|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis显示文摘Wogonoside,a bioactive flavonoid component derived from Scutellaria baicalensis Georgi,has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer,lung cancer,and leukemia cells.However,whether wogonoside could inhibit tumor growth of endometrial cancer has not been elucidated.In this study,we explored the function of wogonoside on tumor growth and the underlying mechanism on endometrial cancer.Firstly,we investigated the effect of wogonoside on endometrial cancer cells and found that wogonoside could significantly decrease cell proliferation and metastasis.Mechanistically,wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1,leading to the activation of the Hippo signaling pathway.Taken together,in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer. | Shaorong Chen Zhuna Wu Yumin Ke Pingping Shu Caihong Chen Ruying Lin Qirong Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 8 |
| 2 | Influence of cementite spheroidization on relieving the micro-galvanic effect of ferrite-pearlite steel in acidic chloride environment显示文摘The corrosion behavior of the as-received steel and the spheroidized steel in acidic chloride environment was investigated. The results indicate the corrosion mode and corrosion rate of two steels are diverse due to their difference in microstructure. For as-received steel with ferrite-pearlite microstructure, severe localized corrosion happens on the pearlite regions, and plenty of cathodic cementite remains in the pits, further strengthening the micro-galvanic effect and accelerating the corrosion rate. While for spheroidized steel with tempered martensite microstructure, the nanosized cementite particles evenly distributed on the ferrite substrate are easy to fall off, which can significantly reduce the cementite accumulation on the steel surface, relieving the acceleration effect of micro-galvanic corrosion. | Hu Liu Jie Wei Junhua Dong Yiqing Chen Yumin Wu Yangtao Zhou Subedi Dhruba Babu Wei Ke | 2021 | Journal of Materials Science & Technology2021，，2： | 1 |
| 3 | Peptide recognition by functional supramolecular nanopores with complementary size and binding sites显示文摘在单个分子的水平在表面上吸附的 biomolecules 的符合构造的精确控制是重要的。然而,因为复杂结构和 biomolecules 的符合构造差异,它仍然是巨大的挑战。此处,限制 nanopore 的识别策略被建议通过 functionalized 的精确设计在房间温度操作单个 valinomycin 分子的吸附结合的 macrocycle (CPN8 ) 有互补体系结构和有约束力的地点的超分子的 nanopores。我们表明 CPN8 与因为在 valinomycin 的 isopropyl 组和 CPN8 的氨基的组之间的强壮的 synergistic 相互作用,有选择地与互补建筑学认出 valinomycin 比比较喜欢,与 valinomycinhighly 面向的 pyrolytic 石墨(HOPG ) 相互作用。我们在单个分子的水平的观点将提供珍贵卓见为非结合的分子的符合构造选择的识别改进超分子的 nanopores 的设计。 | Yumin Chen Hui Nie Ke Deng Shili Wu Jindong Xue Lijin Shu Yue Yu Yanfang Geng Ping Li Yanlian Yang Qingdao Zeng | 2016 | Nano Research2016，9，5： | 1 |
| 4 | Effect of TiO 2 nanoparticles on the antibacterial and physical properties of polyethylene-based film显示文摘 | Yage Xing Xihong Li Li Zhang Qinglian Xu Zhenming Che Weili Li Yumin Bai Ke Li | 2011 | Progress in Organic Coatings2011，，2： | 1 |
| 5 | The synergy between cementite spheroidization and Cu alloying on the corrosion resistance of ferrite-pearlite steel in acidic chloride solution显示文摘In this work,the corrosion behavior of medium-carbon steels(45,45 Cu and 45 Cuq steels)in acidic chloride environment was investigated.The results indicated that the micro-galvanic effect between the anodic ferrite matrix phase and the cathodic cementite secondary phase notably affected the corrosion resistance of the three steels.For 45 steel,serious pitting corrosion happened in and around the pearlite regions,and a large number of lamellar cementite was fixed in the corrosion pits.Meanwhile,the continuously increasing superficial area of cathodic cementite enhanced the micro-galvanic corrosion,resulting in a rapidly increase in corrosion rate with time.While for 45 Cu and 45 Cuq steels,macroscopic uniform corrosion occurred,and the cementite accumulation was markedly reduced as compared with 45 steel,thus the micro-galvanic effect was weakened and the corrosion rate was decreased accordingly.Among these,45 Cuq steel showed the most stable and excellent corrosion resistance during long-term corrosion,indicating the occurrence of a synergistic effect between cementite spheroidization and Cu alloying,thereby significantly improving the corrosion resistance of 45 steel. | Hu Liu Jie Wei Junhua Dong Yangtao Zhou Yiqing Chen Yumin Wu Subedi Dhruba Babu Aniefiok Joseph Umoh Wei Ke | 2021 | Journal of Materials Science & Technology2021，，25： | 1 |
| 6 | A core-satellite-like nanoassembly reverses a decisive tyrosine hydroxylase loss in degenerative dopaminergic neurons显示文摘In recent years,neurodegenerative diseases,such as Parkinson’s or Alzheimer’s diseases,are rapidly rising in prevalence.The main hallmark of Parkinson’s disease is the falling levels of neurotransmitter dopamine in the mid-brain with dopaminergic neurons losing.Typical therapeutic solutions,including drugs,deep brain stimulation,and cell transplantation,can only alleviate the symptoms of Parkinson’s disease.It is a tremendous challenge to reverse the function degeneration of the crucial dopaminergic neurons.Herein,we develop a core-satellite-like nanoassembly(PDA-AFn(by integrating polydopamine nanoparticles and apoferritin))to raise the expression of tyrosine hydroxylase(TH),a rate-limiting enzyme in the formation of the dopamine.Both components in the nanoassembly could cooperate with each other,not only elaborately regulate the iron homeostasis and redox microenvironment,but also utilize excessive reactive oxygen species(ROS)and iron ions in the damaged neurons to supply extra dopamine and enhance TH activity,and consequently restore the function of the degenerated neurons.Remarkably,the nanoassembly-treatment relieves the dyskinesia and dramatical increases the tyrosine hydroxylase and dopamine level in the midbrain of Parkinson’s disease model mice.It is an explicit yet inspiring advance in treatment of the neurodegeneration. | Ke Yao Jiamin Gan Di Zhao Mingding Li Xiaoquan Shen Yumin Yang Peijian Feng Qundong Shen | 2023 | Nano Research2023，16，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员