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| 1 | Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses显示文摘Macrophages are typically identified as classically activated(M1) macrophages and alternatively activated(M2) macrophages,which respectively exhibit pro-and anti-inflammatory phenotypes,and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation,injury,and repair processes.Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles(EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury and vice versa.This review discusses the roles of such EVs in resulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions,and the potential applications,advantage and concerns for using EV-based therapeutic approaches to treat such conditions,including their potential role of drug carriers for the treatment of infectious diseases. | Qian Hu Christopher J.Lyon Jesse K.Fletcher Wenfu Tang Meihua Wan Tony Y.Hu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 22 |
| 2 | MAJOR-EFFICIENT SOLUTIONS AND WEAKLY MAJOR-EFFICIENT SOLUTIONS OF MULTIOBJECTIVE PROGRAMMING显示文摘MAJOR-EFFICIENTSOLUTIONSANDWEAKLYMAJOR-EFFICIENTSOLUTIONSOFMULTIOBJECTIVEPROGRAMMING￥HUYUDA(Dept.ofAppl.Math.,ShanghaiJiaoTon... | HU YUDA(Dept.of Appl.Math.,Shanghai Jiao Tony Univ.,Shanghai 200030) | 1994 | Applied Mathematics(A Journal of Chinese Universities)1994，9，1： | 12 |
| 3 | Clinical applications of exosome membrane proteins显示文摘Extracellular vesicles(EVs)are small membranous particles that can mediate cell-to-cell communication and which are divided into at least three categories according to their subcellular origin and size:exosomes,microvesicles,and apoptotic bodies.Exosomes are the smallest(30–150 nm)of these EVs,and play an important role in EV-mediated cell-to-cell interactions,by transferring proteins,nucleic acids and,lipids from their parental cells to adjacent or distant cells to alter their phenotypes.Most exosome studies in the past two decades have focused on their nucleic acid composition and their transfer ofmRNAs and microRNAs to neighboring cells.However,exosomes also carry specific membrane proteins that can identify the physiological and pathological states of their parental cells or indicate their preferential target cells or tissues.Exosome membrane protein expression can also be directly employed or modified to allow exosomes to serve as drug delivery systems and therapeutic platforms,including in targeted therapy approaches.This review will briefly summarize information on exosome membrane proteins components and their role in exosome–cell interactions,including proteins associated with specific cell-interactions and diseases,and the potential for using exosome membrane proteins in therapeutic targeting approaches. | Qian Hu Hang Su Juan Li Christopher Lyon Wenfu Tang Meihua Wan Tony Ye Hu | 2020 | Precision Clinical Medicine2020，3，1： | 6 |
| 4 | On generation source sites of internal waves in the Luzon Strait显示文摘This effort aims to determine the generation source sites in the Luzon Strait for energetic,long-crest,transbasin internal waves(IW)observed in the northern South China Sea(NSCS).The roles of islands distributed on eastern side of the strait,Kuroshio,submarine ridges,shoaling thermocline,and strait configuration played in the IW generation are examined using the cruise data analysis,satellite data interpretation,and dynamical analysis.The islands and channels on eastern side of the strait are excluded from a list of possible IW source sites owing to their unmatched horizontal dimensions to the scale of IW crest line length,and the relative low Reynolds number.The Kuroshio has a potential to be a radiator for the long-crest IW disturbances,meanwhile,the Kuroshio west(east)wing absorbs the eastward(westward)propagating IW disturbance.Namely,the Kuroshio blockades the outside west-east propagating IW disturbances.The 3-D configuration of the Luzon Strait is characterized by a sudden,more than one order widening of the cross-section areas at the outlets on both sides,providing a favorable condition for IW type initial disturbance formation.In the Luzon Strait,the thermocline is featured by a westward shoaling all the year around,providing the dynamical conditions for the amplitude growth(declination)to the westward(eastward)propagating IW type disturbance.Thus,the west slope of western submarine ridge at the western outlet of the Luzon Strait is a high possibility source sites for energetic,long-crest,transbasin IWs in the NSCS.The interpretation results of satellite SAR images during a 13 a period from 1995 to 2007 provide the convincing evidence for the conclusions. | ZHENG Quanan SONG Y Tony LIN Hui HU Xiaomin MENG Junmin WANG Dan | 2008 | Acta Oceanologica Sinica2008，27，3： | 5 |
| 5 | Computational neuroscience:a frontier of the 21^st century显示文摘THEORY IN NEUROSCIENCE The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors,thoughts,emotions and consciousness.Although comprising only 2%of the total body weight,the brain consumes about 20%of the oxygen entering the body.With the expensive energy demand,the brain enables us to perceive and act upon the external world,as well as reflect on our internal thoughts and feelings. | Xiao-Jing Wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou | 2020 | National Science Review2020，7，9： | 4 |
| 6 | Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection显示文摘Circulating peptide is a potential source of biomarkers for cancer detection.However,the existence of large molecular weight proteins in plasma have a disastrous effect on circulating peptides isolating and detecting.Herein,nanotrap fractionation following by mass spectrometry have been applied to quantify the levels of bradykinin (BK) and hydroxylated bradykinin (Hyp-BK) as a relative measure of KRAS-regulated prolyl-4-hydroxylase alpha-1 (P4HA1) which may serve as early diagnosis marker for pancreatic ductal adenocarcinoma (PDAC).We found that P4HA1 can be upregulated by KRASG12v,which is a PDAC driver mutation,using HPNE/KRAS and HPNE cells.And we revealed that P4HA1 is overexpressed in PDAC tumors,compared to normal and inflamed pancreatic tissues.RNA interference revealed that P4HA1 activity was primarily responsible for Hyp-BK production.Mass spectrometry analysis revealed that plasma Hyp-BK/BK ratio was higher in PDAC than pancreatitis patients and healthy controls,while the area under the receiver operating characteristic (ROC) curve (AUC) is 0.8209 (95%Cl,0.7269-0.9149).The Hyp-BK/BK association with PDAC was reproduced in another cohort,where this ratio was found to increase with advancing tumor stage.These novel findings paved the way for wider applications of Nanotrap coupled mass spectrometry as a powerful tool for revealing biosignatures from plasma. | Zaian Deng Zhen Zhao Bo Ning Jeffery Basilio Karen Mann Jie Fu Yajun Gu Yuanqing Ye Xifeng Wu Jia Fan Paul Chiao Tony Hu | 2019 | Nano Research2019，12，6： | 2 |
| 7 | On mining multi-time-interval sequential patterns 显示文摘 | Hu Yahan Tony Cheng-kui Huang Yang HuiRu | 2009 | Data: Knowledge Engineering2009，，68： | 1 |
| 8 | On mining multi-time-interval sequential patterns显示文摘 | Ya-Han Hu Tony Cheng-Kui Huang Hui-Ru Yang | 2009 | Data & Knowledge Engineering2009，，： | 1 |
| 9 | Identification of Fat4 as a candidate tumor suppressor gene in breast cancers显示文摘 | Qi Chao Zhu giwei Tony Hu Liping | 2009 | Int J Cancer2009，124，4： | 1 |
| 10 | Developing Social Citizenship? A Case Study of Education and Health Services in Yantian Village of Guangdong Province显示文摘社会政策是统治的一个不可缺少的元素,中国的当前的领导移动了政策到更多包括系统基于公民资格的一个观点。社会福利预备的延期在 Yantian 的华南村庄里通过教育和护理的案例研究被检验。Yantian 躺在珍珠河三角洲的核心,它在生产和生产的全球重组成为了一个关键连接。因而村庄在家到补充 3000 个登记居民的大约 80 000 个候鸟工人。教育和保健预备的研究以公平揭示那,登记村民在寻求福利资源享受重要优点。尽管住在一样的村庄,二个组住在不同世界。然而,预备选择,成为了更多包括。现在的研究建议社会公民资格将先于政治公民资格。 | Biliang Hu Tony Saich | 2012 | China & World Economy2012，20，3： | 1 |
| 11 | A Study of Modular AWGs for Large-Scale Optical Switching Systems 显示文摘 | Ye Tong Lee Tony T Hu Weisheng | 2012 | J Lightwave Technol2012，，30： | 1 |
| 12 | Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (?/?) mice显示文摘 | Rong Hu Changjiang Xu Guoxiang Shen Mohit R. Jain Tin Oo Khor Avantika Gopalkrishnan Wen Lin Bandaru Reddy Jefferson Y. Chan Ah-Ng Tony Kong | 2006 | Cancer Letters2006，，2： | 1 |
| 13 | Modulatory Properties of Various Natural Chemopreventive Agents on the Activation of NF-κB Signaling Pathway显示文摘 | Woo-Sik Jeong In-Wha Kim Rong Hu Ah-Ng Tony Kong | 2004 | Pharmaceutical Research2004，，4： | 1 |
| 14 | Evolution of the Raman spectrum of graphene grown on copper upon oxidation of the substrate显示文摘在在一部铜电影上种的单个层的 graphene 的拉曼光谱的重要变化在发生在周围的条件下面的内在的底层的自发的氧化以后被观察。graphene G 和 2D 拉曼模式的频率被发现经历红移动,当二个乐队的紧张由超过一个数量级变化时。为了理解这些的起源,完成,我们进一步由扫描通道描绘了样品显微镜学(STM ) ,扫描通道光谱学(圣) ,和原子力量显微镜学(AFM ) 。没有破坏 graphene overlayer 的水晶的顺序或改变做水平的搬运人,底层的氧化在底层生产了可估计的折皱。我们以 graphene 层的折皱导致的张力的紧张解释拉曼频率的红移动。在有氧化的拉曼紧张的变化从对在散布过程的拉曼结合 graphene 层的光的效率的薄亚铜的氧化物电影的影响产生。 | XiuliYin Yilei Li Fen Ke Chenfang Lin Huabo Zhao Lin Gan Zhengtang Luo Ruguang Zhao Tony F. Heinz Zonghai Hu | 2014 | Nano Research2014，7，11： | 1 |
| 15 | SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites显示文摘Identification of epitopes targeted following virus infection or vaccination can guide vaccine design and development of therapeutic interventions targeting functional sites,but can be laborious.Herein,we employed peptide microarrays to map linear peptide epitopes(LPEs)recognized following SARS-CoV-2 infetion and vaccination.LPEs detected by nonhuman primate(NHP)and patient IgMs after SARS-CoV-2 infection extensively overlapped,localized to functionally important virus regions,and aligned with reported neutralizing antibody binding sies.Similar LPE overlap occurred atfter infection and vaccination,with LPE clusters specifc to each stimulus,where strong and conserved LPEs mapping to sites known or likely to inhibit spike protein function.Vaccine-specifc LPEs tended to map to sites known or likely to be afected by structural changes induced by the proline substitutions in the mRNA vaccine's S protein.Mapping LPEs to regions of known functional importance in this manner may acelerate vaccine evaluation and discovery of targets for sile secific therapeutic interventions. | Li Yang Te Liang Lane M.Pierson Hongye Wang Jesse K.Fletcher Shu Wang Duran Bao Lii Zhang Zhen Huang Wenshu Zheng Xiaomei Zhang Heewon Park Yuwen Li James E.Robinson Amy K.Fechan Christopher J.Lyon Jing Cao Lisa A.Morici Chenzhong Li Chad J.Roy Xiaobo Yu Tony Hu | 2022 | Research2022，，2： | 0 |
| 16 | Exploring the impact of a coordinated variable speed limit control on congestion distribution in freeway显示文摘Over the past few decades,urban freeway congestion has been highly recognized as a serious and worsening traffic problem in the world.To relieve freeway congestion,several active traffic and demand management(ATDM) methods have been developed.Among them,variable speed limit(VSL) aims at regulating freeway mainline flow upstream to meet existing capacity and to harmonize vehicle speed.However,congestion may still be inevitable even with VSL implemented due to extremely high demand in actual practice.This study modified an existing VSL strategy by adding a new local constraint to suggest an achievable speed limit during the control period.As a queue is a product of the congestion phenomenon in freeway,the incentives of a queue build-up in the applied coordinated VSL control situation were analyzed.Considering a congestion occurrence(a queue build-up)characterized by a sudden and sharp speed drop,speed contours were utilized to demonstrate the congestion distribution over a whole freeway network in various scenarios.Finally,congestion distributions found in both VSL control and non-VS control situations for various scenarios were investigated to explore the impact of the applied coordinated VSL control on the congestion distribution.An authentic stretch of Whitemud Drive(WMD),an urban freeway corridor in Edmonton,Alberta,Canada,was employed to implement this modified coordinated VSL control strategy;and a calibrated micro-simulation VISSIM model(model functions) was applied as the substitute of the real-world traffic system to test the above mentioned performance.The exploration task in this study can lay the groundwork for future research on how to improve the presented VSL control strategy for achieving the congestion mitigation effect on freeway. | Jing Cao Dawei Hu Ying Luo Tony Z.Qiu Zhuanglin Ma | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，3： | 0 |
| 17 | Fluorescent probes and functional materials for biomedical applications显示文摘Due to their simplicity in preparation,sensitivity and selectivity,fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields,facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular level.In addition,many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescenceguided disease diagnosis and theranostics(e.g.,fluorogenic prodrugs).Impressive progresses have been made in the development of sensing agents and materials for the detection of ions,organic small molecules,and biomacromolecules including enzymes,DNAs/RNAs,lipids,and carbohydrates that play crucial roles in biological and disease-relevant events.Here,we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues“Fluorescent Probes”and“Molecular Sensors and Logic Gates”recently published in this journal,offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation. | Xi-Le Hu Hui-Qi Gan Fan-De Meng Hai-Hao Han De-Tai Shi Shu Zhang Lei Zou Xiao-Peng He Tony D.James | 2022 | Frontiers of Chemical Science and Engineering2022，16，10： | 0 |
| 18 | Extracellular vesicles in the pathogenesis and treatment of acute lung injury显示文摘Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are common life-threatening lung diseases associated with acute and severe inflammation.Both have high mortality rates,and despite decades of research on clinical ALI/ARDS,there are no effective therapeutic strategies.Disruption of alveolar-capillary barrier integrity or activation of inflammatory responses leads to lung inflammation and injury.Recently,studies on the role of extracellular vesicles(EVs)in regulating normal and pathophysiologic cell activities,including inflammation and injury responses,have attracted attention.Injured and dysfunctional cells often secrete EVs into serum or bronchoalveolar lavage fluid with altered cargoes,which can be used to diagnose and predict the development of ALI/ARDS.EVs secreted by mesenchymal stem cells can also attenuate inflammatory reactions associated with cell dysfunction and injury to preserve or restore cell function,and thereby promote cell proliferation and tissue regeneration.This review focuses on the roles of EVs in the pathogenesis of pulmonary inflammation,particularly ALI/ARDS. | Qian Hu Shu Zhang Yue Yang Jia‑Qi Yao Wen‑Fu Tang Christopher J.Lyon Tony Ye Hu Mei‑Hua Wan | 2023 | Military Medical Research2023，10，4： | 0 |
| 19 | Development and validation of a rapid UPLC/MS method for the simultaneous determination of I3C, DIM, and related metabolites and its application to pharmacokinetics studies显示文摘Indole-3-carbinol(I3C) and diindolylmethane(DIM) are naturally derived dietary phytochemicals with promising anti-cancer properties that have been demonstrated both in vitro and in vivo. Using reversed-phase ultra-performance liquid chromatography(UPLC) coupled with mass spectrometry(MS), a rapid, specific, and high throughput method was developed and validated for the quantification and identification of I3 C, DIM, and other I3 C metabolites in plasma. Samples containing I3 C or DIM and the internal standard 4-methoxy indole(IS) were extracted using a liquid-liquid extraction technique. The mean recovery was 96.21% for I3 C and 108.5% for DIM. Separation was achieved using a Waters Acquity UPLC HSS T3, 1.8 μm, 2.1 mm×150 mm column and acetonitrile–water gradient elution. The flow rate was 0.3 m L/min and the run time was 9 min. The limits of detection and quantification for I3 C and DIM were 15 ng/m L and 25 ng/m L, respectively. Calibration curves for I3 C and DIM were linear(r2>0.99) over a concentration range of 0.025–20 μg/m L. Precision, accuracy, and stability analysis fulfilled the CDER guidelines criteria. The method was successfully applied to the determination of the pharmacokinetic parameters of I3 C or DIM after oral, intravenous, or intraperitoneal administration to Sprague Dawley rats. The method described here is superior over existing analytical methods for I3 C and its metabolites in terms of sensitivity, speed, and separation. | Yury Gomez Hu Wang Ah-Ng Tony Kong | 2016 | Journal of Chinese Pharmaceutical Sciences2016，25，7： | 0 |
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