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| 1 | Biocomposites of Polylactic Acid Reinforced by DL-Lactic Acid-Grafted Microfibrillated Cellulose显示文摘Microfibrillated cellulose(MFC)is often added to polylactic acid(PLA)matrixes as a reinforcing filler to obtain fully-biodegradable composites with improved mechanical properties.However,the incompatibility between MFC and the PLA matrix limits the mechanical performance of MFC-reinforced PLA composites.In this paper,DL-lactic acid-grafted-MFC(MFC-g-DL)was used to improve the compatibility with PLA.Reinforced composites were prepared by melt extrusion and hot-cold pressing.The tensile strength of the PLA/MFC-g-DL composite increased by 22.1%compared with that of PLA after adding 1%MFC-g-DL.Scanning electron microscopy(SEM),differential scanning calorimetry(DSC),and dynamic thermomechanical analysis(DMA)were used to explore the enhancement mechanism.The energy dissipation in the MFC network and the improved compatibility between PLA and MFC-g-DL played important roles in the reinforcement.The SEM results showed that there was a closer combination between PLA and MFC-g-DL.The DSC results showed that the addition of cellulose changed the glass transition temperature,melting temperature,and crystallization temperature of PLA.The TG results showed that the initial and maximum decomposition temperature were lower than those of PLA.The ultraviolet spectra showed that the composite had good transparency at a low concentration of MFC-g-DL. | Chaodong Liu Yutong Yang Boyu Cui Weihong Wang | 2022 | Journal of Renewable Materials2022，10，11： | 0 |
| 2 | Molecular mechanism of lycopene cyclases regulating carotenoids ratio in different branches during tea leaf and flower development显示文摘Carotenoids are essential components in tea quality, contributing to leaf color and aroma. However, little information about carotenoids in different tea cultivars and their biosynthesis regulation mechanism during leaf development is known. Here we analyzed carotenoids by HPLC in the buds and leaves of 113 tea cultivars harvested on the same day. By profile clustering, carotenoids were divided into five groups. Same group cultivars displayed divergence in the total content of carotenoids but a similar molar ratio. To figure out the molecular mechanisms of this phenomenon, we further characterized all functional lycopene cyclases, which are the branch point of the carotenoid biosynthesis pathway. Two β-lycopene cyclases(CsLCYB1 and CsLCYB2) and one ε-lycopene cyclase(CsLCYE1) were cloned. Subcellular localization analysis showed that all cloned CsLCYs were localized in plastids. Enzyme activity assays in E. coli indicated both CsLCYBs catalyzed lycopene into β-carotene, and CsLCYE1 produced δ-carotene and ε-carotene. We found CsLCYB1 and CsLCYE1 predominantly expressed in leaf, while CsLCYB2was mainly expressed during flowering stages. Suppression by antisense oligonucleotides reduced CsLCYB1 and CsLCYE1 transcripts and led to reduction of both β,β-branch and β,ε-branch carotenoids in leaf. The expression levels of CsLCYB1 showed a significant positive correlation withβ,β-branch carotenoids in leaf. Our study provides carotenoid profiles of different tea cultivars, which can assist tea producers in selecting cultivars of interest. Meanwhile, we proposed the molecular mechanism of carotenoids reflecting the tenderness of tea plant leaf from a metabolic flux perspective, and suggested lycopene cyclase that could be applied to the breeding of tea varieties with different branch carotenoids. | Anqi Peng Xiaoyan Tang Yingying Feng Yun Huang Jilai Cui Kai Tian Mengqian Lu Yifan Zhao Yuting Pan Sanjin Wang Yutong Hu Wei Zhao Chuankui Song Qiang Wang | 2023 | Horticultural Plant Journal2023，9，6： | 0 |
| 3 | Simultaneous microwave characterization of wafer-level optoelectronic transceiver chips based on photonic sampling and mapping显示文摘Photonic integrated circuits(PICs)promise future parallelism growths of high-performance communication,computation,and offer unprecedented bandwidth scalability with reduced power consumption as a viable replacement for an electrical wire with an optoelectronic transceiver consisting of a transmitter and a receiver integrated on the same wafer.This wafer-level photonic integration,however,raises challenges for processing optical-electrical(O-E)and electricaloptical(E-O)characterization,which is crucial in chip fabrication and optimization[1]. | Yutong HE Xinhai ZOU Ying XU Zhihui LI Naidi CUI Junbo FENG Yali ZHANG Zhiyao ZHANG Shangjian ZHANG Yong LIU Ninghua ZHU | 2024 | Science China(Information Sciences)2024，67，2： | 0 |
| 4 | Taxifolin attenuates inflammation via suppressing MAPK signal pathway in vitro and in silico analysis显示文摘Objective:Taxifolin is a natural flavonoid compound that can be isolated from onions,grapes,oranges and grapefruit.It also acts as a medicine food homology with extraordinary antioxidant and antiinflammatory activity.This study aims to explain the protective effects and potential mechanisms of taxifolin against inflammatory reaction.Methods:Levels of interleukin(IL)-6,IL-1βand intracellular reactive oxygen species(ROS)were assessed in different time after the treatment of taxifolin in RAW264.7 cells induced by lipopolysaccharide(LPS).Subsequently,the m RNA and protein levels of inducible nitric oxide synthase(i NOS),vascular endothelial growth factor(VEGF),cyclooxygenase(COX)-2,tumor necrosis factor(TNF)-a and the phosphorylation expression levels of the MAPK signal pathway were also evaluated.A silico analysis was used to explain the binding situation for the investigation of taxifolin and MAPK signal pathway.And then MAPK inhibitors were used to reveal the expression level of i NOS,VEGF,COX-2 and TNF-a in RAW264.7 cells.Results:It was demonstrated that cell inflammatory damage induced by LPS was significantly alleviated after the treatment of taxifolin.Then,the m RNA and protein levels of i NOS,VEGF,COX-2 and TNF-a were reduced and the phosphorylation expression levels of the MAPK signal pathway were down-regulated remarkably as well.In silico analysis,taxifolin could form a relatively stable combination with MAPK signal pathway.MAPK inhibitors showed increasing or decreasing effect in the m RNA levels of i NOS,VEGF,COX-2 and TNF-a,which suggesting that taxifolin down-regulated i NOS,VEGF,COX-2 and TNF-a expressions were not entirely through the MAPK pathway.Conclusion:This finding demonstrated that taxifolin improved the inflammatory responses that partly involved in the phosphorylation expression level of MAPK signal pathway in RAW264.7 cells exposed to acute stress. | Xingyan Zhang Xiaoyan Lian Huling Li Wenjing Zhao Xin Li Fujun Zhou Yutong Zhou Tao Cui Yuli Wang Changxiao Liu | 2022 | Chinese Herbal Medicines2022，14，4： | 0 |
| 5 | Two-stage acceleration of interstellar ions driven by high-energy lepton plasma flows显示文摘We present the particle-in-cell(PIC) simulation results of the interaction of a high-energy lepton plasma flow with background electron-proton plasma and focus on the acceleration processes of the protons. It is found that the acceleration follows a two-stage process. In the first stage, protons are significantly accelerated transversely(perpendicular to the lepton flow) by the turbulent magnetic field 'islands' generated via the strong Weibel-type instabilities. The accelerated protons shows a perfect inverse-power energy spectrum. As the interaction continues, a shockwave structure forms and the protons in front of the shockwave are reflected at twice of the shock speed, resulting in a quasi-monoenergetic peak located near 200 Me V under the simulation parameters. The presented scenario of ion acceleration may be relevant to cosmic-ray generation in some astrophysical environments. | CUI YunQian SHENG ZhengMing LU QuanMing LI YuTong ZHANG Jie | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，10： | 0 |
| 6 | Micropeptides: origins, identification, and potential role in metabolism-related diseases显示文摘With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides(miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial function.MiPs are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications. | Yirui LU Yutong RAN Hong LI Jiao WEN Xiaodong CUI Xiaoyun ZHANG Xiumei GUAN Min CHENG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，12： | 0 |
| 7 | A focused transcriptomic analysis of the TP53-regulated genes identifies the GPI-anchored molecule-like protein(GML)as a favorable prognostic predictor of lung cancer显示文摘Lung cancer is the most common cause of cancer-related mortality worldwide.1 The current clinical staging systems cannot adequately predict the prognosis of patients with lung cancer,making it difficult to individualize the clinical treatment of the disease,resulting in poorer outcomes. | Yutong Wang Shanshan Wang Yanmei Cui Jie Zhang Shuang Geng Honglei Yin Simiao Zhang Qiufang Li Yunliang Wang | 2023 | Genes & Diseases2023，10，2： | 0 |
| 8 | Lung adenocarcinoma patients with novel ALK fusion variants and their clinical responses to ALK inhibitors显示文摘Dear Editor,Lung cancer is one of the most common cancers worldwide and is associated with high mortality.Anaplastic lymphoma kinase(ALK)rearrangement,an oncogenic driver,has been identified in 5%to 6%of patients with non-small cell lung cancer(NSCLC)[1].The first identified and the most common ALK fusion partner is echinoderm microtubule-associated protein-like 4(EML4)[2].With the broad application of next-generation sequencing(NGS),an increasing number of novel ALK fusions have been reported.Many ALK tyrosine kinase inhibitors(ALKTKIs),including crizotinib,brigatinib,ceritinib,and ensartinib,have been approved to treat ALK-positive NSCLC patients,and their efficacy may be affected by different ALK fusion variants[3].Here,we report two novel ALK fusions,MAPRE3-ALK and PKNOX2-ALK,detected by an NGS panel targeting 425 cancer-related genes(Nanjing Geneseeq Technology Inc.,Nanjing,Jiangsu,China)[4]in two metastatic lung adenocarcinoma patients who then received ALK-TKI treatments.The drug efficacy of the two novel fusions reported here could have significant referential value and provide useful therapeutic strategies for treating ALK-positive patients. | Dafu Yang Dan Li Zhaoxia Dai Yutong Ma Qiuxiang Ou Xue Wu Saiqiong Cui | 2021 | Cancer Communications2021，41，2： | 0 |
| 9 | Microfluidic chemostatic bioreactor for high-throughput screening and sustainable co-harvesting of biomass and biodiesel in microalgae显示文摘As a renewable and sustainable source for energy,environment,and biomedical applications,microalgae and microalgal biodiesel have attracted great attention.However,their applications are confined due to the cost-efficiency of microalgal mass production.One-step strategy and continuous culturing systems could be solutions.However,current studies for optimization throughout microalgae-based biofuel production pipelines are generally derived from the batch culture process.Better tools are needed to study algal growth kinetics in continuous systems.A microfluidic chemostatic bioreactor was presented here,providing low-bioadhesive cultivations for algae in a cooperative environment of gas,nutrition,and temperature(GNT)involved with high throughput.The chip was used to mimic the continuous culture environment of bioreactors.It allowed simultaneously studying of 8×8 different chemostatic conditions on algal growth and oil production in parallel on a 7×7 cm^(2)footprint.On-chip experiments of batch and continuous cultures of Chlorella.sp.were performed to study growth and lipid accumulation under different nitrogen concentrations.The results demonstrated that microalgal cultures can be regulated to grow and accumulate lipids concurrently,thus enhancing lipid productivity in one step.The developed on-chip culturing condition screening,which was more suitable for continuous bioreactor,was achieved at a half shorter time,64-times higher throughput,and less reagent consumption.It could be used to establish chemostat cultures in continuous bioreactors which can dramatically accelerate the development of renewable and sustainable algal for CO_(2)fixation and biosynthesis and related systems for advanced sustainable energy,food,pharmacy,and agriculture with enormous social and ecological benefits. | Guoxia Zheng Yutong Cui Ling Lu Ming Guo Xuejun Hu Lin Wang Shuping Yu Shenxia Sun Yuancheng Li Xingcai Zhang Yunhua Wang | 2023 | Bioactive Materials2023，，7： | 0 |
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