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| 1 | Detrital zircon age model of Ordovician Wenquan quartzite south of Lungmuco-Shuanghu Suture in the Qiangtang area, Tibet: Constraint on tectonic affinity and source regions显示文摘Early to Middle Ordovician strata, including Wenquan quartzite, occur widely in the Himalaya, Lhasa, and south Qiangtang blocks. The Wenquan quartzite occurs on the south side of the Lungmuco-Shuanghu Suture in the Qiangtang area, Tibet. A total of 145 analyses on detrital zircons from the quartzite show five age ranges of 520-700, ca. 800, 900-1100, 1800-1900, and 2400-2500 Ma, with particularly distinct age peaks of 625 and 950 Ma. The reliable youngest detrital zircon age is 525 Ma, and the oldest, 3180 Ma. Detrital zircons show large variations in Hf isotope composition, with depleted mantle model ages t DM (Hf) ranging from 750 to 3786 Ma. Based on data obtained in this study and by others, the main conclusions are as follows: 1) Low-grade metamorphic sedimentary rocks are distributed extensively in the south of the Lungmuco-Shuanghu Suture and are Phanerozoic in age; 2) Pan-African and Grenville-Jinning tectono-thermal events were well developed in the source region of the Wenquan quartzite; 3) the source region shows crustal addition and recycling of different periods; 4) Wenquan quartzite was derived from the Gondwana metamorphic basement, suggesting that the Qiangtang block is a Gondwanan fragment. | DONG ChunYan LI Cai WAN YuSheng WANG Wei WU YanWang XIE HangQiang LIU DunYi | 2011 | Science China Earth Sciences2011，54，7： | 39 |
| 2 | Biological productivity and carbon cycling in the Arctic Ocean显示文摘Primary production, bacterial production, par-ticulate organic carbon fluxes and organic carbon burial rates were quantified during the summer period of 1999 in the Arctic Ocean via 14C uptake, 3H uptake, 234Th/238U disequilibrium and 210Pbex dating, respectively. The integrated primary production in the water column was as high as 197 mmolC/(m2·d) in the Chukchi shelf and was 3.8 mmolC/(m2·d) in the Canada Basin. These rates are higher than those reported previously. The ratios of bacterial production to primary production in the study region were higher than 0.5, indicating that microbial activity is not depressed but important in cold Arctic waters. 234Th/238U dis-equilibria were evident at the station in the Canada Basin. The presence of significant 234Th deficiency suggested that scavenging and removal processes are also important to bio-geochemical cycles of trace elements in the Arctic Ocean. Particulate organic carbon export flux was estimated to be 1.0 mmolC/(m2·d). Measurements of sediment | CHEN Min HUANG Yipu GUO Laodong CAI Pinghe YANG Weifeng LIU Guangshan QIU Yusheng | 2002 | Chinese Science Bulletin2002，47，12： | 17 |
| 3 | Multi-agents modelling of EV purchase willingness based on questionnaires显示文摘Traditional experimental economics methods often consume enormous resources of qualified human participants,and the inconsistence of a participant’s decisions among repeated trials prevents investigation from sensitivity analyses.The problem can be solved if computer agents are capable of generating similar behaviors as the given participants in experiments.An experimental economics based analysis method is presented to extract deep information from questionnaire data and emulate any number of participants.Taking the customers’willingness to purchase electric vehicles(EVs)as an example,multi-layer correlation information is extracted from a limited number of questionnaires.Multiagents mimicking the inquired potential customers are modelled through matching the probabilistic distributions of their willingness embedded in the questionnaires.The authenticity of both the model and the algorithmis validated by comparing the agent-based Monte Carlo simulation results with the questionnaire-based deduction results.With the aid of agent models,the effects of minority agents with specific preferences on the results are also discussed. | Yusheng XUE Juai WU Dongliang XIE Kang LI Yu ZHANG Fushuan WEN Bin CAI Qiuwei WU Guangya YANG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，2： | 14 |
| 4 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 5 | Comparison of result judgment algorithm of test for interfering factors in the bacterial endotoxins test among Chinese, Japanese, European, American, and Indian pharmacopeias显示文摘 | Pei Yusheng Cai Tong Gao Hua Tan Dejiang Zhang Yuchen Zhang Guolai | 2014 | Chinese Medical Journal2014，，15： | 7 |
| 6 | Synthesis, mechanical investigation, and application of nitrogen and phosphorus co-doped carbon dots with a high photoluminescent quantum yield显示文摘有高 photoluminescent 量收益(PLQY ) 的做 Heteroatom 的碳点(CD ) 最近在化学传感器,光催化, bioimaging,和药交货中由于他们的应用吸引了注意。氮和磷在到在周期表的碳的靠近的最近并且是关键的在生物医学的成像的地里追踪元素。这二个元素改变 CD 的光、电子的性质并且帮助改进他们的 PLQY 的基本理解。这能也在 photoimaging 和 photothermal 治疗导致多功能的用法。然而,源于做 P 的 CD 的合成的大多数 PLQY 当前低于 50% 。这些 CD 在 bioimaging 和药交货的地里限制了实用性。在这研究,一个单个步的、高效率的热水的方法被使用综合氮和磷药的碳点((N, P ) 有有独立排放的多达 53.8% 的 PLQY 的 -CDs) 行为。而且, CD 在一个大 pH 范围上介绍了高 monodispersity,柔韧的刺激无关的光,和稳定性。分光镜的调查显示 PLQY (N, P ) CD 主要由于 P 的增加和氧化表面的钝化效果。优秀荧光性质(N, P ) CD 能被 Hg 2+ 离子有效地并且有选择地熄灭。如此的系统与一短反应时间在 0-900 nM 集中范围显示出线性回答,显示他们为化学和生物学的领域里的应用程序的潜力。 | Quan Xu Bofan Li Yingchun Ye Wei Cai Weijun Li Chuanyao Yang Yusheng Chen Meng Xu Neng Li Xusheng Zheng Jason Street Yan Luo Lulu Cai | 2018 | Nano Research2018，11，7： | 7 |
| 7 | Selective laser melting of near-α titanium alloy Ti-6Al-2Zr-1Mo-1V:Parameter optimization, heat treatment and mechanical performance显示文摘This paper presents a comprehensive study conducted to optimize the selective laser melting(SLM)parameters and subsequent heat-treatment temperatures for near-α high-temperature titanium alloy Ti-6 Al-2 Zr-1 Mo-1 V(TA15),which is widely used in the aerospace industry.Based on the surface morphology and relative density analysis,the optimized process parameters were:laser power from 230 W to 380 W,scan speed from 675 mm/s to 800 mm/s,scan spacing of 0.12 mm,and layer thickness of0.03 mm.The effects of the laser power and the layer thickness on the phase constitutions,microstructure features,as well as room-temperature and high-temperature(500℃) tensile properties,were then studied to obtain an in-depth understanding of SLM-built TA15.Six typical temperatures(650,750,850,950,1000 and 1100℃) covering three representative temperature ranges,i.e.,martensite partial decomposition temperature range,martensite complete decomposition temperature range and above βtransus temperature,were subsequently selected as heat-treatment temperatures.The heat treatmentmicrostructure-mechanical property relationships of SLM-built TA15 were elucidated in detail.These results provide valuable information on the development of SLM-built TA15 alloy for industrial applications,and these findings are also beneficial to additive manufacturing of other near-α Ti alloys with desirable high-temperature properties. | Chao Cai Xu Wu Wan Liu Wei Zhu Hui Chen Jasper Chu Dong Qiu Chen-Nan Sun Jie Liu Qingsong Wei Yusheng Shi | 2020 | Journal of Materials Science & Technology2020，54，22： | 7 |
| 8 | Red/orange dual-emissive carbon dots for pH sensing and cell imaging显示文摘The dual-emissive N,S co-doped carbon dots (N,S-CDs) with a long emission wavelength were synthesized via solvothermal method.The N,S-CDs possess relatively high photoluminescence (PL) quantum yield (QY) (35.7%) towards near-infrared fluorescent peak up to 648 nm.With the advanced characterization techniques including X-ray photoelectron spectroscopy (XPS),Fourier transform infrared spectroscopy (FTIR),etc.It is found that the doped N,S elements play an important role in the formation of high QY CDs.The N,S-CDs exist distinct pH-sensitive feature with reversible fluorescence in a good linear relationship with pH values in the range of 1.0-13.0.What is more,N,S-CDs can be used as an ultrasensitive Ag+ probe sensor with the resolution up to 0.4 μM.This finding will expand the application of as prepared N,S-CDs in sensing and environmental fields. | Miaoran Zhang Rigu Su Jian Zhong Ling Fei Wei Cai Qingwen Guan Weijun Li Neng Li Yusheng Chen Lulu Cai Quan Xu | 2019 | Nano Research2019，12，4： | 6 |
| 9 | Primary energy congestion of power systems显示文摘Primary energy has the potential to bring challenges to the reliability,economic,and eco-friendliness of global electric power systems.The concept of electric power security are proposed,including many factors that are not considered in power system reliability analysis,such as coal supply for power system,fuel price for electricity power market,carbon emissions of power generation,and so on.It is broader than power system reliability and security,which means that providing energy in the form of reliable,economical,and eco-friendly electric power.Following an account of existing blackout defence methods and systems,the processes of transforming various kinds of primary energy into electric power and the interactions between them are described,particularly with regard to flows of energy,capital,and information.Factors that limit the liquidity of these flows are defined as“generalized congestion”,and the challenges presented by primary energy are named“primary energy congestion”.China’s dilemma on coal supply for power generation is presented in some detail as an example of primary energy congestion.To cope with impacts of the primary energy on electric power systems,an idea is introduced to extend the scope of existing coordinated blackout defence systems to account for primary energy,which would lead to an integrated tool to provide decision support to power system operators accounting for primary energy congestion. | Yusheng XUE Bin CAI Geoffrey JAMES Zhaoyang DONG Fushuan WEN Feng XUE | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，1： | 6 |
| 10 | Selectivity regulation of CO2 electroreduction through contact interface engineering on superwetting Cu nanoarray electrodes显示文摘Electrocatalytic CO2 reduction is a promising way to mitigate the urgent energy and environmental issues, but how to increase the selectivity for desired product among multiple competi ng reaction pathways remains a bottle neck. Here, we demonstrate that engineering the gas-liquid-solid contact interface on the electrode surface could tailor the selectivity of CO2 reducti on and meanwhile suppress H2 production through regulated reacti on kin etics. Specifically, polytetrafl uoroethyle ne (PTFE) was utilized to modify a Cu nano array electrode as an example, which is able to cha nge the electrode surface from aerophobic to aerophilic state. The en riched nano-tunnels of the Cu nano array electrode can facilitate CO2 transportation and pin gaseous products on the electrode surface. The latter is believed to be the reason that boosts the Faradaic efficie ncy of liquid products by 67% and limits the H2 producti on to less than half of before. This in terface engin eeri ng strategy also lowered H2O (proton) affinity, therefore promoting CO and HCOOH production. Engineering the electrode contact interface controls the reaction kinetics and the selectivity of products, which should be inspiring for other electrochemical reactions. | Zhao Cai Yusheng Zhang Yuxin Zhao Yueshen Wu Wenwen Xu Xuemei Wen Yang Zhong Ying Zhang Wen Liu Hailiang Wang Yun Kuang Xiaoming Sun | 2019 | Nano Research2019，12，2： | 5 |
| 11 | Single-nucleus transcriptomic landscape of primate hippocampal aging显示文摘The hippocampus plays a crucial role in learning and memory,and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases.Yet a systematic profiling of the aging effects on various hippocampal cell types in primates is still missing.Here,we reported a variety of new aging-associated phenotypic changes of the primate hippocampus.These include,in particular,increased DNA damage and heterochromatin erosion with time,alongside loss of proteostasis and elevated inflammation.To understand their cellular and molecular causes,we established the first single-nucleus transcriptomic atlas of primate hippocampal aging.Among the 12 identified cell types,neural transiently amplifying progenitor cell(TAPC)and microglia were most affected by aging.In-depth dissection of gene-expression dynamics revealed impaired TAPC division and compromised neuronal function along the neurogenesis trajectory;additionally elevated pro-inflammatory responses in the aged microglia and oligodendrocyte,as well as dysregulated coagulation pathways in the aged endothelial cells may contribute to a hostile microenvironment for neurogenesis.This rich resource for understanding primate hippocampal aging may provide potential diagnostic biomarkers and therapeutic interventions against age-related neurodegenerative diseases. | Hui Zhang Jiaming Li Jie Ren Shuhui Sun Shuai Ma Weiqi Zhang Yang Yu Yusheng Cai Kaowen Yan Wei Li Baoyang Hu Piu Chan Guo-Guang Zhao Juan Carlos Izpisua Belmonte Qi Zhou Jing Qu Si Wang Guang-Hui Liu | 2021 | Protein & Cell2021，12，9： | 5 |
| 12 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 13 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 14 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 15 | Effect of the capsule on deformation and densification behavior of nickel-based superalloy compact during hot isostatic pressing显示文摘The Shima yield criterion used in finite element analysis for nickel-based superalloy powder compact during hot isostatic pressing(HIP) was modified through uniaxial compression experiments. The influence of cylindrical capsule characteristics on FGH4096M superalloy powder compact deformation and densification behavior during HIP was investigated through simulations and experiments. Results revealed the simulation shrinkage prediction fitted well with the experimental shrinkage including a maximum shrinkage error of 1.5%. It was shown that the axial shrinkage was 1.7% higher than radial shrinkage for a cylindrical capsule with the size of ∮50 mm × 100 mm due to the force arm difference along the axial and radial direction of the capsule. The stress deviated from the isostatic state in the capsule led to the uneven shrinkage and non-uniform densification of the powder compact. The ratio of the maximum radial displacement to axial displacement increased from0.47 to 0.75 with the capsule thickness increasing from 2 to 4 mm. The pressure transmission is related to the capsule thickness, the capsule material performance, and physical parameters in the HIP process. | Lebiao Yang Xiaona Ren Chao Cai Pengju Xue MIrfan Hussain Yusheng Shi Changchun Ge | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，1： | 1 |
| 16 | Fabrication and microstructure evolution of C_(sf)/ZrB_(2)-SiC composites via direct ink writing and reactive melt infiltration显示文摘Fiber damage and uniform interphase preparation are the main challenges in conventional short fiber reinforced ceramic matrix composites.In this work,we develop a novel processing route in fabrication of short carbon fiber reinforced ZrB_(2)-SiC composites(C_(sf)/ZrB_(2)-SiC)overcoming the above two issues.At first,C_(sf) preforms with oriented designation and uniform PyC/SiC interphase are fabricated via direct ink writing(DIW)of short carbon fiber paste followed by chemical vapor infiltration.After that,ZrB_(2) and SiC are introduced into the preforms by slurry impregnation and reactive melt infiltration,respectively.Microstructure evolution and optimization of the composites during fabrication are investigated in detail.The as-fabricated C_(sf)/ZrB_(2)-SiC composites have a bulk density of 2.47 g/cm^(3),with uniform weak interphase and without serious fiber damage.Consequently,non-brittle fracture occurs in the C_(sf)/ZrB_(2)-SiC composites with widespread toughening mechanisms such as crack deflection and bridging,interphase debonding,and fiber pull-out.This work provides a new opportunity to the material design and selection of short fiber reinforced composites. | Jun LU Dewei NI Chunjing LIAO Haijun ZHOU Youlin JIANG Bowen CHEN Xuegang ZOU Feiyan CAI Yusheng DING Shaoming DONG | 2021 | Journal of Advanced Ceramics2021，10，6： | 1 |
| 17 | Mechanical properties and microstructure characteristics of lattice-surfaced PEEK cage fabricated by high-temperature laser powder bed fusion显示文摘Porous structure design on the contact surface is crucial to promote the osseointegration of the intervertebral cage while preventing subsidence and displacement.However,the stress response will undergo significant changes for the current random porous cages,which can directly affect the mechanical properties and long-term usability.Here,this paper proposed a newly designed polyetheretherketone(PEEK)cage with the triply periodic minimal surface(TPMS)-structured lattice surfaces to provide tailored 3 D microporosity and studied the mechanical performance,stress/strain responses,and microstructure changes in depth.The lattice-surfaced PEEK cage mainly exhibits a multiple-point-plane stress transfer mechanism.The compression modulus and elastic limit can be adjusted by controlling the area of the Diamond TPMS surface while the energy absorption efficiency remains stable.The microstructure of high-strength PEEK is featured by the radial pattern morphology.Meanwhile,the double-stranded orthorhombic phase is more ordered,and the benzene plane subunit and lattice volume become more expanded. | Peng Chen Jin Su Haoze Wang Lei Yang Haosong Cai Maoyuan Li Zhaoqing Li Jie Liu Shifeng Wen Yan Zhou Chunze Yan Yusheng Shi | 2022 | Journal of Materials Science & Technology2022，，30： | 1 |
| 18 | Plasmacytoid dendritic cells promote acute kidney injury by producing interferon-α显示文摘Acute kidney injury(AKI)is a common clinical complication associated with high mortality in patients.Immune cells and cytokines have recently been described to play essential roles in AKI pathogenesis.Plasmacytoid dendritic cells(pDCs)are a unique DC subset that specializes in type Ⅰ interferon(IFN)production.Here,we showed that pDCs rapidly infiltrated the kidney in response to AKI and contributed to kidney damage by producing IFN-α.Deletion of pDCs using DTR^(BDCA2) transgenic(Tg)mice suppressed cisplatin-induced AKI,accompanied by marked reductions in proinflammatory cytokine production,immune cell infiltration and apoptosis in the kidney.In contrast,adoptive transfer of pDCs during AKI exacerbated kidney damage.We further identified IFN-α as the key factor that mediated the functions of pDCs during AKI,as IFN-α neutralization significantly attenuated kidney injury.Furthermore,IFN-α produced by pDCs directly induced the apoptosis of renal tubular epithelial cells(TECs)in vitro.In addition,our data demonstrated that apoptotic TECs induced the activation of pDCs,which was inhibited in the presence of an apoptosis inhibitor.Furthermore,similar deleterious effects of pDCs were observed in an ischemia reperfusion(IR)-induced AKI model.Clinically,increased expression of IFN-α in kidney biopsies was observed in kidney transplants with AKI.Taken together,the results of our study reveal that pDCs play a detrimental role in AKI via IFN-α. | Bo Deng Yuli Lin Yusheng Chen Shuai Ma Qian Cai Wenji Wang Bingji Li Tingyan Liu Peihui Zhou Rui He Feng Ding | 2021 | Cellular & Molecular Immunology2021，18，1： | 1 |
| 19 | Five simple models for interfering factors test of bacterial endotoxins test显示文摘Endotoxins have been credited for over 50% of sepsis cases,with significantly greater mortality.1A literature indicates wide-spread agreement that early detection of endotoxemia,endotoxin in the bloodstream,is the major key for patient survival from sepsis.2 Today the most popular endotoxin detection system is bacterial endotoxins test (BET),adopted by most pharmacopoeias.Interference test is a part of the bacterial endotoxin inspection method,used to judge whether the sample can be applied in BET.However,Limuloid resources are exhausted in China,which is an important source for LAL.Here,we reported 5 simple models for interfering factors test in the BET,and compared new models with the United States Pharmacopoeia 36 (USP36). | Pei Yusheng Cai Tong Gao Hua Tan Dejiang Zhang Yuchen Zhang Guolai | 2014 | Chinese Medical Journal2014，，18： | 1 |
| 20 | MECHANISM MAP OF TORSIONAL FATIGUE FRACTURE显示文摘Studies have been made of the torsional fatigue fracture life of notched specimens,themacroscopic fractography and microscopic fracture mechanism of steel 40Cr after varioustempering treatments under different stresses,With the increase of stress,the fracture modelchanges from normal stress fracture to longitudinal shear one,and then transversal shear one.Under same stress,with the increase of strength,the fracture mode transfers from shear tonormal stress fracture.The mechanism of normal stress fracture may be:transgranular frac-ture→striation+intergranular fracture→dimple+intergranular fracture,and of shear fracturemay be:transgranular fracture→shear trace→dimple.Based on the experimental results,afracture mechanism map of torsional fatigue has been drawn up. | HU Zhizhong WU Yusheng CAI Heping MA Lihua Xi′an jiaotong University,Xi′an,China Senior Engineer,Res.Inst.for Strength of Metals,Xi′an jiaotong University,Xi′an 710049,China | 1991 | Acta Metallurgica Sinica(English Letters)1991，4，2： | 1 |
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