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| 1 | A corn parative study of the treatment of chronic subdural hem atom a - burr Hole drainage versus burr hole irrigation 显示文摘 | YUKO OKADA TAKUYA AKA1 KAZUYA OKAM OTO | 2002 | Surg Neurol2002，57，： | 1 |
| 2 | Genetic polymorphism of CYP2C9 and CYP2C19 in a Bolivian population: an investigative and comparative study显示文摘 | Heydy V. Bravo-Villalta Koujirou Yamamoto Katsunori Nakamura Ana Bayá Yuko Okada Ryuya Horiuchi | 2005 | European Journal of Clinical Pharmacology2005，，3： | 1 |
| 3 | Evaluation of needle-knife precut papillotomy after unsuccessful biliary cannulation, especially with regard to postoperative anatomic factors显示文摘 | Hirotoshi Fukatsu Hirofumi Kawamoto Hironari Kato Ken Hirao Naoko Kurihara Takashi Nakanishi Osamu Mizuno Yuko Okamoto Tsuneyoshi Ogawa Etsuji Ishida Hiroyuki Okada Kohsaku Sakaguchi | 2008 | Surgical Endoscopy2008，，3： | 1 |
| 4 | Evaluation of needle-knife precut papillotomy after unsuccessful biliary cannulation, especially with regard to postoperative anatomic factors显示文摘 | Hirotoshi Fukatsu Hirofumi Kawamoto Hironari Kato Ken Hirao Naoko Kurihara Takashi Nakanishi Osamu Mizuno Yuko Okamoto Tsuneyoshi Ogawa Etsuji Ishida Hiroyuki Okada Kohsaku Sakaguchi | 2008 | Surgical Endoscopy2008，，3： | 1 |
| 5 | A comparative study of the treatment of chronic subdural hematoma-burr hole drainage versus burr hole irrigation 显示文摘 | Yuko Okada Takuya Akai Kazuya Okamoto | 2002 | Surg Neurol2002，57，6： | 1 |
| 6 | Role of proton magnetic resonance spectroscopy in preoperative evaluation of patients with mesial temporal lobe epilepsy显示文摘 | Mikhail F. Chernov Taku Ochiai Yuko Ono Yoshihiro Muragaki Fumitaka Yamane Takaomi Taira Takashi Maruyama Masahiko Tanaka Hiroshi Iseki Osami Kubo Yoshikazu Okada Tomokatsu Hori Kintomo Takakura | 2009 | Journal of the Neurological Sciences2009，，1： | 1 |
| 7 | Enhanced protein secretion from multiprotease-deficient fission yeast by modification of its vacuolar protein sorting pathway显示文摘 | Alimjan Idiris Hideki Tohda Mayumi Sasaki Katsunori Okada Hiromichi Kumagai Yuko Giga-Hama Kaoru Takegawa | 2010 | Applied Microbiology and Biotechnology2010，，3： | 1 |
| 8 | Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study)显示文摘 | Aki Hiuge-Shimizu Ken Kishida Tohru Funahashi Yuko Ishizaka Rie Oka Minoru Okada Shizu Suzuki Norihide Takaya Tohru Nakagawa Toshiki Fukui Hiroshi Fukuda Naoya Watanabe Tohru Yoshizumi Tadashi Nakamura Yuji Matsuzawa Minoru Yamakado Iichiro Shimomura | 2012 | Annals of Medicine2012，，1： | 1 |
| 9 | A comparative study of the treatment of chronic subdural hematoma-burr Hole drainage versus burr hole irrigation显示文摘 | YUKO OKADA TAKUYA AKAI KAZUYA OKAMOTO | 2002 | Surg Neurol2002，57，： | 1 |
| 10 | A comparative study of the treatment of chronic subdural hematoma-burr Hole drainage versus burr hole irrigation显示文摘 | Yuko Okada Takuya Akai Kazuya Okamoto | 2002 | Surg Neurol2002，57，： | 1 |
| 11 | A comparative study of the treatment of chronic subdural hematoma-burr Hole drainage versus burr hole irrigation显示文摘 | Takuya Akai Kazuya Okamoto | 2002 | Surg Neuro12002，57，： | 1 |
| 12 | Thyroid hormone alterations in trauma patients requiring massive transfusion: An observational study显示文摘BACKGROUND: Although non-thyroidal illness syndrome(NTIS) is considered a negative prognostic factor, the alterations in free triiodothyronine(f T3) levels in trauma patients requiring massive transfusion have not been reported.METHODS: A prospective observational study comparing 2 groups of trauma patients was conducted. Group M comprised trauma patients requiring massive transfusions(>10 units of packed red blood cells) within 24 hours of emergency admission. Group C comprised patients with an injury severity score >9 but not requiring massive transfusions. Levels of f T3, free thyroxine(f T4), and thyroidstimulating hormone(TSH) were evaluated on admission and on days 1, 2, and 7 after admission. The clinical backgrounds and variables measured including total transfusion amounts were compared and the inter-group prognosis was evaluated. Results are presented as mean±standard deviation.RESULTS: Nineteen patients were enrolled in each group. In both groups, 32 were men, and the mean age was 50±24 years. In group C one patient died from respiratory failure. The initial f T3 levels in group M(1.95±0.37 pg/m L) were signifi cantly lower than those in group C(2.49±0.72 pg/m L; P<0.01) and remained low until 1 week after admission. Initial inter-group f T4 and TSH levels were not significantly different. TSH levels at 1 week(1.99±1.64 μIU/m L) were higher than at admission(1.48±0.5 μIU/m L) in group C(P<0.05).CONCLUSION: Typical NTIS was observed in trauma patients requiring massive transfusions. When initial resuscitation achieved circulatory stabilization, prognosis was not strongly associated with NTIS. | Toru Hifumi Ichiro Okada Nobuaki Kiriu Eiju Hasegawa Tomoko Ogasawara Hiroshi Kato Yuichi Koido Junichi Inoue Yuko Abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda | 2014 | World Journal of Emergency Medicine2014，5，4： | 0 |
| 13 | Dimethyltyrosine, the Viagra of Opioids显示文摘The introduction of 2′,6′-dimethyl-L-tyrosine(Dmt) [1] at the N-terminus of Tyr-Tic(1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid)-containing δ-opioid antagonists [2—8] enhances receptor affinity and in vitro bioactivity to several orders of magnitude [1] and its application in the formation of ligands with new properties [9], such as potent inverse agonism [10]. For example, the δ_ 2 agonist, [Dmt 1] deltorphin B [11], has become bifunctional and a high affinity δ/μ agonist [12]. [Dmt 1] DALDA has acquired higher μ affinity and activity [13], while enkephalin analogs have gained extraordinary high δ affinity and enhanced stability [14] , similar to those observed for Dmt-pyrazinone derivatives(Okada.Y., personal communications). Thus, Dmt facilitates opioid ligand recognition toward both δ and μ receptors [15] , underscoring similarities in their molecular binding sites within the receptor [16]. The Tic residue appears to be responsible for δ antagonism [17] as the substitution of the Dmt-Tic pharmacophores at the N-terminus of unrelated opioid agonists can transform them into δ antagonists, such as enkephalin(δ) [18], dermorphin(μ) [18] and dynorphin A(1—11) NH_ 2(κ) [19]; however, some Dmt-Tic analogs have mixed δ/μ antagonist/agonist activities [20]. | Lawrence H. Lazarus Sharon D. Bryant Severo Salvadori Remo Geurrini Gianfranco Balboni Yuko Tsuda Yoshio Okada | 2006 | Chemical Research in Chinese Universities2006，22，2： | 0 |
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