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| 1 | Facile synthesis of nanoceria by a molten hydroxide method and its photocatalytic properties显示文摘Ceria nanoparticles were facilely synthesized by a molten NaOH-KOH hydroxide flux method with the precursor of Ce(NO3)3·6H2O under different conditions in alumina crucibles or Teflon-lined stainless steel autoclave.The XRD patterns and TEM images show that both the crystal and particle sizes of synthesized nanoceria are around 10 nm.XPS results reveal that the nanoceria obtained in alumina crucible has a Ce3+fraction of 17.1%which is higher than that of ceria synthesized in the Teflon vessel,the FTIR spectra of nanoceria prepared in alumina crucible show a stronger intensity of O-H stretching mode.UV-DRS and PL spectra results show that the nanoceria synthesized in alumina crucible with a calculated band gap of 2.9 eV has a wider responding light wavelength and a lower photogene rated electron-hole recombination rate,due to a higher concentration of oxygen vacancies(Ce^3+%).The photocatalytic results show that the degradation ratio and rate of the Rhodamine B(RhB)solution with the nanoceria synthesized in alumina crucible are 98.39%and 0.02919 min-1,both of which are larger than those of the ceria obtained from Teflon vessel.This method proves to be a simple and scalable way to synthesize nanoceria with rich oxygen vacancies and high photocatalytic activity. | Xuewen Xia Yuanpei Lan Junqi Li Chaoyi Chen Benjun Xu Xian Luo Xisong Mao | 2020 | Journal of Rare Earths2020，38，9： | 4 |
| 2 | Light-triggered nitric oxide release and structure transformation of peptide for enhanced intratumoral retention and sensitized photodynamic therapy显示文摘Tumor-targeted delivery of nanomedicine is of great importance to improve therapeutic efficacy of cancer and minimize systemic side effects.Unfortunately,nowadays the targeting efficiency of nanomedicine toward tumor is still quite limited and far from clinical requirements.In this work,we develop an innovative peptide-based nanoparticle to realize light-triggered nitric oxide(NO)release and structural transformation for enhanced intratumoral retention and simultaneously sensitizing photodynamic therapy(PDT).The designed nanoparticle is self-assembled from a chimeric peptide monomer,TPP-RRRKLVFFK-Ce6,which contains a photosensitive moiety(chlorin e6,Ce6),aβ-sheet-forming peptide domain(Lys-Leu-Val-Phe-Phe,KLVFF),an oligoarginine domain(RRR)as NO donor and a triphenylphosphonium(TPP)moiety for targeting mitochondria.When irradiated by light,the constructed nanoparticles undergo rapid structural transformation from nanosphere to nanorod,enabling to achieve a significantly higher intratumoral accumulation by 3.26 times compared to that without light irradiation.More importantly,the conversion of generated NO and reactive oxygen species(ROS)in a light-responsive way to peroxynitrite anions(ONOO)with higher cytotoxicity enables NO to sensitize PDT in cancer treatment.Both in vitro and in vivo studies demonstrate that NO sensitized PDT based on the well-designed transformable nanoparticles enables to eradicate tumors efficiently.The light-triggered transformable nanoplatform developed in this work provides a new strategy for enhanced intratumoral retention and improved therapeutic outcome. | Lingdong Jiang Danyang Chen Zhaokui Jin Chao Xia Qingqing Xu Mingjian Fan Yunlu Dai Jia Liu Yuanpei Li Qianjun He | 2022 | Bioactive Materials2022，7，6： | 3 |
| 3 | Enhancer RNAs: A missing regulatory layer in gene transcription显示文摘Enhancers and super-enhancers exert indispensable roles in maintaining cell identity through spatiotemporally regulating gene transcription.Meanwhile,active enhancers and super-enhancers also produce transcripts termed enhancer RNAs(eRNAs) from their DNA elements.Although enhancers have been identified for more than 30 years,widespread transcription from enhancers are just discovered by genome-wide sequencing and considered as the key to understand longstanding questions in gene transcription.RNA-transcribed enhancers are marked by histone modifications such as H3K4m1/2 and H3K27Ac,and enriched with transcription regulatory factors such as LDTFs,P300,CBP,BRD4 and MED1.Those regulatory factors might constitute a Mega-Trans-like complex to potently activate enhancers.Compared to mRNAs,eRNAs are quite unstable and play roles at local.Functionally,it has been shown that e RNAs promote formation of enhancer-promoter loops.Several studies also demonstrated that eRNAs help the binding of RNA polymerase II(RNAPII) or transition of paused RNAPII by de-association of the negative elongation factor(NELF) complex.Nevertheless,these proposed mechanisms are not universally accepted and still under controversy.Here,we comprehensively summarize the reported findings and make perspectives for future exploration.We also believe that super-enhancer derived RNAs(seRNAs) might be informative to understand the nature of super-enhancers. | Renfang Mao Yuanyuan Wu Yue Ming Yuanpei Xu Shouyan Wang Xia Chen Xiaoying Wang Yihui Fan | 2019 | Science China(Life Sciences)2019，62，7： | 1 |
| 4 | The variation of the Kuroshio during 1986-1988显示文摘On the basis of the analysis of the data obtained from five cruises of the R/V Xiangyanghong 09 and the data from Japan, it is shown that a large meander of the Kuroshio appeared again during 1986-1988. The processes of formation , maturity and decline of this large meander are discussed in this study. The variation of the volume transport at Section Kb (PN) in the East China Sea is related to the large meander of the Kuroshio in the area south of Japan. By using maximum entropy spectrum analysis,the volume transport of the Kuroshio and the swing of its axis are analysed and their major periods are obained. | Sun Xiangping, Wang Yuanpei, Yuan Qike and Xu Hongda First Institute of Oceanography, State Oceanic Administration, Qingdao, ChinaNorth Sea Branch of State Oceanic Administration, Qingdao, China | 1991 | Acta Oceanologica Sinica1991，10，3： | 0 |
| 5 | The C-terminal low-complexity domain involved in liquid-liquid phase separation is required for BRD4 function in vivo显示文摘Dear Editor,Recently,liquid-liquid phase separation(LLPS)attracts great interest for its ability to achieve spatial separation and effective organization of macromolecules(Gomes and Shorter,2018).It is believed to be the driving force to form membraneless organelles and thus plays fundamental roles in a large number of biological processes(Shin and Brangwynne,2017).A list of proteins have been identified that could undergo LLPS in vitro and in vivo(Du and Chen,2018).However,the physiological role of LLPS in animals remains largely unknown. | Chenlu Wang Erhao Zhang Fan Wu Yufeng Sun Yingcheng Wu Baorui Tao Yue Ming Yuanpei Xu Renfang Mao Yihui Fan | 2019 | Journal of Molecular Cell Biology2019，11，9： | 0 |
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