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| 1 | TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA显示文摘An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further elucidated.Here,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency factor.We elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation potential.Exposure of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m RNA.Reduced expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland cells.Our finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional level.Moreover,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine. | Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 2 | Effects of confining pressure on acoustic emission and failure characteristics of sandstone显示文摘In this study,uniaxial and triaxial compression acoustic emission(AE)tests were implemented to investigate the AE effect and failure characteristics of sandstone under different confining pressures(σ3).The evolution of AE parameters in the rock failure process and fracture fractal dimension characteristics after failure were analyzed.The results revealed that the activity of the AE signal is strongly related toσ3.The evolution of the Ib value can be divided into the I-fluctuation,II-stability,and III-decrease stages.In the first stage,the Ib value of the AE was relatively high,and the AE energy was low.Then,the Ib value tended to be stable;however,the fluctuation amplitude decreased,and the AE energy rapidly increased.In the stage of decrease,the AE energy sharply increased before the load approached the peak value,and the Ib value significantly decreased and dropped to the lowest point before the peak value.Asσ3 increased,the rock’s failure mode changed from tensile failure to shear failure and became more coordinated.As the confining pressure increased,the shape dimension decreased,and the order degree of rock failure increased.The confining pressure exerted a certain control effect on the rock failure. | Zhen Huang Qixiong Gu Yufan Wu Yun Wu Shijie Li Kui Zhao Rui Zhang | 2021 | International Journal of Mining Science and Technology2021，31，5： | 6 |
| 3 | Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment显示文摘Background:Mammary progenitor cells(MPCs)maintain their reproductive potency through life,and their specific microenvironments exert a deterministic control over these cells.MPCs provides one kind of ideal tools for studying engineered microenvironmental influence because of its accessibility and continually undergoes postnatal developmental changes.The aim of our study is to explore the critical role of the engineered sweat gland(SG)microenvironment in reprogramming MPCs into functional SG cells.Methods:We have utilized a three-dimensional(3D)SG microenvironment composed of gelatin-alginate hydrogels and components from mouse SG extracellular matrix(SG-ECM)proteins to reroute the differentiation of MPCs to study the functions of this microenvironment.MPCs were encapsulated into the artificial SG microenvironment and were printed into a 3D cell-laden construct.The expression of specific markers at the protein and gene levels was detected after cultured 14 days.Results:Compared with the control group,immunofluorescence and gene expression assay demonstrated that MPCs encapsulated in the bioprinted 3D-SG microenvironment could significantly express the functional marker of mouse SG,sodium/potassium channel protein ATP1a1,and tend to express the specific marker of luminal epithelial cells,keratin-8.When the Shh pathway is inhibited,the expression of SG-associated proteins in MPCs under the same induction environment is significantly reduced.Conclusions:Our evidence proved the ability of differentiated mouse MPCs to regenerate SG cells by engineered SG microenvironment in vitro and Shh pathway was found to be correlated with the changes in the differentiation.These results provide insights into regeneration of damaged SG by MPCs and the role of the engineered microenvironment in reprogramming cell fate. | Rui Wang Yihui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2019 | Burns & Trauma2019，7，1： | 5 |
| 4 | Stiffness-mediated mesenchymal stem cell fate decision in 3D-bioprinted hydrogels显示文摘Background:Hydrogels with tuneable mechanical properties are an attractive material platform for 3D bioprinting.Thus far,numerous studies have confirmed that the biophysical cues of hydrogels,such as stiffness,are known to have a profound impact on mesenchymal stem cell(MSC)differentiation;however,their differentiation potential within 3D-bioprinted hydrogels is not completely understood.Here,we propose a protocol for the exploration of how the stiffness of alginate–gelatin(Alg-Gel)composite hydrogels(the widely used bioink)affects the differentiation of MSCs in the presence or absence of differentiation inducing factors.Methods:Two types of Alg-Gel composite hydrogels(Young’s modulus:50 kPa vs.225 kPa)were bioprinted independently of porosity.Then,stiffness-induced biases towards adipogenic and osteogenic differentiation of the embedded MSCs were analysed by co-staining with alkaline phosphatase(ALP)and oil red O.The expression of specific markers at the gene level was detected after a 3-day culture.Results:Confocal microscopy indicated that all tested hydrogels supported MSC growth and viability during the culture period.Higher expression of adipogenic and osteogenic markers(ALP and lipoprotein lipase(LPL))in stiffer 3D-bioprinted matrices demonstrated a more significant response of MSCs to stiffer hydrogels with respect to differentiation,which was more robust in differentiation-inducing medium.However,the LPL expression in stiffer 3D-bioprinted constructs was reduced at day 3 regardless of the presence of differentiation-inducing factors.Although MSCs embedded in softer hydrogels to some extent proceeded toward adipogenic and osteogenic lineages within a few days,their differentiation seemed to be slower and more limited.Interestingly,the hydrogel itself(without differentiation-inducing factors)exhibited a slight effect on whether MSCs differentiated towards an adipogenic or an osteogenic fate.Considering that the mechanoregulated protein Yes-associated protein(YAP)is involved in MSC fate decisions,we further found that inhibition of YAP significantly downregulated the expression of ALP and LPL in MSCs in stiffer constructs regardless of the induced growth factors present.Conclusions:These results demonstrate that the differentiation of MSCs in 3D-bioprinted matrices is dependent on hydrogel stiffness,which emphasizes the importance of biophysical cues as a determinant of cellular behaviour. | Yufan Liu Zhao Li Jianjun Li Siming Yang Yijie Zhang Bin Yao Wei Song Xiaobing Fu Sha Huang | 2020 | Burns & Trauma2020，8，1： | 2 |
| 5 | Roadmap for Additive Manufacturing:Toward Intellectualization and Industrialization显示文摘With the rapid development of Additive Manufacturing(AM)technology in the past 30 years,AM has been shift-ing from prototyping to advanced manufacturing of functional components in industry.Intellectualization and industrialization of AM process and equipment could be the bottlenecks to the wide industrial applications of AM technology in the future,which have been highlighted in this paper,aiming at describing the technological research roadmaps for the next 5 to 10 years.According to the data flow in the process and value chains of AM technologies,state-of-art of design methodology,material,process&equipment,smart structures,and ap-plications in extreme scales and environments has been elaborated respectively.Some suggestions on potential challenges for research and development in AM technologies have been provided in each section,which would finally establish a critical technical platform for the future industrial innovation and entrepreneurship. | Xiaoyong Tian Lingling Wu Dongdong Gu Shangqin Yuan Yufan Zhao Xiao Li Liliang Ouyang Bo Song Tong Gao Jiankang He Xin Lin Feng Lin Jihong Zhu Dichen Li | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，1： | 1 |
| 6 | A Prenyltransferase Gene Confirmed to Be a Carotenogenic CRTE Gene from Sweetpotato显示文摘Sweetpotato(Ipomoea batatas L.Lam.)ranks fifth among the most important food crops,after rice,wheat,maize and cassava,on a fresh-weight basis in developing countries(Scott and Maldonado,1999).Sweetpotato cultivars have white,yellow,purple or orange flesh,but only orange-fleshed sweetpotato cultivars are the rich sources of(3-carotene,which is the precursor of vitamin A(Failla et al.,2009).Accordingly,the orange-fleshed sweetpotato is the main source of(3-carotene for the people in underdeveloped coun- | Yufan Fu Lili Ma Fei Qiu Chunxian Yang Chunxia Hu Ying Zhao Zhi Lin Min Chen Zhihua Liao Xiaozhong Lan | 2014 | Journal of Genetics and Genomics2014，41，11： | 1 |
| 7 | Isothermal γ →ε phase transformation behavior in a Co-Cr-Mo alloy depending on thermal history during electron beam powder-bed additive manufacturing显示文摘Powder bed fusion with electron beam(PBF-EB),allows Co-Cr-Mo(CCM) implants with patientcustomization to be fabricated with high quality and complex geometry.However,the variability in the properties of PBF-EB-built CCM alloy,mainly due to the lack of understanding of the mechanisms that govern microstructural heterogeneity,brings limitations in extensive application.In this study,the microstructural heterogeneity regarding the γ-fcc→ε-hcp phase transformation was characterized.The phase transformation during PBF-EB was analyzed depending on the thermal history that was elucidated by the numerical simulation.It revealed that isothermal γ→ε transformation occurred during the fabrication.Importantly,the difference in γ/ε phase distribution was a result of the thermal history determining which method phase transformation was taking place,which can be influenced by the PBF-EB process parameters.In the sample with a low energy input(Earea=2.6 J/mm2),the martensitic transformation was dominant.As the building height increased from the bottom,the e phase fraction decreased.On the other hand,in the sample with a higher energy input(Earea=4.4 J/mm2),the ε phase fo rmed via diffusional-massive transformation and only appea red in a short range of the lower part away from the bottom. | Yufan Zhao Yuichiro Koizumi Kenta Aoyagi Kenta Yamanaka Akihiko Chiba | 2020 | Journal of Materials Science & Technology2020，47，15： | 1 |
| 8 | A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples显示文摘Human serum albumin(HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared(NIR) fluorescent probe(7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer(TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes. | Yufan Fan Fangyuan Wang Fanbin Hou Lai Wei Guanghao Zhu Dongfang Zhao Qing Hu Tao Lei Ling Yang Ping Wang Guangbo Ge | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 9 | 4-4 Ultracold Plasma: An Experimental Realization显示文摘Ultracold plasma has well defined initial conditions, including the particle densities of more than 105 cm??3 as well as the electron temperature in the range of 11 000 K and ion temperature from tens of millikelvin to a few Kelvin. So the ultracold plasma provides an ideal environment for the study of strongly coupled systems, where the Coulomb interaction is comparable with the thermal kinetic energy. | Zaheer U. Syed Li Yufan Zhao Dongmei Ma Xinwen Yang Jie | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 10 | 4-5 Measurement of the First Ionization Potential of 87Rb显示文摘The Ionization Potential (IP) is qualitatively de ned as the amount of energy to remove the most loosely bound electron of an isolated gaseous atom to form a cation, or the released energy of moving a single electron from in nity to the surface of a cation. So the IP value is related to the electronic structure and is one of the fundamental parameters of the atom. We introduced a new experimental method to measure the Rydberg state energy levels of 87Rb atom and got its rst ionization potential to be 33 690.946(7) cm??1. | Li Yufan Zaheer U. Syed Zhao Dongmei Ma Xinwen Yang Jie | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 11 | Atomistic Modeling of Lithium Materials from Deep Learning Potential with Ab Initio Accuracy显示文摘Lithium has been paid great attention in recent years thanks to its significant appli-cations for battery and lightweight alloy.Developing a potential model with high ac-curacy and efficiency is impor-tant for theoretical simulation of lithium materials.Here,we build a deep learning potential(DP)for elemental lithium based on a concurrent-learning scheme and DP representation of the density-functional theory(DFT)potential energy surface(PES),the DP model enables material simulations with close-to DFT accuracy but at much lower computational cost.The simulations show that basic parameters,equation of states,elasticity,defects and surface are consistent with the first principles results.More notably,the liquid radial distribution func-tion based on our DP model is found to match well with experiment data.Our results demon-strate that the developed DP model can be used for the simulation of lithium materials. | Haidi Wang Tao Li Yufan Yao Xiaofeng Liu Weiduo Zhu Zhao Chen Zhongjun Li Wei Hu | 2023 | Chinese Journal of Chemical Physics2023，36，5： | 0 |
| 12 | Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osginl-Mediated Restoration of Efficient Autophagy显示文摘Pancreatitis is the leading cause of hospitalization in gastroenterology,and no medications are available for treating this disease in current clinical practice.FxR plays an anti-inflammatory role in diverse inflammatory diseases,while its function in pancreatitis remains unknown.In this study,we initially observed a marked increase of nuclear FXR in pancreatic tissues of human patients ithpancratis eleting theFXRinpancreati acinar cels FXRicnara/a)ledto moreseverepancreatitis in mousemodels of caerulein-induced acute and chronic pancreatitis,while the FXR agonist GW4064 significantly attenuated pancreatitis in caerulein or arginine-induced acute pancreatitis and caerulein-induced chronic pancreatitis.FXR deletion impaired the viability and stress responses of pancreatic exocrine organoids(PEOs)in vitro.Utilizing RNA-seq and ChIP-seq of PEOs,we identified Osginl as a direct target of FxR in the exocrine pancreas,which was also increasingly expressed in human pancreatitis tissues compared to normal pancreatic tissues.Pancreatic knockdown of Osgin1 by AAV-pan abolished the therapeutic effects of FXR activation on pancreatitis,whereas pancreatic overexpression of Osginl effectively alleviated caerulein-induced pancreatitis.Mechanistically,we found that the FXR-OSGINl axis stimulated autophagic flux in the pancreatic tissues and cell lines,which was considered as the intrinsic mechanisms through which FXR-OSGINI protecting against pancreatitis.Our results highlight the protective role of the FXR-OSGIN1 axis in pancreatitis and provided a new target for the treatment of this disease. | Yufan Zheng Wenrui Sun Zhengyang Wang Jiaying Liu Cong Shan Chenxi He Borui Li Xiao Hu Wenjia Zhu Liyan Liu Fei Lan Changtao Jiang Chao Zhao Xiaobo Li Ning Sun | 2023 | Research2023，，1： | 0 |
| 13 | Quantification and distribution of extractable metals of MSWI bottom ash in view of its valorization in China显示文摘Metal recovery from bottom ash was deemed to be significant to achieve a higher stability of bottom ash and recycle valuable extractable metals.In China,the existing rugged industrial production ignores the actual metal distribution and thus fails to exploit the utilization potential of recoverable metals in bottom ash.Based on these findings,this work was proposed to obtain a comprehensive and in-depth study on the recoverability of metals in bottom ash.First,the particle size distribution and elemental composition of the bottom ash were analyzed.Then,complete information on the recoverable metals in bottom ash fractions with different sizes was obtained by washing,sorting,crushing,density separation and XRF(X Ray Fluorescence)analysis.The results showed that the smaller than 5 mm fraction accounted for up to 60%of the bottom ash,and the 5–20 mm fractions accounted for about 15%.The material characterization revealed that the contents of recoverable Fe,stainless steel,Al and Cu in bottom ash were averagely 9.01%,0.136%,0.78%and 0.08%,respectively.About 50%of Fe,68%of Al,61%of Cu,and 22%of stainless steel were distributed in smaller than 10 mm fraction.Particularly,Fe was evenly distributed among 0–2 mm,2–5 mm,5–10 mm fractions,and the content was between 5.41%and 7.5%.Non-magnetic stainless steel was mainly distributed in 20–40 mm and larger than 40 mm fractions.The highest share of Al was present in the fractions between 5 mm and 20 mm,accounting for 48%of the total aluminum.About 45.6%of the Cu was enriched in the 5–10 mm fraction.However,the Zn content was less than 0.01%.This work provides an in-depth understanding and information on metal recovery as well as promisingly guide ash utilization. | Yanjun Hu Lingqin Zhao Qianqian Guo Lianming Li Yihong Wang Yufan Ye Fuzhi Mao Wangyang Tian | 2022 | Waste Disposal and Sustainable Energy2022，4，3： | 0 |
| 14 | 磁光肼中光电离离子的速度成像显示文摘Ultracold plasmas(UCPs),created via photoionizing laser-cooling atoms in magneto-optical trap(MOT)[1],have the temperature of ions around 1 K and the temperature of electrons ranging from 1 to 1000 K.Due to the low temperature of the ions,the ultracold plasma is considered to be strongly coupled,in which the Coulomb effect dominants the evolution of plasmas.Here we present an idea and a test to measure the temperature of ions in UCPs[2]using a novel method of velocity map imaging(VMI). | Fang Feng Li Yufan Zhou Wenchang Zhao Dongmei Qian Dongbin Ma Xinwen Yang Jie | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 15 | Laser powder bed fusion of Zr-modified Al-Cu-Mg alloy:Processability and elevated-temperature mechanical properties显示文摘Zr modification is an effective method for improving hot-cracking resistance and elevated-temperature mechanical properties during laser powder bed fusion(L-PBF)of traditional medium and high strength wrought aluminum alloys.This study investigated the l-PBF processability and elevated-temperature mechanical properties of a Zr-modified 2024Al alloy.It was found that the hot-cracking susceptibility increased with the increased scanning speed,which was in reasonable agreement with the modified Rappaz-Drezet-Gremaud criterion.Furthermore,the primary L1_(2)-Al_(3)Zr precipitates,which acted as ef-ficient nucleation sites,precipitated at the fusion boundary of the melt pool,leading to the formation of a heterogeneous grain structure.The yield strength(YS)of the as-fabricated samples at 150,250,and 350℃was 363,210,and 48 MPa,respectively.Despite the slight decrease to 360 MPa of the YS when tested at 150℃,owing to the additional precipitate strengthening from the L1_(2)-Al_(3)Zr precipitates,the YS achieved yield strengths of 253 and 69 MPa,an increase of 20.5%and 30.4%,when tested at 250 and 350℃,respectively.The yield strengths in both the as-fabricated and T6-treated conditions tested at 150 and 250℃were comparable to those of casting Al-Cu-Mg-Ag alloys and superior to those of traditionally heat-resistant 2219-T6 and 2618-T6 of Al-Cu alloys. | Yanfang Wang Xin Lin Yufan Zhao Zihong Wang Xiaobin Yu Xuehao Gao Weidong Huang | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
| 16 | 基于速度图成像光谱仪测量低密度离子束中的空间电荷效应显示文摘Understanding weak space-charge effects(SCEs)is central for the development of the velocity map imaging(VMI)technique for studying the structure,thermodynamics,and dynamics of molecules by imaging photoions and(or)photoelectrons[1,2].However,to our knowledge,it is very difficult to determine the SCEs existing at low-density ion beams due to the limited precision of the present measurement methods.Here,we present a method to directly characterize the weak SCEs employing the high-resolution velocity map imaging spectrometer.The delay ionization of C60 molecules,induced by a nanosecond laser beam,was used to produce ion beams with low density. | Zhou Wenchang Qian Dongbin Li Yufan Zhao Dongmei Ma Xinwen Yang Jie | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 17 | 用于炒冷等离子体实验的离子速度成像仪的搭建和探测效率测试显示文摘In recent years,ultracold neutral plasmas(UNPs),as strongly coupled plasma available in the laboratory,have gradually been the focus in the experimental and theoretical plasma physics studies[1].However,measuring the temperature of UNPs is always a challenge in the experiments.Here,we propose to obtain the kinetic energy distribution of charged particles in UNPs using the ion velocity map imaging(VMI)technique.And then,the temperature of UNPs,as well as the Coulomb coupling parameter,can also be obtained. | Li Yufan Zhou Wenchang Zhao Dongmei Ma Xinwen Yang Jie | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 18 | Diverse synthesis of the C ring fragment of bryostatins via Zn/Cu-promoted conjugate addition of α-hydroxy iodide with enone显示文摘A convergent approach to 1,5-hydroxy ketones,the general precursors for constructing the C ring of bryostatins,has been developed via a Zn/Cu-promoted conjugate addition of a-hydroxy iodides with enones.The reaction leads to direct formation of the C21-C22 bond and tolerates diverse functionalities at the C17-,C18-and C24-positions.The approach also enables a more concise synthesis of the known C ring intermediate(10 longest linear steps and 14 total steps),in contrast to its previous synthesis(17 longest linear steps and 22 total steps) in our total synthesis of bryostatin 8. | Zhiwen Chu Ruiqi Tong Yufan Yang Xuanyi Song Tian bao Hu Yu Fan Chen Zhao Lu Gao Zhenlei Song | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
| 19 | 3-10 State-selective Spontaneous Evolution of Rydberg Atoms into an Ultracold Plasma显示文摘We measured the state distribution of cold Rydberg atoms for various initially excited Rydberg levels and evolution times in order to investigate the collision-induced dynamics.The cold Rydberg atoms were excited into nP states(n=20,25,30,…,97)below the ionization potential.Immediately after the excitation the hot electrons were detected as shown in Fig.1(a),which are due to the slow ionization caused by the collision between hot Rydberg atoms and cold Rydberg atoms[1].A pulsed electric field(~300 mV/cm)was applied after few microseconds and obtained a second peak,that indicates the plasma electrons. | Zaheer U.Syed Li Yufan Zhao Dongmei Ma Xinwen Yang Jie | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 20 | 3D automatic segmentation method for retinal optical coherence tomography volume data using boundary surface enhancement显示文摘With the introduction of spectral-domain optical coherence tomography(SD-OCT),much larger image datasets are routinely acquired compared to what was possible using the previous generation of time-domain OCT.Thus,there is a critical need for the development of three-dimensional(3D)segmentation methods for processing these data.We present here a novel 3D automatic segmentation method for retinal OCT volume data.Brie°y,to segment a boundary surface,two OCT volume datasets are obtained by using a 3D smoothingfilter and a 3D differentialfilter.Their linear combination is then calculated to generate new volume data with an enhanced boundary surface,where pixel intensity,boundary position information,and intensity changes on both sides of the boundary surface are used simultaneously.Next,preliminary discrete boundary points are detected from the A-Scans of the volume data.Finally,surface smoothness constraints and a dynamic threshold are applied to obtain a smoothed boundary surface by correcting a small number of error points.Our method can extract retinal layer boundary surfaces sequentially with a decreasing search region of volume data.We performed automatic segmentation on eight human OCT volume datasets acquired from a commercial Spectralis OCT system,where each volume of datasets contains 97 OCT B-Scan images with a resolution of 496512(each B-Scan comprising 512 A-Scans containing 496 pixels);experimental results show that this method can accurately segment seven layer boundary surfaces in normal as well as some abnormal eyes. | Yankui Sun Tian Zhang Yue Zhao Yufan He | 2016 | Journal of Innovative Optical Health Sciences2016，9，2： | 0 |
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