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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 3 | Comparison of anti-atherosclerotic effects of two different extracts from leaves of Mallotus furetianus显示文摘Objective:To compare the anti-atherosclerotic effects of two different extracts from the leaves of Mallotus fiiretianus by using rat model of atherosclerosis.Methods:The air-flriefl powdered Mallotus fiiretianus leaves were extracted with ethanol and then evaporated.The ethanol extract was experienced Diaion HP-20 CC with a gradient of MeOH and H2O(50:50,100:0,v/v) and two fractions,Mallotus fiiretianus A(Mf A) and Mallotus fiiretianus B(MfB) were obtained.RaLs were divided into control,atherosclerosis and vitamin E,Mf A and Mf B treated groups.Atherosclerotic model was established by administering u loading dose of vitamin D3 and feeding standard diet enriched with 2%cholesterol,0.5%porcine chelate,0.2%methimazole,5%sugar,10%pork fat. Vitamin E(0.20 g/kg),Mf A(0.053 g/kg),Mf B(0.057 g/kg)(with the potential) were administered to interfere with the development of atherosclerosis.After 9 weeks,rats were sacrificed and the blood lipid as well as composition of bile was examined.In addition,the thoracic aorta was harvested to evaluate histological changes and the intima-media thickness ratio.Results: Atherosclerosis model was successfully established,administration of vitamin E,Mf A and Mf B increased excretion of total bilirubin in bile,decreased triglycridc(TO),total cholesterol(TC), low density lipoprotein-cholesterol(LDL-C) level,enhanced ratio of high density lipoprotein-cholesterol and LDL-C in blood,improved histological changes and diminished intimamedia thickness ratio of thoracic aorta in atherosclerotic rats.As for the difference in antiatherosclerotic effects between Mf A and MfB,Mf A may be more powerful in declining TG level and Mf B may be more effective in decreasing TC level.Conclusions:The two different extracts. Mf A and Mf B can prevent the development of atherosclerosis.In detail,Mf A is more effective in regulating TG level and Mf B is more powerful in modulating TC.level in atherosclerotic rats. | Liu Yueli Wang Liqun Wu Haitao Lin Lianbo Yi Xinan | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 15 |
| 4 | Mechanism of intercalation and deintercalation of lithium ions in graphene nanosheets显示文摘Graphene nanosheets (GNSs) were synthesized by reducing exfoliated graphite oxides. Their structure, surface morphology and lithium storage mechanism were characterized and investigated systematically using X-ray diffraction, atomic force microscopy, scanning electron microscopy, charge-discharge tests, cyclic voltammetry and electrochemical impedance spectroscopy. It was found that the GNSs, which were obtained via chemical synthesis, were primarily less than 10 graphene layers. The GNS electrodes, which were fabricated from the reduced GNSs, exhibited an enhanced reversible lithium storage capacity and good cyclic stability when serving as anodes in lithium-ion batteries. Also, the first-cycle irreversible capacities of the system were relatively high, because of the formation of a solid electrolyte interphase film on the surface of the GNS electrode and the spontaneous stacking of GNSs during the first lithiation. The electrochemical impedance spectroscopy results suggest that the solid electrolyte interphase film on the GNS electrode during first lithiation were primarily formed at potentials between 0.95 and 0.7 V. Also, the symmetry factor of the charge transfer was measured to be 0.446. | TIAN LeiLei ZHUANG QuanChao LI Jia SHI YueLi CHEN JianPeng LU Feng SUN ShiGang | 2011 | Chinese Science Bulletin2011，56，30： | 11 |
| 5 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 6 | Synthesis of HTLcs modified by K_(3)PO_(4) for side chain alkylation of toluene with methanol显示文摘A series of calcined HTLcs catalysts were prepared and modified with potassium phosphate by impregnation method to clarify the influence of catalyst alkalinity on the side chain alkylation of toluene with methanol for synthesis of ethylbenzene and styrene.The catalysts were characterized by X-ray diffraction(XRD),N_(2)physical adsorption-desorption,Fourier-transform infrared spectroscopy(FT-IR),Scanning electron microscopy(SEM),X-ray photoelectron spectrometry(XPS),NH_(3)temperature-programmed desorption(NH_(3)-TPD)and CO_(2)temperature-programmed desorption(CO_(2)-TPD).It was found that the selectivity of styrene was highest(39.25%)when the K_(3)PO_(4)loading was 7.5 wt%.And the total yield of styrene and ethylbenzene could reach 65.08%with 10 wt%K_(3)PO_(4)loading.This might due to the fact that the addition of K_(3)PO_(4)could adjust the acid and basic sites of catalysts.In addition,appropriate strength and amount of basic sites were favorable to producing more styrene. | Chunyao Hao Yueli Wen Bin Wang Faraz Ahmad Yuhua Liu Huijun Li Wei Huang | 2021 | Green Energy & Environment2021，6，6： | 6 |
| 7 | ASYMPTOTIC NORMALITY OF QUASI MAXIMUM LIKELIHOOD ESTIMATE IN GENERALIZED LINEAR MODELS显示文摘For the Generalized Linear Model (GLM), under some conditions including that the specification of the expectation is correct, it is shown that the Quasi Maximum Likelihood Estimate (QMLE) of the parameter-vector is asymptotic normal. It is also shown that the asymptotic covariance matrix of the QMLE reaches its minimum (in the positive-definte sense) in case that the specification of the covariance matrix is correct. | YUELI CHENXIRU | 2005 | Chinese Annals of Mathematics,Series B2005，26，3： | 5 |
| 8 | Hollow mesoporous silica nanoparticles as nanocarriers employed in cancer therapy: A review显示文摘Hollow mesoporous silica nanoparticles(HMSNs)have become an attractive drug carrier because of their unique characteristics including stable physicochemical properties,large specific surface area and facile functionalization,especially made into intelligent drug delivery systems(DDSs)for cancer therapy.HMSNS are employed to transport traditional anti-tumor drugs,which can solve the problems of drugs with instability,poor solubility and lack of recognition,etc.,while significantly improving the anti-tumor effect.And an unexpected good result will be obtained by combining functional molecules and metal species with HMSNs for cancer diagnosis and treatment.Actually,HMSNs-based DDSS have developed relatively mature in recent years.This review briefly describes how to successfully prepare an ordinary HMSNs-based DDS,as well as its degradation,different stimuli-responses,targets and combination therapy.These versatile intelligent nanoparticles show great potential in clinical aspects. | Yimin ZHOU Qingni XU Chaohua LI Yuqi CHEN Yueli ZHANG Bo LU | 2020 | Frontiers of Materials Science2020，14，4： | 4 |
| 9 | Simulation of the Pressure-Sensitive Seepage Fracture Network in Oil Reservoirs with Multi-Group Fractures显示文摘Stress sensitivity is a very important index to understand the seepage characteristics of a reservoir.In this study,dedicated experiments and theoretical arguments based on the visualization of porous media are used to assess the effects of the fracture angle,spacing,and relevant elastic parameters on the principal value of the permeability tensor.The fracture apertures at different angles show different change rates,which influence the relative permeability for different sets of fractures.Furthermore,under the same pressure condition,the fractures with different angles show different degrees of deformation so that the principal value direction of permeability rotates.This phenomenon leads to a variation in the water seepage direction in typical water-injection applications,thereby hindering the expected exploitation effect of the original well network.Overall,the research findings in this paper can be used as guidance to improve the effectiveness of water injection exploitation in the oil field industry. | Yueli Feng Yuetian Liu Jian Chen Xiaolong Mao | 2022 | Fluid Dynamics & Materials Processing2022，18，2： | 3 |
| 10 | Precipitation data and their uncertainty as input for rainfallinduced shallow landslide models显示文摘Physical models used toforecast the temporal occurrence of rainfall-induced shallow landslides are based on deterministic laws.Owing to the existing measuring technology and our knowledge of the physical laws controlling landslide initiation,model uncertainties are due to an inability to accurately quantify the model input parameters and rainfall forcing data.An uncertainty analysis of slope instability prediction provides a rationale for refining the geotechnical models.The Transient Rainfall Infiltration and Grid-based Regional Slope Stability-Probabilistic(TRIGRS-P)model adopts a probabilistic approach to compute the changes in the Factor of Safety(FS)due to rainfall infiltration.Slope Infiltration Distributed Equilibrium(SLIDE)is a simplified physical model for landslide prediction.The new code(SLIDE-P)is also modified by adopting the same probabilistic approach to allow values of the SLIDE model input parameters to be sampled randomly.This study examines the relative importance of rainfall variability and the uncertainty in the other variables that determine slope stability.The precipitation data from weather stations,China Meteorological Administration Land Assimilation System 2.0(CLDAS2.0),China Meteorological Forcing Data set precipitation(CMFD),and China geological hazard bulletin are used to drive TRIGRS,SLIDE,TRIGRS-P and SLIDE-P models.The TRIGRS-P and SLIDE-P models are used to generate the input samples and to calculate the values of FS.The outputs of several model runs with varied input parameters and rainfall forcings are analyzed statistically.A comparison suggests that there are significant differences in the simulations of the TRIGRS-P and SLIDE-P models.Although different precipitation data sets are used,the simulation results of TRIGRS-P are more concentrated.This study can inform the potential use of numerical models toforecast the spatial and temporal occurrence of regional rainfall-induced shallow landslides. | Yueli CHEN Linna ZHAO Ying WANG Qingu JIANG Dan QI | 2019 | Frontiers of Earth Science2019，13，4： | 2 |
| 11 | Status and Suggestions of the Pesticide Use in the Protected Vegetable Fields in Shandong Province显示文摘This paper briefly introduced the issues of food safety and environmental pollution caused by pesticide residues in protected vegetables, discussed the status and problems of pesticide use in the protected vegetables in Shandong Province, and analyzed the main factors leading to the pesticide residues, including the low education of most farmers, lack of correct identification of diseases and insect pests, use of pesticides based on personal experience, pesticide preparation by bare hands, large dose of pesticide, frequent application, pesticide spraying without protection, uneven spraying, leakage of pesticide from the sprayers, etc.. Finally, based on the vegetable planting features and advantages in Shandong Province, some suggestions were proposed for references, such as, to enhance the monitoring of pesticide residue, to improve the educational level of farmers and to scentifically use the pesticide. | Bo ZHANG Yan LI Xinhao GAO Changsong LI Junshan QI Yueli ZHANG Wei ZHAO | 2013 | Asian Agricultural Research2013，5，4： | 2 |
| 12 | Photoreceptive reaction spectrum effect and phototactic activity intensity of locusts’ visual display characteristics stimulated by spectral light显示文摘To reveal the nature of locusts’visual reaction when stimulated by light,and to clarify the regulation characteristics of locusts’phototactic visual physiology and obtain good spectral light features for locusts’phototactic action,this study investigated locusts’visual spectrum response by characterizing their photoreceptive reaction to LED light using an AvaSpec fiber-optic spectrometer system.Locusts’phototactic response to spectral light was compared using this system.The results showed that locusts’visual reaction characterization presents a photo-induced vision spectrum effect and that by offsetting the main wavelength of light and the spectral peak intensity,a time-varying bio-regulation effect emerges.In addition,locusts’visual regulation ability to UV light is higher than that to violet light,whereas their reaction intensity is lower than to violet light,and the visual bio-regulatory force of locusts’visual system absorbing orange light to react sensitively becomes gradually higher than when absorbing green light as time goes on.Moreover,corresponding to nominal illumination with the same radiant energy and a visual spectrum response stimulated by UV,violet,orange,and green light,it appears that the visual spectrum window is symmetrical around 382 nm,400 nm,602 nm,and 530 nm,respectively,with no significant difference between spectral amplitudes and having a time-varying incremental characteristic with amplitude peak width.This indicates that the stimulus intensity of UV,violet,orange,and green light exceeds locusts’visual tolerance,causing them to generate regulation inactivation as a visual physiological reaction,whereas the visual window response effect stimulated by UV light presents an illumination timeliness effect.Simultaneously,time-varying characteristics of locusts’bio-behavior intensity show that light intensity can make up for locusts’visual sensitivity differences at various spectral wavelengths.Presented with differential response time,photosensitive behavior intensity,and induction effect induced by orange light,time is superior for orange light,the stimulation effect caused by violet light is the strongest,and the phototactic synergy effect caused by UV light is the best. | Qihang Liu Yueli Jiang Jin Miao Zhongjun Gong Tong Li Yun Duan Yuqing Wu | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 2 |
| 13 | Reduced miR-125a-5p expression is associated with gastric carcinogenesisthrough the targeting of E2F3显示文摘 | Yanjun Xu Zhenxia Huang Yueli Liu | 2014 | Molecular Medicine Reports2014，，5： | 1 |
| 14 | Generated I-fuzzy topological spaces显示文摘 | Yue Yueli Fang Jinming | 2005 | FuzzySets and Systems2005，，154： | 1 |
| 15 | Practical deadlock-free fault-tolerant routing in meshes based on the planar network fault model显示文摘 | Xiang Dong Zhang Yueli | 2009 | IEEE Transaction on Computers2009，58，5： | 1 |
| 16 | Synthesis and growth mechanism of carbon nanotubes and nanofibers in ethanol flame 显示文摘 | Pan Chunxu Liu Yueli Cao Feng | 2004 | Micron2004，35，6： | 1 |
| 17 | Practical Deadlock-free Fault-tolerant Routing in Meshes Based on the Planar Network Fault Model显示文摘 | Xiang Dong Zhang Yueli Pan Yi | 2008 | IEEE Transactions on Computers2008，58，5： | 1 |
| 18 | Sedimentary and biotic evidence of a warm‐water enclave in the cooler oceans of the latest Ordovician glacial phase, Yangtze Platform, South China block显示文摘 | YueLi RyoMatsumoto SteveKershaw | 2005 | Island Arc2005，，4： | 1 |
| 19 | Expression levels and genetic polymorphisms of interleukin-2 and interleukin-10as biomarkers of Graves’ disease显示文摘 | Cuige Liang Wenhua Du Qingyu Dong Xiaomeng Liu Wenxia Li Yueli Wang Guanqi Gao | 2015 | Experimental and Therapeutic Medicine2015，，： | 1 |
| 20 | Modulated structure assisted growth and properties of Fe3O4 nanoneedle films using a thermal oxidation process in the air显示文摘 | Liu Yueli Liao Lei Pan Chunxu | 2008 | The Journal of Physical Chemistry2008，112，4： | 1 |
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