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| 1 | Characteristics of common solid liver lesions and recommendations for diagnostic workup显示文摘Due to the widespread clinical use of imaging modalities such as ultrasonography,computed tomography and magnetic resonance imaging (MRI),previously unsuspected liver masses are increasingly being found in asymptomatic patients.This review discusses the various characteristics of the most common solid liver lesions and recommends a practical approach for diagnostic workup.Likely diagnoses include hepatocellular carcinoma (the most likely;a solid liver lesion in a cirrhotic liver) and hemangioma (generally presenting as a mass in a non-cirrhotic liver).Focal nodular hyperplasia and hepatic adenoma should be ruled out in young women.In 70% of cases,MRI with gadolinium differentiates between these lesions.Fine needle core biopsy or aspiration,or both,might be required in doubtful cases.If uncertainty persists as to the nature of the lesion,surgical resection is recommended.If the patient is known to have a primary malignancy and the lesion was found at tumor staging or follow up,histology is required only when the nature of the liver lesion is doubtful. | Nimer Assy Gattas Nasser Agness Djibre Zaza Beniashvili Saad Elias Jamal Zidan | 2009 | World Journal of Gastroenterology2009，15，26： | 9 |
| 2 | Lower baseline ALT cut-off values and HBV DNA levels better differentiate HBeAg(-) chronic hepatitis B patients from inactive chronic carriers显示文摘AIM:To determine whether new cut-off values for alanine aminotransferase(ALT)and baseline hepatitis B virus(HBV)DNA levels better differentiate HBeAg(-) chronic hepatitis B(CHB)patients from inactive chronic carriers. METHODS:Ninety-one patients[32 HBeAg(+)CHB, 19 inactive carriers and 40 HBeAg(-)CHB]were followed up for 2 years and were tested for HBV DNA levels by a PCR-based assay.ALT was tested twice during the last 6 mo using new cut-off values:ULN(upper limit of normal)30 IU/L for males,19 IU/L for females. Diagnostic accuracy,sensitivity,specificity,positive and negative predictive values were calculated by discriminant analysis. RESULTS:When using the revised ALT cut-off values, the lowest optimal HBV DNA level that differentiated HBeAg(-)CHB patients from inactive carriers was 50000 copies/mL.The diagnostic accuracy of HBV DNA to determine inactive carriers with a cut-off of 50000 copies/mL was similar to the previously recommended cut-off of 100 000 copies/mL(91%).HBV DNA levels were lower than the cut-off value in 95%of inactive carriers and in 28%of HBeAg(-)CHB patients.With ALT<30 IU/L in men and<19 IU/L in women and HBV DNA levels<100 000 copies/mL,the risk of CHB is 5%.On the other hand,if ALT values were>30 IU in men and>19 IU in women and baseline HBV DNA levels were>100000 copies/mL,the risk is 86%. CONCLUSION:New cut-off values for ALT together with HBV DNA levels proposed by AASLD(American Association for the Study of Liver Diseases)and NIH (National Institute of Health)consensus seem appropriate to characterize inactive carriers. | Nimer Assy Zaza Beniashvili Agness Djibre Gattas Nasser Maria Grosovski William Nseir | 2009 | World Journal of Gastroenterology2009，15，24： | 7 |
| 3 | Prevalence of intestinal parasitic infections and its relationship with socio-demographics and hygienic habits among male primary schoolchildren in Al-Ahsa,Saudi Arabia显示文摘Objective:To investigate the prevalence of different intestinal parasitic infections among male primary schoolchildren in Al-Ahsa,Saudi Arabia,and to explore the possible relative socioeconomic, environmental and behavioural sanitary correlates.Methods:A cross-sectional descriptive study was performed.A total of 1 289 male students aged from 7 to 12 years were selected randomly from 20 urban and 12 rural primary schools by multistage sampling method. Data collection was carried out by self administered questionnaire form to the parents/guardians of students and included inquires about socio-demographics,environmental conditions,and behavioural sanitary habits.Stool analysis was carried out to examine the presence of intestinal parasitic infections.Results:Overall prevalence of parasitic infections was 27.2%,more among rural students.Frequently encountered infections included Entamoeba histolytica/dispar(8.2%), Giardia lamblia(6.5%),Entamoeba coli(4.0%) and Enterobius vermicularis(1.6%).Logistic regression revealed that lower maternal educational level and occupational status,low family income,big family size,poor personal hygienic practices and positive history of previous intestinal infections among family members increased the likelihood of infections.Conclusions: Although of low magnitude,intestinal parasitic infections still represent a public health concern among male schoolchildren in Al-Ahsa region.Socio-demographic and poor personal hygienic habits are the main predictors for these infections. | Hamdan Ibrahim Al-Mohammed Tarek Tawfik Amin Elsayed Aboulmagd Hatem Refaat Hablus Burhan Omar Zaza | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，11： | 3 |
| 4 | Reviews of evidence re- garding interventions to increase use of child safety seats 显示文摘 | Zaza S Sleet DA Thompson RS | 2001 | Am J Prev Med2001，21，4： | 1 |
| 5 | Paroxysmal atrioventricular block: clinical experience with 20 patients显示文摘 | Ronit Shohat-Zabarski Zaza Iakobishvili Jairo Kusniec Alexander Mazur Boris Strasberg | 2004 | International Journal of Cardiology2004，，3： | 1 |
| 6 | Downregulation of nuclear-encoded genes of oxidative metabolism in dialyzed chronic kidney disease patients显示文摘 | Zaza G Granata S Masola V | 2013 | Plo S one2013，8，77： | 1 |
| 7 | Cancer pain and psychosocial factors:A crit2ical review of the literature显示文摘 | Zaza C Baine N | 2002 | J Pain Symptom Manage2002，24，5： | 1 |
| 8 | Reviews of evidence regarding interventions to increase use of child safety seats显示文摘 | ZAZA S SLEET D A THOMPSON R S | 2001 | Am J Prey Med2001，21，4： | 1 |
| 9 | Dialysisrelated systemic microinflammation is associated with specific genomic patterns显示文摘 | ZAZA G PONTRELLI P PERTOSA G | 2008 | Nephrol Dial Transplant2008，23，5： | 1 |
| 10 | Baroflex sensitivity and its evaluation during the first year after a myocardial infarction显示文摘 | Zaza A Pala M | 1998 | J Am Coll Cardiol1998，12，： | 1 |
| 11 | Prevalence of symptoms suggestive of gastroparesis in a cohort of patients with diabetes mellitus显示文摘 | Ram Dickman Julia Kislov Mona Boaz Yishai Ron Zaza Beniashvili Itamar Raz Isaac Baigel Yaron Niv Julio Wainstein | 2013 | Journal of Diabetes and Its Complications2013，，4： | 1 |
| 12 | Cancer pain and psychosocial factors: a critical review of the literature显示文摘 | Zaza C Baine N | 2002 | Journal of Pain and Symptom Management2002，24，5： | 1 |
| 13 | Multiple regression analysis of hydrogen sulphide poisoning in molten carbonate fuel cells used for waste-to- energy conversions 显示文摘 | ZAZA F PAOLETTI C LOPRESTI R etal | 2011 | International Journal of Hydrogen Energy2011，36，13： | 1 |
| 14 | Dissection of Z-disc myopalladin gene network involved in the development of restrictive cardiomyopathy using system genetics approach显示文摘AIM To investigate the regulation of Myopalladin(Mypn) and identify its gene network involved in restrictive cardiomyopathy(RCM).METHODS Gene expression values were measured in the heart of a large family of BXD recombinant inbred(RI) mice derived from C57BL/6J and DBA/2J. The proteomics data were collected from Mypn knock-in and knock-out mice. Expression quantitative trait locus(eQ TL) mapping methods and gene enrichment analysis were used to identify Mypn regulation,gene pathway and co-expression networks.RESULTS A wide range of variation was found in expression of Mypn among BXD strains. We identified upstream genetic loci at chromosome 1 and 5 that modulate the expression of Mypn. Candidate genes within these loci include Ncoa2,Vcpip1,Sgk3,and Lgi2. We also identified 15 sarcomeric genes interacting with Mypn and constructed the gene network. Two novel members of this network(Syne1 and Myom1) have been confirmed at the protein level. Several members in this network are already known to relate to cardiomyopathy with some novel genes candidates that could be involved in RCM. CONCLUSION Using systematic genetics approach,we constructed Mypn co-expression networks that define the biological process categories within which similarly regulated genes function. Through this strategy we have found several novel genes that interact with Mypn that may play an important role in the development of RCM. | Qingqing Gu Uzmee Mendsaikhan Zaza Khuchua Byron C Jones Lu Lu Jeffrey A Towbin Biao Xu Enkhsaikhan Purevjav | 2017 | World Journal of Cardiology2017，9，4： | 1 |
| 15 | Pathophysiology and pharmacology of the cardiac 'late sodium current'显示文摘 | Zaza A Belardinelli L Shryock JC | 2008 | Pharmacol Ther2008，119，3： | 1 |
| 16 | Cancer pain and psychosocial fac- tors:A critical review of the literature显示文摘 | Christine Zaza Natalie Baine | 2002 | Journal of Pain and Symptom Management2002，24，5： | 1 |
| 17 | High levels of PEEP may improve survival in acute respiratory distress syndrome: a meta-analysis显示文摘 | Oba Y Thameem DM Zaza T | 2009 | Respir Med2009，103，： | 1 |
| 18 | Cancer pain and psychosocial factors : a criticalreview of the 1 iterature 显示文摘 | Zaza C Baine N | 2011 | J Pain Symptom Manag2011，24，5： | 1 |
| 19 | Migraine and stroke显示文摘 | Zaza Katsarava Christian Weimar | 2010 | Journal of the Neurological Sciences2010，，1： | 1 |
| 20 | Dose current treatment of car- diogenic shock complicating the acute coronary syndromes comply with guidelines显示文摘 | I Zaza I Solomon B Valentina B | 2005 | Am Heart J2005，149，1： | 1 |
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