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| 1 | Experimental investigations for parametric effects of dual synthetic jets on delaying stall of a thick airfoil显示文摘A promising strategy of synthetic jet arrays(SJA) control for NACA0021 airfoil in preventing flow separation and delaying stall is investigated. Through aerodynamic forces, flowfield and velocity profiles measurements, it indicates that the synthetic jet(SJ) could enlarge the mixing of the shear layer and then enhance the stability of boundary layer, resulting in scope reduction of the flow separation zone. Furthermore, the control effects of dual jet arrays positioned at 15%c(Actuator 1) and 40%c(Actuator 2) respectively are systematically investigated with different jet parameters, such as two typical relative phase angles and various incline angles of the jet. The jet closer to the leading edge of airfoil is more advantageous in delaying the stall of airfoil, and overall,the flow control performances of jet arrays are better than those of single actuator. At the angle of attack(Ao A) just approaching and larger than the stall Ao A, jet array with 180° phase difference could increase the lift coefficient more significantly and prevent flow separation. When momentum coefficient of the jet arrays is small, a larger jet angle of Actuator 2 is more effective in improving the maximum lift coefficient of airfoil. With a larger momentum coefficient of jet array, a smaller jet angle of Actuator 2 is more effective. | Zhao Guoqing Zhao Qijun Gu Yunsong Chen Xi | 2016 | Chinese Journal of Aeronautics2016，29，2： | 14 |
| 2 | A review of target gene specificity of flavonoid R2R3-MYB transcription factors and a discussion of factors contributing to the target gene selectivity显示文摘Flavonoid biosynthetic 基因并列地经常在花或水果开发期间以一种时间的方式被调整,导致 flavonoid 混合物的特定的累积侧面。R2R3-MYB-type 抄写因素(TF ) 成员生产 flavonoids 的一套 biosynthetic 基因,并且,因此, R2R3-MYBs 为结构的基因的协调表示负责。尽管很多信息关于鉴别那涉及 flavonoid 累积并且机能上地描绘了 R2R3-MYBs 迄今为止是可得到的,这是在 flavonoid 小径的 MYB 因素的全球规定上的第一评论。在这评论介绍的数据证明 anthocyanin, flavone/flavonol/3-deoxyflavonoid (FFD ) , proanthocyanidin (PA ) ,和 isoflavonoid 被 R2R3-MYBs 的不同亚群独立地调整。而且, FFD 特定的 R2R3-MYBs 作为他们的目标基因为早 biosynthetic 基因(EBG ) 有偏爱;从 dicot 种类的 anthocyanin 特定的 R2R3-MYBs 实质上调整迟了的 biosynthetic 基因(LBG ) ;留下的 R2R3-MYBs 有大量目标基因特性。阐明在 R2R3-MYBs 之间的微分目标基因特性的性质,我们分析了 DNA 有约束力的领域(也称为 MYB 域) R2R3-MYBs 和识别 cis 元素的分发。我们识别了位于或就在可能说明不同识别 DNA 顺序并且随后的 dicot anthocyanin R2R3-MYBs 的 helix-3 前的四保存氨基酸残余不同目标基因特性到留下的 R2R3-MYB TF。 | Yunsong LAI Huanxiu LI Masumi YAMAGISHI | 2013 | Frontiers in Biology2013，8，6： | 13 |
| 3 | Aircraft vulnerability modeling and computation methods based on product structure and CATIA显示文摘Survivability strengthening/vulnerability reduction designs have become one of the most important design disciplines of military aircraft now. Due to progressiveness and complexity of modern combat aircraft, the existing vulnerability modeling and computation methods cannot meet the current engineering application requirements. Therefore, a vulnerability modeling and computation method based on product structure and CATIA is proposed in sufficient consideration of the design characteristics of modern combat aircraft. This method directly constructs the aircraft vulnerability model by CATIA or the digital model database, and manages all the product components of the vulnerability model via aircraft product structure. Using CAA second development, the detailed operations and computation methods of vulnerability analysis are integrated into CATIA software environment. Comprehensive assessment data and visual kill probability Iso-contours can also be presented, which meet the vulnerability analysis requirements of modern combat aircraft effectively. The intact vulnerability model of one hypothetical aircraft is constructed, and the effects of redundant technology to the aircraft vulnerability are assessed, which validate the engineering practicality of the method. | Li Jun Yang Wei Zhang Yugang Pei Yang Ren Yunsong Wang Wei | 2013 | Chinese Journal of Aeronautics2013，26，2： | 12 |
| 4 | Lysine-specific demethylase 1 inhibitor rescues the osteogenic ability of mesenchymal stem cells under osteoporotic conditions by modulating H3K4 methylation显示文摘Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability of autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulation plays an important role in the developmental origins of osteoporosis; however, few studies have investigated the potential of epigenetic therapy to improve or rescue the osteogenic ability of bone marrow mesenchymal stem cells(BMMSCs) under osteoporotic conditions. Here, we investigated pargyline, an inhibitor of lysine-specific demethylase 1(LSD1), which mainly catalyzes the demethylation of the di- and mono-methylation of H3K4. We demonstrated that 1.5 mmol·L^(- 1)pargyline was the optimal concentration for the osteogenic differentiation of human BMMSCs. Pargyline rescued the osteogenic differentiation ability of mouse BMMSCs under osteoporotic conditions by enhancing the dimethylation level of H3K4 at the promoter regions of osteogenesis-related genes. Moreover, pargyline partially rescued or prevented the osteoporotic conditions in aged or ovariectomized mouse models, respectively. By introducing the concept of epigenetic therapy into the field of osteoporosis, this study demonstrated that LSD1 inhibitors could improve the clinical practice of MSC-based bone tissue engineering and proposes their novel use to treat osteoporosis. | Longwei Lv Wenshu Ge Yunsong Liu Guanyou Lai Hao Liu Wenyue Li Yongsheng Zhou | 2016 | Bone Research2016，4，4： | 11 |
| 5 | Research status of biodegradable metals designed for oral and maxillofacial applications:A review显示文摘The oral and maxillofacial regions have complex anatomical structures and different tissue types,which have vital health and aesthetic functions.Biodegradable metals(BMs)is a promising bioactive materials to treat oral and maxillofacial diseases.This review summarizes the research status and future research directions of BMs for oral and maxillofacial applications.Mg-based BMs and Zn-based BMs for bone fracture fixation systems,and guided bone regeneration(GBR)membranes,are discussed in detail.Zn-based BMs with a moderate degradation rate and superior mechanical properties for GBR membranes show great potential for clinical translation.Fe-based BMs have a relatively low degradation rate and insoluble degradation products,which greatly limit their application and clinical translation.Furthermore,we proposed potential future research directions for BMs in the oral and maxillofacial regions,including 3D printed BM bone scaffolds,surface modification for BMs GBR membranes,and BMs containing hydrogels for cartilage regeneration,soft tissue regeneration,and nerve regeneration.Taken together,the progress made in the development of BMs in oral and maxillofacial regions has laid a foundation for further clinical translation. | Dandan Xia Fan Yang Yufeng Zheng Yunsong Liu Yongsheng Zhou | 2021 | Bioactive Materials2021，6，11： | 9 |
| 6 | Gene expression profiles of ERCC1, TYMS, RRM1, TUBB3 and EGFR in tumor tissue from non-small cell lung cancer patients显示文摘 | Yu Daping Li Jie Han Yi Liu Shuku Xiao Ning Li Yunsong Sun Xiaojun Liu Zhidong | 2014 | Chinese Medical Journal2014，，8： | 7 |
| 7 | High-performance Li-ion batteries based on graphene quantum dot wrapped carbon nanotube hybrid anodes显示文摘Since Akira Yoshino first proposed the usage of the carbonaceous materials as an anode of lithium ion batteries(LIBs)in 1985,carbonaceous materials such as graphite and graphene have been widely considered as LIB anodes.Here,we explored the application of novel carbonaceous UB anodes incorporating graphene quantum dots(GQDs).We fabricated a freestanding all-carbon electrode based on a porous carbon nanotube(CNT)sponge via a facile in-situ hydrothermal deposition technique,creating coaxial structure of GQD-coated CNTs(GQD@CNTs)through electrostatic interaction and n-n stacking with tunable loading and functionalization.This hybrid structure combined conductive CNTs with highly active GQDs,in which GQDs with predesigned functional groups provided massive storage sites for Li ions and the 3D CNT frameworks avoided the agglomeration of GQDs,together contributing to a high specific capacity(700 mAh·g^-1 at 100 mA·g^-1 after 100 cycles)and rate performance.Even at a high current density of 1,000 mA·g^-1,the reversible specific capacity remained at 483 mAh g-1 after 350 cycles.In particular,the mechanism study demonstrated the important role of oxygen functional groups of GQDs in promoting the performance of the LIB anodes by controlled grafting of GQDs onto various porous-carbon and metal-foam based structures. | Xuewei Zhao Yizeng Wu Yunsong Wang Huaisheng Wu Yawei Yang Zhipeng Wang Linxiu Dai Yuanyuan Shang Anyuan Cao | 2020 | Nano Research2020，13，4： | 7 |
| 8 | Melting and shrinkage of cryosphere in Tibet and its impact on the ecological environment显示文摘Global warming is having a profound impact on global ecological systems,and has inevitably induced changes in the cryosphere,one of the five layers of the earth.Major changes include the shrinking and reduction in the area and volume of both the mountain glaciers and the ice caps covering the North and South poles,and the melting of permafrost and thickening of the active frost layer.Swift changes in the cryosphere have inevitably induced ecological and environmental changes in its zone.While some of these changes are beneficial to mankind,such as an increase in water circulation,short term increases in water volumes and the enlargement of the cultivatable area,others are extremely hazardous,like the flooding of lowlands caused by an increased sea level elevation,debris flow caused by glaciers,glacier lake bursts,undermined building safety caused by permafrost melting,the deterioration of alpine cold meadows,and the surface aridization and desertification of land.Tibet,having a major part of the cryosphere in China,is home to the most widely spread glaciers and permafrost,which play a vital role in regulating water resources,climate,environment and the ecological safety in China and Asia.However,due to global warming,the glaciers and permafrost in Tibet have recently changed dramatically,exhibiting shrinkage and melting,which threatens long-term water resources,and the ecological and environmental safety of China.Based on existing research,this paper discusses the relationship between global warming and the melting and shrinkage of the cryosphere.The results show that the cryosphere's melting and shrinkage in Tibet are the direct result of global warming.The melting of glaciers has led to a series of disasters,such as changes in river runoff,the heightened frequency of debris flows induced by glaciers and the outbursts of glacier lakes.The melting of the permafrost also resulted in a series of ecological and environmental problems in Tibet,such as the degradation and population succession of the alpine grassland and meadows,the aridization of the land surface,and the occurrence of freeze-thaw erosion. | JianGuo ZHANG YingLi WANG YunSong JI DeZhi YAN | 2011 | Journal of Arid Land2011，3，4： | 4 |
| 9 | Preparation of porous structures on copper microchannel surfaces by laser writing显示文摘A laser writing method is developed to fabricate porous structures on copper microchannel wall surfaces for enhanced microchannel heat sinks(MHSs). The formation feasibility together with its mechanism of such porous structures is explored by the comparison of dry and wet laser writing process, i.e., in both air atmosphere and under de-ionized water. Rectangular microchannels with ripples-like porous structures on the wall surfaces, which consisted of numerous micro-holes and micro-cavities,have been successfully formed in the dry laser writing process. Nevertheless, the microchannel wall surfaces were hardly altered in wet conditions. Besides, the effect of laser fluence on the formation of porous structures on the microchannels was also assessed in both dry and wet conditions. In dry laser writing process, the microchannel depth and surface roughness of wall surface increased monotonically, whereas the microchannel bottom width decreased continuously with increasing the laser fluence. On the other hand, the microchannel wall kept almost unchanged with smooth surfaces with increasing laser fluence in wet conditions. | DENG DaXiang CHEN XiaoLong CHEN Liang LIAN YunSong FU Ting | 2019 | Science China(Technological Sciences)2019，62，12： | 4 |
| 10 | A Microscale Model for Air Pollutant Dispersion Simulation in Urban Areas: Presentation of the Model and Performance over a Single Building显示文摘A microscale air pollutant dispersion model system is developed for emergency response purposes. The model includes a diagnostic wind field model to simulate the wind field and a random-walk air pollutant dispersion model to simulate the pollutant concentration through consideration of the influence of urban buildings. Numerical experiments are designed to evaluate the model's performance, using CEDVAL(Compilation of Experimental Data for Validation of Microscale Dispersion Models) wind tunnel experiment data, including wind fields and air pollutant dispersion around a single building. The results show that the wind model can reproduce the vortexes triggered by urban buildings and the dispersion model simulates the pollutant concentration around buildings well. Typically, the simulation errors come from the determination of the key zones around a building or building cluster. This model has the potential for multiple applications; for example, the prediction of air pollutant dispersion and the evaluation of environmental impacts in emergency situations; urban planning scenarios;and the assessment of microscale air quality in urban areas. | Ning ZHANG Yunsong DU Shiguang MIAO | 2016 | Advances in Atmospheric Sciences2016，33，2： | 3 |
| 11 | Evaluation of a Micro-scale Wind Model's Performance over Realistic Building Clusters Using Wind Tunnel Experiments显示文摘The simulation performance over complex building clusters of a wind simulation model(Wind Information Field Fast Analysis model, WIFFA) in a micro-scale air pollutant dispersion model system(Urban Microscale Air Pollution dispersion Simulation model, UMAPS) is evaluated using various wind tunnel experimental data including the CEDVAL(Compilation of Experimental Data for Validation of Micro-Scale Dispersion Models) wind tunnel experiment data and the NJU-FZ experiment data(Nanjing University-Fang Zhuang neighborhood wind tunnel experiment data). The results show that the wind model can reproduce the vortexes triggered by urban buildings well, and the flow patterns in urban street canyons and building clusters can also be represented. Due to the complex shapes of buildings and their distributions, the simulation deviations/discrepancies from the measurements are usually caused by the simplification of the building shapes and the determination of the key zone sizes. The computational efficiencies of different cases are also discussed in this paper. The model has a high computational efficiency compared to traditional numerical models that solve the Navier–Stokes equations, and can produce very high-resolution(1–5 m) wind fields of a complex neighborhood scale urban building canopy(~ 1 km ×1km) in less than 3 min when run on a personal computer. | Ning ZHANG Yunsong DU Shiguang MIAO Xiaoyi FANG | 2016 | Advances in Atmospheric Sciences2016，33，8： | 3 |
| 12 | Corrosion Behaviors of Nitride Coatings on Titanium Alloy in NaCl-Induced Hot Corrosion显示文摘TiN and TiAlN coatings were deposited by arc ion plating on titanium alloys to study their hot corrosion resistance when they were exposed to NaCl at 600℃.The microstructure and corrosion behaviors of nitride coatings were studied using scanning electron microscope,X-ray diffraction,electro-probe microanalyzer and X-ray photoelectron spectroscopy.The results showed that nitride coatings with the different compositions and the ones with the same composition but different thicknesses presented different hot corrosion resistance.TiN and thin TiAlN coatings showed poor corrosion resistance.Serious internal oxidation attacked the alloy substrate.Their corrosion products were mainly consisted of non-protective TiO2 and sodium salt.By contrast,the thick TiAlN coating presented outstanding corrosion resistance.Besides sodium salt,the corrosion products were composed of protective Al_(2)O_(3).The increasing thickness of TiAlN significantly enhanced the hot corrosion resistance.The corrosion mechanisms of alloy,TiN and TiAlN coatings were discussed in detail. | Mingming Zhang Yipeng Feng Yahui Wang Yunsong Niu Li Xin Yongfeng Li Jianxiu Su Shenglong Zhu Fuhui Wang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，10： | 3 |
| 13 | Advancement in Layered Transition Metal Dichalcogenide Composites for Lithium and Sodium Ion Batteries显示文摘 | Muhammad Yousaf Asif Mahmood Yunsong Wang Yijun Chen Zhimin Ma Ray P. S. Han | 2016 | Journal of Electrical Engineering2016，4，2： | 3 |
| 14 | Experimental Study on Jet Impingement Boiling Heat Transfer in Brass Beads Packed Porous Layer显示文摘Jet impingement boiling has been widely used in industrial facilities as its higher heat transfer coefficient(HTC)and critical heat flux(CHF)can be achieved in comparison with the pool boiling.By covering beads packed porous layer on the heated wall surface,the enlarged heat transfer area and rise of nucleation sites for boiling occur,thus,the heat transfer performance of boiling can be enhanced.For the jet impingement boiling with brass bead packed porous layers,the heat transfer performance is crucially influenced by the characteristics of porous layer and working fluid flow,so the experiments were conducted to investigate the effects of the jet flow rate,fluid inlet subcooling,number of porous layer and brass bead diameter of porous layer.Comparison study shows that impingement boiling promotes the HTC and CHF as 1.5 times and 2.5 times respectively as pool boiling at similar conditions.Higher heat transfer performance can be obtained in the cases of a higher jet flow rate and a higher fluid inlet subcooling,and there exist the optimal layer number and bead diameter for heat transfer.Particularly,a double-layer porous layer results in an increase of 39%in heat flux at superheat of 30 K compared with a single-layer case;a single porous layer at d=8 mm brings an increase of 23%in heat flux at superheat of 30 K compared with that of bare plain surface.Besides,the actual scene of jet impingement boiling was recorded with a camera to investigate the behavior evolution of vapor bubbles which is highly correlated to the heat transfer process. | ZHANG Yunsong CHEN Wei | 2020 | Journal of Thermal Science2020，29，3： | 3 |
| 15 | Al2O3 supported hybrid Pd-CeO2 colloidal spheres and its enhanced catalytic performances for methane combustion显示文摘Fabrication of novel nano-catalyst with improved activity and stability has been a hot topic in heterogeneous catalysis. Herein a novel approach was designed to synthesize Pd-CeO2 colloidal assembled spheres(CASs) in one-pot fashion. The Pd clusters were encompassed by the CeO2 nanocrystals with a high dispersity. Based on this hybrid structure, the Pd/ceria interface area can be greatly improved. After Pd-CeO2 CASs was supported on γ-Al2O3, its catalytic activity for CH4 combustion was evaluated. The result shows that Al2O3 supported Pd-CeO2 CASs exhibits an improved catalytic activity and stability,compared to the Pd/CeO2 catalyst prepared by impregnation method. The results of several characterization techniques indicate that the enhanced catalytic activity of Al2O3 supported Pd-CeO2 CASs can be attributed to the more interfacial Pd-O-Ce species and the more surface active oxygen species. | Xinwei Yang Chenhao Du Yanglong Guo Yun Guo Li Wang Yunsong Wang Wangcheng Zhan | 2019 | Journal of Rare Earths2019，37，7： | 2 |
| 16 | Catalytic wet oxidation of N,N-dimethyl formamide over ruthenium supported on CeO_2 and Ce_(0.7)Zr_(0.3)O_2 catalysts显示文摘A series of Ru supported on CeO_2 and Ce_(0.7)Zr_(0.3)O_2(CeZrO) was prepared by incipient-wet impregnation method and investigated in the catalytic wet oxidation of N,N-dimethyl formamide(DMF) in batch reactor. The physicochemical property of the catalysts was characterized by Brunauer-Emmett-Teller(BET), X-ray diffraction(XRD), H_2 temperature-programmed reduction(H_2-TPR), X-ray photoelectron spectroscopy(XPS) and thermogravimetry(TG). Compared with 3%Ru/CeO_2, 3%Ru/Ce_(0.7)Zr_(0.3)O_2 catalyst exhibits much higher performance for DMF degradation due to the promotion of Ru dispersion and the transfer of active oxygen, and 99% DMF conversion and 97% COD elimination are obtained at 453 K,2.5 MPa oxygen pressure after 5 h. The reaction mechanism of DMF degradation was suggested. The carbonaceous species deposition and oxidation of Ru can be responsible for catalyst deactivation. And the catalyst activity can be recovered by air calcination and H_2 reduction. | Jiawen Gong Dongzhi Li Li Wang Wangcheng Zhan Yanglong Guo Yunsong Wang Yun Guo | 2019 | Journal of Rare Earths2019，37，3： | 2 |
| 17 | Analysis of photoluminescence behavior of high-quality single-layer MoS2显示文摘The ability to tailor and enhance photoluminescence (PL) behavior in two-dimensional (2D) transition metal dichalcogenides (TMDCs) such as molybdenum disulfide (MoS2) is significant for pursuing optoelectronic applications.To achieve this,it has been essential to obtain high-quality single-layer MoS2 and fully explore its intrinsic PL performance.Here,we fabricate single-layer MoS2 by a thermal vapor sulfurization method in which a pre-deposited molybdenum trioxide (MoO3) thin film is sulfurized over a short period (for several minutes) to turn into MoS2.These as-grown MoS2 crystals show quite strong PL,which is about one order of magnitude higher than that of chemical-vapor-deposited MoS2.Temperature- and power-dependent spectroscopy measurements disclose the apparent influence of sulfur (S) vacancies on the PL behavior and the noticeable free-to-bound exciton recombinations in the luminescence process.The fact that PL intensity of the sample in vacuum sharply lowered down relative to in air reveals that the high PL is facilitated by molecular adsorption on S vacancies in air.And multi-channel decay processes coupled with S vacancies are revealed in the time-resolved PL spectroscopy.In our work,single-layer MoS2 with high PL is synthesized and its defect-induced PL features are analyzed,which is of great importance for developing advanced nano-electronics and optoelectronics based on 2D structures. | Lu Xu Liyun Zhao Yunsong Wang Mingchu Zou Qing Zhang Anyuan Cao | 2019 | Nano Research2019，12，7： | 2 |
| 18 | High-PSRR High-Order Curvature-Compensated CMOS Bandgap Voltage Reference显示文摘A high-PSRR high-order curvature-compensated CMOS bandgap voltage reference( BGR),which has the performances of high power supply rejection ratio( PSRR) and low temperature coefficient,is designed in SMIC 0. 18 μm CMOS process. Compared to the conventional curvature-compensated BGR which adopted a piecewise-linear current,the temperature characterize of the proposed BGR is effectively improved by adopting two kinds of current including a piecewise-linear current and a current proportional 1. 5 party to the absolute temperature T. By adopting a low dropout( LDO) regulator whose output voltage is the operating supply voltage of the proposed BGR core circuit instead of power supply voltage VDD,the proposed BGR with LDO regulator achieves a well PSRR performance than the BGR without LDO regulator. Simulation results show that the proposed BGR with LDO regulator achieves a temperature coefficient of 2. 1 × 10-6/ ℃ with a 1. 8 V power supply voltage and a line regulation of 4. 9 μV / V at 27 ℃. The proposed BGR with LDO regulator at 10 Hz,100 Hz,1 k Hz,10 k Hz and 100 k Hz have the PSRR of- 106. 388,- 106. 388,- 106. 38,- 105. 93 and-88. 67 d B respectively. | Qianneng Zhou Yunsong Li Jinzhao Lin Hongjuan Li Yu Pang Wei Luo | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，5： | 2 |
| 19 | Reliability and sensitivity analysis of loop-designed security and stability control system in interconnected power systems显示文摘Security and stability control system(SSCS)in power systems involves collecting information and sending the decision from/to control stations at different layers;the tree structure of the SSCS requires more levels.Failure of a station or channel can cause all the execution stations(EXs)to be out of control.The randomness of the controllable capacity of the EXs increases the difficulty of the reliability evaluation of the SSCS.In this study,the loop designed SSCS and reliability analysis are examined for the interconnected systems.The uncertainty analysis of the controllable capacity based on the evidence theory for the SSCS is proposed.The bidirectional and loop channels are introduced to reduce the layers and stations of the existing SSCS with tree configuration.The reliability evaluation and sensitivity analysis are proposed to quantify the controllability and vulnerable components for the SSCS in different configurations.By aiming at the randomness of the controllable capacity of the EXs,the uncertainty analysis of the controllable capacity of the SSCS based on the evidence theory is proposed to quantify the probability of the SSCS for balancing the active power deficiency of the grid. | Shenghu Li Huimin Zhou Yunsong Yan Wei Han Jianfeng Ren | 2022 | Global Energy Interconnection2022，5，5： | 2 |
| 20 | Three-dimensional biofabrication of an aragoniteenriched self-hardening bone graft substitute and assessment of its osteogenicity in vitro and in vivo显示文摘A self-hardening three-dimensional(3D)-porous composite bone graft consisting of 65 wt%hydroxyapatite(HA)and 35 wt%aragonite was fabricated using a 3D-Bioplotter®.New tetracalcium phosphate and dicalcium phosphate anhydrous/aragonite/gelatine paste formulae were developed to overcome the phase separation of the liquid and solid components.The mechanical properties,porosity,height and width stability of the end products were optimised through a systematic analysis of the fabrication processing parameters including printing pressure,printing speed and distance between strands.The resulting 3D-printed bone graft was confirmed to be a mixture of HA and aragonite by X-ray diffraction,Fourier transform infrared spectroscopy and energy dispersive X-ray spectroscopy.The compression strength of HA/aragonite was between 0.56 and 2.49 MPa.Cytotoxicity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay in vitro.The osteogenicity of HA/aragonite was evaluated in vitro by alkaline phosphatase assay using human umbilical cord matrix mesenchymal stem cells,and in vivo by juxtapositional implantation between the tibia and the anterior tibialis muscle in rats.The results showed that the scaffold was not toxic and supported osteogenic differentiation in vitro.HA/aragonite stimulated new bone formation that bridged host bone and intramuscular implants in vivo.We conclude that HA/aragonite is a biodegradable and conductive bone formation biomaterial that stimulates bone regeneration.Since this material is formed near 37°C,it will have great potential for incorporating bioactive molecules to suit personalised application;however,further study of its biodegradation and osteogenic capacity is warranted.The study was approved by the Animal Ethical Committee at Tongji Medical School,Huazhong University of Science and Technology(IACUC No.738)on October 1,2017. | Yunsong Shi Ruijun He Xiangyu Deng Zengwu Shao Davide Deganello Chunze Yan Zhidao Xia | 2020 | Biomaterials Translational2020，1，1： | 2 |
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