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| 1 | Traditional Chinese medicine in COVID-19显示文摘COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCo V-2)has spread across the globe,posing an enormous threat to public health and safety.Traditional Chinese medicine(TCM),in combination with Western medicine(WM),has made important and lasting contributions in the battle against COVID-19.In this review,updated clinical effects and potential mechanisms of TCM,presented in newly recognized three distinct phases of the disease,are summarized and discussed.By integrating the available clinical and preclinical evidence,the efficacies and underlying mechanisms of TCM on COVID-19,including the highly recommended three Chinese patent medicines and three Chinese medicine formulas,are described in a panorama.We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19,but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM. | Ming Lyu Guanwei Fan Guangxu Xiao Taiyi Wang Dong Xu Jie Gao Shaoqin Ge Qingling Li Yuling Ma Han Zhang Jigang Wang Yuanlu Cui Junhua Zhang Yan Zhu Boli Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 14 |
| 2 | DAMAGE TOLERANCE ANALYSIS ON HOLLOW AXLES OF HIGH SPEED MOTOR TRAINS显示文摘According to the rules of UIC515-3,the service loads of the axles arc defined,which include some different loads cases as follows:the static loads;the impact loads resulted from running through the rail joints and unevenness rails;the loads through curves and fi'om braking.Through the calculating and analysis,the stress distribution of the hollow axles is obtained for 200 km/h high speed motor trains used in China.At the same time,the fatigue crack growth of hollow axles is studied,and the initial surface cracks of 2 mm depth caused by hard objects strike or the other causes are discussed.On the basis of the linear elastic fracture mechanics theory,the stress intensity factor of the crack of the geometry transition outside the wheel scat is also studied.Associated with fatigue crack propagation equation and the corresponding crack propagation threshold,the crack propagation characteristics under different shapes are calculated.Then the running distances arc educed with different shapes propagating to the critical length,and the estimation of the residual lives about hollow axles which are the reference values of examine and repair limit of the hollow axle is given. | ZHOU Suxia XIE Jilong YANG Guangxue XIAO Nan | 2008 | Chinese Journal of Mechanical Engineering2008，21，5： | 2 |
| 3 | Structure and Growth Mechanism of V/Ag Multilayers with Different Periodic Thickness Fabricated by Magnetron Sputtering Deposition显示文摘 | Hongxiu Zhang Feng Ren Mengqing Hong Xiangheng Xiao Guangxu Cai Changzhong Jiang | 2013 | Journal of Materials Science & Technology2013，，： | 1 |
| 4 | Structure and Growth Mechanism of V/Ag Multilayers with Different Periodic Thickness Fabricated by Magnetron Sputtering Deposition显示文摘V/Ag multilayers with different periodic thicknesses were fabricated by magnetron sputtering deposition.The columnar structure and the orientation relationship of the multilayers were investigated by transmission electron microscopy,high resolution transmission electron microscopy,selected-area electron diffraction and X-ray diffraction.It was found that the multilayered structure became flatter as increasing individual layer thickness from 2 to 6 nm,and then became waved as the individual layer thickness increases to 8 nm.At the beginning of the growth,the morphology of the multilayers with small periodic thickness was influenced mainly by thermodynamic instabilities,and the morphology of the multilayers with larger periodic thickness was mainly influenced mainly by the columnar growth of V.When the waved interfaces were formed,the continuum growth of the multilayers was also influenced by the shadowing effect and the finite atomic size effect.All of these factors resulted in the columnar structure of the multilayers.Multilayers with small periodic thickness presented strong orientation relationship.Nano-hardness tests indicated that multilayers with flat sublayer morphology and clear interfaces exhibited larger hardness. | Hongxiu Zhang Feng Ren Mengqing Hong Xiangheng Xiao Guangxu Cai Changzhong Jiang | 2014 | Journal of Materials Science & Technology2014，30，10： | 1 |
| 5 | “Three medicines and three formulas”in COVID-19:from bench to bedside显示文摘Chinese guideline has proven effective in the fight against coronavirus disease 2019(COVID-19)during the global spread of the epidemic.Traditional Chinese medicine(TCM)is widely recognized for its effectiveness in alleviating symptoms,inhibiting disease progress,reducing mortality,and improving the cure rate of patients with COVID-19.During the pandemic,“three medicines and three formulas”(TMTFs)stood out from hundreds of others in registered clinical studies,which became highly recommended as TCM for COVID-19 treatment.The TMTFs not only effectively relieve the clinical symptoms of fever,cough,fatigue,and phlegm,but also substantially shorten the time of nucleic acid negative conversion,improve lung computed tomography imaging features and inflammation,ameliorate clinical biochemical indicators,and reduce sequelae.Their potential pharmacological mechanisms are mainly related to the crosstalk between viral toxicity,endothelial damage,cytokine storm,immune response,and microthrombus.In brief,the clinical effects and the potential mechanisms of TMTFs on COVID-19 were systematically analyzed and summarized covering the entirety of disease development,including virus invasion and replication,immune response and cytokine storm,and acute respiratory distress syndrome and multiple organ dysfunction syndrome.This review provides a theoretical basis and reference for the in-depth understanding of the positive role of TMTFs in COVID-19 treatment. | Guangxu Xiao Simeng Wang Ruijiao Wang Li Tan Shibo Ma Shuang He Guanwei Fan Yan Zhu Ming Lyu | 2023 | Acupuncture and Herbal Medicine2023，3，4： | 1 |
| 6 | 4T1 cell membrane-derived biodegradable nanosystem for comprehensive interruption of cancer cell metabolism显示文摘Glycolysis inhibition can effectively block the energy supply and interrupt tumorigenesis in many types of cancers.However,when glycolysis is inhibited,tumor cells will break down glutamine as the raw material for the replenishment pathway to maintain the tricarboxylic acid cycle ensuring energy supply,therefore inducing ineffective interruption of metabolic.Herein,we designed glutamine transporter antagonist L-γ-glutamyl-p-nitroanilide(GPNA)loaded and 4T1 cancer cell membrane coated iridium oxide nanoparticles(IrO_(2)-GPNA@CCM)to realize a comprehensive inhibition of tumor energy supply which synergistically mediated by glycolysis and glutamine cycle.IrO_(2)NPs were used to catalyze the O_(2)generation by facilitating the decomposition of endogenous H_(2)O_(2)in tumor cells,which further downregulated the expression of HIF-1αand PI3K/pAKT to interrupt the generation of lactate.Meanwhile,the loaded GPNA was released under NIR irradiation to bind to alanine-serine-cysteine transporter(ASCT2)for glutamine uptake suppression,therefore realizing the comprehensive dysfunction of cell metabolism.Moreover,both in vitro and in vivo results convinced the thorough energy inhibition effect based on Ir O_(2)-GPNA@CCM NPs,which provided an inspiring strategy for future construction of tumor therapeutic regimen. | Yingzi Ren Huaqing Jing Yue Zhou Chuchu Ren Guangxu Xiao Siyu Wang Xiaoyang Liang Yunsheng Dou Ziqiao Ding Yan Zhu Xinxing Wang Nan Li | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 7 | Method for the distinguish of normal modes in shallow water under near field显示文摘This paper proposes a method to distinguish the normal modes in shallow water under near field.The method,which is based on frequency-wavenumber(F-K)transform,employs the 2D matrix comprising near field horizontal multi-channel signals.These signals are transformed from the time-space domain to the frequency-wavenumber domain,and the normal modes in the signals are distinguished by extracting the wavenumbers component at each frequency for each order in the frequency-wavenumber domain.The practical reliability and validity of this method are verified by performing numerical simulation and a tank experiment,and the results showed that the normal modes in the Pekeris waveguide below 200 Hz could be obtained reliably at 500 m by using this method. | ZHU Hanhao XIAO Rui ZHU Jun ZHENG Guangxue TANG Jun TANG Yunfeng | 2020 | Chinese Journal of Acoustics2020，39，3： | 0 |
| 8 | Effects of sediment acoustic characteristics on low-frequency acoustic field distribution in shallow water显示文摘Most of the published literatures on low-frequency underwater sound propagation are focused on the sound propagation features in the water column,while studies on sound propagation features in the sediment layer or the semi-infinite basement are rare.In this paper,based on the wave equation,a computational model for sound energy flux in the sediment layer and the basement as well as in the water column is proposed under a cylindrical coordinate system.On this basis,the effects of various sediment acoustic parameters on the sound energy distribution and the corresponding mechanisms are elaborated through numerical examples and acoustic theory.Simulation results reveal that,in a situation where sediment P-wave speed>water sound speed> sediment S-wave speed,the greater the values of density and P-wave speed in sediment,the more likely it is that the sound energy remains in the water column without leaking to the sea floor.Conversely,the influence of the variation of S-wave speed is reversed.Basement influence on the sound propagation in the fluid layer is approximately negligible if the sediment layer is sufficiently thick. | ZHU Hanhao XIAO Rui ZHU Jun TANG Jun ZHANG Haigang ZHENG Guangxue | 2021 | Chinese Journal of Acoustics2021，40，1： | 0 |
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