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| 1 | Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus显示文摘BACKGROUND Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs(miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic fibrosis.AIM To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.METHODS This prospective study included 208 patients and 82 age-and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological scoring.RESULTS The ADC value decreased significantly with the progression of fibrosis, from controls(F0) to patients with early fibrosis(F1 and F2) to those with late fibrosis(F3 and F4)(median 1.92, 1.53, and 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off ADC value used to differentiate patients from controls was 1.83 × 10^(-3) mm^2/s with an area under the curve(AUC) of 0.992. Combining ADC and miR-200 b revealed the highest AUC(0.995) for differentiating patients from controls with an accuracy of 96.9%. The cut-off ADC used to differentiate early fibrosis from late fibrosis was 1.54 × 10^(-3) mm^2/s with an AUC of 0.866. The combination of ADC and miR-200 b revealed the best AUC(0.925) for differentiating early fibrosis from late fibrosis with an accuracy of 80.2%. The ADC correlated with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), and miR-29(r = 0.52,P = 0.001).CONCLUSION Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C. | Tarek Besheer Hatem Elalfy Mohamed Abd El-Maksoud Ahmed Abd El-Razek Saher Taman Khaled Zalata Wagdy Elkashef Hossam Zaghloul Heba Elshahawy Doaa Raafat Wafaa Elemshaty Eman Elsayed Abdel-Hady El-Gilany Mahmoud El-Bendary | 2019 | World Journal of Gastroenterology2019，25，11： | 9 |
| 2 | Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?显示文摘AIM: To evaluate transient elastography(TE) as a noninvasive tool in staging liver fibrosis compared with liver biopsy and morphometry in children with different chronic liver diseases.METHODS: A total of 90 children [50 with chronic hepatitis C virus(HCV), 20 with autoimmune hepatitis(AIH) and 20 with Wilson disease] were included in the study and underwent liver stiffness measurement(LSM) using TE. Liver biopsies were evaluated for fibrosis, qualitatively, by Ishak score and quantitatively by fibrosis area fraction(FAF) using digital image analysis(morphometry). LSM was correlated with fibrosis and other studied variables using spearman correlation. A stepwise multiple regression analysis was alsoperformed to examine independent factors associated with LSM. Different cut-off values of LSM were calculated for predicting individual fibrosis stages using receiveroperating characteristic curve. Cut-off values with optimal clinical performance(optimal sensitivity and specificity simultaneously) were selected.RESULTS: The majority of HCV group had minimal activity(80%) and no/mild fibrosis(72%). On the other hand, the majority of AIH group had mild to moderate activity(70%) and moderate to severe fibrosis(95%) and all Wilson disease group had mild to moderate activity(100%) and moderate to severe fibrosis(100%). LSM correlated significantly with both FAF and Ishak scores and the correlation appeared better with the latter(r = 0.839 vs 0.879, P < 0.0001 for both). LSM discriminated individual stages of fibrosis with high performance. Sensitivity ranged from 81.4% to 100% and specificity ranged from 75.0% to 97.2%. When we compared LSM values for the same stage of fibrosis, they varied according to the different etiologies. Higher values were in AIH(16.15 ± 7.23 k Pa) compared to Wilson disease(8.30 ± 0.84 k Pa) and HCV groups(7.43 ± 1.73 k Pa). Multiple regression analysis revealed that Ishak fibrosis stage was the only independent variable associated with higher LSM(P < 0.0001).CONCLUSION: TE appears reliable in distinguishing different stages of liver fibrosis in children. However, its values vary according to the disease type. For that, a disease-specific estimation of cut-off values for fibrosis staging is worthy. | Behairy El-Sayed Behairy Mostafa Mohamed Sira Khaled Refat Zalata El-Sayed Ebrahem Salama Mohamed Ahmed Abd-Allah | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 3 | Evaluation of serum biomarkers of fibrosis and injury in Egyptian patients with chronic hepatitis C显示文摘 | Gamal Esmat Mohamed Metwally Khalid R. Zalata Shahinaz Gadalla Mohamed Abdel-Hamid Amr Abouzied Abdel-Aziz Shaheen Maissa El-Raziky Hani Khatab Sherif El-Kafrawy Nabiel Mikhail Laurence S. Magder Nezam H. Afdhal G. Thomas Strickland | 2007 | Journal of Hepatology2007，，4： | 2 |
| 4 | Ibrahim Modulation of carbon tetrachloride-induced hepatic oxidative stress,injury and fibrosis by olmesartan and omega-3显示文摘 | Shabaan AA Shaker ME Zalata KR | 2013 | Chem Biol Interact2013，2797，13： | 1 |
| 5 | p53, Bcl-2 and C-Myc ex- pressions in colorectal carcinoma associated with schistosomiasis in Egypt显示文摘 | Zalata KR Nasif WA Ming SC | 2005 | Cell Oncol2005，27，4： | 1 |
| 6 | Frequency of central nervous system tumors in delta region,Egypt显示文摘 | Zalata K R El-Tantawy D A Abdel-Aziz A | 2011 | Indian J Pathol Microbiol2011，54，2： | 1 |
| 7 | Relationship between resazurin reduction test, reactive oxygen species generation, and gamma-glutamyltransferase 显示文摘 | Zalata A Hafez T Mahmoud A | 1995 | Human Reproduction1995，10，5： | 1 |
| 8 | Influence of inhaled beclomethasone and montelukast on airway remodeling in mice 显示文摘 | ABDEL AZIZ R R HELALY N Y ZALATA K R | 2012 | Inflammopharmacology2012，，： | 1 |
| 9 | Influence of inhaled beclomethasone and montelukast on airway remodeling in mice 显示文摘 | Abdel Aziz RR Helaly NY Zalata KR | 2013 | Inflammopharmacology2013，21，1： | 1 |
| 10 | Evaluation of beta-endorphin and interleukin-6 in seminal plasma of patients with certain and rological diseases显示文摘 | Zalata A Hafez T Van Hoecke MI et a1 | 1995 | HumReprod1995，10，12： | 1 |
| 11 | Patophysiological effect of varicocele treatment显示文摘 | Comhaire F Zalata A Mahmoud A | 1998 | Urologe1998，37，3： | 1 |
| 12 | Wives Involevement in Tourism De-cision Processes 显示文摘 | Antoine Zalata Miao Xueling | 1998 | Annals of Tourism Research1998，25，4： | 1 |
| 13 | p53, Bcl-2 and C-Myc expressions in colorectal carcinoma associated with schistosomiasis in Egypt显示文摘 | Zalata KR Nasif WA Ming SC | 2005 | Cell Oncol2005，27，4： | 1 |
| 14 | Morphometric assessment of liver fibrosis may enhance early diagnosis of biliary atresia显示文摘 | Abdalla AF Fathy A Zalata KR | | 0，，04： | 1 |
| 15 | 查看详情显示文摘 | Canhaire F Zalata A Mahmoud A | | 0，，： | 1 |
| 16 | Evaluation of beta- endorphin and interleukin - 6 in seminal plasma of patients with certain andrological diseases显示文摘 | Hafez T Van Hoecke MI | 1995 | Hum Reprod1995，10，12： | 1 |
| 17 | Relationship between resazurin reduction test,reactive oxygen species generation,and gamma-glutamyltransferase显示文摘 | Zalata A Hafez T Mahmoud A | 1995 | Hum Reprod1995，10，5： | 1 |
| 18 | Evalution of the role of reactive oxygen species in male infertility显示文摘 | Zalata A Hafez T Comhaire F | 1995 | Hum Reprod1995，10，： | 1 |
| 19 | ACE Gene Insertion/Deletion Polymorphism Seminal Associations in Infertile Men 显示文摘 | Zalata AA Morsy HK Badawy A | 2012 | J Urol2012，187，5： | 1 |
| 20 | Late post-cesarean surgical complication 显示文摘 | FAWZY M ZALATA K | 2010 | J Obstet Gynaecol2010，36，3： | 1 |
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