|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Survey of Birth Defects Rate Based on Birth Registration System显示文摘 | Min Yu Zhiguang Ping Shuiping Zhang Yuying He Rui Dong Xiong Guo | 2015 | Chinese Medical Journal2015，，1： | 10 |
| 2 | A SEMI-ANALYTICAL AND SEMI-NUMERICAL METHOD FOR SOLVING 2-D SOUND-STRUCTURE INTERACTION PROBLEMS显示文摘Based on the transfer matrix method and the virtual source simulation technique,this paper proposes a novel semi-analytical and semi-numerical method for solving 2-D sound-structure interaction problems under a harmonic excitation. Within any integration segment,as long as its length is small enough, along the circumferential curvilinear coordinate, the nonhomogeneous matrix differential equation of an elastic ring of complex geometrical shape can be rewritten in terms of the homogeneous one by the method of extended homogeneous capacity proposed in this paper. For the exterior fluid domain, the multi-circular virtual source simulation technique is adopted. The source density distributed on each virtual circular curve may be ex-panded as the Fourier''s series. Combining with the inverse fast Fourier transformation, a higher accuracy and efficiency method for solving 2-D exterior Helmholtz's problems is presented in this paper. In the aspect of solution to the coupling equations, the state vectors of elastic ring induced by the given harmonic excitation and generalized forces of coefficients of the Fourier series can be obtained respectively by using a high precision integration scheme combined with the method of extended homogeneous capacity put forward in this paper. According to the superposition principle and compatibility conditions at the interface between the elastic ring and fluid, the algebraic equation of system can be directly constructed by using the least square approximation. Examples of acoustic radiation from two typical fluid-loaded elastic rings under a harmonic concentrated force are presented. Numerical results show that the method proposed is more efficient than the mixed FE-BE method in common use. | Xiang Yu Huang Yuying (College of Civil Engineering and Mechanics,Huazhong University of Science and Technology,Wuhan 430074,China) | 2003 | Acta Mechanica Solida Sinica2003，16，2： | 8 |
| 3 | TRANSFER MATRIX METHOD FOR ANALYZING VIBRATION AND DAMPING CHARACTERISTICS OF ROTATIONAL SHELL WITH PASSIVE CONSTRAINED LAYER DAMPING TREATMENT显示文摘The first order differential matrix equations of the host shell and constrained layer for a sandwich rotational shell are derived based on the thin shell theory.Employing the layer wise principle and first order shear deformation theory, only considering the shearing deformation of the viscoelastic layer, the integrated first order differential matrix equation of a passive constrained layer damping rotational shell is established by combining with the normal equilibrium equation of the viscoelastic layer.A highly precise transfer matrix method is developed by extended homogeneous capacity precision integration technology.The numerical results show that present method is accurate and effective. | Jing Lu Yu Xiang Yuying Huang Xiaoni Li Qiao Ni | 2010 | Acta Mechanica Solida Sinica2010，23，4： | 5 |
| 4 | Distributed Vibration Sensor With Laser Phase-Noise Immunity by Phase-Extraction φ-OTDR显示文摘We have demonstrated a distributed vibration sensor based on phase-sensitive optical time-domain reflectometer (φ-OTDR) system exhibiting immunity to the laser phase noise. Two laser sources with different linewidth and phase noise levels are used in the φ-OTDR system, respectively. Based on the phase noise power spectrum density of both lasers, the laser phase is almost unchanged during an extremely short period of time, hence, the impact of phase noise can be suppressed effectively through phase difference between the Rayleigh scattered light from two adjacent sections of the fiber which define the gauge length. Based on the phase difference method, the external vibration can be located accurately at 41.01 km by the(φ-OTDR system incorporating these two lasers. Meanwhile, the average signal-to-noise ratio (SNR) of the retrieved vibration signal by using Laser I is found to be -37.7 dB, which is comparable to that of -37.5 dB by using Laser II although the linewidth and the phase noise level of the two lasers are distinct. The obtained results indicate that the phase difference method can enhance the performance of(φ-OTDR system with laser phase-noise immunity for distributed vibration sensing, showing potential application in oil-gas pipeline monitoring, perimeter security, and other fields. | Yuying SHAO Huanhuan LIU Peng PENG Fufei PANG Guoqin YU Zhen CHEN Na CHEN Tingyun WANG | 2019 | Photonic Sensors2019，9，3： | 5 |
| 5 | Blastic Plasmacytoid Dendritic Cell Neoplasm:Progress in Cell Origin,Molecular Biology,Diagnostic Criteria and Therapeutic Approaches显示文摘Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare hematological malignancy characterized by recurrent skin nodules,an aggressive clinical course with rapid involvement of hematological organs,and a poor prognosis with poor overall survival.BPDCN is derived from plasmacytoid dendritic cells(pDCs)and its pathogenesis is unclear.The tumor cells show aberrant expression of CD4,CD56,interleukin-3 receptor alpha chain(CD 123),blood dendritic cell antigen 2(BDCA 2/CD303),blood dendritic cell antigen 4(BDCA4)and transcription factor(E protein)E2-2(TCF4).The best treatment drugs are based on experience by adopting those used for either leukemia or lymphoma.Relapse with drug resistance generally occurs quickly.Stem cell transplantation after the first complete remission is recommended and tagraxofusp is the first targeted therapy.In this review,we summarize the differentiation of BPDCN from its cell origin,its connection with normal pDCs,clinical characteristics,genetic mutations and advances in treatment of BPDCN.This review provides insights into the mechanisms of and new therapeutic approaches for BPDCN. | Wei CHENG Tian-tian YU Ai-ping TANG Ken HE YOUNG Li YUI | 2021 | Current Medical Science2021，41，3： | 4 |
| 6 | Economic evaluation of cervical cancer screening strategies in urban China显示文摘Objective:This study evaluated the feasibility of different cervical cancer screening strategies in urban China.Methods:A Markov model was constructed to simulate a hypothetical cohort of 100,000 females aged 30-59 years in a 20-year period.Screening strategies included liquid-based cytology(LBC)every three years,human papillomavirus(HPV)DNA testing every three and five years,respectively,and a combination of HPV DNA testing and LBC(HPV+LBC)every three and five years,respectively.Model outcomes included cumulative incidence over 20 years,cumulative risk of cervical cancer,costs,life year saved(LYS),quality-adjusted life years(QALYs)and benefits.The cost-effectiveness ratios(CERs),incremental cost-effectiveness ratios(ICERs),costutility ratios(CURs),and benefit-cost ratios(BCRs)were used as outcomes in the health economic evaluation analysis.Univariate sensitivity analyses were performed to examine the stability of the results.Results:The cumulative incidence of the five screening strategies ranged from 833.02 to 1,158.07 cases per100,000 females.HPV DNA testing was most effective in reducing the cumulative risk of cervical cancer,saving life years and QALYs and gaining benefits.The CERs of HPV DNA testing every three and five years,and LBC every three years were considered to be very cost-effective if they were below China's GDP per capita.The CERs of HPV+LBC were considered to be cost-effective if they were below three times GDP per capita.The incremental cost-effectiveness analysis showed that HPV DNA testing every three and five years,LBC every three years and HPV+LBC every five years were dominant strategies.Conclusions:The findings of this study indicated that HPV DNA testing every five years or LBC every three years should be recommended in urban China. | Li Ma Yuying Wang Xiaohong Gao Yi Dai Yu Zhang Zhaojing Wang Xiaoxia Wang Limin Wang Jing Jiang Xinhua Jing Chunxia Yang Fanghui Zhao Jinghe Lang Youlin Qiao | 2019 | Chinese Journal of Cancer Research2019，31，6： | 4 |
| 7 | A bacterial effector protein uncovers a plant metabolic pathway involved in tolerance to bacterial wilt disease显示文摘Bacterial wilt caused by the soil-borne plant pathogen Ralstonia solanacearum is a devastating disease worldwide.Upon plant colonization,R.solanacearum replicates massively,causing plant wilting and death;collapsed infected tissues then serve as a source of inoculum.In this work,we show that the plant metabolic pathway mediated by pyruvate decarboxylases(PDCs)contributes to plant tolerance to bacterial wilt disease.Arabidopsis and tomato plants resp ond to R.solanacearum infection by in creasing PDC activity,and plants with deficient PDC activity are more susceptible to bacterial wilt.Treatment with either pyruvic acid or acetic acid(substrate and product of the PDC pathway,respectively)enhances plant tolerance to bacterial wilt disease.An effector protein secreted by R.solanacearum,RipAK,interacts with PDCs and inhibits their oligomerization and enzymatic activity.Collectively,our work reveals a metabolic pathway involved in plant resistance to biotic and abiotic stresses,and a bacterial virulence strategy to promote disease and the completion of the pathogenic life cycle. | Yaru Wang Achen Zhao Rafael J.L.Morcillo Gang Yu Hao Xue Jose S.Rufian Yuying Sang Alberto P.Macho | 2021 | Molecular Plant2021，14，8： | 3 |
| 8 | ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI显示文摘Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P? | Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han | 2019 | Science Bulletin2019，64，14： | 3 |
| 9 | A New Ductile Fracture Criterion and Its Application to the Prediction of Forming Limit in Deep Drawing显示文摘With considering the influence of equivalent plastic strain on void-damage and taking Lemaitre damage equivalent stress as plastic potential, based on continuous damage mechanics theory, a new criterion for ductile fracture is derived. The two key material constants in the criterion are determined by the combination of tension tests with FE (finite element) simulation. On the basis of the values of stress and strain calculated from commercial finite element software, the forming limit in cylindrical deep drawing of annealed aluminum alloy LY12(M) is predicted by means of the new ductile fracture criterion. Experiments verify that the predicted results are in agreement with the experimental ones. Hence, it is reliable to predict the forming limit in deep drawing by means of the new ductile fracture criterion. | Yuying YANG Zhongqi YU Xuechun LI Zhenzhong SUN | 2003 | Journal of Materials Science & Technology2003，19，z1： | 3 |
| 10 | MODELING AND DYNAMICS ANALYSIS OF SHELLS OF REVOLUTION BY PARTIALLY ACTIVE CONSTRAINED LAYER DAMPING TREATMENT显示文摘A new model for a smart shell of revolution treated with active constrained layer damping(ACLD)is developed,and the damping efects of the ACLD treatment are discussed.The motion and electric analytical formulation of the piezoelectric constrained layer are presented first.Based on the authors’recent research on shells of revolution treated with passive constrained layer damping(PCLD),the integrated first-order diferential matrix equation of a shell of revolution partially treated with ring ACLD blocks is derived in the frequency domain.By virtue of the extended homogeneous capacity precision integration technology,a stable and simple numerical method is further proposed to solve the above equation.Then,the vibration responses of an ACLD shell of revolution are measured by using the present model and method.The results show that the control performance of the ACLD treatment is complicated and frequency-dependent.In a certain frequency range,the ACLD treatment can achieve better damping characteristics compared with the conventional PCLD treatment. | Qiao Ni Yu Xiang Yuying Huang Jing Lu | 2013 | Acta Mechanica Solida Sinica2013，26，5： | 3 |
| 11 | Biochar-Induced Priming Effects in Young and Old Poplar Plantation Soils显示文摘The priming effect(PE)induced by biochar provides a basis for evaluating its carbon(C)sequestration potential in soils.A 60 days’laboratory incubation was conducted,which involved the amendment of biochar(1%of soil mass)produced from rice straw at 300℃(B300)and 500℃(B500)to young(Y)and old(O)poplar plantation soils,with the aim of studying the responses of biochar-induced PEs to poplar plantation ages.This incubation included six treatments:Y+CK(control),Y+B300,Y+B500,O+CK,O+B300,and O+B500.Carbon dioxide(CO_(2))emissions were significantly increased(p<0.05)in the B300 amended soils,while it was decreased in the B500 amended soils compared to the CK.The primed CO_(2) emissions were 2.35 times higher in the Y+B300 than the O+B300 treatments,which was measured to be 18.6 and 5.56 mg C·kg^(-1) with relative PEs of 12.4%and 3.35%,respectively.However,there was little difference between the primed CO_(2) emissions in Y+B500 and O+B500 treatments,which were measured to be-24.9 and-29.6 mg·C·kg^(-1) with relative PEs of-16.6%and-17.8%,respectively.Dissolved organic carbon(DOC)was significantly lower in the young poplar plantation soil than that in the old poplar plantation soil regardless of biochar amendment throughout the incubation,indicating greater C-limit of soil microorganisms in the young poplar plantation soil.Using ^(13)C isotope tracing,neither B300 nor B500 decreased native soil-derived DOC,which indicated that the negative B500-induced PEs were not due to a reduction in the availability of native soil-derived C.In conclusion,the response of biochar-induced PEs to poplar plantation age depends on biochar types while soil available C indirectly affects biochar-induced PEs.Further studies should focus on how the interactive effects between soil C availability and microbial community impacts biochar-induced PEs. | Weiwei Lu Yirui Zhang Yixian Yao Yuying Wu Han Y.H.Chen Hailin Zhang Jia Yu Caiqin Shen Qi Liu Honghua Ruan | 2020 | Phyton-International Journal of Experimental Botany2020，89，1： | 2 |
| 12 | Intra-strain Elicitation and Suppression of Plant Immunity by Ralstonia solanacearum Type-III Effectors in Nicotiana benthamiana显示文摘Effector proteins delivered inside plant cells are powerful weapons for bacterial pathogens,but this exposes the pathogen to potential recognition by the plant immune system.Therefore,the effector repertoire of a given pathogen must be balanced for a successful infection.Ralstonia solanacearum is an aggressive pathogen with a large repertoire of secreted effectors.One of these effectors,RipE1,is conserved in most R.solanacearum strains sequenced to date.In this work,we found that RipE1 triggers immunity in N.benthamiana,which requires the immune regulator SGT1,but not EDS1 or NRCs.Interestingly,RipE1-triggered immunity induces the accumulation of salicylic acid(SA)and the overexpression of several genes encoding phenylalanine-ammonia lyases(PALs),suggesting that the unconventional PALmediated pathway is responsible for the observed SA biosynthesis.Surprisingly,RipE1 recognition also induces the expression of jasmonic acid(JA)-responsive genes and JA biosynthesis,suggesting that both SA and JA may act cooperatively in response to RipE1.We further found that RipE1 expression leads to the accumulation of glutathione in plant cells,which precedes the activation of immune responses.R.solanacearum secretes another effector,RipAY,which is known to inhibit immune responses by degrading cellular glutathione.Accordingly,RipAY inhibits RipE1-triggered immune responses.This work shows a strategy employed by R.solanacearum to counteract the perception of its effector proteins by plant immune system. | Yuying Sang Wenjia Yu Haiyan Zhuang Yali Wei Lida Derevnina Gang Yu Jiamin Luo Alberto P.Macho | 2020 | Plant Communications2020，1，4： | 2 |
| 13 | Short- and midterm repeatability of magnetic resonance elastography in healthy volunteers at 3.0T显示文摘 | Yu Shi Qiyong Guo Fei Xia Jiaxing Sun Yuying Gao | 2014 | Magnetic Resonance Imaging2014，，： | 1 |
| 14 | ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques显示文摘During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains unclear.As the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial cells.As an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 infection.However,the molecular mechanism regulating ACE2 expression remains unclear. | Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu Nannan Zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo Zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 15 | A variational solution of 2-D sound-structure interaction problems显示文摘基于联合理论的液体结构,为从有弹性的结构分析健全放射的一个局部性的变化原则由于泛音刺激在水里沉没了被介绍。为结构声学的系统的稳定的反应提出各种各样的数字方法将是一个强大的工具。借助于一个混合元素方法,在大多数包围的水里有效的一个分析答案与有限元素在被合并在结构和它的附近的水散布了的这个变化原则,被设计。计算例子然后被给表明它的高精确性并且时间节省。 | Yuying Huang Haidong Su Yu Xiang | 2006 | Acta Mechanica Sinica2006，22，2： | 1 |
| 16 | Single-cell brain atlas of Parkinson's disease mouse model显示文摘Parkinson's disease(PD)is a neurodegenerative disease,leading to the impairment of movement execution.PD pathogenesis has been largely investigated,either limited to bulk transcriptomic levels or at certain cell types,which failed to capture the cellular heterogeneity and intrinsic interplays among distinct cell types.Here,we report the application of single-nucleus RNA-seq on midbrain,striatum,and cerebellum of theα-syn-A53 T mouse,a well-established PD mouse model,and matched controls,generating the first single cell transcriptomic atlas for the PD model mouse brain composed of 46,174 individual cells.Additionally,we comprehensively depicte the dysfunctions in PD pathology,covering the elevation of NF-k B activity,the alteration of ion channel components,the perturbation of protein homeostasis network,and the dysregulation of glutamatergic signaling.Notably,we identify a variety of cell types closely associated with PD risk genes.Taken together,our study provides valuable resources to systematically dissect the molecular mechanism of PD pathogenesis at the single-cell resolution,which facilitates the development of novel approaches for diagnosis and therapies against PD. | Jixing Zhong Gen Tang Jiacheng Zhu Weiying Wu Ge Li Xiumei Lin Langchao Liang Chaochao Chai Yuying Zeng Feiyue Wang Lihua Luo Jiankang Li Fang Chen Zhen Huang Xiuqing Zhang Yu Zhang Hongde Liu Xin Qiu Shengping Tang Dongsheng Chen | 2021 | Journal of Genetics and Genomics2021，48，4： | 1 |
| 17 | Preparation and cellular uptake of PLGA particles loaded with lamivudine显示文摘Poly (D, L-lactide-co-glycolide )(PLGA ) nanoparticles 与 lamivudine 装载了并且与牛的浆液白朊(BSA ) 涂经由一个双乳剂方法被准备。象内部水的阶段,器官的阶段的集中和粒子尺寸和药陷阱效率上的 ultrasonication 时间的体积那样的实验参数的影响被调查,获得有 260 nm 的一条直径和 35% 的药陷阱效率的 PLGA 粒子。粒子被扫描电子显微镜学和发射度电子显微镜学观察,显示出核心壳结构。发现那 58 mg BSA 的 BCA 试金在 1 个 g LPB 粒子上 / 在是在场的。装载 lamivudine 在开始显示出一个爆炸版本并且处于生理的条件支撑了版本直到 24 h。低 pH 能从 PLGA 粒子加速 lamivudine 的版本,使 PLGA 粒子成为潜在的聪明的细胞内部的药搬运人。PLGA 粒子乐意地在一短时间以内被使内在化进人的肝房间并且不管装载 lamivudine 与孵化时间的延伸逐渐地增加了。粒子任何一个在 lysosomes 以内住了或转了到细胞质,但是不能进入房间原子核。房间生存能力显著地没不管 lamivudine 封装面对粒子被影响,建议这种粒子可以是细胞内部的反肝炎 B 药交货的一个好候选人。 | WANG Bing CHEN GuanQun MAO ZhengWei ZHANG YuYing YU DaHai GAO ChangYou | 2012 | Chinese Science Bulletin2012，57，31： | 1 |
| 18 | Docosahexaenoic acid supplementation failed to attenuate chronic alcoholic fatty liver in mice显示文摘n-3 多元不堡和的角色包括在含酒精的脂肪肝(AFL ) 的 docosahexaenoic 酸(DHA ) 的丰满的酸(PUFA ) 在一系列研究被调查了。DHA 和 DHA 富有的鱼油被发现对尖锐 AFL 提供保护[1,2 ] ,当时他们长期的 AFL 上的效果仍然是一个争论问题。尽管歌等。[3 ] 发现 DHA 和 arachidonic 酸阻止了长期的 AFL,几另外的研究表明鱼油支持了长期的 AFL 的致病,当浸透时,丰满的酸对长期的 AFL 是保护的[4-6 ] 。n-3 PUFA 的剂量和质量可能是为这些冲突结果的可能的原因,这被推测[1,3 ] 。不管怎样,在长期的 AFL 的 DHA 的角色尚待被调查。 | Yi Wang Yuying Zhao Mingzhuo Li Yunxuan Wang Shuqing Yu Tao Zeng | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 1 |
| 19 | Receptor for Advanced-Glycation End Products: Key Modulator of Myocardial Ischemic Injury显示文摘 | Loredana G. Bucciarelli Michiyo Kaneko Radha Ananthakrishnan Evis Harja Larisse K. Lee Yuying C. Hwang Shulamit Lerner Soliman Bakr Qing Li Yan Lu Fei Song Wu Qu Teodoro Gomez Yu Shan Zou Shi Fang Yan Ann Marie Schmidt Ravichandran Ramasamy | 2006 | Circulation2006，，9： | 1 |
| 20 | Determination of effective shear modulus of shock-compressed LY12 A1 from particle velocity profile measurements显示文摘 | Yu Yuying Tan Hua Hu Jianbo | 2008 | Journal of Applied Physics2008，103，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员