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| 1 | Traditional Chinese medicine in COVID-19显示文摘COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCo V-2)has spread across the globe,posing an enormous threat to public health and safety.Traditional Chinese medicine(TCM),in combination with Western medicine(WM),has made important and lasting contributions in the battle against COVID-19.In this review,updated clinical effects and potential mechanisms of TCM,presented in newly recognized three distinct phases of the disease,are summarized and discussed.By integrating the available clinical and preclinical evidence,the efficacies and underlying mechanisms of TCM on COVID-19,including the highly recommended three Chinese patent medicines and three Chinese medicine formulas,are described in a panorama.We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19,but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM. | Ming Lyu Guanwei Fan Guangxu Xiao Taiyi Wang Dong Xu Jie Gao Shaoqin Ge Qingling Li Yuling Ma Han Zhang Jigang Wang Yuanlu Cui Junhua Zhang Yan Zhu Boli Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 14 |
| 2 | Optimal design of high voltage bushing electrode in transformer with evolution strategy显示文摘 | Zhang Guoqiang Zhang Yuanlu Cui Xiang | 1999 | IEEE Trans on Magnetics1999，35，1： | 1 |
| 3 | Effects of the con- trolled-released basic fibroblast growth factor from chitosan-gelatin microspheres on human fibroblasts cultured on a chitosan-gelatin scaffold显示文摘 | Haifeng Liu Hongbin Fan Yuanlu Cui | 2007 | Biomacromolecules2007，8，5： | 1 |
| 4 | Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment显示文摘Oxidative stress injury and mitochondrial dysfunction are major obstacles to neurological functional recovery after ischemic stroke.The development of new approaches to simultaneously diminish oxidative stress and resist mitochondrial dysfunction is urgently needed.Inspired by the overproduced reactive oxygen species(ROS)at ischemic neuron mitochondria,multifunctional nanoparticles with ROS-responsiveness and mitochondrial-targeted(SPNPs)were engineered,achieving specific targeting delivery and controllable drug release at ischemic penumbra.Due to the nose-to-brain pathway.SPNPs which were encapsulated in a thermo-sensitive gel by intranasal administration were directly delivered to the ischemic penumbra bypassing the blood-brain barrier(BBB)and enhancing delivery efficiency.The potential of SPNPs for ischemic stroke treatment was systematically evaluated in vitro and in rat models of middle cerebral artery occlusion(MCAO).Results demonstrated the mitochondrialtargeted and protective effects of SPNPs on H2O2-induced oxidative damage in SH-SY5Y cells.In vivo distribution analyzed by fuorescence imaging proved the rapid and enhanced active targeting of SPNPs to the ischemic area in MCAO rats.SPNPs by intranasal administration exhibited superior therapeutic efficacy by alleviating oxidative stress,diminishing infammation,repairing mitochondrial function,and decreasing apoptosis.This strategy provided a multifunctional delivery system for the effective treatment of ischemic injury,which also implies a potential application prospect for other central nervous diseases. | Yan Zhang Haiyun Zhang Faquan Zhao Zhengping Jiang Yuanlu Cui Meitong Ou Lin Mei Qiangsong Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 1 |
| 5 | Biomimetic surface modification of poly (L-lactic acid) with gelatin and its effects on articular chondrocytes in vitro 显示文摘 | Cui Yuanlu Hou Xin Qi Aidi | 2003 | J Biomed Mater Res A2003，66，： | 1 |
| 6 | Effects of hyaluronic acid-chitosan-gelatin complex on the apoptosis and cell cycle of L929 cells显示文摘With the development in the field of tissue en-gineering, the interaction between biomaterials and cells has been deeply studied. Viewing the cells seeded on the surface of materials as an organic whole, cell cycle and apoptosis are analyzed to deepen the study of cell compatibility on bioma-terials, while cell proliferation and differentiation are stud-ied at the same time. In this paper, hyaluronic acid is incor-porated into the chitosan-gelatin system. Propidium iodide(PI) was used in cell cycle analysis and the double-staining of cells with annexin-V and PI was applied in cell apoptosisanalysis. The results show that incorporated hyaluronic acid shortens the adaptation period of cells on the material sur-face, and then cells enter the normal cell cycle quickly. Inaddition, added hyaluronic acid inhibits cell apoptosis trig-gered by the membranes. Therefore, hyaluronic acid im-proves the cell compatibility of chitosan-gelatin system andbenefits the design of biomimetic materials. | MAO Jinshu, WANG Xianghui, CUI Yuanlu & YAO Kangde Research Institute of Polymeric Materials, Tianjin University, Tianjin300072, China | 2003 | Chinese Science Bulletin2003，48，17： | 1 |
| 7 | A study on the fabrication of porous chitosan/gelatin network scaffold for tissue engineering显示文摘 | Shen Feng Cui Yuanlu Yang Lifang | 2000 | Polymer International2000，49，12： | 1 |
| 8 | Influence of different surface modifcation treatments on poly(d,l-lactic acid)with silk? broin and their efects on the culture of osteoblast in vitro显示文摘 | Kangde Yao KD Yuanlu Cui YL | 2002 | Biomaterials2002，23，： | 1 |
| 9 | The“Top 50 High Impact Researches of Traditional Medicine”published in 2021显示文摘In recent years,significant progress has been achieved in both basic and clinical research within the field of traditional medicine,garnering increasing attention worldwide.To further promote a high-quality and international development of traditional medicine,the editorial board of Acupuncture and Herbal Medicine provided a collection of the“Top 50 High-impact Researches of Traditional Medicine”published in 2021 through objective indicators and a strict selection process.The findings of the selected articles have a significant academic influence and possess considerable academic value both nationally and internationally.The selected articles cover a wide range of topics,including clinical research,acupuncture,pharmacology,chemistry,biosynthesis,medicinal plant resources,and new formulation and drug delivery system research on traditional medicine.Therefore,this article outlines the selection process of the top 50 high-impact research articles,analyzes their research characteristics,and provides a brief summary of their new findings and perspectives in the field of traditional medicine. | Xiao Li Dong Xu Jianfeng Tu Bo Pang Xiaohui Yan Yuanlu Cui Yuefei Wang Cunzhi Liu Yi Wang Junhua Zhang | 2023 | Acupuncture and Herbal Medicine2023，3，4： | 0 |
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