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| 1 | Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus显示文摘By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. | Haiyang Yu Yuwei Zhao Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，4： | 25 |
| 2 | Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3]. | Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang | 2022 | National Science Review2022，9，10： | 3 |
| 3 | A composite coating by electrolysis-induced collagen self-assembly and calcium phosphate mineralization显示文摘 | Fan Yuwei Duan Ke Wang Rizhi | 2005 | Biomaterials2005，26，： | 1 |
| 4 | Motion direction prediction through spike timing based on micro Capsnet networks显示文摘Neural activity extraction and neural decoding from neural signals are an important part of critical components of brain-computer interface systems.With the development of brain-computer interface technology,the demand for precise external control and nervous activities in macaque monkey during unilateral hand grasp has increased the complexity of control and neural decoding,which puts forward higher requirements for the accuracy and stability of feature extraction and neural decoding.In this study,a micro Capsnet network architecture that consists of a few network layers,a vector feature structure,and optimization network parameters,is proposed to decrease the computing time and complexity,decrease artificial debugging,and improve the decoding accuracy.Compared with KNN,SVM,XGBOOST,CNN,Simple RNN,and LSTM,the algorithm in this study improves the decoding accuracy by 98.03%,and achieves state-of-the-art accuracy and stronger robustness.Furthermore,the proposed algorithm can further enhance the control accuracy in the brain-computer interface. | ZHANG HuaLiang LIU Ji WANG BaoZeng DAI Jun LIAN JinLing KE Ang ZHAO YuWei ZHOU Jin WANG ChangYong | 2022 | Science China(Technological Sciences)2022，65，11： | 1 |
| 5 | A chromosome-level genome assembly reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in the shoot apex of Isodon rubescens显示文摘The ent-kaurenoids(e.g.,oridonin and enmein)from the Isodon genus(Lamiaceae)are one class of diterpenoids with rich structural diversity and intriguing pharmaceutical activity.In contrast to the well-established gibberellin pathway,oxidative modifications diversifying the ent-kaurene skeleton in Isodon have remained undetermined for half a century.Here we report a chromosome-level genome assembly of I.rubescens,a well-recognized oridonin producer long favored by Asian people as a traditional herb with antitumor effects.The shoot apex was confirmed to be the actual region actively producing ent-kaurene diterpenoids.Through comparative genomics and phylogenetic analyses,we discovered a cluster of tandem-duplicated CYP706V oxygenase-encoding genes located on an ancient genomic block widely distributed in eudicots,whereas almost exclusively emerged in Isodon plants.In the shoot apex,IrCYP706V2 and IrCYP706V7 oxidized the ent-kaurene core in the initial stage of oridonin biosynthesis.Loss of CYP706Vs in other Lamiaceae plants offered an explanation for the specific kaurenoid production in Isodon plants.Moreover,we found that the Isodon genomes encode multiple diterpenoid synthases that are potentially involved in generating diterpenoid diversity.These findings provided new insights into the evolution of the lineage-specific diterpenoid pathway and laid a foundation for improving production of bioactive ent-kaurene-type diterpenoids by molecular breeding and synthetic biology approaches. | Yuwei Sun Jie Shao Haili Liu Hua Wang Guangyi Wang Jianhua Li Yaping Mao Zhuo Chen Ke Ma Lin Xu Yong Wang | 2023 | Molecular Plant2023，16，3： | 0 |
| 6 | Activated carbon fiber mediates efficient activation of peroxymonosulfate systems:Modulation of manganese oxides and cycling of manganese species显示文摘Manganese oxides show a strong catalytic activity in the peroxymonosulfate(PMS)advanced oxidation process but have poor chemical stability and a propensity to cause the aggregation of nanoparticles.Here,a novel composite material(abbreviated as MnO_(x)@ACF)was synthesized,characterized,and applied.Activated carbon fiber(ACF)was selected as a carrier,which modulated the composition of manganese oxides.The results showed that MnO_(x)@ACF had a strong adsorption ability and successfully activated PMS to degrade tetracycline hydrochloride(TCH),with a removal eficiency of 89.0%in 30 min.Influencing factors such as pH and coexisting ion species were investigated,and a five-cycle test was conducted.Singlet oxygen(^(1)O_(2))was predominated in the MnO_(x)@ACF/PMS system.A possible explanatory pathway of TCH was proposed based on the results of the high performance liquid chromatography-mass spectrometry.It was concluded that this study provides a novel insight into the activation of PMS for the degradation of organic matter by carbon-loaded multivalent manganese oxides. | Lixi Xiao Yuwei Deng Huo Zhou Fengjun Lu Chong Ke Yuxuan Ye Xuanyuan Pei Dongsheng Xia Fei Pan | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 7 | Preliminary exploration of the mechanism of compound Qinlan oral liquid against new coronavirus pneumonia based on network pharmacology and molecular docking technology显示文摘Objective:Applying Traditional Chinese Medicine(TCM)network pharmacology and molecular docking technology to explore the mechanism of anti-coronary virus pneumonia(Corona Virus Disease 2019,COVID-19)of Compound Qinlan oral liquid.Methods:Traditional Chinese Medicines Integrated Database(TCMID),Traditional Chinese Medicine Systems Pharmacology(TCMSP),OMIM,GeneCards,String and others online databases were used for building a series of networks,and selecting the core targets and analyzing the signal pathways.Finally,Discovery Studio 2016 software was used to conduct molecular docking of the main compounds(Chinese Medicine Legal Quality Control Compound)of Compound Qinlan oral liquid with key targets ACE2,3CLpro,etc.Results:the results showed that Compound Qinlan oral liquid has specific effects in lung,heart and stomach diseases.The Compound Qinlan oral liquid compound-pneumonia target network contained 98 compounds and 184 corresponding targets,and the core targets involved INS,TP53,IL6,VEGFA,ALB and JUN.GO(GeneOntology)function enrichment analysis yielded 653 GO entries,and KEGG(KyotoEncyclopedia of Genes and Genomes)enrichment screening yielded 112 related pathways,including hypoxia inducible factor-1(HIF-1)and Toll-like receptor(TLRs)signaling pathway related to pneumonia,as well as Influenza A signaling pathway and Hepatitis B signaling pathway related to microbial infection.The results of molecular docking show that Isochlorogenic acid C,Baicalein,etc have good binding capacity with ACE2,3CLpro,AKT1 and other proteins.Conclusion:In this paper,we preliminarily explored the potential therapeutic mechanism for Compound Qinlan oral liquid to against coronavirus pneumonia(COVID-19)and predicted the active ingredients.We hope that the results will help to further study on the active ingredients and mechanism of Compound Qinlan oral liquid for anti-COVID-19. | Hao Wu Chuanxin Liu Yuwei Yang Juan Xue Zhunwei Ke Wei Zheng Tianyi Li Yikun Sun Chenning Zhang | 2020 | TMR Modern Herbal Medicine2020，3，3： | 0 |
| 8 | Response of Urban Planning to Climate Change in Rapidly Urbanizing Area: A Case Study of Nanjing显示文摘Global climate change is the greatest challenge for the survival of civilization in human history, to which a lot of countries all over the world have taken measures including the administrative and technical approaches in the field of urban planning. However, those approaches are mainly in line with the traditional urban planning principles and methodologies, with weak guidance to practice. Especially for the areas which are undergoing rapid urbanization, it is urgent to work on the critical problem of how to draw up city and regional plans to deal with the challenge of climate change by innovating the existing urban planning principles and methodologies. Taking Nanjing as example, this paper firstly puts forward the strategic principles to deal with the climate change in city master planning, including controlling urbanization speed and restricting disordered urban sprawl, balancing ecological system, protecting green spaces and ecologically fragile areas, enhancing the resilient ability to natural disasters and protecting urban security, and promoting sustainable development, etc., then presents the sustainable and flexible urban planning methods including adaptability assessment on spatial development, identification and delimitation of important ecological protection zones, risk assessment and early warning of disasters, clean pro- duction and energy-saving approaches, etc. It further explores some measures to addressing the issue of climate change that are applied in the new City Master Plan of Nanjing, including ① controlling the sprawl of construction land and protecting the ecological carbon sink spaces in order to weaken the impacts of climate change; ② guaranteeing the safety of ecological pattern and maintaining the balance of the urban eco-system in order to ensure the stability of local micro-climate and livable environment; ③ strengthening the regional flood-prevention in order to weaken the threat of natural disasters caused by climate change; ④ giving priority to public transportation and reducing carbon emissions in order to reduce the impacts of urban activities on the atmosphere. | Yuwei QI Chaolin GU Ke SHI | 2013 | China City Planning Review2013，22，2： | 0 |
| 9 | Internal Reference Gene Selection for Quantitative Real-Time RT-PCR Normalization in Potato Tissues显示文摘Quantitative real-time PCR(qRT-PCR)is widely used for investigating gene expression patterns and has many advantages,including its high sensitivity,fidelity,and specificity.Selecting a satisfactory internal reference gene is crucial for obtaining precise gene expression results in qRT-PCR analyses.In this study,the transcriptomic data of 2 potato varieties were screened for housekeeping genes with stable expression patterns.A total of 77 putative genes were selected,which were highly and stably expressed.Then,qRT-PCR analyses were performed to examine the expression levels of these 77 candidate reference genes in various potato tissues,including leaves,flowers,stolons,and tubers.Gene expression was represented by analyzing the Ct values at given threshold.Through geNorm and NormFinder program analyses,10 candidate genes with the most stable expression patterns were obtained,including RPL19,RPS15,RPS9,EF1α,TrxP1,RPS8,NTF,CAM,AACM,and RPS28.Moreover,through the comprehensive analyses of 4 statistical algorithms(i.e.,geNorm,NormFinder,BestKeeper,and RefFinder),results indicated that the most appropriate internal reference genes were RPL19 and EF1α.The obtained stable reference genes will contribute to future qRT-PCR analyses on potato tissue-related gene expression. | Gang Li Yao Zhou Yaqi Zhao Yaxue Liu Yuwei Ke Xiaoqing Jin Haoli Ma | 2020 | Phyton-International Journal of Experimental Botany2020，89，2： | 0 |
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