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| 1 | Regulating effects of arsenic trioxide on cell death pathways and inflammatory reactions of pancreatic acinar cells in rats显示文摘背景煽动性的 cytokines 在尖锐胰腺炎的发展起一个关键作用,这被接受,那么堵住煽动性的反应的开始可以减轻尖锐胰腺炎的病理学的变化。我们在 vitro 在胰腺的 acinar 房间的 apoptosis 和 oncosis 上学习了砷三氧化物(As2O3 ) 的规章的效果,在尖锐 pancreatitis.Methods 上的 vivo 和它的治疗学的效果,胰腺的 acinar 房间被 collagenase 消化方法孤立。孤立的胰腺的 acinar 房间的 Apoptosis 和 oncosis 与 Hoechst 33258+PI 或 Annexin V+PI 被检测两倍荧光灯的染色。淀粉酶并且喂奶脱氢酶版本被测量。尖锐胰腺炎被 caerulein 的 intraperitoneal 注射在 Wistar 老鼠导致,并且 apoptosis 与把方法标记的终端 dUTP 刻痕结束被检测。肿瘤 necorsis 因素(TNF-) mRNA, myeloperoxidase,原子 factor-B 并且胰腺的损坏的组织学的分级是在那里的 measured.Results 是增加的 apoptosis 但是在有 As2O3 的处理以后的胰腺的 acinar 房间的减少的 oncosis。层次喂奶脱氢酶和淀粉酶版本显著地在在对待的 As2O3 的对待的 group.Myeloperoxidase 内容,TNF- mRNA 水平,原子 factor-B 激活和病理学的分数组织的 As2O3 被减少比在未经治疗的 group.Conclusions As2O3 能导致 apoptosis 和胰腺的 acinar 的还原剂 oncosis 的显著地低房间,因此导致 acinar 房间的 endocellular 酶的减少的版本,减少了煽动性的房间渗入并且减少 inflamma | XUE Dong-bo ZHANG Wei-hui YUN Xiao-guang SONG Chun ZHENG Biao SHI Xing-ye WANG Hai-yang | 2007 | Chinese Medical Journal2007，，8： | 26 |
| 2 | Comparative studies on histological and ultra-structure of the pituitary of different ploidy level fishes显示文摘The histological and ultra-structure of the pituitary in diploid red crucian carp(Carassius auratus red var.),triploid crucian carp and allotetraploid hybrids within and after the breeding season were comparatively studied.The result showed that there were six endocrine cell types in the pituitary of these three kinds of fishes,and there was an obvious difference in cell size among different ploidy level fishes.As for the same type of pituitary cells,the cell size was increased gradually with the in- creasing ploidy level.In the breeding season,the allotetraploid hybrids had higher proportion of go- nadotropin cells(GTH)than triploids,and the triploids had higher proportion of GTH than diploids.The results were related to the earlier sexual maturity of allotetraploid hybrids and sterility of triploid cru- cian carp.On the other hand,among the three kinds of fishes,the proportion of somatotropin(STH) cells in triploids crucian carp was the highest,whereas that in allotetraploid hybrids was the lowest. The results might be connected with the faster growth rate of triploids and slower growth rate of al- lotetraploid hybrids.In addition,in GTH cells of meso-adenohypophysis after the breeding season, there were many endocrine particles in triploids,while those endocrine particles were released from the cells in allotetraploids and diploids.This result showed that the sterility of triploid crucian carp might be related to the hormone which was not released from the GTH cells.In a word,the present study indicated that the differences in the structure of pituitary among different ploidy level fishes contributed to their difference in the growth rate and gonadal development. | LONG Yu LIU Shaojun HUANG Weiren ZHANG Jian SUN Yuandong ZHANG Chun CHEN Song LIU Jinghui LIU Yun | 2006 | Science China(Life Sciences)2006，49，5： | 13 |
| 3 | Formation and biological characterization of three new types of improved crucian carp显示文摘The improved tetraploids (G1×AT) were obtained by distant crossing and gynogenesis and the high-body individuals accounted for 2% among G1×AT. After mating with each other, the high-body in- dividuals produced three kinds of bisexual fertile diploid fishes: high-body red crucian carp, high-body fork-like-tails goldfish and gray common carp. The high-body red crucian carp mating with each other formed three types of improved crucian carp (ICC) including improved red crucian carp (IRCC), im- proved color crucian carp (ICCC) and improved gray crucian carp (IGCC). The phenotypes, chromo- some numbers, gonadal structure and fertility of the three kinds of ICC and their offspring were observed. All the three kinds of ICC possessed some improved phenotypes such as higher body, smaller head and shorter tail. The ratios of the body height to body length of IRCC, ICCC and IGCC were 0.54, 0.51 and 0.54, respectively. All of them were obviously higher than that of red crucian carp 0.41 (P<0.01). Three kinds of ICC had the same chromosome number as red crucian carp with 100 chromosomes. All the ICC possessed normal gonads producing mature eggs or sperm, which was important for the production of an improved diploid population. Compared with red crucian carp, all the ICC had stronger fertility such as higher gametes production, higher fertilization rate and higher hatchery rate. Three types of improved diploid fish population were generated from the three kinds of ICC by self-crossing, respectively. The ICC can serve as ornamental fish and edible fish. They are also ideal parents to produce triploids by mating with tetraploids. The new ICC plays an important role in biological evolution and fish genetic breeding. | WANG Jing, QIN QinBo, CHEN Song, LIU ShaoJun, DUAN Wei, LIU JinHui, ZHANG Chun, LUO KaiKun, XIAO Jun & LIU Yun Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education of China, College of Life Sciences, Hunan Normal University, Changsha 410081, China | 2008 | Science China(Life Sciences)2008，51，6： | 8 |
| 4 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 5 | Polyploid organisms显示文摘Polyploids are organisms with three or more complete chromosome sets. Polyploidization is widespread in plants and animals, and is an important mechanism of speciation. Genome sequencing and related molecular systematics and bioinformatics studies on plants and animals in recent years support the view that species have been shaped by whole genome duplication during evolution. The stability of polyploids depends on rapid genome recombination and changes in gene expression after formation. The formation of polyploids and subsequent diploidization are important aspects in long-term evolution. Polyploids can be formed in various ways. Among them, hybrid organisms formed by distant hybridization could produce unreduced gametes and thus generate offspring with doubled chromosomes, which is a fast, efficient method of polyploidization. The formation of fertile polyploids not only promoted the interflow of genetic materials among species and enriched the species diversity, but also laid the foundation for polyploidy breeding. The study of polyploids has both important theoretical significance and valuable applications. The production and application of polyploidy breeding have brought remarkable economic and social benefits. | SONG Can LIU ShaoJun XIAO Jun HE WeiGuo ZHOU Yi QIN QinBo ZHANG Chun LIU Yun | 2012 | Science China(Life Sciences)2012，55，4： | 7 |
| 6 | Cytogenetic comparisons between A and G genomes in Oryza using genomic in situ hybridization显示文摘Oryza sativa (一个染色体) 和 O 的 genomic 结构。meyeriana (G 染色体) 比较地在 situ 杂交(GISH ) 用二色的 genomic 被学习。GISH 清楚地能在 O 的染色体之间区别。sativa 和 O。在没有堵住 DNA 的种间的 F1 混血儿的 meyeriana,和合作杂交几乎没被检测。O 的平均有丝分裂的染色体长度。meyeriana 被发现是乘 O 的的 1.69。sativa。染色的 4,6-diamidino-2-phenylindole 的比较出现了 O 的染色体。meyeriana 更广泛地被标记,建议 G 染色体与更重复的序列比被放大一个染色体。在分裂期间原子核, 9-12 多彩石印版中心通常被检测,将近,所有多彩石印版中心组成了 G 染色体特定的 DNA。中心由相应于 G 染色体的染色质压缩形成了的更多和更大的多彩石印版与它的父母相比在混血儿被检测。在 F1 混血儿的 pachytene 期间, A 和 G 的大多数染色体互相,除了 1-2,染色体在他们的手臂的结束配对的触处。在 meiotic 中期我, chromosomal 协会的三种类型,即 O。sativa-O。sativa (A-A ) , O。sativa-O。meyeriana (A-G ) 和 O。meyeriana-O。meyeriana (G-G ) ,在 F1 混血儿被观察。配对配置的 A-G 染色体包括了 bivalents 和 trivalents。结果向学习染色体组织和 O 的进化提供了一个基础。meyeriana。 | Zhi Yong Xiong Guang Xuan Tan Guang Yuan He Guang Cun He Yun Chun Song | 2006 | Cell Research2006，16，3： | 4 |
| 7 | The formation of improved tetraploid population of red crucian carp×common carp hybrids by androgenesis显示文摘Bisexual fertile diploid androgenetic individuals (A0) (2n=100) were formed by androgenesis. In this way, the diploid spermatozoa from male allotetraploid hybrids (AT) (4n=200) of red crucian carp (Carassius auratus red var.) (♀) × common carp (Cyprinus carpio L.) (♂) were used to fertilize the UV-treated hap- loid eggs of goldfish (Carassius auratus), and living androgenetic diploid fish were developed. The A0 became sexually mature at the age of 2 years, and they fertilized with each other to form their offspring (A1). In this study, we observed the chromosomal number, gonadal structure and appearance of A1 fish. The results are as follows: (1) In A1, there were 85% tetraploids (A1-4n), 10% triploids (A1-3n) and 5% diploids (A1-2n), suggesting that diploid A0 could produce diploid gametes. It was concluded that the formation of diploid gametes generated from diploid A0 was probably related to the mechanism of pre-meiotic endoreduplication. (2) Among A1, only A1-4n possessed normal ovaries and testes. The mature males of A1-4n produced white semen. Under the electron microscope, the head of diploid sperm generated by A1-4n was bigger than that of haploid sperm generated by red crucian carp. In the testes of the A1-4n, there were many mature normal spermatozoa with a head bearing plasma mem- brane and a tail having the typical structure of '9+2' microtubules. Between the head and the tail, there were some mitochondria. The ovaries of A1-4n developed well and mainly contained II, III and IV-stage oocytes. The IV-stage oocytes were surrounded by inner and outer follicular cells. The micropyle was observed on the oolemma of follicular cells. There were abundant yolks and plenty of endoplasmic reticulum in the cytoplasm of IV-stage oocytes. Because A1-2n and A1-3n were distant crossing diploid hybrids and triploid hybrids respectively, they possessed abnormal gonads, and no mature semen and eggs were observed. (3) Compared with allotetraploids, the A1-4n fish not only had advantages such as fast growth rate and strong resistibility but also showed some new good performances such as high ratio of body width to body length, smaller heads and shorter tails. These results indicated that an- drogenesis could produce bisexual fertile tetraploids and improve the shape of allotetraploid hybrids as well, which will be of great significance in both the cell genetics research and fish breeding. | DUAN Wei QIN QinBo CHEN Song LIU ShaoJun WANG Jing ZHANG Chun SUN YuanDong LIU Yun | 2007 | Science China(Life Sciences)2007，50，6： | 4 |
| 8 | Expression of Maspin in Colon Cancers: Its Relationship with p53 Expression and Microvessel Density显示文摘 | Sang Yong Song Se Kyung Lee Duck Hwan Kim Hee Jung Son Hong Joo Kim Yun Jeong Lim Woo Yong Lee Ho-Kyung Chun Jong Chul Rhee | 2002 | Digestive Diseases and Sciences2002，，8： | 1 |
| 9 | Clinical outcome of treatment with a combined regimen of decitabine and aclacinomycin/cytarabine for patients with refractory acute myeloid leukemia显示文摘 | Lu Xi Song Li Xu Xiao Li Chun Kang Chang Yi Zhang Ling Yun Wu Qi He Qing Xia Zhang Xiang Li | 2012 | Annals of Hematology2012，，12： | 1 |
| 10 | Synthesis and Antitumor Activity of 7-Substituted Derivatives of Homocamptothecin显示文摘Thirteen homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by the standard MTT method. The results showed that some of the homocamptothecin derivatives had higher antitumor activity than topotecan. | Zhen Yuan MIAO Wan Nian ZHANG Jian Zhong YAO Chun Quan SHENG Yun Long SONG Hui XU Min ZHANG Jing ZHANG | 2006 | Chinese Chemical Letters2006，17，6： | 1 |
| 11 | Experimental study on a model azimuthing podded propulsor in ice显示文摘 | Jungyong Wang Ayhan Akinturk Neil Bose Stephen J. Jones Yun Young Song Ho Hwan Chun Moon Chan Kim | 2008 | Journal of Marine Science and Technology2008，，3： | 1 |
| 12 | Matrix metalloproteinase-9 activity is associated with poor prognosis in T3-T4 node-negative colorectal cancer显示文摘 | Yong Beom Cho Woo Yong Lee Sang Yong Song Hee Jung Shin Seong Hyeon Yun Ho-Kyung Chun | 2007 | Human Pathology2007，，11： | 1 |
| 13 | Comparison of long non?coding RNAs, microRNAs and messenger RNAs involvedin initiation and progression of esophageal squamous cell carcinoma显示文摘 | Su?Qing Li Feng Li Yun Xiao Chun?Mei Wang Lei Tuo Jing Hu Xiao?Bin Yang Jin?Song Wang Wei?Hong Shi Xia Li Xiu?Feng Cao | 2014 | Molecular Medicine Reports2014，，2： | 1 |
| 14 | A new chromosome fluorescence banding technique combining DAPI staining with image analysis in plants显示文摘 | Jing Yu Liu Chao Wen She Zhong Li Hu Zhi Yong Xiong Li Hua Liu Yun Chun Song | 2004 | Chromosoma2004，，1： | 1 |
| 15 | Glucose deprivation triggers protein kinase C-dependentβ-catenin proteasomal degradation显示文摘 | Choi SW Song JK Yim YS Yun HG Chun KH | 2015 | J Biol Chem2015，290，15： | 1 |
| 16 | Sufficiency and Deficiency Indices of Soil Available Zinc for Rice in the Alluvial Soil of the Coastal Yellow Sea显示文摘To determine the sufficiency and deficiency indices of soil available Zn by the Agro Services International (ASI) method (ASI-Zn) for Zn fertilizer recommendation in rice production in the alluvial soil of the coastal Yellow Sea, the relationship between relative rice yield and soil available ASI-Zn concentration was analyzed from a ten-field experiment with various soil test classes ranging from low to high fertility in 2005 and 2006, and nine Zn fertilizer application rates (0, 7.5, 15, 22.5, 30, 37.5, 45, 52.5 and 60 kg Zn/ha) arranged at random with three replications in each field. There was a significant quadratic relationship between soil available ASI-Zn and rice yield, and a significant linear relationship between soil available ASI-Zn concentration and Zn fertilization rate. For rice variety Wuyujing 3, soil available ASI-Zn was deficient when the value was at lower than 1 mg Zn/L, low at 1 to 2 mg Zn/L, sufficient at 1 to 2 mg Zn/L, excessive at higher than 7.5 mg Zn/L. Thus, Zn fertilizer recommendation could be done according to the sufficiency and deficiency indices of soil ASI-Zn. For most of alluvial soils of the coastal Yellow Sea in the study, the available ASI-Zn was lower than 1 mg Zn/L, and then the optimum application rate of Zn fertilizer was about 20 kg Zn/ha. | WEI Yi chang BAI You lu JIN Ji yun YANG Li ping YAO Zheng XU Si xin Luo Guo an SONG Wei ZHU Chun mei | 2007 | Rice science2007，14，3： | 1 |
| 17 | Prevalence of human metapneumovirus in children with acute lower respiratory infection in Changsha, China显示文摘 | Ni‐guang Xiao Bing Zhang Zhi‐ping Xie Qiong‐hua Zhou Rong‐fang Zhang Li‐li Zhong Xiao‐fang Ding Jia Li Jing‐rong Song Han‐chun Gao Yun‐de Hou Zhao‐jun Duan | 2013 | J. Med. Virol2013，，： | 1 |
| 18 | Angiotensin-Converting Enzyme-2 Overexpression Improves Left Ventricular Remodeling and Function in a Rat Model of Diabetic Cardiomyopathy显示文摘 | Bo Dong Qing Tao Yu Hong Yan Dai Yan Yan Gao Zhao Li Zhou Lei Zhang Hong Jiang Fei Gao Shu Ying Li Yue Hui Zhang Hong Jun Bian Chun Xi Liu Nan Wang Hui Xu Chun Ming Pan Huai Dong Song Cheng Zhang Yun Zhang | 2012 | Journal of the American College of Cardiology2012，，8： | 1 |
| 19 | Improving ionic conductivity of von-Alpen-type NASICON ceramic electrolytes via magnesium doping显示文摘NASICON (sodium (Na) superionic conductor) compounds have attracted considerable attention as promising solid electrolyte materials for advanced Na-based batteries. In this study, we investigated the improvement in ionic conductivities of von-Alpen-type NASICON (vA-NASICON) ceramic electrolytes by introducing a magnesium ion (Mg^(2+)) as a heterogeneous element. The optimal Mg-doped vA-NASICON exhibited a high ionic conductivity of 3.64×10^(−3) S·cm^(−1), which was almost 80% higher than that of un-doped vA-NASICON. The changes in physicochemical properties of the vA-NASICONs through the Mg introduction were systematically analyzed, and their effects on the ionic conductivities of the vA-NASICON were studied in detail. When the optimal ratio of Mg^(2+) was used in a synthetic process, the relative density (96.6%) and grain boundary ionic conductivity (σgb) were maximized, which improved the total ionic conductivity (σt) of the vA-NASICON. However, when Mg^(2+) was introduced in excess, the ionic conductivity decreased because of the formation of an undesired sodium magnesium phosphate (NaxMgyPO_(4)) secondary phase. The results of this study are expected to be effectively applied in the development of advanced sodium-based solid electrolytes with high ionic conductivities. | Il-Seop Jang Wooseok Go Bo-Ye Song Hayoung Park Yun Chan Kang Jinyoung Chun | 2023 | Journal of Advanced Ceramics2023，12，5： | 0 |
| 20 | HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF KR-008 IN BIOLOGICAL FLUIDS显示文摘A high-performance liquid chromatographic method for the simultaneousdetermination of KR-008 and its metabolite in biological fluids was developed The samples wereinjected directly without further treatment,the compounds were separated and analysed on a reversed-phase column under isocratic conditions,including ion pairing.Concentrations in urine and bile weredetermined by an external standard method.The detection limit was 0.8μg/ml in urine.Preliminarydata showed that,following i.p.administration(120mg/kg)of KR-008 to rats,approximately 2.8% ofthe dose was excreted in urine as unchanged compound and more than 8.9% was as a metabolite;inbile it was 0.73% excreted as unchanged form and above 0.29% as the metabolite.The peak biliaryconcentration of KR-008 was 0.39mg/ml at 20min after dosing. | Yun Seon SONG Jae Chun RYU Myungsoo KIM | 1993 | Chinese Chemical Letters1993，4，12： | 0 |
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