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| 1 | The minor collagens in articular cartilage显示文摘关节的软骨是由统治它的湿、干燥的重量的体积的一个专业化细胞外的矩阵(ECM ) 组成的一个结缔组织。类型 II 骨胶原和 aggrecan 是在软骨的主要 ECM 蛋白质。然而,很少注意都没对不太丰富的分子的部件,特别次要的骨胶原,包括的类型 IV, VI, IX, X, XI, XII, XIII,和 XIV 被给予,等等。尽管为仅仅成熟矩阵的小部分的财务,这些次要的骨胶原不仅在关节的软骨的机械性质,组织,和形状起必要结构的作用,而且完成特定的生物功能。这些次要的骨胶原的基因研究表明了他们与多重结缔组织疾病被联系,特别退化的联合疾病。软骨的进步破坏包括这些次要的骨胶原包含矩阵成分的降级。碎裂的分子的产生和版本能与能力产生新奇生物化学的标记监视疾病前进,便于药开发并且增加存在工具箱为在 vitro 研究,现出症状之前的潜的研究和临床的试用。 | Yunyun Luo DovUe Sinkeviciute Yi He Morten Karsdal Yves Henrotin Ali Mobasheri Patrik Onnerfjord Anne Bay-Jensen | 2017 | Protein & Cell2017，8，8： | 18 |
| 2 | PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis显示文摘Prostaglandin E2(PGE2), a major cyclooxygenase-2(COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis(OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of novel drug targets of PGE2 signaling in OA progression is urgently needed. Osteoclasts play a critical role in subchondral bone homeostasis and OA-related pain. However, the mechanisms by which PGE2 regulates osteoclast function and subsequently subchondral bone homeostasis are largely unknown. Here, we show that PGE2 acts via EP4 receptors on osteoclasts during the progression of OA and OA-related pain. Our data show that while PGE2 mediates migration and osteoclastogenesis via its EP2 and EP4 receptors, tissue-specific knockout of only the EP4 receptor in osteoclasts(EP4 Lys M) reduced disease progression and osteophyte formation in a murine model of OA. Furthermore, OA-related pain was alleviated in the EP4 Lys M mice, with reduced Netrin-1 secretion and CGRP-positive sensory innervation of the subchondral bone. The expression of plateletderived growth factor-BB(PDGF-BB) was also lower in the EP4 Lys Mmice, which resulted in reduced type H blood vessel formation in subchondral bone. Importantly, we identified a novel potent EP4 antagonist, HL-43, which showed in vitro and in vivo effects consistent with those observed in the EP4 Lys Mmice. Finally, we showed that the Gαs/PI3 K/AKT/MAPK signaling pathway is downstream of EP4 activation via PGE2 in osteoclasts. Together, our data demonstrate that PGE2/EP4 signaling in osteoclasts mediates angiogenesis and sensory neuron innervation in subchondral bone, promoting OA progression and pain, and that inhibition of EP4 with HL-43 has therapeutic potential in OA. | Wenhao Jiang Yunyun Jin Shiwei Zhang Yi Ding Konglin Huo Junjie Yang Lei Zhao Baoning Nian Tao PZhong Weiqiang Lu Hankun Zhang Xu Cao Karan Mehul Shah Ning Wang Mingyao Liu Jian Luo | 2022 | Bone Research2022，10，2： | 7 |
| 3 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 4 | Establishment of kinetic models based on electrical conductivity and freshness indictorsfor the forecasting of crucian carp (Carassius carassius)freshness显示文摘 | Yao Lei Luo Yongkang Sun Yunyun | 2011 | Journal of Food Engineering2011，107，2： | 1 |
| 5 | Establishment of kinetic models based on electrical conductivity and freshness indictors for the forecasting of crucian carp (Carassius carassius) freshness显示文摘 | YAO Lei LUO Yongkang SUN Yunyun | 2011 | Journal of Food Engineering2011，107，： | 1 |
| 6 | Establishment of kinetic models based on electrical conductivity and freshness indictors for the forecasting of crucian carp (Carassius carassius) freshness显示文摘 | YAO Lei LUO Yongkang SUN Yunyun | 2011 | Journal of Food Engineering2011，107，2： | 1 |
| 7 | Phase diagram of the CsBr-CaBr_2 system显示文摘The phase diagram of the CsBr-CaBr2 system was re-determined by using differential thermal analysis and high temperature and room temperature X-ray diffraction analysis. It is concluded that there are three intermediate compounds in this system: a congruently melting compound, CsCaBr3, with a melting point of 823°C and two incongruently melting compounds, Cs2CaBr4 and Cs3Ca2Br7, whose peritectic points being 597°C and 635°C, respectively. X-ray diffraction analysis indicated that compound CsCaBr3 is of slightly distorted perovskite structure. | BAO Xinhua CHEN Nianyi LU Wencong CHENG Zhixuan LUO Yunyun LU Weiying XIA Yiben | 2006 | Rare Metals2006，25，3： | 1 |
| 8 | Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice显示文摘 | Yu Luo Ying Liu Meng Liu Jie Wei Yunyun Zhang Jinpao Hou Weifeng Huang Tao Wang Xun Li Ying He Feng Ding Li Yuan Jianchun Cai Feng Zheng James Y. Yang | 2014 | BBA - Gene Regulatory Mechanisms2014，，2： | 1 |
| 9 | Highly sensitive piezoresistive and thermally responsive fibrous networks from the in situ growth of PEDOT on MWCNT-decorated electrospun PU fibers for pressure and temperature sensing显示文摘Flexible electronics have demonstrated various strategies to enhance the sensory ability for tactile perception and wearable physiological monitoring.Fibrous microstructures have attracted much interest because of their excellent mechanical properties and fabricability.Herein,a structurally robust fibrous mat was first fabricated by electrospinning,followed by a sequential process of functionalization utilizing ultrasonication treatment and in situ polymerization growth.Electrospun polyurethane(PU)microfibers were anchored with multi-walled carbon nanotubes(MWCNTs)to form conductive paths along each fiber by a scalable ultrasonic cavitation treatment in an MWCNT suspension.After,a layer of poly(3,4-ethylene dioxythiophene)(PEDOT)was grown on the surface of PU fibers decorated with MWCNTs to enhance the conductive conjunctions of MWCNTs.Due to the superior electromechanical behaviors and mechanical reinforcement of PEDOT,the PEDOT/MWCNT@PU mat-based device exhibits a wide working range(0–70 kPa),high sensitivity(1.6 kPa−1),and good mechanical robustness(over 18,000 cycles).The PEDOT/MWCNT@PU mat-based sensor also demonstrates a good linear response to different temperature variations because of the thermoelectricity of the PEDOT/MWCNT composite.This novel strategy for the fabrication of multifunctional fibrous mats provides a promising opportunity for future applications for high-performance wearable devices. | Yunyun Luo Libo Zhao Guoxi Luo Linxi Dong Yong Xia Min Li Ziping Li Kaifei Wang Ryutaro Maeda Zhuangde Jiang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 10 | Formability of Rare Earth-Containing Solid Solution Based on Compounds with Scheelite-Type Structure显示文摘The regularities of the solid solutions between the scheelite-type compounds and rare earth molybdates or tungstates were investigated by the atomic parameter-support vector machine method and the intelligent database of phase diagrams of molten salt systems. The crystal structure of scheelite-type compounds having MIM′Ⅲ(XO4)2 (X=Mo, W) as common formula and the formability of the continuous solid solution between these compounds and rare earth molybdates or tungstates were also investigated. Besides, the cell constants of these compounds can be calculated by some semi-empirical equations. Based on the obtained relationships, the results of computerized prediction of the solid solubility of TlPr(MoO4)2-Pr2(MoO4)3 system have good agreement with experimental results. | Luo Yunyun Bao Xinhua Lu Wencong Chen Nianyi Xia Yiben | 2005 | Journal of Rare Earths2005，23，4： | 0 |
| 11 | A thin-film temperature sensor based on a flexible electrode and substrate显示文摘Accurate temperature measurements can efficiently solve numerous critical problems and provide key information.Herein,a flexible micro-three-dimensional sensor,with a combination of platinum and indium oxide to form thermocouples,is designed and fabricated by a microfabrication process to achieve in situ real-time temperature measurements.The stability and reliability of the sensor are greatly improved by optimizing the process parameters,structural design,and preparation methods.A novel micro-three-dimensional structure with better malleability is designed,which also takes advantage of the fast response of a two-dimensional thin film.The as-obtained flexible temperature sensor with excellent stability and reliability is expected to greatly contribute to the development of essential components in various emerging research fields,including bio-robot and healthcare systems.The model of the application sensor in a mask is further proposed and designed to realize the collection of health information,reducing the number of deaths caused by the lack of timely detection and treatment of patients. | Zhaojun Liu Bian Tian Bingfei Zhang Jia ngjiang Liu Zhongkai Zhang Song Wang Yunyun Luo Li bo Zhao Peng Shi Qijing Lin Zhuangde Jiang | 2021 | Microsystems & Nanoengineering2021，7，3： | 0 |
| 12 | Positive direction of polarization-induced electric field improves formic acid electrooxidation on Pd显示文摘Adjusting the adsorption energy of adsorbates on catalyst can directly regulate the catalytic performance and reaction pathways of heterogeneous catalysis.Herein,we report a novel strategy,introducing polarization-induced electric field(PIEF)with different directions,to manipulate the adsorption energy of intermediates and reaction pathway of formic acid electrooxidation on Pd.Tourmaline nanoparticles are applied as the PIEF provider,of which the direction is successfully controlled via aligning the dipoles in tourmaline in a strong external electric field.Experimental and theoretical results systematically reveal that positive PIEF leads to an electron-deficient state of Pd,reduced adsorption energy of COad,enhanced adsorption energy of*HCOOH and*OH,and promoted formate pathway of formic acid electrooxidation.Pd/TNP+/FTO,with the aid of positive PIEF,shows three-fold enhancement in the formic acid electrooxidation(4.74 mA·cm^(−2))with high durability and anti-poisoning ability compared with pristine Pd.This study leads a new route to design formic acid electrocatalysts and provides an understanding on how to control the adsorption energy of adsorbates on electrocatalysts by an internal electric field. | Shuozhen Hu Yunyun Cheng Guoming Luo Kai Huang Cheng Shi Jie Xu Cheng Lian Shigang Sun Xinsheng Zhang | 2023 | Nano Research2023，16，8： | 0 |
| 13 | Comparison of pathological findings between patients with relapsed and non-relapsed immunoglobin G4-related disease显示文摘Immunoglobin(Ig)G4-related disease(IgG4-RD)is an immune-mediated fibroinflammatory condition characterized by elevated serum IgG4 levels and multi-organ involvement.The characteristic histological findings of IgG4-RD are dense lymphoplasmacytic infiltration,fibrosis,and massive IgG4 positive plasma cells infiltrating the affected tissues.[1]Previous studies have demonstrated various relapse predictors corresponding to demographic,clinical characteristics,laboratory test results,and treatment agents.However,no study has revealed the risk factors of flares in pathology.This study aimed to ascertain whether the pathological characteristics are related to therapeutic outcomes. | Hui Lu Shan Wang Mu Wang Xiaowei Liu Linyi Peng Jiaxin Zhou Jieqiong Li Zheng Liu Xuan Luo Yu Peng Yunyun Fei Yan Zhao Xiaofeng Zeng Ruie Feng Wen Zhang | 2022 | Chinese Medical Journal2022，，4： | 0 |
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