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| 1 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 2 | Service-oriented manufacturing:A literature review and future research directions显示文摘This study presents a systematic review of the literature on service-oriented manufacturing(SOM).Specifically,we focus on the impact of SOM on firm operating decisions,which distinguishes this work from previous reviews.This study proposes a classification framework for SOM research based on product flow,from its design to its final disposal.Although SOM has been studied for many years,most related research remains conceptual.Our criterion for choosing papers is that they must be relevant to practical problems.This review aims to provide readers a guide that will facilitate their search for papers in their field of interest.More importantly,we hope that this review can provide insightful managerial implications for SOM. | Zhong-Zhong JIANG Guangqi FENG Zelong YI Xiaolong GUO | 2022 | Frontiers of Engineering Management2022，9，1： | 6 |
| 3 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 4 | Thermodynamical properties of dark energy with the equation of state ψ=ψ0 q-ψz显示文摘 | ZhangYongping Yi Zelong Zhang Tongjie | 2008 | Phys Rev D2008，77，： | 1 |
| 5 | How organizational flexibility affects new product development in an uncertain environment : Evidence from China 显示文摘 | Liu Yi LiYuan Wei Zelong | 2009 | International Journal of Production Economics2009，，120： | 1 |
| 6 | How organizational flexibility affects new product development in an uncertain environment: Evidence from China显示文摘 | Yi Liu Yuan Li Zelong Wei | 2008 | International Journal of Production Economics2008，，1： | 1 |
| 7 | Ambidextrous organizational learning, environmental munificence and new product performance: Moderating effect of managerial ties in China显示文摘 | Yuan Li Zelong Wei Jie Zhao Chenlu Zhang Yi Liu | 2012 | International Journal of Production Economics2012，，： | 1 |
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