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| 1 | Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection显示文摘Circulating peptide is a potential source of biomarkers for cancer detection.However,the existence of large molecular weight proteins in plasma have a disastrous effect on circulating peptides isolating and detecting.Herein,nanotrap fractionation following by mass spectrometry have been applied to quantify the levels of bradykinin (BK) and hydroxylated bradykinin (Hyp-BK) as a relative measure of KRAS-regulated prolyl-4-hydroxylase alpha-1 (P4HA1) which may serve as early diagnosis marker for pancreatic ductal adenocarcinoma (PDAC).We found that P4HA1 can be upregulated by KRASG12v,which is a PDAC driver mutation,using HPNE/KRAS and HPNE cells.And we revealed that P4HA1 is overexpressed in PDAC tumors,compared to normal and inflamed pancreatic tissues.RNA interference revealed that P4HA1 activity was primarily responsible for Hyp-BK production.Mass spectrometry analysis revealed that plasma Hyp-BK/BK ratio was higher in PDAC than pancreatitis patients and healthy controls,while the area under the receiver operating characteristic (ROC) curve (AUC) is 0.8209 (95%Cl,0.7269-0.9149).The Hyp-BK/BK association with PDAC was reproduced in another cohort,where this ratio was found to increase with advancing tumor stage.These novel findings paved the way for wider applications of Nanotrap coupled mass spectrometry as a powerful tool for revealing biosignatures from plasma. | Zaian Deng Zhen Zhao Bo Ning Jeffery Basilio Karen Mann Jie Fu Yajun Gu Yuanqing Ye Xifeng Wu Jia Fan Paul Chiao Tony Hu | 2019 | Nano Research2019，12，6： | 2 |
| 2 | A unified framework for protecting sensitive association rules in business collaboration 显示文摘 | Oliveira SRM Zaiane OR | 2006 | Int''l Journal of Business Intelligence and Data Mining2006，1，3： | 1 |
| 3 | Building Virtual Web Views显示文摘 | | 2001 | Data and Knowledge Engineering2001，，39： | 1 |
| 4 | An optimized cost -sensitive SVM for imbalanced data learning显示文摘 | Cao P Zhao D Zaiane O | 2013 | Lecture Notes in Computer Science2013，，： | 1 |
| 5 | Privacy preserving clustering by data transformation 显示文摘 | OLIVEIRA S R M ZAIANE 0 R | 2010 | Journal of Information and Data Management2010，1，1： | 1 |
| 6 | A Unified Framework for Protecting Sensitive Association Rules in Business Collaboration显示文摘 | Oliveira S R M Zaiane O R | 2006 | Int''l Journal of Business Intelligence and Data Mining2006，1，3： | 1 |
| 7 | Associative Classifiers for Medical image 显示文摘 | Maria- Luiza Antonie Osmar R Zaiane | 2003 | Mining Multimedia and Canplex Data2003，27，： | 1 |
| 8 | Associative Clas- sifters for Medical image 显示文摘 | Maria- Luiza Antonie Osmar R Zaiane | 2003 | Mining Multimedia and Complex Data2003，27，： | 1 |
| 9 | Clustering highdimensional data: A graph-based relaxed optimizationapproach显示文摘 | Lee C H Zaiane O R Park H-H | 2008 | Information Sciences2008，178，23： | 1 |
| 10 | An optimized cost-sensitive SVM for imbalanced data learning显示文摘 | Cao P Zhao D Z Zaiane O | 2013 | Lecture Notes in Computer Science2013，7819，1： | 1 |
| 11 | Clustering High Dimen sional Data: A Graph-based Relaxed Optimization Approach显示文摘 | Lee C-H Zaiane O R Park H H | 2008 | Information Sciences2008，178，23： | 1 |
| 12 | DMQL:A Data Mining Query Lan guage for Relational Database显示文摘 | Jiawei Han Yongjian Fu Wei Wang Krzysztof Kopers ki Osmar Zaiane | | VLDB0，96，： | 1 |
| 13 | A Unified Framework for Protecting Sensitive Association Rules in Business Collaboration显示文摘 | Oliveira S R M Zaiane O R | 2006 | International Journal of Business Intelligence and Data Mining2006，1，3： | 1 |
| 14 | Associative Classifiers for Medical irnage显示文摘 | Maria - Luiza Antonie Osmar R Zaiane | 2003 | Mining Multimedia and Complex Data2003，2797，： | 1 |
| 15 | Classifying text documents by associating terms with text categories 显示文摘 | Osmar R Zaiane Maria-Luiza Antonie | 2002 | Australian Computer Science Communications2002，24，2： | 1 |
| 16 | Density Measurement of Liquid Ni-Ta Alloy by a Modified Pycnometric Method显示文摘 | Fang Liang(方亮) Tao Zaian(陶再南) Xiao Feng(肖锋) | 2003 | Rare Metal Materials and Engineering(稀有金属材料与工程)2003，329，： | 1 |
| 17 | On data clustering analysis;scalability, constraints, and validation显示文摘 | ZAIANE O R FOSS A LEE C H | 2002 | Lecture Notes in Computer Science2002，2336，： | 1 |
| 18 | Classifying text documents by associating terms with text categories显示文摘 | Osmar R Zaiane Maria-Luiza Antonie | 2002 | Australian Computer Science Communications2002，24，2： | 1 |
| 19 | MultiMediaMiner:A System Prototype for Multimedia Data Mining显示文摘 | Zaiane | 1998 | Procceedings ACMSIGMOD International Conference on Management of Data Washington June1998，1998，： | 1 |
| 20 | Building Virtual Web Views 显示文摘 | Zaiane Osmar R | 2001 | Data and Knowledge Engineering2001，39，2： | 1 |
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