication technology all play key roles towards the survival of the patients and their rehabilitation.Conclusions:LT can be performed in end-stage patients with respiratory failure due to COVID-19-related pulmonary fibrosis.If confirmed positive-turned-negative virology status without organ dysfunction that could contraindicate LT,LT provided the final option for these patients to avoid certain death,with proper protection of transplant surgeons and medical staffs.By ensuring instant seamless care for both patients and medical teams,the goal of reducing the mortality rate and salvaging the lives of patients with COVID-19 can be attained. | Jing-Yu Chen Kun Qiao Feng Liu Bo Wu Xin Xu Guo-Qing Jiao Rong-Guo Lu Hui-Xing Li Jin Zhao Jian Huang Yi Yang Xiao-Jie Lu Jia-Shu Li Shu-Yun Jiang Da-Peng Wang Chun-Xiao Hu Gui-Long Wang Dong-Xiao Huang Guo-Hui Jiao Dong Wei Shu-Gao Ye Jian-An Huang Li Zhou Xiao-Qin Zhang Jian-Xing He | 2020 | Chinese Medical Journal2020，，12： | 19 |
| 13 | Suppression of human lung cancer cell proliferation and metastasis in vitro by the transducer of ErbB-2.1 (TOB1)显示文摘瞄准: 在 vitro 在人的肺癌症房间的增长,迁居和侵略上调查 ErbB-2.1 (TOB1 ) 的变换器的效果。 | Yang JIAO Ke-kang SUN Lin ZHAO Jia-ying XU Li-li Wang Sai-jun FAN | 2012 | Acta Pharmacologica Sinica2012，33，2： | 18 |
| 14 | A review of ecological restoration techniques in fluvial rivers显示文摘Rivers play an important role in people's living and agricultural production,however,intense human activities have broken the original ecological balance,and affected structures and functions of the river ecosystem.To restore the damaged river ecosystem back to a healthy status,effective ecological restoration measures need to be implemented.The main problems that the damaged rivers face are either the locally altered hydrological processes affected by construction of hydraulic facilities,or the deterioration of water quality resulted from pollution emissions,or both.In this study,ecological restoration techniques of the rivers affected by engineering control or pollution are reviewed respectively.In addition,three kinds of methods,i.e.physical,chemical and biological-ecological methods are introduced in details for the rivers affected by water pollution.At present,the development of river restoration techniques shows the following trends:1) the scale of ecological restoration is becoming larger;2) ecological restoration measures are required to meet multiple objectives;and 3) the management of water environment is changing from water quality management to aquatic ecosystem management. | Baozhu Pan Jianping Yuan Xinhua Zhang Zhaoyin Wang Jiao Chen Jinyou Lu Wenjun Yang Zhiwei Li Na Zhao Mengzhen Xu | 2016 | International Journal of Sediment Research2016，31，2： | 18 |
| 15 | Traditional Chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis显示文摘OBJECTIVE: Traditional Chinese medicine(TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer.METHODS: In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status(KPS) score were measured as the main outcome.RESULTS: The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3-and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups(χ2 = 42.244, P < 0.001). After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively(P < 0.001). The Cox regression analysis showed that TCM treatment is a protective factor for patients' overall survival. CONCLUSION: This study demonstrated that TCM integrated with chemotherapy may prolong overall survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer. | xuan liu li-juan xiu jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue | 2017 | Journal of Integrative Medicine2017，15，6： | 18 |
| 16 | Agriculture Green Development: a model for China and the world显示文摘Realizing sustainable development has become a global priority.This holds,in particular,for agriculture.Recently,the United Nations launched the Sustainable Development Goals(SDGs),and the Nineteenth National People’s Congress has delivered a national strategy for sustainable development in China—realizing green development.The overall objective of Agriculture Green Development(AGD)is to coordinate'green'with'development'to realize the transformation of current agriculture with high resource consumption and high environmental costs into a green agriculture and countryside with high productivity,high resource use efficiency and low environmental impact.This is a formidable task,requiring joint efforts of government,farmers,industry,educators and researchers.The innovative concept for AGD will focus on reconstructing the whole crop-animal production and food production-consumption system,with the emphasis on high thresholds for environmental standards and food quality as well as enhanced human well-being.This paper addresses the significance,challenges,framework,pathways and potential solutions for realizing AGD in China,and highlights the potential changes that will lead to a more sustainable agriculture in the future.Proposals include interdisciplinary innovations,whole food chain improvement and regional solutions.The implementation of AGD in China will provide important implications for the countries in developmental transition,and contribute to global sustainable development. | Jianbo SHEN Qichao ZHU Xiaoqiang JIAO Hao YING Hongliang WANG Xin WEN Wen XU Tingyu LI Wenfeng CONG Xuejun LIU Yong HOU Zhenling CUI Oene OENEMA William JDAVIES Fusuo ZHANG | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 18 |
| 17 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 18 | Using Hourly Measurements to Explore the Role of Secondary Inorganic Aerosol in PM_(2.5)during Haze and Fog in Hangzhou, China显示文摘This paper explores the role of the secondary inorganic aerosol(SIA) species ammonium, NH+4, nitrate, NO-3, and sulfate,SO2-4, during haze and fog events using hourly mass concentrations of PM2.5measured at a suburban site in Hangzhou,China. A total of 546 samples were collected between 1 April and 8 May 2012. The samples were analyzed and classified as clear, haze or fog depending on visibility and relative humidity(RH). The contribution of SIA species to PM2.5mass increased to ~50% during haze and fog. The mass contribution of nitrate to PM2.5increased from 11% during clear to 20%during haze episodes. Nitrate mass exceeded sulfate mass during haze, while near equal concentrations were observed during fog episodes. The role of RH on the correlation between concentrations of SIA and visibility was examined, with optimal correlation at 60%–70% RH. The total acidity during clear, haze and fog periods was 42.38, 48.38 and 45.51 nmol m-3,respectively, indicating that sulfate, nitrate and chloride were not neutralized by ammonium during any period. The nitrate to sulfate molar ratio, as a function of the ammonium to sulfate molar ratio, indicated that nitrate formation during fog started at a higher ammonium to sulfate molar ratio compared to clear and haze periods. During haze and fog, the nitrate oxidation ratio increased by a factor of 1.6–1.7, while the sulfur oxidation ratio increased by a factor of 1.2–1.5, indicating that both gaseous NO2 and SO2were involved in the reduced visibility. | Roeland Cornelis JANSEN SHI Yang CHEN Jianmin HU YunJie XU Chang HONG Shengmao LI Jiao ZHANG Min | 2014 | Advances in Atmospheric Sciences2014，31，6： | 15 |
| 19 | Liver-Adipose Tissue Crosstalk:A Key Player in the Pathogenesis of Glucolipid Metabolic Disease显示文摘Glucolipid metabolic disease(GLMD),a complex of interrelated disorders in glucose and lipid metabolism,has become one of the leading chronic diseases causing public and clinical problem worldwide.As the metabolism of lipid and glucose is a highly coordinated process under both physiological and diseased conditions,the impairment in the signals corresponding to the metabolism of either lipid or glucose represents the common mechanism underlying the pathogenesis of GLMD.The liver and adipose tissue are the major metabolic organs responsible for energy utilization and storage,respectively.This review article aims to summarize the current advances in the investigation of the functional roles and the underling mechanisms of the interplay between the liver and adipose tissue in the modulation of GLMD development.Fibroblast growth factor 21(FGF21) and adiponectin represent the two major hormones secreted from the liver and adipose tissues,respectively.FGF21 exerts pleiotropic effects on regulating glucose and lipid homeostasis majorly through inducing the expression and secretion of adiponectin.Therefore,FGF21-adiponectin axis functions as the key mediator for the crosstalk between the liver and adipose tissue to exert the beneficial effects on the maintenance of the homeostasis of energy consumption.The liver-and adipose tissue-derived factors with pleiotropic effects on regulating of lipid and glucose metabolism function as the key mediator for the crosstalk between these two highly active metabolic organs,thereby coordinating the initiation and development of GLMD. | YE De-wei RONG Xiang-lu XU Ai-min GUO Jiao | 2017 | Chinese Journal of Integrative Medicine2017，23，6： | 14 |
| 20 | Effects of light intensity on leaf microstructure and growth of rape seedlings cultivated under a combination of red and blue LEDs显示文摘The aim of this study was to evaluate the growth of rape(Brassica napus L.) seedlings under different light intensities to select appropriate conditions for cultivation in an indoor system.Seedlings were grown under different light intensities of red and blue light provided by light-emitting diodes(LEDs) and their self-adjustment ability and changes in leaf microstructure were evaluated.Light was supplied by red LEDs with peak wavelengths of 630(R_1) and 660 nm(R_2) and by blue LEDs(B) with a peak wavelength of 445 nm(the light intensity ratio of R_1:R_2:B was 3:3:2),at intensities of 400(R_1R_2B400),300(R_1R_2B300),and 200 μmol m^(-2)s^(-1)(R_1R_2B200).Natural solar light served as the control(C).Plant height,stem diameter,root length,leaf area,and dry weight of rape seedlings gradually increased with increasing light intensity.The seedlings in the R_1R_2B400 treatment grew more vigorously,while those in the R_1R_2B200 treatment were weaker.The photosynthetic pigment contents did not differ significantly between the R_1R_2B400 treatment and C,but were significantly lower in the R_1R_2B300 and R_1R_2B200 treatments.The highest intercellular CO_2 concentration,stomatal conductance,and transpiration rate were in the R_1R_2B300 treatment.The highest photosynthetic rate was in the R_1R_2B400 treatment,and was related to more compact leaves,thicker and tidier palisade and spongy tissues,and well-developed chloroplasts.In contrast,the seedlings in the R_1R_2B200 treatment had disordered mesophyll cells,round chloroplasts,and fractured and fuzzy grana lamellae,all of which inhibited plant growth.In conclusion,the seedlings in the R_1R_2B400 treatment had well-developed leaves,which favored photosynthesis.Compared with the light intensities below 300 μmol m^(-2)s^(-1),the light intensity of 400μmol m^(-2)s^(-1) provided by a combination of red and blue LEDs was beneficial for cultivating strong and healthy rape seedlings in an artificial system. | YAO Xu-yang LIU Xiao-ying XU Zhi-gang JIAO Xue-lei | 2017 | Journal of Integrative Agriculture2017，16，1： | 13 |
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