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| 1 | Maintenance for healed erosive esophagitis:PhaseⅢcomparison of vonoprazan with lansoprazole显示文摘AIM To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis(EE).METHODS A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg(n = 201), vonoprazan 10 mg(n = 202), or vonoprazan 20 mg(n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period. The secondary endpoint was the EE recurrence rate at Week 12 during maintenance treatment. Additional efficacy endpoints included the incidence of heartburn and acid reflux, and the EE healing rate 4 wk after the initiation of maintenance treatment. Safety endpoints comprised adverse events(AEs), vital signs, electrocardiogram findings, clinical laboratory results, serum gastrin and pepsinogen Ⅰ/Ⅱ levels, and gastric mucosa histopathology results.RESULTS Rates of EE recurrence during the 24-wk maintenance period were 16.8%, 5.1%, and 2.0% with lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg, respectively. Vonoprazan was shown to be non-inferior to lansoprazole 15 mg(P < 0.0001 for both doses). In a post-hoc analysis, EE recurrence at Week 24 was significantly reduced with vonoprazan at both the 10 mg and the 20 mg dose vs lansoprazole 15 mg(5.1% vs 16.8%, P = 0.0002, and 2.0% vs 16.8%, P < 0.0001, respectively); by contrast, the EE recurrence rate did not differ significantly between the two doses of vonoprazan(P = 0.1090). The safety profiles of vonoprazan 10 and 20 mg were similar to that of lansoprazole 15 mg in patients with healed EE. Treatment-related AEs were reported in 11.4%, 10.4%, and 10.3% of patients in the lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg arms, respectively.CONCLUSION Our findings confirm the non-inferiority of vonoprazan 10 and 20 mg to lansoprazole 15 mg as maintenance therapy for patients with healed EE. | Kiyoshi Ashida Katsuhiko Iwakiri Naoki Hiramatsu Yuuichi Sakurai Tetsuharu Hori Kentarou Kudou Akira Nishimura Eiji Umegaki | 2018 | World Journal of Gastroenterology2018，24，14： | 18 |
| 2 | Radioprotective Effect of Lyophyllum Decastes and the Effect on Immunological Functions in Irradiated Mice显示文摘In this study, to explore the radiation protection effects of Lyophyllum Decastes Sing (LDS), a hot distilled-water extract of LDS was orally administered at a dosage of 250mg/kg every other day for a period of 2 weeks in irradiated mice. An automatic blood cell counter was used to measure white blood cells (lymphocytes, monocyte, and granulocytes) one day before X-ray irradiation, and 3 hours, 12 hours, 24 hours, 3 days, 7 days, 15 days and 30 days after irradiation. The Dunnett test was used to examine statistical significance of differences. The peripheral blood cell counts in the Lyophyllum-administered non-irradiation group revealed an increase in the numbers of leukocytes, lymphocytes and monocytes. For 2 Gy whole body radiation, a significant statistical difference was found between the X-ray group and the Lyophyllum plus X-ray group in the numbers of leukocytes, lymphocytes and monocytes. The results suggest that Lyophyllum restrains blood cell-count falling after irradiation, which is probably mediated at least in part by hemopoietic function, and NK and LAK activities seems to play a role in preventing secondary infections associated with irradiation. | Takashi Nakamura Yuka Itokawa Masayuki Tajima Yuuichi Ukawa Kwang-Ho Cho Jung-Sook Choi Torao Ishida Yeunhwa Gu | 2007 | Journal of Traditional Chinese Medicine2007，27，1： | 13 |
| 3 | 静脉输注大剂量盐酸吡哆醇治疗小儿惊厥的疗效观察显示文摘盐酸吡哆醇(Pyridoxine,vitB_6)是促进氨基酸和脂肪代谢的一种水溶性维生素,主要用于治疗妊娠呕吐及脂溢性皮炎等疾病。近年来国外报道采用大剂量Vit B_6治疗婴儿痉挛症及新生儿破伤风等惊厥性疾病。1992年我科与日本东京庆应义塾大学医学部儿科合作进行大剂量 VitB_6治疗小儿惊厥的临床研究,现报告如下。 | 焦富勇 高德义 武胜 曹亚敏 张逊凯 葛卓黎 白爱宁 崔魏 李慧荣 Yuuichi Takuma | 1995 | 中国实用儿科杂志1995，10，5： | 7 |
| 4 | Heteropoly anionmodified palladiurn catalyst for reductive carbonylation of nitrobenzene显示文摘 | Yusuke Izumi Yuuichi Satoh | 1990 | Chem Lett1990，221，5： | 1 |
| 5 | Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor显示文摘 | Hoang Anh Vu Yuuichi Beppu Hoang Thanh Chi Kousuke Sasaki Hideaki Yamamoto Phan Thi Xinh Takashi Tanii Yukihiko Hara Toshiki Watanabe Yuko Sato Iwao Ohdomari Gary E. Gallick | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 6 | A new approach to the preparation of MoVNbTe mixed oxide catalysts for the oxidation of propane to acrylic acid 显示文摘 | Tu Xinlin Furuta Naomasa Sumida Yuuichi | 2006 | Catalysis Today2006，117，： | 1 |
| 7 | Development of dry-cleaned and agglomerated precompaction system (DAPS) for metallurgical cokemaking显示文摘 | Kenji K Yoshiaki N Yuuichi Y | 2006 | Nippon Steel Technical Report2006，94，： | 1 |
| 8 | Analysis of vinylene carbonate derived SEI layers on graphite Anode显示文摘 | Hitoshiota Yuuichi Sakata Atsuyoshi Inone | 2004 | Journal of The Electrochemical Society2004，151，10： | 1 |
| 9 | Analysis of vinylene carbonate derived SEI layers on graphite anode显示文摘 | Ota Hitoshi Sakata Yuuichi Inoue Atsuyoshi | 2004 | Journal of the Electrochemical Society2004，151，10： | 1 |
| 10 | Molecular Biologic Approach to the Diagnosis of Pancreatic Carcinoma Using Specimens Obtained by EUS-Guided Fine Needle Aspiration显示文摘 | Kiyohito Kato Hideki Kamada Takayuki Fujimori Yuuichi Aritomo Masahiro Ono Tsutomu Masaki Grazyna Rydzewska | 2012 | <journal-title>Gastroenterology Research and Practice2012，，： | 1 |
| 11 | Sedation-Free Colonoscopy显示文摘 | Yuuichi Takahashi M.D. Hideaki Tanaka M.D. Mitsuyo Kinjo M.D. Ken Sakumoto M.D | 2005 | Diseases of the Colon & Rectum2005，，4： | 1 |
| 12 | Experimental study on automotive cooling and heating air conditioning system using CO2 as a refrigerant显示文摘 | Tamura Tomoichiro Yakumaru Yuuichi Nishiwaki Fumitoshi | | 0，，28： | 1 |
| 13 | ( - )-Camoensidine N-Oxide; a new alkaloid from Maackia tashiroi 显示文摘 | Shigeru Ohmiya Hajime Kubo Yuuichi Nakaaze | 1991 | Chem Pharm Bull1991，39，5： | 1 |
| 14 | Development of High Efficiency Swing Compressor for R32 Refrigerant显示文摘 | Yuuichi Yamamoto Takehiro Kanayama Kenichi Yuasa Hideki Matsua | 2015 | Journal of Energy and Power Engineering2015，9，2： | 1 |
| 15 | Production of xylitol from D-xylose by Candida tropicalis:Optimization of production rate显示文摘 | Yuuichi Y Kazuhiro T | 1992 | Biotachnol Bioeng1992，40，： | 1 |
| 16 | Experimentalstudy on automotive cooling and heating air conditionsystem using CO2 as a refrigerant显示文摘 | Tamura Tomoichiro Yakumaru Yuuichi Nishiwaki Fumitoshi | 2005 | International Journal of Refrigeration2005，，28： | 1 |
| 17 | Green tea catechins prevent low-density lipoprotein oxidation via their accumulation in low-density lipoprotein particles in humans显示文摘 | Norie Suzuki-Sugihara Yoshimi Kishimoto Emi Saita Chie Taguchi Makoto Kobayashi Masaki Ichitani Yuuichi Ukawa Yuko M. Sagesaka Emiko Suzuki Kazuo Kondo | 2016 | Nutrition Research2016，，1： | 1 |
| 18 | Prospective Evaluation of Factors Predicting Difficulty and Pain During Sedation-Free Colonoscopy显示文摘 | Yuuichi Takahashi M.D. Hideaki Tanaka M.D. Mitsuyo Kinjo M.D. Ken Sakumoto M.D | 2005 | Diseases of the Colon & Rectum2005，，6： | 1 |
| 19 | 'Module' Method Applied on Machinery Outfitting显示文摘 | Yuuichi Hamada Toshio Tanabe Kazumasa Inoue | 2000 | Journal of the M E S J2000，35，12： | 1 |
| 20 | Sedation-Free Colonoscopy显示文摘 | Yuuichi Takahashi M.D. Hideaki Tanaka M.D. Mitsuyo Kinjo M.D. Ken Sakumoto M.D | 2005 | Diseases of the Colon & Rectum2005，，4： | 1 |
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