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| 1 | Adjustment Model and Algorithm Based on Ellipsoid Uncertainty显示文摘In surveying adjustment models,there is usually some uncertain additional information or prior information on parameters,which can constrain the parameters,and guarantee the uniqueness and stability of parameter solution.In this paper,we firstly use ellipsoidal sets to describe uncertainty,and establish a new adjustment model with ellipsoidal uncertainty.Furthermore,we give a new adjustment criterion based on minimization trace of an outer ellipsoid with two ellipsoid intersections,and analyze the propagation law of uncertainty.Correspondingly,we give a new algorithm for the adjustment model with ellipsoid uncertainty.Finally,we give three examples to test and verify the effectiveness of our algorithm,and illustrate the relation between our result and the weighted mixed estimation. | Yingchun SONG Yuguo XIA Xuemei XIE | 2020 | Journal of Geodesy and Geoinformation Science2020，3，3： | 7 |
| 2 | Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-related protein SOX9A显示文摘Anti-Müllerian hormone(amh) is one of the earliest functional genes expressed during testicular differentiation. It has been suggested that androgen signaling regulates critical genes for the differentiation and development of the testis. To elucidate the exact regulatory mechanisms involved in amh transcription mediated by androgen signaling, androgen signaling was manipulated in zebrafish by cytochrome P45017a1(cyp17a1) knockout and Flutamide treatment. In cyp17a1-deficient and Flutamide-treated testes,up-regulated sry-box9a(sox9a) and down-regulated amh were observed. Moreover, a physical association of the zebrafish androgen receptor(AR) and SOX9 A was found. The interaction between AR and SOX9 A was mediated via the DNA binding domain(DBD) of AR and the transactivation domain(TA) of SOX9 A,and was further enhanced by 5-alpha dihydrotestosterone(DHT), one of the most potent androgens.Intriguingly, together with SOX9 A, androgen signaling synergistically promoted amh transcription,mainly through the proximal 1 kb of the amh promoter region. Taken together, our data demonstrate a critical mechanism underlying the direct synergy of androgen signaling and SOX9 A in the regulation of amh transcription. | Gang Zhai Tingting Shu Yuguo Xia Xia Jin Jiangyan He Zhan Yin | 2017 | Science Bulletin2017，62，3： | 7 |
| 3 | Investigation into the transient flow characteristics of noble gas propellants using the pulsed inductive discharge in electric propulsion显示文摘The Pulsed Inductive Thruster(PIT)has the advantages of repeatable startup,no corruption and in-situ propellant feed.To study the flow expansion and circuit characteristics of PITs,the circuit-fluid model is developed,and the high temperature thermodynamic and transport models are combined with the circuit-fluid model to predict the critical plasma parameters.The flow fields of initial mass of 2–8 mg and charge voltages of 10–14 k V are simulated.Comparison of the flow fields of argon and helium propellants suggests that,the flow field structures are similar.Slight differences exist on the magnitude of the density and magnetic field,caused by larger velocity in lighter atom case and difference on the ionization gap between adjacent ionization levels.Analysis of the circuit characteristics by the two-dimensional results indicates that the ratio of coil inductance to circuit inductance affects both the rise rate and phase of the plasma current,the larger the ratio,the greater the rise rate and the better the following characteristic.The calculations show that the magnetic energy obtained within the decoupling distance determines the overall performance the thruster can be obtained;self-induced field maintained by the thermal motion after the main pulse leads to the long attenuation process and difference on the total impulse when the angle of conical pylon is varied under constant coil dimension. | Yuguo CHENG Guangqing XIA | 2020 | Chinese Journal of Aeronautics2020，33，9： | 2 |
| 4 | Eliminating the original cargos of glioblastoma cell-derived small extracellular vesicles for efficient drug delivery to glioblastoma with improved biosafety显示文摘Tumor derived small extracellular vesicles(TsEVs)display a great potential as efficient nanocarriers for chemotherapy because of their intrinsic targeting ability.However,the inherited risks of their original cargos(like loaded proteins or RNAs)from parent cancer cells in tumor progression severely hinder the practical application.In this study,a saponin-mediated cargo elimination strategy was established and practiced in glioblastoma(GBM)cell-derived small extracellular vesicles(GBM-sEVs).A high eliminating efficacy of the cargo molecules was confirmed by systematic analysis of the original proteins and RNAs in GBM-sEVs.In addition,the inherited functions of GBM-sEVs to promote GBM progression vanished after saponin treatment.Moreover,the results of cellular uptake analysis and in vivo imaging analysis demonstrated that saponin treatment preserved the homotypic targeting ability of GBM-sEVs.Thus,we developed an efficient nanocarrier with improved biosafety for GBM suppression.Furthermore,doxorubicin(DOX)transported by the saponin-treated GBM-sEVs(sa-GBM-sEVs)displayed an effective tumor suppression in both subcutaneous and orthotopic GBM models of mouse.Collectively,this study provides a feasible way to avoid the potential protumoral risks of TsEVs and can advance the clinical application of TsEVs in chemotherapy. | Yuhang Guo Guowen Hu Yuguo Xia HaiYan Li Ji Yuan Juntao Zhang Yu Chen Hua Guo Yunlong Yang Yang Wang Zhifeng Deng | 2022 | Bioactive Materials2022，7，10： | 1 |
| 5 | Enlightenment of Successful Experience of Rural Tourism in South Korea to Rural Tourism in Tai'an City显示文摘To revitalize rural tourism and improve the quality of life of rural residents,the successful experience of rural tourism in South Korea is used for reference,with an important significance for promoting the development of rural tourism in Tai'an City.In this paper,three successful rural tourism cases of South Korea(Shuchuan,Hannong Village,Xinli Mupianwa Village)are analyzed first,and their successful experience is summarized.On the basis of accurately grasping current situation and problems of rural tourism development in Tai'an City,the countermeasures of promoting the development of rural tourism in Tai'an City are proposed:mobilizing the enthusiasm of villagers,multi-channel access to funds,diversified talent cultivation methods,product marketing system,and rural tourism management system. | Xiu LI Xia WANG Yuguo WANG | 2022 | Asian Agricultural Research2022，14，1： | 1 |
| 6 | Strong interface interaction and internal electric field promote electron transfer of Bi_(2)O_(2)S/NiFe_(2)O_(4) heterojunction for photocatalytic antibiotic degradation显示文摘Heterojunction photocatalysts have shown considerable activities for organic pollutants degradation.However,the faint connection interface and inferior charge shift efficiency critically block the property of heterojunction photocatalysis.Herein,Bi_(2)O_(2)S/NiFe_(2)O_(4) nanosheets heterojunction with ultrastrong inter-face interaction and high internal electric field are designed by an in-situ growth method.Tentative and theoretical consequences prove that the interfacial interaction and internal electric field not only act as the electron flow bridge but also decrease the electrons shift energy obstacle,thus speeding up electrons transfer and achieving effective spatial electron-hole separation.Therefore,a large amount of·O_(2)^(-)and holes as active species were generated.Remarkably,Bi_(2)O_(2) S/NiFe_(2)O_(4) establishes a considerably boosted photocatalytic performance for tetracycline degradation(0.032 min^(-1)),which is about 14.2-fold and 7.8-fold of the pristine BOS and NFO,respectively.This work provides a promising motivation for modulating charge transfer by interface control and internal electric field to boost photocatalytic performance. | Shaoxuan Pang Yilin Dong Dongyu Xu Qiuwen Wang Weihong Gao Lijun Zhang Kang Wang Guangming Zhang Longyi Lv Yuguo Xia Zhijun Ren Pengfei Wang | 2023 | Journal of Materials Science & Technology2023，，27： | 0 |
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