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| 1 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 2 | Early Paleozoic granite in Nujiang River of northwest Yunnan in southwestern China and its tectonic implications显示文摘沿着在西方的云南的中国缅甸边阶的 Nujiang 区域收到了很多注意并且被认为是西藏的高原的向东南的逃跑的重要隧道。这条隧道被红 River-Ailao 山左文字的 strick 滑倒差错在这条隧道以内在西方在东方和英雄传奇 Gaoligong 正确文字的 strick 滑倒差错毗邻,它仍然不对贡尚·布洛克哪个构造单位合适清楚。尽管一些研究人员建议它是 Sundaland 岩层的北方结束,它的构造定义是相当模糊的。这篇论文报导我们 U-Pb 同位素的 geochronological 在贡尚·布洛克以内在 Gudang 片麻岩的花岗石上学习的新锆石。这研究在理解起源和西北的云南的构造环境起一个重要作用。 | SONG ShuGuang JI JianQing WEI ChunJing SU Li ZHENG YaDong SONG Biao ZHANG LiFei | 2007 | Chinese Science Bulletin2007，52，17： | 31 |
| 3 | Paleoproterozoic crustal evolution of the Hengshan-Wutai—Fuping region,North China Craton显示文摘An arguable point regarding the Neoarchean and Paleoproterozoic crustal evolution of the North China Craton(NCC)is whether the tectonic setting in the central belt during the mid-Paleoproterozoic(2.35-2.0 Ga)was dominated by an extensional regime or an oceanic subduction-arc regime.A review of the midPaleoproterozoic magmatism and sedimentation for the Hengshan-Wutai-Fuping region suggests that a back-arc extension regime was dominant in this region.This conclusion is consistent with the observation that the 2.35-2.0 Ga magmatism shows a typical bimodal distribution where the mafic rocks mostly have arc affinities and the acidic rocks mainly comprise highly-fractioned calc-alkaline to alkaline(or A-type)granites,and that this magmatism was coeval with development of extensional basins characteristic of transgressive sequences with volcanic interlayers such as in the Hutuo Group.Although the final amalgamation of the NCC was believed to occur at ~1.85 Ga,recent zircon U-Pb age dating for mica schist in the Wutai Group suggests a collisional event may have occurred at ~1.95 Ga.The metamorphic ages of ~1.85 Ga,obtained mostly from the high-grade rocks using the zircon U-Pb approach,most probably indicate uplifting and cooling of these high-grade terranes.This is because(i)phase modeling suggests that newly-grown zircon grains in highgrade rocks with a melt phase cannot date the age of peak pressure and temperature stages,but the age of melt crystallization in cooling stages;(ii)the metamorphic P-T paths with isobaric cooling under 6-7 kb for the Hengshan and Fuping granulites suggest their prolonged stay in the middle-lower crust;and(iii)the obtained metamorphic age data show a continuous distribution from 1.95 to 1.80 Ga.Thus,an alternative tectonic scenario for the Hengshan-Wutai-Fuping region involves:(i)formation of a proto-NCC at ~2.5 Ga;(ii)back-arc extension during 2.35-2.0 Ga resulting in bimodal magmatism and sedimentation in rifting basins on an Archean basement;(iii)a crustal thickening event in the extended region resulting in a kyanitetype metamorphism at ~1.95 Ga,and(iv) uplifting and cooling of the thickened crust from 1.93 to 1.80 Ga. | Chunjing Wei Jiahui Qian Xiwen Zhou | 2014 | Geoscience Frontiers2014，5，4： | 32 |
| 4 | A new interpretation of the tectonic setting and age of meta-basic volcanics in the Ondor Sum Group, Inner Mongolia显示文摘The Ondor Sum Group in the central Inner Mongolia is mainly composed of meta-basic volcanics intercalated with ferruginous quartzite and quartz schist,and has been interpreted as slices of oceanic crust or an ophiolite suite of the Early Paleozoic or much older ages.This paper presents new LA-ICP-MS zircon U-Pb dating and geochemical data for the meta-basic volcanics.The results show that zircons in the meta-basic volcanics were derived from complicated sources,most of which may be captured by basic magma from the country rocks or other sources.They yield a large age range from the Late Archean to Early Mesozoic with the youngest age group between 246 and 261 Ma,constraining the protolith of the meta-basic volcanics formed in the Late Permian to Early Triassic.The meta-basic volcanics have an affinity to E-MORB in geochemistry,and also a similarity toward OIB,representing a tectonic setting of limited intra-continental ocean basin.This limited basin might have been related to the continuous extension of the area since the Early Permian and finally closed in the Early Mesozoic. | CHU Hang ZHANG JinRui WEI ChunJing WANG HuiChu REN YunWei | 2013 | Chinese Science Bulletin2013，58，28： | 25 |
| 5 | A huge oceanic-type UHP metamorphic belt in southwestern Tianshan, China: Peak metamorphic age and P-T path显示文摘Recent progress in the study of the UHP metamorphic belt in southwestern Tianshan,China,is summarized in this paper.This about 80-km-long and over 10-km-wide UHP belt has been recognized by the discovery of coesite,coesite pseudomorphs and other UHP minerals.It is the largest oceanic-type UHP metamorphic belt reported so far.It has formed due to northward subduction of the Tianshan Paleo-Ocean.U-Pb dating of metamorphic rims of zircons from a coesite-bearing garnet-phengite schist yields a peak UHP metamorphic ages of 320±3.7 Ma.Combined with ages of 233–226 Ma obtained from rims of zircons from retrograded eclogites,a long retrograde metamorphic evolution(>70 Ma)has been revealed.According to phase equilibria modeling,the P-T paths of both coesite-bearing eclogites and garnet-phengite schists are characterized by thermal relaxation,i.e.,the metamorphic temperature peak lags behind the pressure peak,indicating that the UHP rocks experienced slow and long heating and decompression during exhumation in the subduction channel.On the basis of the field observation that a small amount of eclogite lenses is wrapped in large volumes of metapelites,and the similar P-T paths of both rock types,we propose that the exhumation of the UHP eclogites from southwestern Tianshan,China,may have resulted from the exhumation of large volumes of low-density metapelites,which carried the denser eclogites to the Earth’s surface. | ZHANG LiFei DU JinXue Lü Zeng YANG Xin GOU LongLong XIA Bin CHEN ZhenYu WEI ChunJing SONG ShuGuang | 2013 | Chinese Science Bulletin2013，58，35： | 19 |
| 6 | Determination and geological significance of the eclogites from the northern Dabie Mountains, central China显示文摘Numerous eclogite_amphibolite blocks have been found along the Mayanling fault in the northern Dabie complex. Most of the eclogites are strongly retrograded and contain garnet, rutile and the amphibole_plagioclase symplectite. The occurrence of these eclogites may have something to do with the inverted movement of the Mayanling thrust fault. | Chunjing Wei Zhengang Shan Lifei Zhang Shiguang Wang Zongguang Chang | 1998 | Chinese Science Bulletin1998，43，3： | 18 |
| 7 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 8 | Confirmation of pelitic granulite in the Altai orogen and its geological significance显示文摘The existence of pelitic granulite in the Altai orogen was confirmed for the first time by detailed petrographic research and P-T pseudosection modeling. The pelitic granulite has the assemblage of garnet + cordierite + K-feldspar + biotite + sillimanite + plagioclase + quartz with some samples containing the paragenesis of cordierite + spinel. Peak conditions of the pelitic granulite determined from the P-T pseudosection involved P = 0.5―0.6 GPa, T = 780―800℃, belonging to medium-to low-pressure type. SHRIMP U-Pb dating of zircon presented a metamorphic age of 292.8 ± 2.3 Ma. The discovery of pelitic granulite reflects an extensional environment with high heat flow in the southern margin of the Altai orogen during the Early Permian, which provides an important petrological constraint on the evolution of the Altai orogen. | WANG Wei WEI ChunJing WANG Tao LOU YuXing CHU Hang | 2009 | Chinese Science Bulletin2009，54，14： | 11 |
| 9 | Structure Design of Lower Limb Exoskeletons for Gait Training显示文摘Due to the close physical interaction between human and machine in process of gait training, lower limb exoskeletons should be safe, comfortable and able to smoothly transfer desired driving force/moments to the patients. Correlatively, in kinematics the exoskeletons are required to be compatible with human lower limbs and thereby to avoid the uncontrollable interactional loads at the human-machine interfaces. Such requirement makes the structure design of exoskeletons very difficult because the human-machine closed chains are complicated. In addition, both the axis misalignments and the kinematic character difference between the exoskeleton and human joints should be taken into account. By analyzing the DOF(degree of freedom) of the whole human-machine closed chain, the human-machine kinematic incompatibility of lower limb exoskeletons is studied. An effective method for the structure design of lower limb exoskeletons, which are kinematically compatible with human lower limb, is proposed. Applying this method, the structure synthesis of the lower limb exoskeletons containing only one-DOF revolute and prismatic joints is investigated; the feasible basic structures of exoskeletons are developed and classified into three different categories. With the consideration of quasi-anthropopathic feature, structural simplicity and wearable comfort of lower limb exoskeletons, a joint replacement and structure comparison based approach to select the ideal structures of lower limb exoskeletons is proposed, by which three optimal exoskeleton structures are obtained. This paper indicates that the human-machine closed chain formed by the exoskeleton and human lower limb should be an even-constrained kinematic system in order to avoid the uncontrollable human-machine interactional loads. The presented method for the structure design of lower limb exoskeletons is universal and simple, and hence can be applied to other kinds of wearable exoskeletons. | LI Jianfeng ZHANG Ziqiang TAO Chunjing JI Run | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 11 |
| 10 | Successful generation of cloned mice using nuclear transfer from induced pluripotent stem cells显示文摘 | Shuya Zhou Chenhui Ding Xiaoyang Zhao Eryao Wang Xiangpeng Dai Lei Liu Wei Li Zichuan Liu Haifeng Wan Chunjing Feng Tang Hai Liu Wang Qi Zhou | 2010 | Cell Research2010，20，7： | 10 |
| 11 | Phase transition in the subducted oceanic lithosphere and generation of the subduction zone magma显示文摘Two metamorphic processes, i.e. subsolidus dehydration and partial melting occurring in MORB, metasediments and peridotite of subducted oceanic lithosphere are discussed on the basis of available experimental work and phase equilibrium modeling. Phase diagrams of hydrous MORB show that in most cold subduction P-T (pressure-temperature) regimes a large portion of water in the basic layer has released below the onset of blueschist facies (< 20 km), and at a depth (60―70 km) of transition from lawsonite blueschist to lawsonite eclogite facies through glaucophane dehydration; only a smaller portion of water will escape from the slab through dehydration of lawsonite and chloritoid in the depth range suitable for arc magma formation; and a very small portion of water stored in lawsonite and phengite will fade into the deeper mantle. The role of amphibole for arc magma formation is still arguable. In cold subduction P-T regimes, the dehydration of chlorite and talc in Al-poor metasediments, and chloritoid and carpholite in Al-rich metapelites at a depth around 80―100 km will make some con- tributions to the formation of arc magma. Comparatively, dehydration of serpentine in hydrated peridotite occurs at depths of 120―180 km, playing an important role in the arc magmatism. Subduction of oceanic crust along warm P-T regimes will cross the solidi at a depth over 80 km, resulting in partial melting under fluid-saturated and fluid-absent conditions in the metasediments involving biotite and phengite, and in the basic rocks involving epidote and amphibole. The melt compositions of the basic crust are adakitic at pressures < 3.0 GPa, but become peraluminous granitic at higher pressures. | WEI ChunJing ZHANG YingHui | 2008 | Chinese Science Bulletin2008，53，23： | 10 |
| 12 | Research on continuous core-filling casting forming process of copper-clad aluminum bimetal composite material显示文摘A single forming equipment of bimetal continuous core-filling casting was designed and manufactured for the purpose of developing copper-aluminum composite materials.The characteristics of the equipment were as follows:the crystallizer composed of water jacket copper sleeve in which graphite sleeve was set, two melting furnaces with different diameters vertically distributed, the low furnace of melting copper linked with the crystallizer, continuous casting and core-filling proceeded at the meantime.The rational processing parameters were determined through a series of experiments:contact length from down crucible to water-cooling cupreous crystallizer, 20 mm;length of recooling spray jet under crystallizer, 95 mm;temperature of copper and aluminum, 1250-1320℃ and 700℃ respectively;pulling rate, 16 mm/min.The qualified copper-clad aluminum composite rods, the external and inner diameter of which was 40 mm and 24 mm respectively, could be drawn successfully on that basis.Tested by hydrostatic extrusion and drawing process, the boss ratios of the copperclad aluminum composite rods were maintained a relatively stable scope of about 0.59-0.65, which was not obviously changed by subsequent plastic processing. | He LIANG Zhiyong XUE Chunjing WU Qing LIU Yuan WU | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，3： | 9 |
| 13 | Analysis of the Wenchuan Ms8.0 Earthquake's Co-seismic Stress and Displacement Change by Using the Finite Element Method显示文摘The variation of in situ stress before and after earthquakes is an issue studied by geologists. In this paper, on the basis of the fault slip dislocation model of Wenchuan Ms8.0 earthquake, the changes of co-seismic displacement and the distribution functions of stress tensor around the Longmen Shan fault zone are calculated. The results show that the co-seismic maximum surface displacement is 4.9 m in the horizontal direction and 6.5 m in the vertical direction, which is almost consistent with the on-site survey and GPS observations. The co-seismic maximum horizontal stress in the hanging wall and footwall decreased sharply as the distance from the Longmen Shan fault zone increased. However, the vertical stress and minimum horizontal stress increased in the footwall and in some areas of the hanging wall. The study of the co-seismic displacement and stress was mainly focused on the long and narrow region along the Longmen Shan fault zone, which coincides with the distribution of the earthquake aftershocks. Therefore, the co-seismic stress only affects the aftershocks, and does not affect distant faults and seismic activities. The results are almost consistent with in situ stress measurements at the two sites before and after Wenchuan Ms8.0 earthquake. Along the fault plane, the co-seismic shear stress in the dip direction is larger than that in the strike direction, which indicates that the faulting mechanism of the Longmen Shan fault zone is a dominant thrust with minor strike-slipping. The results can be used as a reference value for future studies of earthquake mechanisms. | SUN Dongsheng WANG Lianjie WANG Hongcai MA Yinsheng ZHOU Chunjing CUI Junwen | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 9 |
| 14 | Continuous unidirectional solidification of QAl9-4 Cu-Al alloy显示文摘A continuous unidirectional solidification equipment with the advantages of electric slag remelting, induction heating, continuous casting and unidirectional solidification was built to study the QAl9 4 Cu Al alloy. The results show that the electro slag induction continuous unidirectional solidification process can be used for the steady continuous unidirectional solidification of QAl9 4, and revitalizes the down pulling continuous unidirectional solidification process; that the temperature distribution in the mold wall reflects that of the molten metal in the mold, thus the temperature distribution in the mold wall can be used to control the electric slag induction continuous unidirectional solidification process; and that the mutual matching of the technological parameters is the key to stabilize the solidification process. | Chang Guowei(常国威) Yuan Junping(袁军平) Wang Zidong(王自东) Wu Chunjing(吴春京) Hu Hanqi(胡汉起) Miao Zhimin(苗治民) | 1999 | 中国有色金属学会会刊:英文版1999，9，3： | 8 |
| 15 | Metamorphism and zircon U–Pb dating of garnet amphibolite in the Baoyintu Group, Inner Mongolia显示文摘Garnet amphibolite in the Baoyintu Group,Inner Mongolia, is mainly composed of garnet, hornblende,plagioclase, quartz and minor rutile/ilmenite. Garnet occurs as porphyroblasts surrounded by plagioclase, forming typical ‘‘white-eye socket'' texture. Garnet shows grossular content of 0.26–0.28 and pyrope of 0.11–0.13, without significant zoning. Plagioclase is generally zoned with anorthite(An) increasing from core to rim. The P–T pseudosection calculated using THERMOCALC in the system Mn NCKFMASHTO shows that the garnet amphibolite experienced a clockwise P–T path with a peak at*1.3 GPa/725 °C defined from the minimum An content in plagioclase and maximum pyrope content in garnet,followed by an isothermal decompression. LA-ICP-MS zircon dating for the garnet amphibolite indicates metamorphic ages of 399 ± 6 Ma. The peak P–T condition corresponds to a thermal gradient of *18 °C/km, indicating typical medium-pressure type that commonly occurs in orogenic process with crustal thickening. We prefer to interpret this orogenic event to be a result of collision,following the closure of the Paleo-Asian Ocean before theearly Devonian although there is a popular view that the Paleo-Asian Ocean may have lasted to the early Mesozoic. | Yaping Chen Chunjing Wei Jinrui Zhang Hang Chu | 2015 | Science Bulletin2015，60，19： | 8 |
| 16 | Metamorphism of the East Sector of the Southern Qinling Orogenic Belt and Its Geological Significance显示文摘The east sector of the southern Qinling belt is, lithologically, composed mainly of metapelites,quartzites, marbles and small amount of metabasites and gneisses, whose protoliths are the Silurian, Devonian andless commonly the Sinian and Upper Palaeozoic. They have been subjected at least to two epochs of metamorphism.The early epoch belongs to progressive metamorphism which is centered on high amphibolite-granulite facies in theFuping area and changed outwards into low amphibolite facies (staurolite-kyanite zone), epidote amphibolite facies(garnet zone) and greenschist facies (chlorite and biotite zones), the metamorphic age of which is about 220-260 Ma.This early-epoch metamorphism belongs to different pressure types: the rocks from greenschist to low amphibolitefacies belong to the typical medium-pressure type which shows geothermal gradients of about 17-20℃/km and wasprobably produced by a crustal thickening process related to continental collision, and the high amphibolite-granulitefacies belongs to the low-pressure type which shows geothermal gradients of about 25-38℃/km and was probablyaffected by some magmatic heats. Based on the basic characteristics of the P-T paths of the different facies calculatedfrom the garnet zonations, it can be deduced that the metamorphism of medium-pressure facies series took place dur-ing an imbricated thickening process, rather than during the uplifting process after thickening. The late-epoch meta-morphism belongs to dynamic metamorphism of greenschist facies which is overprinted on the early-epoch meta-morphic rocks and is Yanshanian or Himalayan in age, probably related to intracontinental orogeny. | WEI Chunjing YANG Chonghui ZHANG Shouguang | 1999 | Acta Geologica Sinica(English Edition)1999，73，1： | 7 |
| 17 | Phase Equilibria of Hornblende-Bearing Eclogite in the Western Dabie Mountain,Central China显示文摘高压(HP ) 在西方的 Dabie 山的 eclogite 围住众多的角闪石,主要 barroisite。变形的磅状况,磅路径和它的矿物质同等发育不全仍然在争论的山峰上的意见。通常, HP eclogite 包含石榴石, omphacite,角闪石和石英,与或没有 glaucophane,黝帘石和 phengite。石榴石与 X Mg 增加, X Ca 和 X Mn 从核心减少到边界,它显示进步变态。最近开发的磅假节方法建模的 HP eclogite 的阶段 equilibria 显示出下列:(1 ) 石榴石的生长带状配列记录一条进步的变形的磅路径从预先达到顶点在到一座山峰的 508 ° C -514 ° C 的 1.9 2.1 GPa 的状况在为 HP eclogite 的 528 ° C -531 ° C 的 2.3 2.5 GPa 之一;(2 ) 山峰矿物质集合是 garnet+omphacite+glaucophane+quartz ± p hengite,与 lawsonite 基因的可能的帕拉;( 3 )广泛的角闪石由于解压缩主要源于 glaucophane ,部分 omphacite 甚至一点石榴石,一些在山峰以后的阶段期间加热,主要代表大约 1.4 1.6 GPa 和 580 °C -640°C,和他们的生长的条件被 lawsonite 的脱水赞成进黝帘石或绿帘石,但是大多数在 HP eclogite 的石榴石, omphacite 或 phengite 仍然以山峰状况保存他们的作文,并且他们不显然是有角闪石的 equilibrious 。 | ZHANG Jingsen WEI Chunjing LOU Yuxing SU Xiangli | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 7 |
| 18 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 19 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 20 | Effect of ferrovanadium inoculation on microstructure and properties of high speed steel显示文摘The effect of ferrovanadium inoculation on the microstructure and properties of high speed steel (HSS) used for rolls was studied. The results showed that the as-cast eutectic carbide network tends to be broken after ferrovanadium inoculation, and the carbides are changed to rod-like or nodular shape. After heat treatment, the carbides in the inoculated HSS are spheroidized and distributed more uniformly in the matrix. The impact toughness of high speed steel with ferrovanadium inoculation is obviously improved. The action mechanism of ferrovanadium inoculation on the microstructure of the alloy is also discussed. | Zhang Xipeng Kou Guojun Wu Chunjing Gan Zhaiping Zhao Wanzi Chuan Xiangzhao Ma Ye | 2008 | China Foundry2008，5，2： | 6 |
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