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| 1 | 颌面部骨修复材料的应用与研究进展显示文摘颌面部骨缺损发病率居高不下,其骨修复重建正在追求个性化、精准化、微创化和高效率,颌面部骨修复材料一直是临床医学和生物组织工程学中的研究热点。该综述对颌面部骨缺损的特点及病因、颌面部骨缺损的修复方法作了介绍,对颌面部骨修复材料的特点及临床应用进行了全面的总结对比。纵观全局,目前颌面部骨修复材料仍面临许多瓶颈问题,其研究前景十分广阔。 | 吴茜 王永前 | 2022 | 中华整形外科杂志2022，38，6： | 2 |
| 2 | Photocrosslinkable Col/PCL/Mg composite membrane providing spatiotemporal maintenance and positive osteogenetic effects during guided bone regeneration显示文摘Guided bone regeneration membranes have been effectively applied in oral implantology to repair bone defects.However,typical resorbable membranes composed of collagen(Col)have insufficient mechanical properties and high degradation rate,while non-resorbable membranes need secondary surgery.Herein,we designed a photocrosslinkable collagen/polycaprolactone methacryloyl/magnesium(Col/PCLMA/Mg)composite membrane that provided spatiotemporal support effect after photocrosslinking.Magnesium particles were added to the PCLMA solution and Col/PCLMA and Col/PCLMA/Mg membranes were developed;Col membranes and PCL membranes were used as controls.After photocrosslinking,an interpenetrating polymer network was observed by scanning electron microscopy(SEM)in Col/PCL and Col/PCL/Mg membranes.The elastic modulus,swelling behavior,cytotoxicity,cell attachment,and cell proliferation of the membranes were evaluated.Degradation behavior in vivo and in vitro was monitored according to mass change and by SEM.The membranes were implanted into calvarial bone defects of rats for 8 weeks.The Col/PCL and Col/PCL/Mg membranes displayed much higher elastic modulus(p<0.05),and a lower swelling rate(p<0.05),than Col membranes,and there were no differences in cell biocompatibility among groups(p>0.05).The Col/PCL and Col/PCL/Mg membranes had lower degradation rates than the Col membranes,both in vivo and in vitro(p<0.05).The Col/PCL/Mg groups showed enhanced osteogenic capability compared with the Col groups at week 8(p<0.05).The Col/PCL/Mg composite membrane represents a new strategy to display space maintenance and enhance osteogenic potential,which meets clinical needs. | Feilong Wang Dandan Xia Siyi Wang Ranli Gu Fan Yang Xiao Zhao Xuenan Liu Yuan Zhu Hao Liu Yongxiang Xu Yunsong Liu Yongsheng Zhou | 2022 | Bioactive Materials2022，7，7： | 1 |
| 3 | Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration显示文摘The restoration of bone defects caused by osteoporosis remains a challenge for surgeons.Strontium ranelate has been applied in preventative treatment approaches due to the biological functions of the trace element strontium(Sr).In this study,we aimed to fabricate bioactive scaffolds through Sr incorporation based on our previously developed modified amino-functional mesoporous bioactive glass(MBG)and to systematically investigate the bioactivity of the resulting scaffold in vitro and in vivo in an osteoporotic rat model.The results suggested that Sr-incorporated amino-functional MBG scaffolds possessed favorable biocompatibility.Moreover,with the incorporation of Sr,osteogenic and angiogenic capacities were upregulated in vitro.The in vivo results showed that the Sr-incorporated amino-functional MBG scaffolds achieved better bone regeneration and vessel formation.Furthermore,bioinformatics analysis indicated that the Sr-incorporated amino-functional MBG scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model by activating the cAMP/PKA signaling pathway,thus playing an anti-osteoporosis role while promoting osteogenesis.This study demonstrated the feasibility of incorporating trace elements into scaffolds and provided new insights into biomaterial design for facilitating bone regeneration in the treatment of osteoporosis. | Qianju Wu Longwei Hu Ran Yan Junfeng Shi Hao Gu Yuwei Deng Ruixue Jiang Jin Wen Xinquan Jiang | 2022 | Bone Research2022，10，4： | 1 |
| 4 | Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials显示文摘Over the past two decades,biodegradable metals(BMs)have emerged as promising materials to fabricate temporary biomedical devices,with the purpose of avoiding potential side effects of permanent implants.In this review,we first surveyed the current status of BMs in neuroscience,and briefly summarized the representative stents for treating vascular stenosis.Then,inspired by the convincing clinical evidence on the in vivo safety of Mg alloys as cardiovascular stents,we analyzed the possibility of producing biodegradable cerebrovascular Mg alloy stents for treating ischemic stroke.For these novel applications,some key factors should also be considered in designing BM brain stents,including the anatomic features of the cerebral vasculature,hemodynamic influences,neuro-cytocompatibility and selection of alloying elements.This work may provide insights into the future design and fabrication of BM neurological devices,especially for brain stents. | Ming Li Miaowen Jiang Yuan Gao Yufeng Zheng Zhi Liu Chen Zhou Tao Huang Xuenan Gu Ang Li Jiancheng Fang Xunming Ji | 2022 | Bioactive Materials2022，7，5： | 0 |
| 5 | 骨修复中可吸收材料降解行为的研究进展显示文摘可降解骨植入物因可避免骨修复后植入物取出的二次手术,或减少永久性植入物存在的炎症等问题,备受临床医生和研究者们的关注。然而,用于构建植入物的生物材料因其固有属性而存在降解太快或太慢、机械性能或成骨能力不足等问题,从而限制了其临床转化应用。为了解决现有可降解植入物在临床应用中的瓶颈,学者们通过表面功能涂层修饰、晶体结构或多孔结构优化、功能元素/小分子掺杂等方式,以调控生物材料的降解行为和成骨能力。综述可降解植入材料(包括金属、生物陶瓷、天然聚合物和合成聚合物)的降解机制、降解行为的调控方法及其对力学性能和骨再生的影响,以期为开发降解行为依附于新生骨形成的新型可降解骨植入材料提供参考。 | 马静 苏秀云 唐斌 王林 裴国献 | 2023 | 中国生物医学工程学报2023，42，5： | 0 |
| 6 | 使用可降解金属材料制备定向骨再生膜的可行性与挑战显示文摘定向骨再生手术是一种用于增加牙槽骨体积的治疗手段.目前,商用的不吸收薄膜(钛膜等)需要二次手术去除,而可吸收薄膜(胶原膜等),由于强度较低,在覆盖大部分病变骨骼时可能会失效.理想的定向骨再生薄膜仍处于发展中.近年来,生物可降解金属被认为是潜在的骨再生薄膜候选材料.因此,本文主要从力学和生物学角度评估了可降解金属作为定向骨再生薄膜的可行性.结果表明,可降解金属具有良好的生物相容性、足够的机械强度、可控的降解速率、良好的成骨性能、广谱抗菌能力和较好的创面愈合能力等优点,能够被用于制备定向骨再生薄膜.然而,对于镁合金来说,其较快的降解速率、析氢行为和应力腐蚀现象制约了其应用.对于锌合金而言,其降解速率适中且无氢气产生,似乎具有更好的应用前景.目前,可降解金属的发展已经为其在口腔临床中的应用奠定了一定的基础. | 陈凯 赵莉 孙洁 顾雪楠 黄晨阳 苏皓然 樊瑜波 | 2022 | Science China Materials2022，65，10： | 0 |
| 7 | 可降解金属研究前沿进展显示文摘可降解金属研究是目前医用金属领域最活跃的研究方向。经过全世界科研机构与医疗器械企业界20余年的数据积累,先后有镁基可降解金属、铁基可降解金属和锌基可降解金属植介入器械进入临床或开展了人体实验研究,未来前景向好。本文回顾了可降解金属的定义、生物降解性与生物相容性双判据及其分类,分别介绍了镁基可降解金属、铁基可降解金属和锌基可降解金属的研究现状及尚未解决的科学问题,并对可降解金属未来的发展机遇与挑战进行了展望。随着人们对可降解金属植入体内的力学适配、降解适配和组织适配等科学问题更加深入的理解,未来将有更多的可降解金属新材料、新技术和新方法被研发,有效实现可降解金属材料降解与机体组织修复两个事件在时间和几何空间上的精准适配。 | 郑玉峰 | 2023 | 材料科学与工艺2023，31，2： | 0 |
| 8 | 生物可降解镁基材料在颅颌面外科的应用及其研究进展显示文摘作为一种新型骨植入材料,生物可降解镁基材料在颅颌面外科显示出广阔的应用前景。与传统骨植入材料相比,镁具有良好的降解特性、生物相容性、力学特性和成骨特性,其降解产物镁离子具有抗凋亡、抗炎的作用,能够促进骨折和骨缺损部位的愈合。多项研究将生物可降解镁基材料应用于颅颌面部骨内固定、引导骨再生技术、骨替代材料、药物负载、种植体表面涂层等领域,其结果显示该类材料能够为骨愈合提供稳定的支持,并发挥出良好的促进成骨作用。此外,镁在口腔其他领域,如牙组织工程、促进软组织愈合等方面也表现出应用潜能,显示出生物可降解镁基材料具有重要的研究价值。 | 常欣楠 刘磊 | 2024 | 国际口腔医学杂志2024，51，1： | 0 |
| 9 | 熔融沉积制造技术在口腔医学领域中应用的研究进展显示文摘熔融沉积制造(FDM)技术是众多3D打印技术中的一种,因其具有结构简单、操作方便、产品精度好和成型速度快等优点,广泛应用于口腔医学领域,其打印产品包括教学模型、术前分析模型、正畸修复牙颌模型、手术导板、颌面部软硬组织缺损赝复体和骨组织工程支架等,应用范围几乎涵盖包括口腔颌面外科、种植科、正畸科、修复科、牙体牙髓科和牙周科等在内的全部口腔科室,以及骨组织工程支架的制备领域,对传统口腔疾病诊疗方式和制造方式产生重大影响。现结合国内外最新研究进展,从FDM技术的打印原理和步骤入手,分析其精度的影响因素,并对其材料体系和材料性质从人工合成高分子聚合物、天然高分子聚合物、生物陶瓷和复合材料4个方面进行总结归纳。重点从口腔医学模型、手术辅助工具、颌面部组织缺损赝复体和骨组织工程支架的制造及应用4个方面对FDM技术在口腔医学领域的应用进行分析,总结其优点和不足,并展望未来发展趋势,以期为FDM技术的改进及其在口腔医学领域的应用提供参考。 | 夏德庚 张庆宇 矫君君 徐庭瑞 张天翼 仲杨 赵竹兰 马宁 张莉 | 2023 | 吉林大学学报(医学版)2023，49，2： | 0 |
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