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| 1 | Research progresses on Cherenkov and transit-time high-power microwave sources at NUDT显示文摘Research progresses on Cherenkov and transit-time high-power microwave(HPM)sources in National University of Defense Technology(NUDT)of China are presented.The research issues are focused on the following aspects.The pulse-shortening phenomenon in O-type Cerenkov HPM devices is suppressed.The compact coaxial relativistic backward-wave oscillators(RBWOs)at low bands are developed.The power efficiency in M-Type HPM tubes without guiding magnetic field increased.The power capacities and power efficiencies in the triaxial klystron amplifier(TKA)and relativistic transit-time oscillator(TTO)at higher frequencies increased.In experiments,some exciting results were obtained.The X-band source generated 2 GW microwave power with a pulse duration of 110 ns in 30 Hz repetition mode.Both L-and P-band compact RBWOs generated over 2 GW microwave power with a power efficiency of over 30%.There is approximately a 75% decline of the volume compared with that of conventional RBWO under the same power capacity conditions.A 1.755 GHz MILO produced 3.1 GW microwave power with power efficiency of 10.4%.A 9.37 GHz TKA produced the 240 MW microwave power with the gain of 34 dB.A 14.3 GHz TTO produced 1 GW microwave power with power efficiency of 20%. | Jiande Zhang Xingjun Ge Jun Zhang Juntao He Yuwei Fan Zhiqiang Li Zhenxing Jin Liang Gao Junpu Ling Zumin Qi | 2016 | Matter and Radiation at Extremes2016，1，3： | 7 |
| 2 | Influence of Surface-functionalized Graphene Oxide on the Cell Morphology of Poly(methyl methacrylate) Composite显示文摘The surface chemistry of filler is closely related to the structure and morphology of nanocomposite foams.Changing the property of filler is widely used to control the cell structures and functionalize the composite foams.Surface-functionalized graphene oxide(GO-ODA) was prepared by grafting octadecylamine(ODA) on the surface of graphene oxide(GO) to make the filler disperse better in the nanocomposites and have a strong interfacial interaction with polymer matrix.Poly(methyl methacrylate)(PMMA)/GO-ODA nanocomposite foams were obtained by solution blending and foamed using supercritical carbon dioxide(scCO_2).Compared to neat PMMA and PMMA/GO samples,the PMMA/GO-ODA nanocomposite foams showed improved cell structures with smaller size,higher cell density and more homogeneous distribution,which should be attributed to the heterogeneous nucleation caused by well-dispersed GO-ODA nanosheets.This work not only improved the compatibility and interfacial interaction of GO with polymer matrix but also indicated that the modified GO sheets can act as ideal filler to control the cell density,size and size distribution efficiently. | Yuwei Wang Xia Liao Yong Luo Qi Yang Guangxian Li | 2015 | Journal of Materials Science & Technology2015，31，5： | 3 |
| 3 | A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver显示文摘尽管纳米技术很快在指向的肿瘤被开发了并且适用,化疗的结果仍然保持极大地在正常纸巾和房间由细胞毒素的药的毒性限制了。因此,与在正常房间的很少副作用,其他的交货系统的开发吸引了增加的注意。精力限制是癌症治疗的一条新奇、有希望的途径,它能经由细胞的精力新陈代谢的抑制限制肿瘤生长。在这研究,指向系统的一个新奇肿瘤,基于叶酸结合牛的浆液白朊(BSA ) ,被开发到共同交付 albendazole 和 nanosilver 同时,制止肿瘤房间的精力新陈代谢。没有 folic 酸修正, nanosilver,或 albendazole,这 nanosystem 用 nanoparticles 比那些显示出更强壮的反肿瘤功效,在 vitro 并且在 vivo。这 nanosystem 弄空经由 glycolytic 酶和 mitochondrial 损坏的直接抑制的细胞的 ATP,导致肿瘤房间的增长,房间周期拘捕,和 apoptosis 的抑制。提高的反肿瘤活动贡献了这个系统的指向肿瘤的能力,导致在肿瘤房间的特定的精力抑制。毒性评估被执行证实这个系统的安全。这 nanosystem 为肿瘤治疗提供有效、安全的策略。 | Jianming Liang Ruixiang Li Yuwei He Chengli Ling Qi Wang Yongzhuo Huang Jing Qin Weigen Lu Jianxin Wang | 2018 | Nano Research2018，11，9： | 3 |
| 4 | Construction of Hierarchical Nanostructured N-doped TiO2 Immobilized Activated Carbon Fiber Porous Composites for Toluene Removal显示文摘The hierarchical nanostructured N-doped TiO2 immobilized activated carbon fiber(N-TiO2/ACF)porous composites are fabricated to removal dynamic toluene gas.The results show that nitrogen ions doping and ACF modification can decrease the band gap of TiO2,leading to red shift toward visible light region.Interestingly,N-TiO2/ACF exhibits strongly synergistic effect owing to high surface area,good crystallinity,enhanced bandgap structure and light harvesting.The toluene removal rate of N-TiO2/ACF composites is 2.29 times higher than that of TiO2.The N-TiO2/ACF for toluene degradation followed the Langmuir-Hinshelwood kinetic model,and the rate constant is enhanced 8 times compared with TiO2.The possible photodegradation pathway and mechanisms are proposed. | Li Yuwei Li Wei Li Meng Liu Fang Qi Xuejin Wang Yongqiang | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，3： | 3 |
| 5 | Association of a potential functional pre‐miR‐218 polymorphism and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk显示文摘 | Yifang Han Rui Pu Xue Han Jun Zhao Weiping Li Jianhua Yin Yuwei Zhang Qiuxia Shen Jiaxin Xie Qi Zhang Shuang Jiang Juhong Li Hongwei Zhang Hongyang Wang Guangwen Cao | 2014 | Liver Int2014，，5： | 1 |
| 6 | A Review of Methods Based on Nanofluids and Biomimetic Structures for the Optimization of Heat Transfer in Electronic Devices显示文摘Nowadays,the utilization rate of electronic products is increasing while showing no obvious sign of reaching a limit.To solve the associated“internal heat generation problem”,scientists have proposed two methods or strategies.The first approach consists of replacing the heat exchange medium with a nanofluid.However,the high surface energy of the nanoparticles makes them prone to accumulate along the heat transfer surface.The second method follows a different approach.It tries to modify the surface structure of the electronic components in order to reduce the fluid-dynamic drag and improve the rate of heat exchange.This article reviews these effects considering different types of nanofluid and different shapes,sizes,and arrangements of“biomimetic grooves”.The idea to use these two methods in a combined fashion(to improve heat transfer and reduce flow resistance at the same time)is also developed and discussed critically to a certain extent. | Lanqi Chen Yuwei Wang Cong Qi Zhibo Tang Zhen Tian | 2022 | Fluid Dynamics & Materials Processing2022，18，5： | 1 |
| 7 | HLA-DP Polymorphisms Affect the Outcomes of Chronic Hepatitis B Virus Infections, Possibly through Interacting with Viral Mutations显示文摘 | Qi Zhang Jianhua Yin Yuwei Zhang Yang Deng Xiaowei Ji Yan Du Rui Pu Yifang Han Jun Zhao Xue Han Hongwei Zhang Guangwen Cao | 2013 | Journal of Virology2013，，22： | 1 |
| 8 | Green‑Solvent Processed Blade‑Coating Organic Solar Cells with an Efficiency Approaching 19%Enabled by Alkyl‑Tailored Acceptors显示文摘Power-conversion-efficiencies(PCEs)of organic solar cells(OSCs)in laboratory,normally processed by spin-coating technology with toxic halogenated solvents,have reached over 19%.However,there is usually a marked PCE drop when the bladecoating and/or green-solvents toward large-scale printing are used instead,which hampers the practical development of OSCs.Here,a new series of N-alkyl-tailored small molecule acceptors named YR-SeNF with a same molecular main backbone are developed by combining selenium-fused central-core and naphthalene-fused endgroup.Thanks to the N-alkyl engineering,NIR-absorbing YR-SeNF series show different crystallinity,packing patterns,and miscibility with polymeric donor.The studies exhibit that the molecular packing,crystallinity,and vertical distribution of active layer morphologies are well optimized by introducing newly designed guest acceptor associated with tailored N-alkyl chains,providing the improved charge transfer dynamics and stability for the PM6:L8-BO:YRSeNF-based OSCs.As a result,a record-high PCE approaching 19%is achieved in the blade-coating OSCs fabricated from a greensolvent o-xylene with high-boiling point.Notably,ternary OSCs offer robust operating stability under maximum-power-point tracking and well-keep>80%of the initial PCEs for even over 400 h.Our alkyl-tailored guest acceptor strategy provides a unique approach to develop green-solvent and blade-coating processed high-efficiency and operating stable OSCs,which paves a way for industrial development. | Hairui Bai Ruijie Ma Wenyan Su Top Archie Dela Pea Tengfei Li Lingxiao Tang Jie Yang Bin Hu Yilin Wang Zhaozhao Bi Yueling Su Qi Wei Qiang Wu Yuwei Duan Yuxiang Li Jiaying Wu Zicheng Ding Xunfan Liao Yinjuan Huang Chao Gao Guanghao Lu Mingjie Li Weiguo Zhu Gang Li Qunping Fan Wei Ma | 2023 | Nano-Micro Letters2023，15，12： | 1 |
| 9 | Dye sensitized solar cells using freestanding TiO 2 nanotube arrays on FTO substrate as photoanode显示文摘 | Qi Pang Limin Leng Lijuan Zhao Liya Zhou Chunjie Liang Yuwei Lan | 2010 | Materials Chemistry and Physics2010，，3： | 1 |
| 10 | Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer显示文摘 | Yuwei Wang Yadong Long Ye Xu Zuqing Guan Peng Lian Junjie Peng Sanjun Cai Guoxiang Cai Qi Li | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 11 | Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway显示文摘Taurolidine(TRD),a derivative of taurine,has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls,endotoxins and exotoxins to inhibit the adhesion of microorganisms.However,its application in antiviral therapy is seldom reported.Here,we reported that TRD significantly inhibited the replication of influenza virus H5N1 in MDCK cells with the half-maximal inhibitory concentration(EC_(50))of 34.45μg/mL.Furthermore,the drug inhibited the amplification of the cytokine storm effect and improved the survival rate of mice lethal challenged with H5N1(protection rate was 86%).Moreover,TRD attenuated virus-induced lung damage and reduced virus titers in mice lungs.Administration of TRD reduced the number of neutrophils and increased the number of lymphocytes in the blood of H5N1 virus-infected mice.Importantly,the drug regulated the NF-κB signaling pathway by inhibiting the separation of NF-κB and IκBa,thereby reducing the expression of inflammatory factors.In conclusion,our findings suggested that TRD could act as a potential anti-influenza drug candidate in further clinical studies. | Chaoxiang Lv Yuanguo Li Tiecheng Wang Qiqi Zhang Jing Qi Mingwei Sima Entao Li Tian Qin Zhuangzhuang Shi Fangxu Li Xuefeng Wang Weiyang Sun Na Feng Songtao Yang Xianzhu Xia Ningyi Jin Yifa Zhou Yuwei Gao | 2023 | Virologica Sinica2023，38，1： | 0 |
| 12 | CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation显示文摘The G protein-coupled receptor ADGRE5(CD97)binds to various metabolites that play crucial regulatory roles in metabolism.However,its function in the antiviral innate immune response remains to be determined.In this study,we report that CD97 inhibits virus-induced type-I interferon(IFN-I)release and enhances RNA virus replication in cells and mice.CD97 was identified as a new negative regulator of the innate immune receptor RIG-I,and RIG-1 degradation led to the suppression of the IFN-I signaling pathway.Furthermore,overexpression of CD97 promoted the ubiquitination of RIG-I,resulting in its degradation,but did not impact its mRNA expression.Mechanistically,CD97 upregulates RNF125 expression to induce RNF125-mediated RIG-I degradation via K48-linked ubiquitination at Lys181 after RNA virus infection.Most importantly,CD97-deficient mice are more resistant than wild-type mice to RNA virus infection.We also found that sanguinarine-mediated inhibition of CD97 effectively blocks VSV and SARS-CoV-2 replication.These findings elucidate a previously unknown mechanism through which CD97 negatively regulates RIG-I in the antiviral innate immune response and provide a molecular basis for the development of new therapeutic strategies and the design of targeted antiviral agents. | Huasong Chang Peili Hou Xuefeng Wang Aibiao Xiang Hao Wu Wenjing Qi Rukun Yang Xue Wang Xingyu Li Wenqi He Guimin Zhao Weiyang Sun Tiecheng Wang Daniel Chang He Hongmei Wang Yuwei Gao Hongbin He | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 13 | Immediate and long-term outcomes after treat-all among people living with HIV in China:an interrupted time series analysis显示文摘Background In 2003,China implemented free antiretroviral therapy(ART)for people living with HIV(PLHIV),establishing an eligibility threshold of CD4<200 cells/μl.Subsequently,the entry criteria were revised in 2012(eligibility threshold:CD4≤350 cells/μl),2014(CD4≤500 cells/μl),and 2016(treat-all).However,the impact of treat-all policy on HIV care and treatment indicators in China is unknown.We aimed to elucidate the immediate and long-term impact of the implementation of treat-all policy in China.Methods Anonymized programmatic data on ART initiation and collection in PLHIV who newly started ART were retrieved between 1 January 2015 and 31 December 2019,from two provincial and municipal Centers for Disease Control and Prevention and ten major infectious disease hospitals specialized in HIV care in China.We used Poisson and quasi-Poisson segmented regression models to estimate the immediate and long-term impact of treat-all on three key indicators:monthly proportion of 30-day ART initiation,mean CD4 counts(cells/μl)at ART initiation,and mean estimated time from infection to diagnosis(year).We built separate models according to gender,age,route of transmission and region.Results Monthly data on ART initiation and collection were available for 75,516 individuals[gender:83.8%males;age:median 39 years,interquartile range(IQR):28-53;region:18.5%Northern China,10.9%Northeastern China,17.5%Southern China,49.2%Southwestern China].In the first month of treat-all,compared with the contemporaneous counterfactual,there was a significant increase in proportion of 30-day ART initiation[+12.6%,incidence rate ratio(IRR)=1.126,95%CI:1.033-1.229;P=0.007]and mean estimated time from infection to diagnosis(+7.0%,IRR=1.070,95%CI:1.021-1.120;P=0.004),while there was no significant change in mean CD4 at ART initiation(IRR=0.990,95%CI:0.956-1.026;P=0.585).By December 2019,the three outcomes were not significantly different from expected levels.In the stratified analysis,compared with the contemporaneous counterfactual,mean CD4 at ART initiation showed significant increases in Northern China(+3.3%,IRR=1.033,95%CI:1.001-1.065;P=0.041)and Northeastern China(+8.0%,IRR=1.080,95%CI:1.003-1.164;P=0.042)in the first month of treat-all;mean estimated time from infection to diagnosis showed significant increases in male(+5.6%,IRR=1.056,95%CI:1.010-1.104;P=0.016),female(+14.8%,IRR=1.148,95%CI:1.062-1.240;P<0.001),aged 26-35(+5.3%,IRR=1.053,95%CI:1.001-1.109;P=0.048)and>50(+7.8%,IRR=1.078,95%CI:1.000-1.161;P=0.046),heterosexual transmission(+12.4%,IRR=1.124,95%CI:1.042-1.213;P=0.002)and Southwestern China(+12.9%,IRR=1.129,95%CI:1.055-1.208;P<0.001)in the first month of treat-all.Conclusions The implementation of treat-all policy in China was associated with a positive effect on HIV care and treatment outcomes.To advance the work of rapid ART,efforts should be made to streamline the testing and ART initiation process,provide comprehensive support services,and address the issue of uneven distribution of medical resources. | Xinsheng Wu Guohui Wu Ping Ma Rugang Wang Linghua Li Yinghui Sun Junjie Xu Yuwei Li Tong Zhang Quanmin Li Yuecheng Yang Lijing Wang Xiaoli Xin Ying Qiao Bingxue Fang Zhen Lu Xinyi Zhou Yuanyi Chen Qi Liu Gengfeng Fu Hongxia Wei Xiaojie Huang Bin Su Hui Wang Huachun Zou | 2023 | Infectious Diseases of Poverty2023，12，4： | 0 |
| 14 | Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis显示文摘Successful wound healing depends on the reconstruction of proper tissue homeostasis,particularly in the posttraumatic inflammatory tissue microenvironment.Diabetes jeopardizes tissues’immune homeostasis in cutaneous wounds,causing persistent chronic inflammation and cytokine dysfunction.Previously,we developed an autologous regeneration factor(ARF)technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound healing.However,treatment efficacy was significantly compromised in diabetic conditions.Therefore,we proposed that a combination of melatonin and ARF,which is beneficial for proper immune homeostasis reconstruction,could be an effective treatment for diabetic wounds.Our research showed that the utilization of melatonin-mediated ARF biogel(AM gel)promoted diabetic wound regeneration at a more rapid healing rate.RNA-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic inflammation.Currently,AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning. | Yixi Yang Le Wang Yonglin Zhou Yijun He Shaozhang Lin Yuwei Zeng Yunhe Zhou Wei Li Zaopeng He Qi Zhao Lihao Chen Zijie Li Wenhao Wang Zhi-Yong Zhang | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 15 | Robust,self-adhesive,and low-contact impedance polyvinyl alcohol/polyacrylamide dual-network hydrogel semidry electrode for biopotential signal acquisition显示文摘Herein,we fabricated a flexible semidry electrode with excellent mechanical performance,satisfactory self-adhesiveness,and low-contact impedance using physical/chemical crosslinked polyvinyl alcohol/polyacrylamide dual-network hydrogels(PVA/PAM DNHs)as an efficient saline reservoir.The resultant PVA/PAM DNHs showed admirable adhesive and compliance to the hairy scalp,facilitating the establishment of a robust electrode/skin interface for biopotential signal transmission.Moreover,the PVA/PAM DNHs steadily released trace saline onto the scalp to achieve the minimized potential drift(1.47±0.39 mV/min)and low electrode–scalp impedance(18.2±8.9 kΩ@10 Hz).More importantly,the application feasibility of real-world brain−computer interfaces(BCIs)was preliminarily validated by 10 participants using two classic BCI paradigms.The mean temporal cross-correlation coefficients between the semidry and wet electrodes in the eyes open/closed and the N200 speller paradigms are 0.919±0.054 and 0.912±0.050,respectively.Both electrodes demonstrate anticipated neuroelectrophysiological responses with similar patterns.This semidry electrode could also effectively capture robust P-QRS-T peaks during electrocardiogram recording.Considering their outstanding advantages of fast setup,user-friendliness,and robust signals,the proposed PVA/PAM DNH-based electrode is a promising alternative to wet electrodes in biopotential signal acquisition. | Guangli Li Ying Liu Yuwei Chen Yonghui Xia Xiaoman Qi Xuan Wan Yuan Jin Jun Liu Quanguo He Kanghua Li Jianxin Tang | 2024 | SmartMat2024，5，2： | 0 |
| 16 | Response of Urban Planning to Climate Change in Rapidly Urbanizing Area: A Case Study of Nanjing显示文摘Global climate change is the greatest challenge for the survival of civilization in human history, to which a lot of countries all over the world have taken measures including the administrative and technical approaches in the field of urban planning. However, those approaches are mainly in line with the traditional urban planning principles and methodologies, with weak guidance to practice. Especially for the areas which are undergoing rapid urbanization, it is urgent to work on the critical problem of how to draw up city and regional plans to deal with the challenge of climate change by innovating the existing urban planning principles and methodologies. Taking Nanjing as example, this paper firstly puts forward the strategic principles to deal with the climate change in city master planning, including controlling urbanization speed and restricting disordered urban sprawl, balancing ecological system, protecting green spaces and ecologically fragile areas, enhancing the resilient ability to natural disasters and protecting urban security, and promoting sustainable development, etc., then presents the sustainable and flexible urban planning methods including adaptability assessment on spatial development, identification and delimitation of important ecological protection zones, risk assessment and early warning of disasters, clean pro- duction and energy-saving approaches, etc. It further explores some measures to addressing the issue of climate change that are applied in the new City Master Plan of Nanjing, including ① controlling the sprawl of construction land and protecting the ecological carbon sink spaces in order to weaken the impacts of climate change; ② guaranteeing the safety of ecological pattern and maintaining the balance of the urban eco-system in order to ensure the stability of local micro-climate and livable environment; ③ strengthening the regional flood-prevention in order to weaken the threat of natural disasters caused by climate change; ④ giving priority to public transportation and reducing carbon emissions in order to reduce the impacts of urban activities on the atmosphere. | Yuwei QI Chaolin GU Ke SHI | 2013 | China City Planning Review2013，22，2： | 0 |
| 17 | Construction and applications of DNA-based nanomaterials in cancer therapy显示文摘As a biologically active macromolecule, deoxyribonucleic acid(DNA) has the advantages of sequence programmability and structure controllability and can accurately transmit sequence information to specific biological functions. Facing the complex internal microenvironment and heterogeneity in tumor treatment, the construction and applications of DNA-based nanomaterials have become a focus point of research. In particular, the hybridization of DNA molecules with other materials endows DNA-based nanomaterials with multiple functions such as targeting, stimulus responsiveness and regulations of biological activities, making DNA nanostructures great potential in the treatment of major human diseases.In this review, the construction and characteristics of DNA-based nanomaterials are introduced. Then,the functions and applications of DNA-based nanomaterials in the delivery of chemotherapy drugs and gene drugs, stimulus-responsive release and regulation of cell homeostasis are reviewed. Finally, the future development and challenges of DNA-based nanomaterials are prospected. We envision that DNAbased nanomaterials can enrich the nanomaterial system by rational design and synthesis and address the growing demands on biological and biomedical applications in the real world. | Hedong Qi Yuwei Xu Pin Hu Chi Yao Dayong Yang | 2022 | Chinese Chemical Letters2022，33，3： | 0 |
| 18 | SrTiO_(3)-CaCr_(0.5)Nb_(0.5)O_(3) solid solutions as p-type photocatalysts for Z-scheme water splitting under visible light illumination显示文摘P-type semiconductivity has been observed in solid solution series(SrTiO_(3))_(1-x)(CaCr_(0.5)Nb_(0.5)O_(3))x(0.0≤x≤0.15),which all adopt cubic symmetry and own intense absorption in the visible light region.These solid solutions are superior H2 evolution photocatalysts under visible light illumination(λ≥400 nm).An AQE as high as 1.02%at 420±20 nm has been achieved at optimal composition(SrTiO_(3))_(0.85)(CaCr_(0.5)Nb_(0.5)O_(3))0.15 which significantly surpasses the parent compounds.Stoichiometric H_(2)/O_(2) production under visible light illumination has been successfully realized using Z-scheme system containing(SrTiO_(3))_(0.85)(CaCr_(0.5) Nb_(0.5) O_(3))_(0.15),WO_(3) and I^(-)/IO_(3)^(-)redox couple. | Zeming Gu Qi Wang Xiaoqin Sun Lingwei Lu Yuwei Zhang Ran Wang Shu Jin Yinlin Shao Jun Qian Xiaoxiang Xu | 2021 | Journal of Materials Science & Technology2021，，28： | 0 |
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