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| 1 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 2 | A supply chain network equilibrium model显示文摘 | Anna Nagurney June Dong Ding Zhang | 2002 | Transportation Research Part E2002，，5： | 4 |
| 3 | A supply chain network equilibrium model with random demands显示文摘 | June Dong Ding Zhang Anna Nagurney | 2004 | European Journal of Operational Research2004，，1： | 3 |
| 4 | Structural basis for specific self-incompatibility response in Brassica显示文摘自我障碍(SI ) 是在阻止自体受精的 flowering 植物的普遍机制并且使近交。在 Brassica,高度多态的 S 地点充满半胱氨酸的蛋白质的识别(SCR;或 S 地点蛋白质 11 ) 由同样多态的 S 地点受体, kinase (SRK ) 支配 SI 特性。这里,我们从 Brassica rapa 与 SCR9 在建筑群报导 SRK9 (eSRK9 ) 的细胞外的领域的水晶结构。SCR9 绑定导致 eSRK9 homodimerization,形成 2:2 eSRK : 有象信 A 一样的形状的 SCR heterotetramer。SCR9 的特定的识别通过三超(hv ) 被调停 eSRK9 的区域。每 SCR9 同时从第二 eSRK9 单体从一 eSRK9 单体和 hvII 的另外的一半与 hvII 的 hvI 和一个一半交往,起在调停的一个主要作用没有包含在二个 SCR9 分子之间的相互作用的 SRK9 homodimerization。为 eSRK9-SCR9 相互作用批评的残余的单个变化在 vitro 破坏他们的绑定。我们的学习文饰由 SRK 的 SCR 的特定的识别上的数据的身体并且为理解在 SRK 和 SCR 之间的合作进化提供一个结构的模板。 | Rui Ma Zhifu Han Zehan Hu Guangzhong Lin Xinqi Gong Heqiao Zhang June B Nasrallah Jijie Chai | 2016 | Cell Research2016，26，12： | 3 |
| 5 | Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy显示文摘Osteosarcoma(OS)is a malignant tumor with a high rate of recurrence.Recently,biodegradable Mg-based implants have become a new therapeutic platform for bone-related diseases.However,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of OS.Herein,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was proposed.Compared with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly enhanced.Cytocompatibility experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR irradiation.Therefore,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic effects.This study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS. | Huihui Du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan Shuhan Chen Feng Peng Shi Qian Xuanyong Liu | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 6 | Sectional distribution of salinity and its indication of Kuroshio'sintrusion in the southern Taiwan Strait and northeastern South China Sea late summer, 1994显示文摘Using the CTD data investigated at about 330 stations in the southern Taiwan Strait, the northeastern South China Sea and their adjacent seas in August and September of 1994, this paper anayses the sectional distributions of salinity in 10 selected sections and discusses the possibility of the Kuroshio’s intrusion into the northeastern South China Sea and the southern Taiwan Strait. The results show that: as the main stream of Kuroshio passes by the northern Luzon Strait during the survey period, the 'Kuroshio-influenced water' with some hydrological features of the Kuroshio may extend through the Luzon Strait to the sea areas near both the Dongsha Islands and the Taiwan Shoal of the southern Taiwan Strait. | Hu Jianyu Liang Hongxing and Zhang Xuebin 1. Institute of Subtropical Oceanography, Xiamen University, Xiamen 361005, China 2. Fujian Institute of Oceanology, Xiamen 361012, China (Received June 3, 1998 accepted August 8, 1998) | 1999 | Acta Oceanologica Sinica1999，18，2： | 2 |
| 7 | A supply chain network equilibrium model with random demands 显示文摘 | DONG June ZHANG Ding NAGURNEY A | 2004 | Europe- an Journal of Operational Research2004，156，1： | 1 |
| 8 | A supply chain network equilibrium model显示文摘 | Nagurney Anna Dong June Zhang Ding | 2002 | Transportation Research: Part E2002，38，5： | 1 |
| 9 | A supply chain network equilibrium model with random demands显示文摘 | Ding Zhang Anna Nagurney | 2004 | European Journal of Operational Research2004，156，： | 1 |
| 10 | Supply chain networks,electronic commerce,and supply side and demand side risk显示文摘 | Jose Cruz June Dong Ding Zhang | 2005 | European Journal of Operational Research2005，164，： | 1 |
| 11 | Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors 显示文摘 | Zhang Shou Edelmann Lambert Liu June | 2008 | J Neurosci2008，28，2： | 1 |
| 12 | A supply chain network equilibrium model显示文摘 | Nagurney Anna June Dong Ding Zhang | 2002 | Transportation Research: Part E2002，38，5： | 1 |
| 13 | Tectonic evolution of early Paleozoic HP metamorphic rocks in the North Qilian Mountains, NW China: New perspectives显示文摘 | Shuguang Song Yaoling Niu Lifei Zhang Chunjing Wei June G. Liou Li Su | 2008 | Journal of Asian Earth Sciences2008，，3： | 1 |
| 14 | A supply chain network equilibrium model, Transportation Research Part 显示文摘 | Tapiero Nagurney Anna Dong June Zhang Ding | 2002 | Logistics and Transportation Review2002，38，5： | 1 |
| 15 | Multitiered supply chain networks:multicriteria decision-making under uncertainty显示文摘 | June Dong Ding Zhang Hong Yan Anna nagurney | 2005 | Annals of Operations Research2005，138，1： | 1 |
| 16 | A supply chain network equilibrium model显示文摘 | Nagurney Anna Dong June Zhang Ding | 2002 | Transportation Research:Part E2002，38，5： | 1 |
| 17 | A supply chain network equilibrium model 显示文摘 | Nagurney A Dong June Zhang Ding | 2002 | Transportation Research Part E2002，38，： | 1 |
| 18 | A supply chain network equilibrium model with random demands 显示文摘 | Dong June Zhang Ding Nagurney A | 2004 | European Journal of Operational Research2004，156，： | 1 |
| 19 | A Supply Chain Network Equilibrium Model with Random Demands显示文摘 | June Dong Ding Zhang Anna Nagurney | 2004 | European Journal of Operational Research2004，156，1： | 1 |
| 20 | Multitiered supply chain networks: Muhicriteria decision-making under uncertainty显示文摘 | Dong June Zhang Ding Yan Hong | 2005 | Annals of Operations Research2005，135，： | 1 |
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