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| 1 | Numerical simulation of powder transport behavior in laser cladding with coaxial powder feeding显示文摘Laser cladding with coaxial powder feeding is one of the new processes applied to produce well bonding coating on the component to improve performance of its surface. In the process, the clad material is transported by the carrying gas through the coaxial nozzle, generating gas-powder flow. The powder feeding process in the coaxial laser cladding has important influence on the clad qualities. A 3D numerical model was developed to study the powder stream structure of a coaxial feeding nozzle. The predicted powder stream structure was well agreed with the experimental one. The validated model was used to explore the collision behavior of particles in the coaxial nozzle, as well as powder concentration distribution. It was found that the particle diameter and restitution coefficient greatly affect the velocity vector at outlet of nozzle due to the collisions, as well as the powder stream convergence characteristics below the nozzle. The results indicated a practical approach to optimize the powder stream for the coaxial laser cladding. | LIU Hao HE XiuLi YU Gang WANG Zhong Bin LI ShaoXia ZHENG CaiYun NING WeiJian | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，10： | 17 |
| 2 | CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。 | Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang | 2014 | Cell Research2014，24，6： | 7 |
| 3 | Pilot study for the treatment of sodium and fluoridecontaminated groundwater by using high-pressure membrane systems显示文摘高压的膜过程是为包含过多的溶解固体的地下水的处理的划算的技术之一。这份报纸在在包含过多的钠,硫酸盐和氟化物离子的 Huaibei 平原对待典型地下水报导一个预研项目。三个膜系统被建立并且反向的渗透(RO ) 的二张品牌,四低压的 RO (LPRO ) 和一紧密的 nanofiltration (NF ) 膜在这个预研项目下面被测试。在大约 75% 点的明显的恢复率被采用。在有 dosing antiscalent 的联合,子弹过滤不是足够的减少未加工的水的犯规潜力。所有 RO 和 LPRO 系统(除了二严重地由膜犯规影响了) 传导性(98.5%) 的表明的类似的拒绝比率,钠(98.5%) 和氟化物(99%) 。膜犯规实质地减少了犯规的膜的拒绝表演。紧密的 NF 膜也在电导率(95%) 上有好拒绝,钠(94%) 和氟化物(95%) 。所有膜几乎完全拒绝了硫酸盐离子(超过 99%) 。为 RO, LPRO 和 NF 系统的电消费是 1.74, 1.10 和 0.72 kWh 吗?? | Xiaomao WANG Hongwei YANG Zhenyu LI Shaoxia YANG Yuefeng XIE | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 3 |
| 4 | Single-row laser beam with energy strengthened ends for continuous scanning laser surface hardening of large metal components显示文摘For laser surface hardening of metal components with large superficies,a binary grating is proposed to generate single-row laser beam with proportional-intensity diffractive orders.To obtain a uniform hardened band distribution and improve the wear resistance of the sample surface,the binary grating is designed to produce single-row laser beam with energy strengthened at the two ends.The profile of the laser beam spot was designed to be strip with high length-width ratio to improve the machining efficiency of the hardening of large surfaces.A new advantage is suggested to obtain proportional intensity spots with evenness.The design results show that the diffractive efficiency of the binary grating is more than 70%,and the uniformity is less than 3%.The surface profile of the grating fabricated was measured,which shows that the fabrication error is less than 2%.The application of the binary grating in the laser surface hardening of metal components with large superficies is experimentally investigated,and the results show that the hardness distribution of the modified layer is more uniform than that hardened by Gaussian laser beam or array spots with equal intensity distribution. | LI ShaoXia YU Gang ZHANG JingChuan TAN QiaoFeng XU NingHan SUN PeiPei ZHENG CaiYun | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 3 |
| 5 | Quasi-Dammann grating with proportional intensity of array spots for surface hardening of metal显示文摘For surface hardening of metal,a quasi-Dammann grating (QDG) is proposed and fabricated to generate array spots with proportional-intensity distribution.To get uniformly hardened band distribution and improve the wear resistance of the sample surface,a three-order QDG is designed to produce array spots with enhanced intensity in the edge.The design and fabrication of the QDG are described in detail.The surface profile of the fabricated grating was measured,which shows that the fabrication error is less than 2%.The laser beam intensity distribution shaped by the QDG was tested by a laser beam analyzer to verify the validity of the QDG.The application of the QDG in the laser surface hardening of metal was experimentally investigated,and the results show that the hardness distribution of the modified layer and the wear resistance of the sample surface are improved significantly by using the QDG. | LI ShaoXia TAN QiaoFeng YU Gang WANG HengHai JIN GuoFan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，1： | 2 |
| 6 | Driving mechanism of keyhole evolution during multi-pulse drilling with a millisecond laser显示文摘To better understand the physical processes of multi-pulse laser drilling,this study investigates the keyhole evolution and its driving mechanism in a time-resolved observation system.The evolution characteristics suggested a two-phase process of rapid penetration followed by moderate penetration.As revealed in the ejection and vaporization behavior,the keyhole evolution was dominated by ejection and vaporization during the rapid and moderate penetration stages,respectively.In a single laser-pulsed drilling experiment,the driving mechanism itself was found to be affected by the dimensionless laser power density.The effect of dimensionless laser power density on depth increment was then discussed by comparing the experimental observations with numerical simulation results.The results further confirmed the driving mechanism of the keyhole evolution.The results in this paper are useful for understanding the driving mechanism of the keyhole evolution during multi-pulse laser drilling. | Yue Zhang Gang Yu XiuLi He ShaoXia Li WeiJian Ning | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，10： | 2 |
| 7 | Oligomeric Proanthocyanidins from Grape Seeds Effectively Inhibit Ultraviolet-Induced Melanogenesis of Human Melanocytes in Vitro显示文摘 | Zi Shaoxia Ma Huijun Li You | 2009 | International Journal of Molecular Medicine2009，23，2： | 1 |
| 8 | The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity显示文摘 | Yurong Li Jiannan Feng Shaoxia Geng Shusheng Geng Huawei Wei Guojiang Chen Xinying Li Liyan Wang Renxi Wang Hui Peng Gencheng Han Beifen Shen Yan Li | 2010 | Molecular Immunology2010，，4： | 1 |
| 9 | Pancreatitis-Associated Protein Inhibits Human Pancreatic Stellate Cell MMP-1 and -2, TIMP-1 and -2 Secretion and RECK Expression显示文摘 | Ling Li Max G. Bachem Shaoxia Zhou Zilin Sun Jinfei Chen Marco Siech Daniel Bimmler Rolf Graf | 2009 | Pancreatology . 2009 (1-2)2009，，1： | 1 |
| 10 | Organoeatalyzed anion elay leading to functionalized 2,3-dihydrofurans 显示文摘 | Li Mengru Lin Shaoxia Dong Zhiyong | 2013 | Org Lett2013，15，15： | 1 |
| 11 | A novel intelligent adaptive control of laser-based ground thermal test显示文摘Laser heating technology is a type of potential and attractive space heat flux simulation technology, which is characterized by high heating rate, controlled spatial intensity distribution and rapid response. However, the controlled plant is nonlinear, time-varying and uncertainty when implementing the laser-based heat flux simulation. In this paper, a novel intelligent adaptive controller based on proportion–integration–differentiation(PID) type fuzzy logic is proposed to improve the performance of laser-based ground thermal test. The temperature range of thermal cycles is more than 200 K in many instances. In order to improve the adaptability of controller,output scaling factors are real time adjusted while the thermal test is underway. The initial values of scaling factors are optimized using a stochastic hybrid particle swarm optimization(H-PSO)algorithm. A validating system has been established in the laboratory. The performance of the proposed controller is evaluated through extensive experiments under different operating conditions(reference and load disturbance). The results show that the proposed adaptive controller performs remarkably better compared to the conventional PID(PID) controller and the conventional PID type fuzzy(F-PID) controller considering performance indicators of overshoot, settling time and steady state error for laser-based ground thermal test. It is a reliable tool for effective temperature control of laser-based ground thermal test. | Gan Zhengtao Yu Gang Li Shaoxia He Xiuli Chen Ru Zheng Caiyun Ning Weijian | 2016 | Chinese Journal of Aeronautics2016，29，4： | 1 |
| 12 | High-power laser beam shaping by inseparable two-dimensional binary-phase gratings for surface modification of stamping dies显示文摘 | Li Shaoxia Yu Gang Zheng Caiyun | 2008 | Optics and Lasers in Engineering2008，46，： | 1 |
| 13 | Application of a nuclear localization signal gene in transgene mice显示文摘Efficient gene transfer by cytoplasm co-injec-tion will offer a powerful means for transgenic animals. Us-ing co-injection in cytoplasm, two independent gene con-structs, including bovine a-s1-casein-hG-CSF and a mammal expression vector expressing a nuclear localization signal (mNLS), were introduced into fertilized mouse eggs. The target gene construct was docked into host nucleus probably by the nuclear localization signal. Transgene mice have been obtained at 58% (29/50) of integration ratio. Ex-pression level of the positive transgene mice was detected by Western blotting. Maximal expression of human G-CSF was estimated about 540 mg/L of milk. The expression ratio was up to 75% (9/12). The results here have important practical implications for the generation of mammary gland bioreac-tors and other transgene studies. Co-injection of a target gene with an expression vector of a mammal nuclear localization signal by cytoplasm appears to be a useful, efficient and easy strategy for generating | Jingpu Zhang Yuge Wang Guangsan Li Yu Shen Shaoxia Zhu Miao Du | 2002 | Chinese Science Bulletin2002，47，3： | 1 |
| 14 | Quasi-dammann grating with proportional intensity array spots显示文摘 | Li Shaoxia Yu Gang Zheng Caiyun | 2008 | Optics Letters2008，33，18： | 1 |
| 15 | Catalytic activity, stability and structure of multi-walled carbon nanotubes in the wet air oxidation of phenol 显示文摘 | Yang Shaoxia Li Xiang Zhu Wanpeng Wang dianbing Descorme Claude | 2008 | Carbon2008，46，3： | 1 |
| 16 | IMPROVEMENT OF ADHESION BETWEEN ION PLATED TiN COATING AND BASE METAL BY ADDING Y显示文摘The adhesion between the ion plated TiN coating and the base metal is improved byadding Y.The machenism of the effect of Y has been discussed as well. | JIN Zhujing YU Li DAI Shaoxia YU Zhiming Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang,China Institute of Corrosion and Protection of Metals,Academia Sinica,Wencui Road,Shenyang,China | 1989 | Acta Metallurgica Sinica(English Letters)1989，2，10： | 1 |
| 17 | Multi-walled carbon nanotubes(MWNTs) as an efficient catalyst for catalytic wet air oxidation of phenol显示文摘 | Yang Shaoxia Zhu Wangpeng Li Xiang | | 0，，12： | 1 |
| 18 | Catalytic activity,stability and structure of multi-walled carbon nanotubes in the wet air oxidation of phenol显示文摘 | Yang Shaoxia Li Xiang Zhu Wangpeng | | 0，，03： | 1 |
| 19 | Catalytic activity,stability and structure of multi-walled carbon nanotuhes in the wet air oxidation of phenol显示文摘 | Yang Shaoxia Li Xiang Zhu Wanpeng | | 0，，03： | 1 |
| 20 | Experimental and numerical study of thermal fatigue behavior under variable amplitude induced by pulsed laser显示文摘Thermal fatigue is the typical failure mode of high-temperature combustion chamber components used in power plants and in the aerospace and transportation industries[1-3].With growing demand for good performance and high reliability,thermal fatigue is becoming a serious problem.The thermal working conditions of combustion chamber components include start-stop cycles and routine | SiNing Pan Gang Yu XiuLi He ShaoXia Li Ru Chen | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，10： | 0 |
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