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| 1 | The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent显示文摘P2X7 受体的激活导致阳离子的快速的、双向流动,引起包括 cytotoxicity 的生物回答的宽广范围。然而,调停 P2X7 的 cytotoxicity 的机制仍然保持大部分未经勘探。在我们的以前的学习,在正常条件下面的调停 P2X7 的钙反应的缺乏在 P2X7+ 造血的房间线被发现。在这研究,在房间的不同类型的调停 P2X7 的 cytotoxicity (P2X7 ? ,有钙反应的 P2X7+ ,和没有钙反应的 P2X7+) 被调查。我们的结果证明 P2X7 收缩筋,腺苷 5-triphosphate ( ATP )或2,3-O-( 4 benzoylbenzoyl )-ATP, dose-dependently 在测试的所有P2X7+房间减少了房间生存能力,包括为 调停P2X7 的钙反应否定的 J6-1 , LCL ,和 Namalva 房间,尽管这些效果比在有正常 P2X7 功能的 KG1a 房间观察的那些低。细胞毒素的效果能被 P2X7 对手,氧化 ATP 和 1- 堵住[N, O 二度(5-isoquinolinesulfonyl )-N-methyl-l-tyrosyl]-4-phenylpiperazine。另外, phosphatidylserine 的外表表现能以一种时间依赖者方式和 apoptotic 被检测词法变化能在 J6-1 房间在 P2X7 受体的激活以后被观察。而且,调停 P2X7 的毛孔形成能在低离子的条件下面,然而并非在低二价的条件下面在 KG1a 和 J6-1 房间被检测。这些效果不能在 P2X7 被观察吗?Ramos 房间。这些结果建议 P2X7 调停受体的细胞毒素的效果可以发生独立于钙反应。 | Xiujun Zhang Lijun Meng Baoling He Jing Chen Peng Liu Jie Zhao Yufen Zhang Ming Li Dong An | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 7 |
| 2 | HIV Prevention and Health Poverty Alleviation-Liangshan Prefecture,Sichuan Province,China,2017-2020显示文摘BACKGROUND Liangshan,officially the Liangshan Yi Autonomous Prefecture,is an autonomous prefecture occupying much of the southern portion of Sichuan Province.It has been a remote and deeply impoverished area and also has the largest population of ethnic Yi people in China(1).For many years,due to geographical environment conditions,traffic conditions,and other historic restrictions,the human immunodeficiency virus(HIV)epidemic in Liangshan Prefecture has become the focus of HIV prevention and control in China since the first acquired immunodeficiency syndrome(AIDS)case was reported in this area in 1995(2-3). | Zhongfu Liu Xuefeng Tang Yufen Liu Linglin Zhang Yihui Yang Yongli Zheng Weixin Liu Chunnong Jike Hong Mai Heying Fan Gang Yu Mengjie Han George F.Gao | 2021 | China CDC weekly2021，3，48： | 4 |
| 3 | N-phosphoryl amino acid models for P–N bonds in prebiotic chemical evolution显示文摘Post-translational modification of proteins by N-phosphorylation of the basic amino acid residues plays important roles in biological processes. The high-energy P–N bond might have contributed to the evolution of prebiotic chemistry. N-phosphoryl amino acids(PAAs) can serve as interesting small molecular models for the study of P–N bonds in prebiotic chemical evolution. PAAs are capable of simultaneously producing several important biomolecules such as polypeptides and oligonucleotides under mild reaction conditions. In this review, we describe the chemistry of PAAs, discusse their likely prebiotic origins and their reactivity and how they relate to biological P–N bond species. We also depict a possible prebiotic scenario mediated by PAAs in which PAAs may have acted as one of the essential forces driving prebiotic biomolecules to the first protocell. | Feng Ni Chuan Fu Xiang Gao Yan Liu Pengxiang Xu Liu Liu Ye Lv Songsen Fu Ying Sun Daxiong Han Yan-Mei Li Yufen Zhao | 2015 | Science China Chemistry2015，58，3： | 3 |
| 4 | Exploring the binding mechanism of thioflavin-T to the β-amyloid peptide by blind docking method显示文摘Using blind dock method,we find that thioflavin-T(ThT) can bind to both monomers and fibrils of the full-length β-amyloid peptide(Aβ1-42) and has a higher binding affinity to the fibrils.It is shown that the hydrophobic interaction between the ligand(ThT) and substrate(Aβ1-42) are stronger than hydrogen bonds.Furthermore,ThT tends to be located near the C-terminus of Aβ monomer through hydrophobic and electrostatic interactions,while it tends to contact the residues Met35 and Gly27 of the fibril surface mainly through hydrophobic interaction.Finally,according to the docking results and ThT fluorescence assay,a kinetic equation is proposed to deduce the aggregation rate coefficient of Aβ1-42. | ZHAO DeSheng CHEN YongXiang LIU Qian ZHAO YuFen LI YanMei | 2012 | Science China Chemistry2012，55，1： | 3 |
| 5 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 6 | Biochemical characterization of RNase HII from Aeropyrum pernix显示文摘Aeropyrum pernix 包含 ribonuclease H (RNase H ) 的一个相当或相同的事物,一。pernix RNase HII (Ape-RNase HII ) 。活动描述证明 Ape-RNase HII 面对 5 公里 Mn2+ , 1 公里 Co2+ ,或 10 公里展出了最高的活动 Mg2+ 分别地;然而,它在为 Mn2+ 和 Mg2+ 的不同劈开地点的劈开效率是不同的。Ape-RNase HII 在多重地点劈开 12-bp RNA/DNA 底层,最佳 pH 价值是 11.0。而且, 16-bp DNA-r4-DNA/DNA 和 13-bp DNA-r1-DNA/DNA 妄想的底层在 DNARNA 被劈开连接。Ape-RNase HII 是 thermostable,稳定与增加的盐集中被提高。这个工作被相信在 Ape-RNase HII 和结果的功能的学习应该贡献的 vitro 是第一另外的 archaeal 种类的 RNase H 的分析。 | Jingli Hou Yufen Liu Zheng Lu Xipeng Liu Jiarthua Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 2 |
| 7 | Synthesis of urea derivatives from amines and CO2 in the absence of catalyst and solvent 显示文摘 | Wu Chaoyong Cheng Haiyang Liu Ruixia Wang Qiang Hao Yufen Yu Yancun Zhao Fengyu | 2010 | Green Chemistry2010，12，： | 1 |
| 8 | Suppression of ETI by PTI priming to balance plant growth and defense through an MPK3/MPK6-WRKYs-PP2Cs module显示文摘Pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)are required for host defense against pathogens.Although PTI and ETI are intimately connected,the underlying molecular mechanisms remain elusive.In this study,we demonstrate that flg22 priming attenuates Pseudomonas syringae pv.tomato DC3000(Pst)AvrRpt2-induced hypersensitive cell death,resistance,and biomass reduction in Arabidopsis.Mitogen-activated protein kinases(MAPKs)are key signaling regulators of PTI and ETI.The absence of MPK3 and MPK6 significantly reduces pre-PTI-mediated ETI suppression(PES).We found that MPK3/MPK6 interact with and phosphorylate the downstream transcription factor WRKY18,which regulates the expression of AP2C1 and PP2C5,two genes encoding protein phosphatases.Furthermore,we observed that the PTI-suppressed ETI-triggered cell death,MAPK activation,and growth retardation are significantly attenuated in wrky18/40/60 and ap2c1 pp2c5 mutants.Taken together,our results suggest that the MPK3/MPK6-WRKYs-PP2Cs module underlies PES and is essential for the maintenance of plant fitness during ETI. | Dacheng Wang Lirong Wei Ting Liu Jinbiao Ma Keyi Huang Huimin Guo Yufen Huang Lei Zhang Jing Zhao Kenichi Tsuda Yiming Wang | 2023 | Molecular Plant2023，16，5： | 1 |
| 9 | Exploring the binding mechanism of thioflavin-T to the β-amyloid peptide by blind docking method显示文摘Using blind dock method,we find that thioflavin-T(ThT) can bind to both monomers and fibrils of the full-length β-amyloid peptide(Aβ1-42) and has a higher binding affinity to the fibrils.It is shown that the hydrophobic interaction between the ligand(ThT) and substrate(Aβ1-42) are stronger than hydrogen bonds.Furthermore,ThT tends to be located near the C-terminus of Aβ monomer through hydrophobic and electrostatic interactions,while it tends to contact the residues Met35 and Gly27 of the fibril surface mainly through hydrophobic interaction.Finally,according to the docking results and ThT fluorescence assay,a kinetic equation is proposed to deduce the aggregation rate coefficient of Aβ1-42. | ZHAO DeSheng CHEN YongXiang LIU Qian ZHAO YuFen LI YanMei | 2012 | 中国科学:化学2012，42，2： | 1 |
| 10 | Estimation of genetic parameters for growth traits of Japanese flounder Paralichthys olivaceus using an animal model显示文摘 | Yongxin Liu Guixing Wang Yufen Wang | 2011 | Fisheries Science2011，77，： | 1 |
| 11 | Optimized protocol of RBCs lysis for immunophenotypic analysis in the peripheral blood of tree shrew显示文摘 | Xintong Li Yufen Tao Jiansheng Liu Wei Lu Hongqi Liu Jiejie Dai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 1 |
| 12 | Insight into the critical factors determining the particle number concentrations during summer at a megacity in China显示文摘To identify the critical factors impacting the number concentration of particles with the aerodynamic diameters less than 2.5 μm(PNC_(2.5)), the continuous measurement of PNC_(2.5),chemical components in PM_(2.5), gaseous pollutants and meteorological conditions were conducted at an urban site in Tianjin in June 2015. Results indicated that the average PNC_(2.5) was 2839 ± 2430 d N/dlog Dp 1/cm^3 during the campaign. Compared to other meteorological parameters, the relative humidity(RH) had the strongest relationship with PNC_(2.5), with a Pearson's correlation coefficient of 0.53, and RH larger than 30% influenced strongly PNC_(2.5).The important influence of secondary reactions on PNC_(2.5) was inferred due to higher correlation coefficients between PNC_(2.5) and SO_4^(2-), NO_3^-, NH_4^+(r = 0.78–0.89; p < 0.01) and between PNC_(2.5) and ratios that represent the conversion of nitrogen and sulfur oxides to particulate matter(r = 0.42–0.49; p < 0.01). Under specific RH conditions, there were even stronger correlations between PNC_(2.5) and NO_3^-, SO_4^(2-), NH_4^+, while those between PNC_(2.5) and EC, OC were relatively weak, especially when RH exceeded 50%. Principal component analysis(PCA) and Pearson's correlation analysis indicated that secondary sources, vehicle emission and coal combustion might be major contributors to PNC_(2.5). Backward trajectory and potential source contribution function(PSCF) analysis suggested that the transport of air masses originated from these regions around Tianjin(Liaoning, Hebei, Shandong and Jiangsu) influenced critically PNC_(2.5). The north of Jiangsu, the west of Shandong, and the east of Hebei were distinguished as major potential source-areas of PNC_(2.5) by PSCF model. | Baoshuang Liu Xiaohui Bi Jiaying Zhang Jie Yuan Zhimei Xiao Qili Dai Yinchang Feng Yufen Zhang | 2019 | Journal of Environmental Sciences2019，31，1： | 1 |
| 13 | A Fault Detection Mechanism in Erasure-Code Byzantine Fault-Tolerance Quorum显示文摘Fault-tolerance is increasingly significant for large-scale storage systems in which Byzantine failure of storage nodes may happen. Traditional Byzantine Quorum systems that tolerate Byzantine failures by using replication have two main limitations: low space-efficiency and static quorum variables. We propose an Erasure-code Byzantine Fault-tolerance Quorum that can provide high reliability with far lower storage overhead than replication by adopting erasure code as redundancy scheme. Through read/write operations of clients and diagnose operation of supervisor, our Quorum system can detect Byzantine nodes, and dynamically adjust system size and fault threshold. Simulation results show that our method improves performance for the Quorum with relatively small quorums. | LIU Gang ZHOU Jingli SUN Yufen QIN Leihua | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 1 |
| 14 | PU.1-Bim axis is involved in Trichostatin A-induced apoptosis in murine pro-B lymphoma FL5.12 cells显示文摘Trichostatin A (TSA ) 是被报导了在癌症房间线的一些类型显示出有势力反肿瘤能力的一个著名 histone deacetylases (HDAC ) 禁止者。然而,在要描述的淋巴瘤遗体上详细说明了 TSA 行动的机制。在现在的学习, TSA 的 anti-proliferative 效果用鼠科的 pro-B 淋巴瘤房间线 FL5.12 被调查。MTT 试金表明 TSA potently 在一个时间依赖者和剂量依赖者举止禁止了 FL5.12 房间的增长。FL5.12 房间的明亮地的显微镜学在 TSA 治疗以后在 24 h 显示出 apoptotic 形态学。一致地, TSA 治疗导致了 DNA 破碎并且增加了劈开的 caspase 的蛋白质层次 3 并且由西方的污点分析揭示了的 PARP。探索 FL5.12 房间的导致 TSA 的 apoptosis 的内在的机制,我们进一步由西方的污点分析分析了造血的抄写因素嘌呤富有的 Box-1 (PU.1 ) 。TSA 治疗在 FL5.12 房间导致了 PU.1 的抑制。相反, apoptotic 蛋白质 Bim 被 TSA 导致,它相反地与 FL5.12 房间的幸存被相关。这些结果经由 PU.1-Bim 轴在鼠科的 pro-B 淋巴瘤 FL5.12 房间建议导致 TSA 的 apoptosis 的可能的机制。 | Chao Li Yufen Tao Bo Liu Jiansheng Liu Guanlin Wang Hongqi Liu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 1 |
| 15 | Current studies on antiendotoxicchemical components of traditional Chinese medical in China显示文摘 | Liu Yunhai Liu Yufen Guo Xianxi | 2001 | Acta Pharmacologica2001，22，12： | 1 |
| 16 | 显示文摘 | HUANG Yufen CHIANG Chengkang LIN Yangwei LIU Kungtien HU Chochen BAIR Mingjong CHANG Huantsung | 2008 | Electrophoresis2008，29，9： | 1 |
| 17 | Off/On Fluorescent Chemosensors for Organotin Halides Based on Binuclear Ruthenium Complexes显示文摘 | Yufen Niu Feifei Han Qian Zhang Tingwan Xie Liu Lu Shunhua Li Haiping Xia | 2013 | Angew Chem Int Ed2013，，21： | 1 |
| 18 | Overexpression of CaWRKY27 , a subgroup IIe WRKY transcription factor of Capsicum annuum , positively regulates tobacco resistance to Ralstonia solanacearum infection显示文摘 | Fengfeng Dang Yuna Wang Jianju She Yufen Lei Zhiqin Liu Thomas Eulgem Yan Lai Jing Lin Lu Yu Dan Lei Deyi Guan Xia Li Qian Yuan Shuilin He | 2014 | Physiol Plantarum2014，，3： | 1 |
| 19 | Application of MBR for hospital wastewater treatment in China显示文摘 | Liu Qiaoling Zhou Yufen Chen Lingyun | 2010 | Desalination2010，250，2： | 1 |
| 20 | Mo- lecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells 显示文摘 | Huang Yufen Shangguan Dihua Liu Haipeng | 2009 | Chem Bio Chem2009，10，5： | 1 |
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