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| 1 | The temporal and spatial distribution of ancient rice in China and its implications显示文摘The relics of ancient rice have been regarded as the most important objective evidence of the origina- tion and spread of rice cultivation.Based on the records of 280 rice relics sites and the rice cropping regionalization as well as the distribution map of paddy soils,the current study compiled the temporal and spatial distribution map of ancient rice distribution in China.The map shows that the distribution of ancient rice is spatially extensive and meantime comparatively concentrated,temporarily covering a long and relatively continuous time-span.The rice relics in the Central China double and single rice cropping regions are among the earliest and the most abundant ones,possessing continuity in time sequence.Combined with the discovery of ancient rice and paddy filed relics,soil micromorphology, pollen combination and element geochemistry,it is suggested that Central China was the origin center of rice cultivation in China.Rice had been spread to the rest part of China in three major waves,also to the East Asian part like Korea and Japan.The temporal and spatial distribution of ancient rice reflects the past environmental change,which is also meaningful to the current rice regionalization and plan- ning as well as food security in China. | GONG ZiTong CHEN HongZhao YUAN DaGang ZHAO YuGuo WU YunJin ZHANG GanLin | 2007 | Chinese Science Bulletin2007，52，8： | 11 |
| 2 | Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most common causes of cancer worldwide.Although many studies have focused on oncogene characteristics,the genomic landscape of Chinese HCC patients has not been fully clarified.Methods:A total of 165 HCC patients,including 146 males and 19 females,were enrolled.The median age was 55 years(range,27-78 years).Corresponding clinical and pathological information was collected for further analysis.A total of 168 tumor tissues from these patients were selected for next-generation sequencing(NGS)-based 450 panel gene sequencing.Genomic alterations including single nucleotide variations(SNV),short and long insertions and deletions(InDels),copy number variations,and gene rearrangements were analyzed.Tumor mutational burden(TMB)was measured by an algorithm developed in-house.The top quartile of HCC was classified as TMB high.Results:A total of 1,004 genomic alterations were detected from 258 genes in 168 HCC tissues.TMB values were identified in 160 HCC specimens,with a median TMB of 5.4 Muts/Mb(range,0-28.4 Muts/Mb)and a 75%TMB of 7.7 Muts/Mb.The most commonly mutated genes were TP53,TERT,CTNNB1,AXIN1,RB1,TSC2,CCND1,ARID1A,and FGF19.SNV was the most common mutation type and C:G>T:A and guanine transformation were the most common SNVs.Compared to wild-type patients,the proportion of Edmondson grade III-IV and microvascular invasion was significantly higher in TP53 mutated patients(P<0.05).The proportion of tumors invading the hepatic capsule was significantly higher in TERT mutated patients(P<0.05).The proportion of Edmondson grade I-II,alpha fetoprotein(AFP)<25μmg/L,and those without a history of hepatitis B was significantly higher in CTNNB1 mutated patients(P<0.05).CTNNB1 mutations were associated with TMB high in HCC patients(P<0.05).Based on correlation analysis,the mutation of TP53 was independently correlated with microvascular invasion(P=0.002,OR=3.096)and Edmondson grade III-IV(P=0.008,OR=2.613).The mutation of TERT was independently correlated with tumor invasion of the liver capsule(P=0.001,OR=3.030),and the mutation of CTNNB1 was independently correlated with AFP(<25μmg/L)(P=0.009,OR=3.414).Conclusions:The most frequently mutated genes of HCC patients in China were TP53,TERT,and CTNNB1,which mainly lead to the occurrence and development of HCC by regulating the P53 pathway,Wnt pathway,and telomere repair pathway.There were more patients with microvascular invasion and Edmondson III-IV grade in TP53 mutated patients and more patients with hepatic capsule invasion in TERT mutated patients,while in CTNNB1 mutated patients,there were more patients with Edmondson I-II grade,AFP<25μmg/L,and a non-hepatitis B background.Also,the TMB values were significantly higher in CTNNB1 mutated patients than in wild type patients. | Shuo Wang Huasheng Shi Tao Liu Manjiang Li Sanshun Zhou Xuan Qiu Zusen Wang Weiyu Hu Weidong Guo Xiaoqian Chen Honglin Guo Xiaoliang Shi Junping Shi Yunjin Zang Jingyu Cao Liqun Wu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 8 |
| 3 | Effects of Lizhong Tang on gastrointestinal motility in mice显示文摘AIM To investigate the effects of Lizhong Tang,a traditional Chinese medicine formula,on gastrointestinal motility in mice.METHODS The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates(ITRs) and gastric emptying(GE) values in normal mice and in mice with experimentally induced GI motility dysfunction(GMD).RESULTS In normal ICR mice,the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang(ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%,P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%,P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%,P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%,P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice,which were significantly and dose-dependently reversed by Lizhong Tang. Additionally,in loperamide- and cisplatin-induced models of GE delay,Lizhong Tang administration reversed the GE deficits.CONCLUSION These results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract. | Min Cheol Lee Wooram Ha Jinhyeong Park Junghoon Kim Yunjin Jung Byung Joo Kim | 2016 | World Journal of Gastroenterology2016，22，34： | 4 |
| 4 | An adaptive scaled boundary finite element method by subdividing subdomains for elastodynamic problems显示文摘The scaled boundary finite element method(SBFEM) is a semi-analytical numerical method,which models an analysis domain by a small number of large-sized subdomains and discretises subdomain boundaries only.In a subdomain,all fields of state variables including displacement,stress,velocity and acceleration are semi-analytical,and the kinetic energy,strain energy and energy error are all integrated semi-analytically.These advantages are taken in this study to develop a posteriori h-hierarchical adaptive SBFEM for transient elastodynamic problems using a mesh refinement procedure which subdivides subdomains.Because only a small number of subdomains are subdivided,mesh refinement is very simple and efficient,and mesh mapping to transfer state variables from an old mesh to a new one is also very simple but accurate.Two 2D examples with stress wave propagation were modelled.The results show that the developed method is capable of capturing propagation of steep stress regions and calculating accurate dynamic responses,using only a fraction of degrees of freedom required by adaptive finite element method. | ZHANG ZiHua 1,2,YANG ZhenJun 2,LIU GuoHua 1 & HU YunJin 1 1 College of Civil Engineering and Architecture,Zhejiang University,Hangzhou 310058,China 2 School of Engineering,University of Liverpool,L69 3GQ,UK | 2011 | Science China(Technological Sciences)2011，54，S1： | 4 |
| 5 | Note on the permanence of a competitive system with infinite delay and feedback controls显示文摘 | Fengde Chen Zhong Li Yunjin Huang | 2006 | Nonlinear Analysis: Real World Applications2006，，2： | 2 |
| 6 | A fast antibiotic detection method for simplified pretreatment through spectra-based machine learning显示文摘Antibiotics are widely used in medicine and animal husbandry.However,due to the resistance of antibiotics to degradation,large amounts of antibiotics enter the environment,posing a potential risk to the ecosystem and public health.Therefore,the detection of antibiotics in the environment is necessary.Nevertheless,conventional detection methods usually involve complex pretreatment techniques and expensive instrumentation,which impose considerable time and economic costs.In this paper,we proposed a method for the fast detection of mixed antibiotics based on simplified pretreatment using spectral machine learning.With the help of a modified spectrometer,a large number of characteristic images were generated to map antibiotic information.The relationship between characteristic images and antibiotic concentrations was established by machine learning model.The coefficient of determination and root mean squared error were used to evaluate the prediction performance of the machine learning model.The results show that a well-trained machine learning model can accurately predict multiple antibiotic concentrations simultaneously with almost no pretreatment.The results from this study have some referential value for promoting the development of environmental detection technologies and digital environmental management strategies. | Yicai Huang Jiayuan Chen Qiannan Duan Yunjin Feng Run Luo Wenjing Wang Fenli Liu Sifan Bi Jianchao Lee | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 2 |
| 7 | Caffeic acid phenethyl ester-mediated Nrf2 activation and IκB kinase inhibition are involved in NFκB inhibitory effect: Structural analysis for NFκB inhibition显示文摘 | Youna Lee Dong-ha Shin Ji-Hye Kim Sungchae Hong Daekyu Choi Yung-Jin Kim Mi-Kyoung Kwak Yunjin Jung | 2010 | European Journal of Pharmacology2010，，1： | 2 |
| 8 | Stability Analysis of a Prey-predator Model with Holling Type Ⅲ Response Func- tion Incorporating a Prey Refuge 显示文摘 | HUANG Yunjin CHEN Fengde ZHONG Li | 2006 | Applied Mathematics and Computation2006，182，1： | 1 |
| 9 | Stability analysis of a prey-predator model with Holling type Ⅲ response function incorporating a prey refuge显示文摘 | HUANG Yunjin CHEN Fengde LI Zhong | 2006 | Applied Mathematics and Computation2006，182，： | 1 |
| 10 | Line drawings via abstracted shading显示文摘 | Yunjin Lee Lee Markosian Seungyong Lee | | 0，，03： | 1 |
| 11 | Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles显示文摘 | Bo Xiao Mingzhen Zhang Emilie Viennois Yuchen Zhang Na Wei Mark T. Baker Yunjin Jung Didier Merlin | 2015 | Biomaterials2015，，： | 1 |
| 12 | Dynamic globularization kinetics during hot working of Ti-17 alloy with initial lamellar microstructure显示文摘 | Kaixuan Wang Weidong Zeng Yongqing Zhao Yunjin Lai Yigang Zhou | 2010 | Materials Science & Engineering A2010，，10： | 1 |
| 13 | ZnO Microtube Ultraviolet Detectors显示文摘 | Jiping Cheng Yunjin Zhang Ruyan Guo | 2008 | Journal of Crystal Growth2008，310，1： | 1 |
| 14 | Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication显示文摘 | Daekyu Choi Jeongoh Han Youna Lee Jungyun Choi Songyi Han Sungchae Hong Hyunchu Jeon Young Mi Kim Yunjin Jung | 2010 | The Journal of Nutritional Biochemistry2010，，9： | 1 |
| 15 | Synthesis of magnetic cobalt nanoparticles anchored on graphene nanosheets and catalytic decomposition of orange II显示文摘 | Yao Yunjin Xu Chuan Qin Jiacheng | 2013 | Industrial&Engineering Chemistry Research2013，52，17： | 1 |
| 16 | Magnetic CoFe204 -Grapheue Hybrids: Facile Synthesis, Characterization, and Catalytic Properties 显示文摘 | Yunjin Yao Zeheng Yang Dawei Zhang Wenehao Peng Hongqi Sun Shaobin Wang | 2012 | I&EC reserrch2012，51，： | 1 |
| 17 | Microwave Sintering of Transparent Alumina 显示文摘 | Cheng Jiping Dinesh A Yunjin Z | 2002 | Mater Lett2002，56，： | 1 |
| 18 | Stability analysis of a prey-predator model with Holling type Ill response function incorporating a prey refuge显示文摘 | HUANG Yunjin CHEN Fengde ZHONG Li | 2006 | Applied Mathematics and Computation2006，182，1： | 1 |
| 19 | Stability analysis of a prey–predator model with holling type III response function incorporating a prey refuge显示文摘 | Yunjin Huang Fengde Chen Li Zhong | 2006 | Applied Mathematics and Computation2006，，1： | 1 |
| 20 | Stability analysis of a prey-predator model with Holling type III response function incorporating a prey refuge显示文摘 | Huang Yunjin Chen Fengde Zhong Li | 2006 | Applied Mathematics and Computation2006，182，1： | 1 |
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