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| 1 | Dynamic expression of apoptosis-related genes during development of laboratory hepatocellular carcinoma and its relation to apoptosis显示文摘AIM:To explore the expression of p53,bcl-2,bax,survivin and the cell apoptosis during the development of tree shrew hepatocellular carcinoma(HCC),the relationship between expression of these genes,its impact on HCC development,and its relation to cell apoptosis.METHONS:Tree shrew HCC was induced with aflatoxin B1(AFB1),and regular biopsy of liver tissues was carried out and the biopsy tissues were collected during cancer inducement.Liver biopsy tisue and HCC tissue were collected from 35pre-cancerous experimental animats at wk 30 and 60 and at the 30th_,60th_,and 90th-wk,Liver biopsy tissues were collected from 13 blank control animals at wk 30,60,and 90.Expression of p53,bcl-2,bax,and survivin at each stage was examined by immunohistochemistry method.Apoptotic cells were detected in situ by the terminal deoxynucleotidyl transferase-mediated nick end labeling(tunel)technique.RESULTS:The apoptosis rate of normal hepatic cells was extremely low,whereas it increased during the formation of HCC.Expression of the apoptosis-related genes p53,bd-2,bax,and suvivin during the formation of HCC presented an increasing tendency.Expression of p53 did not noticeably relate to that of bcl-2,bax,and survivin,whereas expression of bcl-2 and bax was closely related.In HCC,p53 did not present a distinct relation to cell apoptosis,whereas its high level expression was probably related to liver cell proliferation.Survivin negetively correlated apoptosis index,and its overexpression could inhibit cell apoptosis.CONCLUSION:Apoptosis-related genes p53,bcl-2,bax,and survivin are all related to the occurrence of HCC.The anti-apoptosis effect of bcl-2 is influenced by bax,and ratio bcl/bax reflects more correctly the extent of cell apoptosis. | Xiao-Xian Duan Jing-Sheng Ou Yuan Li Jian-Jia Su Chao Ou Chun Yang Hui-Fen Yue Ke-Chen Ban | 2005 | World Journal of Gastroenterology2005，11，30： | 38 |
| 2 | Alteration of p53 and p21 during hepatocarcinogenesis in tree shrews显示文摘AIM: To investigate p53 mutation and p21 expression in hepatocarcinogenesis induced by hepatitis B virus (HBV) and aflatoxin B1 (AFB1) in tree shrews, and to reveal the role of these genes in hepatocarcinogenesis.METHODS: Tree shrews were divided into four groups:group A, those infected with HBV and fed with AFB1 (n = 39);group B, those infected with HBV alone (n = 28); group C,those fed with AFB1 alone (n = 29); and group D, normal controls (n = 20). The tree shrews underwent liver biopsies once every 15 wk. Expression of p53 and p21 proteins and genes in the biopsies and tumor tissues of the experimental tree shrews was detected, respectively, by immunohistochemistry,and by Southem blotting and reverse transcription-polymerase chain reaction and sequencing.RESULTS: The incidence of hepatocellular carcinomas (HCC) was higher in group A (66.7%) than that in group B (3.57%) and C (30%). The time of HCC occurrence was also earlier in group A than that in group C (120.0±16.6 wk vs 153.3±5.8 wk, respectively, P<0.01). p53 protein was not detected by immunohistochemistry in all groups before the 75^th wk of the experiment. At the 105^th wk, the positive rates fo p53 were 78.6%, 60% and 71.4% in groups A, B and C, respectively, which were significantly higher than that in group D (10%) (all P<0.05). An abnormal band of p53 gene was observed in groups A and C. The mutation points of p53gene in tree shrews with HCC were at codons 275, 78 and 13. The nucleotide sequence and amino acid sequence of tree shrew's wild-type p53 showed 91.7% and 93.4% homologies with those of human p53,respectively. The immunopositivity for p21 was found before HCC development. The incidence of HCC was significantly higher in tree shrews that were positive for p21 than those negative for p21 (80.0% vs 11.0%, P<0.001).The incidence of HCC in p21 positive animals in group A was significantly higher than those positive for p21 in group C (P | Jian-Jia Su Yuan Li Ke-Chen Ban Liu-Liang Qin Chun Yang Chao Ou Xiao-Xian Duan Hui-Yun Wang Rui-Qi Yang Young-Lk Lee | 2004 | World Journal of Gastroenterology2004，10，24： | 21 |
| 3 | An overview of the resources and environment conditions and major geological problems in the Yangtze River economic zone, China显示文摘Focusing on the Yangtze River economic zone,the previous geological researches are systematically summarized,resources and environment conditions and major geological problems which are needing to be concerned in land planning and construction are studied.The results show that the resource conditions of cultivated land,shale gas,geotherm,lithium and so on are superior in the Yangtze River economic zone,and the resources and environment conditions are conducive to develop the modern agriculture,clean energy industry and strategic emerging industries.3×1013 m^2 farmlands without heavy metal pollution are concentrated;there are three national level shale gas exploration and development bases with explored reserves of 5.441×1011 m^3;geothermal availability is 2.4×109 t of standard coal each year,equivalent to 19% of the amount of coal in 2014;Asia's largest energy lithium metal ore deposit is found.In some parts of Yangtze River economic zone,there are some major geological problems such as active faults,karst collapse,ground subsidence,landslide-collapse-debris flow,affecting the river-crossing channels,high-speed railway,urban agglomeration and green ecological corridor planning and construction.Those problems should be concerned,and the relevant suggestions and countermeasures are put forward.Meanwhile,the ideas to further support the development of the Yangtze River economic zone are put forward. | Yue-hua Jiang Liang-jun Lin Li-de Chen Hua-yong Ni Wei-ya Ge Hang-xin Cheng Gang-yi Zhai Gui-ling Wang Yi-zhong Ban Yuan Li Ming-tang Lei Cheng-xuan Tan Jing-wen Su Quan-ping Zhou Tai-li Zhang Yun Li Hong-ying Liu Ke Peng Han-mei Wang | 2018 | China Geology2018，1，3： | 6 |
| 4 | Low phosphorus promotes NSP1–NSP2 heterodimerization to enhance strigolactone biosynthesis and regulate shoot and root architecture in rice显示文摘Phosphorus is an essential macronutrient for plant development and metabolism,and plants have evolved ingenious mechanisms to overcome phosphate(Pi)starvation.However,the molecular mechanisms underlying the regulation of shoot and root architecture by low phosphorus conditions and the coordinated utilization of Pi and nitrogen remain largely unclear.Here,we show that Nodulation Signaling Pathway 1(NSP1)and NSP2 regulate rice tiller number by promoting the biosynthesis of strigolactones(SLs),a class of phytohormones with fundamental effects on plant architecture and environmental responses.We found that NSP1 and NSP2 are induced by Oryza sativa PHOSPHATE STARVATION RESPONSE2(OsPHR2)in response to low-Pi stress and form a complex to directly bind the promoters of SL biosynthesis genes,thus markedly increasing SL biosynthesis in rice.Interestingly,the NSP1/2–SL signaling module represses the expression of CROWN ROOTLESS 1(CRL1),a newly identified early SL-responsive gene in roots,to restrain lateral root density under Pi deficiency.We also demonstrated that GR24^(4DO) treatment under normal conditions inhibits the expression of OsNRTs and OsAMTs to suppress nitrogen absorption but enhances the expression of OsPTs to promote Pi absorption,thus facilitating the balance between nitrogen and phosphorus uptake in rice.Importantly,we found that NSP1p:NSP1 and NSP2p:NSP2 transgenic plants show improved agronomic traits and grain yield under low-and medium-phosphorus conditions.Taken together,these results revealed a novel regulatory mechanism of SL biosynthesis and signaling in response to Pi starvation,providing genetic resources for improving plant architecture and nutrient-use efficiency in low-Pi environments. | Kun Yuan Hao Zhang Chaoji Yu Nan Luo Jijun Yan Shuang Zheng Qingliang Hu Dahan Zhang Liquan Kou Xiangbing Meng Yanhui Jing Mingjiang Chen Xinwei Ban Zongyun Yan Zefu Lu Jian Wu Yu Zhao Yan Liang Yonghong Wang Guosheng Xiong Jinfang Chu Ertao Wang Jiayang Li Bing Wang | 2023 | Molecular Plant2023，16，11： | 2 |
| 5 | Role of Peripheral Regulatory T Lymphocytes in Patients with Thyroid Associated Ophthalmopathy During Systemic Glucocorticoid Treatment:A Prospective Observational Study显示文摘Objective Thyroid-associated ophthalmopathy(TAO)is an autoimmune disorder involving the orbital tissue.This study aimed to understand the role of regulatory T cells(Tregs)in TAO during 12-week systemic glucocorticoid(GC)treatment.Methods Thirty-two moderate-severe TAO patients with a clinical activity score(CAS)≥3/7 or with prolonged T2 relaxation time(T2RT)on at least one side of extraocular muscle(EOM)were enrolled.The percentage of the peripheral CD4+CD25(high)CD127(−/low)Tregs was analyzed using flow cytometry before and after the GC treatment.The activity and severity of TAO,T2RT,and the clinical outcomes after the GC treatment were assessed.Their correlation with the peripheral Tregs was investigated.Results There was no significant association between the baseline Treg fraction and the activity and severity of TAO or the treatment response.A significant reduction of Tregs was observed after the GC therapy merely in patients without any clinical improvement.Conclusion Treg reduction after systemic GC therapy is indicative of a poor therapeutic response.Accordingly,dynamic alterations of Tregs could help to evaluate the effectiveness of the GC treatment. | Qin-qin XU Xiao-ling ZHANG Ban LUO Tao LI Gang YUAN Shi-ying SHAO | 2023 | Current Medical Science2023，43，1： | 2 |
| 6 | Epidemiological and clinical characteristics of 65 hospitalized patients with COVID-19 in Liaoning, China显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has spread rapidly to multiple countries through its infectious agent severe acute respiratory syndrome coronavirus 2.The severity,atypical clinical presentation,and lack of specific anti-viral treatments have posed a challenge for the diagnosis and treatment of COVID-19.Understanding the epidemiological and clinical characteristics of COVID-19 cases in different geographical areas is essential to improve the prognosis of COVID-19 patients and slow the spread of the disease.AIM To investigate the epidemiological and clinical characteristics and main therapeutic strategy for confirmed COVID-19 patients hospitalized in Liaoning Province,China.METHODS Adult patients(n=65)with confirmed COVID-19 were enrolled in this retrospective study from January 20 to February 29,2020 in Liaoning Province,China.Pharyngeal swabs and sputum specimens were collected from the patients for the detection of severe acute respiratory syndrome coronavirus 2 nucleic acid.Patient demographic information and clinical data were collected from the medical records.Based on the severity of COVID-19,the patients were divided into nonsevere and severe groups. All patients were followed until March 20,2020.RESULTSThe mean age of 65 COVID-19 patients was 45.5 ± 14.4 years, 56.9% were men,and 24.6% were severe cases. During the 14 d before symptom onset, 25 (38.5%)patients lived or stayed in Wuhan, whereas 8 (12.3%) had no clear history ofexposure. Twenty-nine (44.6%) patients had at least one comorbidity;hypertension and diabetes were the most common comorbidities. Compared withnonsevere patients, severe patients had significantly lower lymphocyte counts[median value 1.3 × 10^(9)/L (interquartile range 0.9-1.95) vs 0.82 × 10^(9)/L (0.44-1.08),P < 0.001], elevated levels of lactate dehydrogenase [450 U/L (386-476) vs 707 U/L(592-980), P < 0.001] and C-reactive protein [6.1 mg/L (1.5-7.2) vs 52 mg/L (12.7-100.8), P < 0.001], and a prolonged median duration of viral shedding [19.5 d (16-21) vs 23.5 d (19.6-30.3), P = 0.001]. The overall median viral shedding time was19.5 d, and the longest was 53 d. Severe patients were more frequently treatedwith lopinavir/ritonavir, antibiotics, glucocorticoid therapy, immunoglobulin,thymosin, and oxygen support. All patients were discharged following treatmentin quarantine.CONCLUSIONOur findings may facilitate the identification of severe cases and inform clinicaltreatment and quarantine decisions regarding COVID-19. | Wei Zhang Yuan Ban Yun-Hai Wu Jin-Yang Liu Xing-Hai Li Hao Wu Huan Li Rui Chen Xiao-Xu Yu Rui Zheng | 2021 | World Journal of Clinical Cases2021，9，10： | 1 |
| 7 | 显示文摘 | BAN S HUANG C YUAN X Z | 2012 | J Phys Chem C2012，116，17： | 1 |
| 8 | The influence of public perception on risk acceptance of the chemical industry and the assistance for risk communication显示文摘 | Lei Huang Jie Ban Kai Sun Yuting Han Zengwei Yuan Jun Bi | 2013 | Safety Science2013，，1： | 1 |
| 9 | B2SMatcher:fine-Grained version identification of open-Source software in binary files显示文摘Codes of Open Source Software(OSS)are widely reused during software development nowadays.However,reusing some specific versions of OSS introduces 1-day vulnerabilities of which details are publicly available,which may be exploited and lead to serious security issues.Existing state-of-the-art OSS reuse detection work can not identify the specific versions of reused OSS well.The features they selected are not distinguishable enough for version detection and the matching scores are only based on similarity.This paper presents B2SMatcher,a fine-grained version identification tool for OSS in commercial off-the-shelf(COTS)software.We first discuss five kinds of version-sensitive code features that are trackable in both binary and source code.We categorize these features into program-level features and function-level features and propose a two-stage version identification approach based on the two levels of code features.B2SMatcher also identifies different types of OSS version reuse based on matching scores and matched feature instances.In order to extract source code features as accurately as possible,B2SMatcher innovatively uses machine learning methods to obtain the source files involved in the compilation and uses function abstraction and normalization methods to eliminate the comparison costs on redundant functions across versions.We have evaluated B2SMatcher using 6351 candidate OSS versions and 585 binaries.The result shows that B2SMatcher achieves a high precision up to 89.2%and outperforms state-of-the-art tools.Finally,we show how B2SMatcher can be used to evaluate real-world software and find some security risks in practice. | Gu Ban Lili Xu Yang Xiao Xinhua Li Zimu Yuan Wei Huo | 2021 | Cybersecurity2021，4，1： | 1 |
| 10 | Continuous-Time Prediction of Industrial Paste Thickener System With Differential ODE-Net显示文摘It is crucial to predict the outputs of a thickening system,including the underflow concentration(UC)and mud pressure,for optimal control of the process.The proliferation of industrial sensors and the availability of thickening-system data make this possible.However,the unique properties of thickening systems,such as the non-linearities,long-time delays,partially observed data,and continuous time evolution pose challenges on building data-driven predictive models.To address the above challenges,we establish an integrated,deep-learning,continuous time network structure that consists of a sequential encoder,a state decoder,and a derivative module to learn the deterministic state space model from thickening systems.Using a case study,we examine our methods with a tailing thickener manufactured by the FLSmidth installed with massive sensors and obtain extensive experimental results.The results demonstrate that the proposed continuous-time model with the sequential encoder achieves better prediction performances than the existing discrete-time models and reduces the negative effects from long time delays by extracting features from historical system trajectories.The proposed method also demonstrates outstanding performances for both short and long term prediction tasks with the two proposed derivative types. | Zhaolin Yuan Xiaorui Li Di Wu Xiaojuan Ban Nai-Qi Wu Hong-Ning Dai Hao Wang | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，4： | 1 |
| 11 | Fiber Bragg grating sensor fatigue crack real-time monitoring based on spectrum cross-correlation anal- ysis显示文摘 | Ban P Yuan M Dong S | 2013 | Journal of Sound and Vibration2013，332，1： | 1 |
| 12 | Flow visual ization of dragonfly hovering via an electromechanical rnodel显示文摘 | LU Yuan SHEN Gong-xin SU Wen ban | 2007 | AIAA J2007，45，3： | 1 |
| 13 | Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization显示文摘Echinacea purpurea modulates tumor progression,but the underlying mechanism is poorly defined.We isolated and purified a novel homogeneous polysaccharide from E.purpurea(EPPA),which was shown to be an arabinogalactan with a mean molecular mass(Mr)of 3.8×10^(4)Da and withα-(1→5)-L-Arabinan as the backbone and a-L-Araf-(1→,→6)-b-D-Galp-(1→,and →4)-α-D-GalpA-(1/as the side chains.Interestingly,oral administration of EPPA suppresses tumor progression in vivo and shapes the immune cell profile(e.g.,facilitating M1 macrophages)in tumor micro-environment by single-cell RNA sequencing(scRNA-seq)analysis. | Wenkai Ren Junfeng Ban Yaoyao Xia Fang Zhou Caihong Yuan Huanhuan Jia Hailan Huang Mingmin Jiang Minjian Liang Zhaodong Li Youyong Yuan Yulong Yin Hong Wu | 2023 | The Innovation2023，4，2： | 1 |
| 14 | Preparation of functionalized graphene oxide/polypropylene nanocomposite with significantly improved thermal stability and studies on the crystallization behavior and mechanical properties显示文摘 | Yuan Bihe Ban Chenlu Song Lei | 2014 | Chem Eng J2014，237，5： | 1 |
| 15 | A phase III randomized,double-blind,placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk显示文摘The current study evaluated the efficacy and safety of a denosumab biosimilar,QL1206(60 mg),compared to placebo in postmenopausal Chinese women with osteoporosis and high fracture risk.At 31 study centers in China,a total of 455 postmenopausal women with osteoporosis and high fracture risk were randomly assigned to receive QL1206(60 mg subcutaneously every 6 months)or placebo.From baseline to the 12-month follow-up,the participants who received QL1206 showed significantly increased bone mineral density(BMD)values(mean difference and 95%CI)in the lumbar spine:4.780%(3.880%,5.681%),total hip:3.930%(3.136%,4.725%),femoral neck 2.733%(1.877%,3.589%)and trochanter:4.058%(2.791%,5.325%)compared with the participants who received the placebo.In addition,QL1206 injection significantly decreased the serum levels of C-terminal crosslinked telopeptides of type 1 collagen(CTX):−77.352%(−87.080%,−66.844%),and N-terminal procollagen of type l collagen(P1NP):−50.867%(−57.184%,−45.217%)compared with the placebo over the period from baseline to 12 months.No new or unexpected adverse events were observed.We concluded that compared with placebo,QL1206 effectively increased the BMD of the lumbar spine,total hip,femoral neck and trochanter in postmenopausal Chinese women with osteoporosis and rapidly decreased bone turnover markers.This study demonstrated that QL1206 has beneficial effects on postmenopausal Chinese women with osteoporosis and high fracture risk. | Hao Zhang Jie-mei Gu Ai-jun Chao Qun Cheng Dong-hui Teng Jin-ming Yu Bing-wu Wang Ya-nan Huo Li Mao Qiu Zhang Hong Yang Shi-gui Yan Ke-qin Zhang Xue-ling Zhao Hua Lin Yu Pei Zhong Yuan Ru-chun Dai Liang He Li Chen Yong-feng Su Zhong-liang Deng Li You Bo Ban Mei Zhu You-liang Cao Yi-kun Zhu Zhi-jun Li Zhi Zhang Cheng-qing Yi Yi-bing Lu Guang Wang Cui-cui Han Zhen-jiang Wang Xian-xing Li Zhen-lin Zhang | 2023 | Acta Pharmacologica Sinica2023，44，2： | 1 |
| 16 | XUE Huifeng Met the Publisher of the Journal Science Bill Moran显示文摘Mr.XUE Huifeng,President of China Aerospace Academy of Systems Science and Engineering(CAASSE),Editor in Chief of the journal Aerospace China,met the Publisher of the journal Science Bill Moran and his delegation on November 10,2016.Both parties reviewed the monograph The Rise of Systems Engineering in China that was jointly issued by the two sides and its influence,looking forward to further cooperation,in the | YUAN Ban | 2016 | Aerospace China2016，17，4： | 0 |
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