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| 1 | Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells显示文摘声音的刺猬(嘘) 小径在正常胚胎开始和 carcinogenesis 起一个关键作用,但是它在与 5 氟尿嘧啶(5-FU ) 对待的癌症房间的功能仍然保持未知。我们检验了表明小径基因的嘘的一个子集的表示,包括嘘, SMO, PTC1,苏(Fu ) 和在人的 hepatocellular 癌(HCC ) 的臀部房间线, Hep3BandHepG2,由反向的抄写聚合酶链反应与 5-FU 对待。用尝试平底锅蓝色分析, 3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazoliumbromide 试金和终端 deoxynucleotidyl 调停 transferase 的 digoxigenin-dUTP 刻痕结束标记试金,我们也检测了源于表示向量与 5-FU 治疗相结合的 pCS2-Glil 的 transfection 的 Hep3B 房间的 apoptosis。房间的活动性被擦伤创伤闭合试金检测。在 5-FU 对待的 Hep3B 房间的 PTC1 蛋白质的细胞的地点也是的表示和潜水艇由西方的污点分析和免疫调查了荧光灯的显微镜学。结果显示在送信人 RNA 和蛋白质层次的嘘小径目标分子的表示在与 5-FU 对待的 Hep3B 房间是显然下面调整的。过去图形用户界面的表示恢复房间生存能力并且到某程度,移植能力由 5-FU 禁止了。而且, 5-FU 处理影响潜水艇 PTC1 蛋白质的细胞的本地化,在嘘发信号的一个关键成员小径。我们的数据证明表明小径活动的嘘的下面规定在激活刺猬的 HCC 房间线涉及 5-FU-induced apoptosis 和活动性的抑制。这暗示表明小径禁止者和 5-FU-based 化疗的嘘的联合可能对 HCC 代表更有希望的策略。 | Qiyu Wang Shuhong Huang Ling Yang Ling Zhao Yuxia Yin Zhongzhen Liu Zheyu Chen Hongwei Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 10 |
| 2 | Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression. | Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，2： | 2 |
| 3 | BJ-TSA-9 , a Novel Human Tumor-Specific Gene, Has Potential as a Biomarker of Lung Cancer显示文摘 | Yunyan Li Xueyuan Dong Yanhui Yin Yanrong Su Qingwen Xu Yuxia Zhang Xuewen Pang Yu Zhang Weifeng Chen | 2005 | Neoplasia2005，，： | 1 |
| 4 | A Patient-Specific Computational Fluid Dynamic Model of Middle Cerebral Artery Aneurysm Before and One Year After Surgery显示文摘Computational fluid dynamics(CFD)has been widely used for studying intracranial aneurysm hemodynamics,while its use for guiding clinical strategy is still in development.In this study,CFD simulations helped inform treatment decision for a middle cerebral artery(MCA)aneurysm case was investigated.A patient with a 10.4×9.8 mm aneurysm attached with a small aneurysm at the edge of the trifurcation in the left MCA was included in this study.For removing the MCA aneurysm,two scenarios were considered:Plan-A involved clipping the small aneurysm and Plan-B involved clipping the whole aneurysm.A suitable treatment plan was decided by comparing the clinical measurements and CFD analysis between these two plans.One-year after the surgery,the CFD analysis was conducted again on the post-operative aneurysm model to verify the selected surgical plan in terms of morphometric and hemodynamic properties changes in the aneurysm.Based on the CFD simulation and clinical experience,surgical Plan-A was adopted.One-year after the surgery,both the hemodynamic and morphological properties improved in the post-operative aneurysm model,indicating the recovery of the patient.The patient-specific aneurysm CFD analysis can help to determine a better surgical plan for patients with special cerebral aneurysms.This study showed how CFD analysis can be used to aid clinical diagnosis and treatment. | Shicheng He Juhui Qiu Wanling Liu Tieying Yin Dechuan Zhang Donghua Liao Haijun Zhang Yuxia Yin Guixue Wang | 2020 | Molecular & Cellular Biomechanics2020，17，2： | 0 |
| 5 | Preparation and characterization of sodium silicate/epoxy resin composite bonded Nd-Fe-B magnets with high performance显示文摘As an organic binder for bonded Nd-Fe-B magnets, epoxy resin(EP) has poor heat resistance but good moisture resistance, while sodium silicate(SS) has poor moisture absorption but better heat resistance and corrosion resistance. In order to improve high temperature stability and decrease moisture absorption of bonded Nd-Fe-B magnets, EP/SS composites were applied as the binder to prepare bonded Nd-Fe-B magnets. The magnetic properties, moisture absorption, corrosion resistance, compressive strength and microstructure of composite bonded magnets were investigated. The results show that EP/SS bonded magnets can obtain excellent magnetic properties at room temperature, and even useable magnetic properties a thigh temperature environments at 200°C. EP/SS composite binder effectively improves heat resistance and corrosion resistance of bonded Nd-Fe-B magnets, and reduces the hygroscopic properties. The molecule of sodium silicateis rigid and keeps it original shape at high temperature environments. In addition, SS in composite binder improves the mobility of the magnetic powders during the pre-pressing process, which makes the magnetic powders attain a more regular structure. These two factors will increase the mechanical properties. Moreover, sodium silicate in the composite binder can also cover the surfaces protecting the magnetic powders from oxidation and corrosion. EP in composite binder can cover SS surface to reduce the water absorption of SS as epoxy is a hydrophobic material. The EDX analysis shows that the composite binder has accumulated in the gaps of the magnet powders, which not only improves heat resistance and corrosion resistance, but also increases the mechanical properties. Therefore, EP/SS composite binder endows bonded Nd-Fe-B magnets excellent comprehensive properties. | Weiqiang Liu Wang Xi Ruijin Hu Ming Yue Yuxia Yin Jingang Guo Dongtao Zhang Hongguo Zhang | 2019 | Journal of Rare Earths2019，37，10： | 0 |
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