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| 1 | Neoadjuvant chemotherapy for locally advanced cervical cancer显示文摘Neoadjuvant chemotherapy followed by surgery(NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy(NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials(RCTs) have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy(CCRT) has markedly improved the outcome of radiotherapy(RT), and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT. | Takashi Iwata Azumi Miyauchi Yukako Suga Hiroshi Nishio Masaru Nakamura Akiko Ohno Nobumaru Hirao Tohru Morisada Kyoko Tanaka Hiroki Ueyama Hidemichi Watari Daisuke Aoki | 2016 | Chinese Journal of Cancer Research2016，28，2： | 20 |
| 2 | Simultaneously disrupting AtPrx2,AtPrx25 and AtPrx71 alters lignin content and structure in Arabidopsis stem显示文摘Plant class III heme peroxidases catalyze lignin polymerization. Previous reports have shown that at least three Arabidopsis thaliana peroxidases, At Prx2, At Prx25 and At Prx71,are involved in stem lignification using T-DNA insertion mutants,atprx2, atprx25, and atprx71. Here, we generated three double mutants, atprx2/atprx25, atprx2/atprx71, and atprx25/atprx71,and investigated the impact of the simultaneous de ficiency of these peroxidases on lignins and plant growth. Stem tissue analysis using the acetyl bromide method and derivatization followed by reductive cleavage revealed improved lignin characteristics, such as lowered lignin content and increased arylglycerolb-aryl(b-O-4) linkage type, especially b-O-4 linked syringyl units, in lignin, supporting the roles of these genes in lignin polymerization. In addition, none of the double mutants oexhibited severe growth defects, such as shorter plant stature, dwar fing, or sterility, and their stems had improved cell wall degradability. This study will contribute to progress in lignin bioengineering to improve lignocellulosic biomass. | Jun Shigeto Yoshitaka Itoh Sakie Hirao Kaori Ohira Koki Fujita Yuji Tsutsumi | 2015 | Journal of Integrative Plant Biology2015，57，4： | 7 |
| 3 | Increased Oocyte Production after Acupuncture Treatment during Superovulation Process in Mice显示文摘Objective To investigate whether acupuncture treatment during superovulation process improves ovarian response and increases egg production. Methods ICR female mice aged 12-15 weeks were divided into control group, anaesthesia group and acupuncture group. Female mice were injected intraperitoneally with pregnant mare's serum gonadotropin (PMSG), followed by human chorionic gonadotropin (hCG) injection 56 h later. Anaesthesia group and acupuncture group were anaesthetized three times by injecting 10% nembutal solution according to 7.5-10.0 μl/g weight. Acupuncture group was treated three times with puncture Sanyinjiao Points(SP6) under anaesthesia. After 17 h of hCG injection, eggs were recovered and ovaries were isolated. Matured eggs were counted, ovarian histology and expression of follicle stimulating hormone receptor(FSH-R) in ovary were analyzed. Results Acupuncture treatment statistically increased the number of ovulated eggs. Histological section showed that some matured follicles left in the ovaries of control and anaesthesia groups after ovulation. On the contrary, all matured follicles ruptured and converted into corpus lutea in Acupuncture group. Expression of FSH-R in ovary was decreased in acupuncture group compared with those of the two others. Conclusion Acupuncture treatment during superovulation process improves ovarian response so as to increase egg production. The positive effect of acupuncture may be associated with regulated FSH-R expression. | Chun-lan JIN Kazuo Tohya Koichi Kuribayashi Michio Kimura Yuki-hisa Hirao | 2009 | Journal of Reproduction and Contraception2009，20，1： | 3 |
| 4 | 飞秒激光空间选择性诱导玻璃微结构及应用显示文摘利用飞秒激光与玻璃的非线性相互作用,可以对玻璃进行空间选择性微观改性与修饰,赋予新的光功能。本文介绍飞秒激光的特点及其对玻璃微结构的改性,以及近年来利用飞秒激光进行玻璃的缺陷控制、光活性离子(稀土、过渡和重金属离子)价态操作、微晶析出与折射率调控及其在光开关、波分复用、波导型有源器件、光子晶体等微光学器件的制备及光学集成领域应用的进展。 | 邱建荣 钱国栋 Kazuyuki Hirao | 2003 | 材料研究学报2003，17，1： | 3 |
| 5 | Long lasting phosphorescence in Eu2+-doped calcium aluminoborate glasses 显示文摘 | Jianrong Qiu Hirao K | 1998 | Solid State Communication1998，12，106： | 2 |
| 6 | Comparison of Perioperative and Long-term Outcomes of Total and Proximal Gastrectomy for Early Gastric Cancer: A Multi-institutional Retrospective Study显示文摘 | Toru Masuzawa Shuji Takiguchi Motohiro Hirao Hiroshi Imamura Yutaka Kimura Junya Fujita Isao Miyashiro Shigeyuki Tamura Masahiro Hiratsuka Kenji Kobayashi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2014 | World Journal of Surgery2014，，5： | 2 |
| 7 | A comparison of postoperative quality of life and dysfunction after Billroth I and Roux-en-Y reconstruction following distal gastrectomy for gastric cancer: results from a multi-institutional RCT显示文摘 | Shuji Takiguchi Kazuyoshi Yamamoto Motohiro Hirao Hiroshi Imamura Junya Fujita Masahiko Yano Kenji Kobayashi Yutaka Kimura Yukinori Kurokawa Masaki Mori Yuichiro Doki | 2012 | Gastric Cancer2012，，2： | 2 |
| 8 | Prognostic value of cyclin E and p53 expression in gastric carcinoma显示文摘 | Sakaguchi T Watanabe A SawadaH Yamada Y Yamashita J Matsuda M Nakajima M Miwa T Hirao T Nakano H | | 0，，： | 2 |
| 9 | 飞秒激光作用下光学与激光玻璃的暗化阈值测量显示文摘报道了各种商用光学玻璃和激光玻璃在 80 0 nm、 12 0 fs、 1k Hz钛宝石脉冲激光作用下 。 | 姜雄伟 邱建荣 朱从善 Hirao K 干福熹 | 2000 | 光学学报2000，20，12： | 2 |
| 10 | IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro显示文摘 | Shoichi Kaneshiro Kosuke Ebina Kenrin Shi Chikahisa Higuchi Makoto Hirao Michio Okamoto Kota Koizumi Tokimitsu Morimoto Hideki Yoshikawa Jun Hashimoto | 2014 | Journal of Bone and Mineral Metabolism2014，，4： | 2 |
| 11 | Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells显示文摘 | Ito K Hirao A Arai F | 2006 | Nat Med2006，12，： | 1 |
| 12 | Long lasting phosphorescence in Eu2+-doped calcium aluminoborate glasses显示文摘 | Qiu J Hirao K | 1998 | Solid State Commun1998，106，12： | 1 |
| 13 | The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease:A longitudinal SPECT study显示文摘 | Haruo Hanyu Tomohiko Sato Kentaro Hirao | | 0，，01： | 1 |
| 14 | Processing strategy for producing highly anisotropic silicon nitride 显示文摘 | Hirao K Ohashi M Brito M E | 1995 | Journal of the American Ceramic Society1995，78，6： | 1 |
| 15 | Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells 显示文摘 | Ito K Hirao A Arai F | 2004 | Nature2004，431，： | 1 |
| 16 | Novel room-temperature molten salts by neutralization of amines显示文摘 | Hirao M Sugimoto H Ohno H | 2000 | J Electro Chem Soc2000，147，11： | 1 |
| 17 | Effect of applied stresses on magnetostriction of low carbon steel显示文摘 | YAMASAKI T YAMAMOYO S HIRAO M | 1996 | NDT & E International1996，29，5： | 1 |
| 18 | Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTR Delta FS08显示文摘 | Morito D Hirao K Oda Y | 2008 | Mol biol cell2008，19，4： | 1 |
| 19 | Fabrication of low cost fine-grained alumina powders by seeding for high performance sintered bodies 显示文摘 | Yoshizawa Y Hirao K Kanzaki S | 2004 | Journal of the European Ceramic Society2004，24，2： | 1 |
| 20 | Isolation and structure determination of algicidal compounds from Ulva fasciata 显示文摘 | ALAMSJAH M A HIRAO S ISHIBASHI F | 2005 | Bioscience Biotechnology and Biochemistry2005，69，： | 1 |
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