|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Engineering Ruthenium-Based Electrocatalysts for Effective Hydrogen Evolution Reaction显示文摘The investigation of highly effective,durable,and cost-effective electrocatalysts for the hydrogen evolution reaction(HER)is a prerequisite for the upcoming hydrogen energy society.To establish a new hydrogen energy system and gradually replace the traditional fossil-based energy,electrochemical water-splitting is considered the most promising,environmentally friendly,and efficient way to produce pure hydrogen.Compared with the commonly used platinum(Pt)-based catalysts,ruthenium(Ru)is expected to be a good alternative because of its similar hydrogen bonding energy,lower water decomposition barrier,and considerably lower price.Analyzing and revealing the HER mechanisms,as well as identifying a rational design of Ru-based HER catalysts with desirable activity and stability is indispensable.In this review,the research progress on HER electrocatalysts and the relevant describing parameters for HER performance are briefly introduced.Moreover,four major strategies to improve the performance of Ru-based electrocatalysts,including electronic effect modulation,support engineering,structure design,and maximum utilization(single atom)are discussed.Finally,the challenges,solutions and prospects are highlighted to prompt the practical applications of Rubased electrocatalysts for HER. | Yingjie Yang Yanhui Yu Jing Li Qingrong Chen Yanlian Du Peng Rao Ruisong Li Chunman Jia Zhenye Kang Peilin Deng Yijun Shen Xinlong Tian | 2021 | Nano-Micro Letters2021，13，10： | 5 |
| 2 | Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. | Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 3 | Attenuation ofβ-Amyloid Toxicity In Vitro and In Vivo by Accelerated Aggregation显示文摘Accumulation and aggregation of β-amyloid(Aβ) peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer's disease. The self-assembled Aβ molecules form various intermediate aggregates including oligomers that are more toxic to neurons than the mature aggregates, including fibrils. Thus, one strategy to alleviate Aβ toxicity is to facilitate the conversion of Aβ intermediates to larger aggregates such as fibrils. In this study, we designed a peptide named A3 that significantly enhanced the formation of amorphous aggregates of Aβ by accelerating the aggregation kinetics. Thioflavin T fluorescence experiments revealed an accelerated aggregation of Aβ monomers, accompanying reduced Aβ cytotoxicity. Transgenic Caenorhabditis elegans over-expressing amyloid precursor protein exhibited paralysis due to the accumulation of Aβ oligomers, and this phenotype was attenuated by feeding the animals with A3 peptide. These findings suggest that the Aβ aggregation-promotion effect can potentially be useful for developing strategies to reduce Aβ toxicity. | Aihua Yang Chenxuan Wang Baomin Song Wendi Zhang Yuanyuan Guo Rong Yang Guangjun Nie Yanlian Yang Chen Wang | 2017 | Neuroscience Bulletin2017，33，4： | 3 |
| 4 | Vacuum-tuned-atmosphere induced assembly of Au@Ag core/shell nanocubes into multi-dimensional superstructures and the ultrasensitive IAPP proteins SERS detection显示文摘Utilizing vacuum-tuned-atmosphere induced dip coating method,we achieve the cross-dimensional macroscopic diverse self-assemblies by using one building block with one chemical functionality.Coordinated modulating the vacuum degree,colloid concentration and evaporation atmosphere,Au@Ag core/shell nanocubes (NCs) can controllably assemble into diverse multi-dimensional superstructures.Under 0.08 MPa,we obtained the two-dimensional (2D) stepped superstructures with continuously tunable step width.In addition,we generated a series of tailorable nanoscale-roughened 2D Au@Ag NCs superstructures at 0.04 MPa,which exhibited the label-free ultrasensitive SERS detection for the different mutants of IAPP8-37 proteins.Under 0.01 MPa,we obtained the cross-dimensional tailorable Au@Ag NCs assemblies from random to macroscale 2D and three-dimensional (3D) densest superstructures by adjusting the capping ligand-environmental molecule interactions.This is a flexible method to generate as-prepared Au@Ag core/shell NCs into well-defined macroscopic diverse superstructures and to promote the exploitation into biological applications. | Meng Xu Guopeng Tu Muwei Ji Xiaodong Wan Jiajia Liu Jia Liu Hongpan Rong Yanlian Yang Chen Wang Jiatao Zhang | 2019 | Nano Research2019，12，6： | 3 |
| 5 | Micro-tribologic Properties of a Covalently Attached Nanostructured Self-Assembly Film Fabricated from Fullerene Carboxylic Acid and Diazoredin显示文摘 | Cao Tingbing Wei Fang Yang Yanlian | 2002 | Langmuir2002，18，： | 1 |
| 6 | Designer self-assembling peptide nanomaterials显示文摘 | Yang Yanlian Khoe Ulung Wang Xiumei Akihiro Horii Hidenori Yokoi Zhang Shuguang | 2009 | Nano Today2009，，2： | 1 |
| 7 | Lectric-field- enhanced assembly of single-walled carbon nanotubes on a solid surface显示文摘 | Chen Zhuo Yang Yanlian Wu Zhongyun | 2005 | Journal of Physical Chemistry B2005，109，： | 1 |
| 8 | Peptide recognition by functional supramolecular nanopores with complementary size and binding sites显示文摘在单个分子的水平在表面上吸附的 biomolecules 的符合构造的精确控制是重要的。然而,因为复杂结构和 biomolecules 的符合构造差异,它仍然是巨大的挑战。此处,限制 nanopore 的识别策略被建议通过 functionalized 的精确设计在房间温度操作单个 valinomycin 分子的吸附结合的 macrocycle (CPN8 ) 有互补体系结构和有约束力的地点的超分子的 nanopores。我们表明 CPN8 与因为在 valinomycin 的 isopropyl 组和 CPN8 的氨基的组之间的强壮的 synergistic 相互作用,有选择地与互补建筑学认出 valinomycin 比比较喜欢,与 valinomycinhighly 面向的 pyrolytic 石墨(HOPG ) 相互作用。我们在单个分子的水平的观点将提供珍贵卓见为非结合的分子的符合构造选择的识别改进超分子的 nanopores 的设计。 | Yumin Chen Hui Nie Ke Deng Shili Wu Jindong Xue Lijin Shu Yue Yu Yanfang Geng Ping Li Yanlian Yang Qingdao Zeng | 2016 | Nano Research2016，9，5： | 1 |
| 9 | Site-specific determination of TTR-related functional peptides by using scanning tunneling microscopy显示文摘为功能的肽的设计和优化, unravelling 单个积木的结构以及整体的性质是首要的。TTR1,源于人的 transthyretin,形成纤丝的肽在象家庭淀粉的 polyneuropathy 和老年的全身的淀粉样变性病那样的疾病被含有。基于 TTR1 脚手架,功能的肽 TTR1-RGD 被设计明确地与房间交往。这里,我们过去常扫描通道显微镜学(STM ) 与反向的顺序和修改前面的顺序分析 TTR1 相关的肽的集会结构。sitespecific 分析显示出下列:我) TTR1 肽涉及汇编,将近在订的表以内盖住全部长度组织。ii ) 为 TTR1-RGD 肽集会,当 RGDS 主题采用允许它支持房间粘附的灵活符合构造时, TTR1 主题形成订的表。关键地点清楚地作为连接器残余 Gly13 被识别。iii ) 尽管有在化学的差别,他们显示类似的集合的前面、反向的肽集会表演的仔细的检查特征,说明这些肽的柔韧的性质。iv ) Glycine 连接器残余在强烈建议顺序能被增加更多的连接器残余优化的 -strands, 被包括。进这些肽的装配结构的这些积累的卓见帮助解开驾驶肽集会的机制并且在新窗户中指示 sequenceprogrammed 肽 architectures.Open | Lanlan Yu Yongfang Zheng JingXu Fuyang Qu Yuchen Lin Yimin Zou Yanlian Yang Sally L. Gras Chen Wang | 2018 | Nano Research2018，11，1： | 1 |
| 10 | Microtribologic Properties of a Covalently Attached Nanostructured Self-Assembly Film Fabricated From Fullerene Carboxylic Acid and Diazoredin 显示文摘 | Cao Tingbing Wei Fang Yang Yanlian | 2002 | Langmuir2002，18，： | 1 |
| 11 | Designer self-assembling peptide nanomaterials 显示文摘 | Yang Yanlian Ulung Khoe Wang Xiumei | 2009 | Nano Today2009，4，： | 1 |
| 12 | Microtribologic Properties of a Covalently Attached Nanostructured Self-Assembly Film Fabricated from Fullerene Carboxylic Acid and Diazoresin显示文摘 | Tingbing Cao Fang Wei Yanlian Yang | 2002 | Langmuir2002，18，13： | 1 |
| 13 | Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand显示文摘 | Jingfei Hou Jiaxi Peng Yue Yu Yuchen Lin Changliang Liu Hongyang Duan Yanlian Yang Chen Wang | 2017 | Chinese Journal of Chemistry2017，35，8： | 1 |
| 14 | Identifi cation of Molecular Flipping of an Asymmetric Tris(phthalocyaninato)Lutetium Triple-Decker Complex by Scanning Tunneling Microscopy/Spectroscopy显示文摘The assembling behavior and electronic properties of asymmetric tris(phthalocyaninato)lutetium triple-decker sandwich complex molecules(Lu2Pc3)on highly oriented pyrolytic graphite(HOPG)surfaces have been studied by scanning tunneling microscopy/spectroscopy(STM/STS)methods.Phase transitions were observed at different bias polarities,involving an ordered packing arrangement with fourfold symmetry at negative bias and an amorphous arrangement at positive bias.Molecular switching behaviour for individual Lu2Pc3 molecules was reported here according to the bias-polarity-induced flipping phenomena and the peak shift in dI/dV versus V curves at different voltage scanning directions.The sensitive response of the strong intrinsic molecular dipole to an external electric field is proposed to be responsible for molecular switching of Lu_(2)Pc_(3)at the solid/liquid interface. | Xianghua Kong Shengbin Lei Yanlian Yang Ke Deng Guicun Qi Chen Wang | 2009 | Nano Research2009，2，3： | 0 |
| 15 | Site-specific Analysis of Amyloid Assemblies by Using Scanning Tunneling Microscopy显示文摘The assembly of amyloid peptides into highly organized fibrils is one of the major characteristics of many de-generative diseases such as Alzheimer’s disease and type II diabetes.Assembly structures of amyloid peptides at liquid-solid interface can be visualized by scanning tunneling microscopy(STM)with site-specific resolution.The STM analysis can provide valuable information on the folding mechanism of amyloid peptides based on the corre-lation of surface assembly structures and fibrillation behaviors.Cases on mutational analysis of amyloid peptides by STM are also reviewed which illustrate the capacities of STM studies on amyloid assemblies. | Yue Yu Yanlian Yang Chen Wang | 2015 | Chinese Journal of Chemistry2015，33，1： | 0 |
| 16 | Formulated nano-liposomes for reversal of cisplatin resistance in NSCLC with nucleus-targeting peptide显示文摘Cell membrane-engineered nano-delivery systems have evolved as a promising strategy to enhance drug bioavailability,offering an alternative for reversing drug resistance in cancer therapy.Herein,a formulated nano-liposome that fabricated by hybridizing cisplatin-resistant A549 cell line(A549/cis)cancer cell membrane and phospholipids for co-delivery of cisplatin and nuclear protein zeste homolog 2(EZH2)-targeting peptide EIP103,referred to as cLCE,was developed.In vitro results indicated that the formulated nano-liposome can efficiently inhibit A549/cis cancer cell invasion and metastasis through the down-regulation of Ncadherin and vimentin proteins.Mechanistic studies demonstrated that the reduction of nerve growth factor receptor(NGFR)levels and the increase of peroxisome proliferator-activated receptorγ(PPARγ)levels achieved by EIP103 may contribute to the reversal of cisplatin resistance.In vivo results demonstrated that the encapsulation of both cisplatin and EIP103 within cLCE leads to increased intratumoral accumulation and prolonged survival in A549/cis cancer-bearing mice as compared to the individual drugs alone.This can be attributed to the enhanced tumor homing capability of cLCE achieved through the presence of inherited membrane proteins derived from A549/cis cells.Taken together,this study may provide a highly promising therapeutic strategy to improve clinical treatments for cisplatin-resistance non-small-cell lung cancer(NSCLC)as well as other malignant cancers. | Minxian Li Mei Jiang Mengting Chen Lilusi Ma Xiaocui Fang Yanlian Yang Chen Wang | 2023 | Nano Research2023，16，11： | 0 |
| 17 | Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression显示文摘Emerging evidence has demonstrated that stromal cell-derived factor 1(SDF-1)and its cognate receptor CXCR4 have critical roles in tumorigenesis,angiogenesis and metastasis.In this study,we demonstrated the significant inhibitory effects of a novel chemically synthetic peptide(E5)on the CXCR4/CXCL12 axis in breast cancer both in vitro and in vivo.E5 was capable of specifically binding to the murine breast cancer cell line 4T1,remarkably inhibiting CXCL12-or stromal cell(MS-5)-induced migration,and adhesion and sensitizing 4T1 cells to multiple chemotherapeutic drugs.Furthermore,E5 combined with either paclitaxel or cyclophosphamide significantly inhibited tumor growth in a breast cancer model.Mechanistic studies implied that E5 can inhibit the expression of CXCR4 to block the CXCL12-mediated recruitment of endothelial progenitor cells and repress CXCR4 downstream of the Akt and Erk signaling pathway,which are involved in tumor angiogenesis and progression.Further pharmacokinetic evaluation suggested that E5 has an acceptable stability,with a half-life of 10 h in healthy mice.In conclusion,E5 demonstrates a promising anti-tumor effect and could be a potential chemotherapeutic sensitizer to improve current clinical breast cancer therapies. | Hua Guo Yangyang Ge Xiaojin Li Yanlian Yang Jie Meng Jian Liu Chen Wang Haiyan Xu | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 18 | Nanoscale structural and electronic evolution for increased efficiency in polymer solar cells monitored by electric scanning probe microscopy显示文摘Control of blend morphology at multi-scale is critical for optimizing the power conversion efficiency(PCE)of plastic solar cells.To better understand the physics of photoactive layer in the organic photovoltaic devices,it is necessary to gain understanding of morphology and the corresponding electronic property.Herein we report the correlation between nanoscale structural,electric properties of bulk heterojunction(BHJ)solar cells and the annealing-induced PCE change.We demonstrate that the PCE of BHJ solar cells are dramatically improved(from1.3%to 4.6%)by thermal annealing,which results from P3HT crystalline stacking and the PCBM aggregation for interpenetrated network.The similar trend for annealinginduced photovoltage and PCE evolution present as an initial increase followed by a decrease with the annealing time and temperature.The surface roughness increase slowly and then abruptly after the same inflection points observed for photovoltage and PCE.The phase images in electric force microscopy indicate the optimized P3HT and PCBM crystallization for interpenetrating network formation considering the spectroscopic results as well.From the correlation between surface photovoltage,blend morphology,and PCE,we propose a model to illustrate the film structure and its evolution under different annealing conditions.This work would benefit the better design and optimization of the morphology and local electric properties of solar cell active layers for improved PCE. | Denghua Li Han Yan Chao Li Yanlian Yang Zhixiang Wei Chen Wang | 2014 | Chinese Science Bulletin2014，59，4： | 0 |
| 19 | Nano-imaging agents for brain diseases: Environmentally responsive imaging and therapy显示文摘Precise imaging is essential for the accurate diagnosis and surgical guidance of brain diseases but it is challenging due to the difficulties in crossing the blood-brain barrier(BBB),the difficulties in disease lesion targeting,and the limited contrast in the brain environment.Nano-imaging agents were characterized by functionalized modifications,high contrast,small size,and high biocompatibility,thus providing advantages in BBB crossing,brain targeting,imaging resolution,and real-time monitoring,holding great potential in brain disease imaging.Specific characteristics in brain environment and brain diseases(e.g.,marker proteins on the BBB,the pathogenic proteins in the neurodegenerative diseases or brain tumors,and the tumor and inflammatory microenvironment)provide opportunities for the functionalized nano-imaging agents to improve BBB crossing and disease targeting.Moreover,the versatile nano-imaging agents are endowed with therapeutic agents to facilitate the theranostics of brain diseases.Here,we summarized the common materials and imaging techniques of nano-imaging agents and their imaging treatment applications.We discussed their BBB penetration,environmental response for disease targeting,and therapeutic effects.We also provided insights on the advantages,challenges,and application of nano-imaging agents in detecting and treating brain diseases such as neurodegenerative diseases,brain tumors,stroke,and traumatic brain injury.These discussions will help develop nano-imaging agents-based theranostic platforms for the precise diagnosis and treatment of brain diseases. | Fuming Liang Qing You Xiaopeng Ma Huayi Wang Chen Wang Zhaohui He Yanlian Yang Ling Zhu | 2023 | Nano Research2023，16，12： | 0 |
| 20 | Nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition显示文摘Preoperative localization of the tumor sites and intraoperative real-time monitoring are essential for precise surgery but are meanwhile challenging due to the lack of high-resolution,easy-to-operate,and fast visualization techniques.On the other hand,tumor recurrence and metastasis after surgery greatly reduce the survival rate of patients.Intervening tumor recurrence during surgery is a future direction of tumor treatment.Nanomaterials with external condition responsiveness(light,ultrasound,and magnetic field)can accurately assist intraoperative detection and surgical resection due to their functions such as tumor cell targeting,fluorescence imaging,and real time monitoring,providing a more accurate,shorter duration,and visualization method of surgical resection.Moreover,nanomaterials are versatile and can easily be tailored for application in different tumors.Locally filled or systemically circulating nanomaterials with slow drug release and residual tumor cell-targeting ability have promising applications in inhibiting tumor recurrence.Here,we review surgical navigation and postoperative recurrence interventional nanomaterials and their landscape in guiding tumor treatment.We summarize the classification and characteristics of these nanomaterials and discuss their application in the surgical navigation and recurrence inhibition of different tumors.We also provide an outlook on the challenges and future development of nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition. | Fuming Liang Qing You Hongjiang Ye Wenqiao Fu Xiaopeng Ma Jiahe Tan Yinrui Ma Chen Wang Yanlian Yang Zhaohui He Ling Zhu | 2023 | Nano Research2023，16，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员