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| 1 | Analysis of risk factors affecting the prognosis of pancreatic neuroendocrine tumors显示文摘 | Tao Ming Yuan Chunhui Xiu Dianrong Shi Xueying Tao Liyuan Ma Zhaolai Jiang Bin Zhang Zhipeng Zhang Lingfu Wang Hangyan | 2014 | Chinese Medical Journal2014，，16： | 13 |
| 2 | Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in pancreatic ductal adenocarcinoma显示文摘Objective: To investigate the frequency of parasympathetic neurogenesis and determine its association with tumor budding and prognosis in pancreatic ductal adenocarcinoma(PDAC).Methods: Parasympathetic neurogenesis was defined as the distribution of abnormal parasympathetic nerves in the stroma tissue. Staining of vesicular acetylcholine transporter(VACh T), as a marker for parasympathetic neurogenesis, was performed on a representative specimen of the tumor for 59 PDAC patients with available clinical, pathologic, and follow-up information. Three specimens containing normal pancreatic tissues were stained in parallel. The number of parasympathetic nerve fibers was counted in five high-power microscopic fields(5×0.785 mm^2). Cut-off values were calculated by receiver operating characteristic curve analysis.Results: VACh T-positive parasympathetic nerve fibers were not seen in the stroma of 3 cases of normal pancreatic tissues. In 59 PDAC cases, the range of parasympathetic neurogenesis was 4-38 fibers/(5×0.785) mm^2, with a median of 18 fibers/(5×0.785) mm^2. Patients with parasympathetic neurogenesis >15 fibers/(5×0.785) mm^2 were defined as the high-density group(39 patients, 66.1%), and those with parasympathetic neurogenesis ≤15 fibers/(5×0.785) mm^2 as the low-density group(20 patients, 33.9%). The high-density group had a higher occurrence of tumor budding(P=0.001) and a higher rate of early recurrence(P=0.035). Parasympathetic neurogenesis appeared to be an independent adverse prognostic factor [hazard ratio(HR)=2.45, 95% confidence interval(95% CI): 1.25-4.81, P=0.009], in addition to American Joint Committee on Cancer(AJCC) stage(P=0.010) and tumor budding(P=0.009).Conclusions: Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in PDAC. | Lingfu Zhang Limei Guo Ming Tao Wei Fu Dianrong Xiu | 2016 | Chinese Journal of Cancer Research2016，28，2： | 8 |
| 3 | Laparoscopic treatment for suspected gallbladder cancer confined to the wall: a 10-year study from a single institution显示文摘Objective: Although laparoscopic treatment of gallbladder cancer(GBC) has been explored in the last decade,long-term results are still rare. This study evaluates long-term results of intended laparoscopic treatment for suspected GBC confined to the gallbladder wall, based on our experience over 10 years.Methods: Between August 2006 and December 2015, 164 patients with suspected GBC confined to the wall were enrolled in the protocol for laparoscopic surgery. The process for GBC treatment was analyzed to evaluate the feasibility of computed tomography(CT) and/or magnetic resonance imaging(MRI) combined with frozen-section examination in identifying GBC confined to the wall. Of 159 patients who underwent the intended laparoscopic radical treatment, 47 with pathologically proven GBC were investigated to determine the safety and oncologic outcomes of a laparoscopic approach to GBC.Results: Among the 164 patients, 5 patients avoided further radical surgery because of unresectable disease and12 were converted to open surgery; in the remaining 147 patients, totally laparoscopic treatment was successfully accomplished. Extended cholecystectomy was performed in 37 patients and simple cholecystectomy in 10. The T stages based on final pathology were Tis(n=6), T1 a(n=2), T1 b(n=9), T2(n=26), and T3(n=4). Recurrence was detected in 11 patients over a median follow-up of 51 months. The disease-specific 5-year survival rate of these 47 patients was 68.8%, and rose to 85% for patients with a normal cancer antigen 19-9(CA19-9) level.Conclusions: The favorable long-term outcomes demonstrate the feasibility of combined CT/MRI and frozensection examination in the selection of patients with GBC confined to the gallbladder wall, confirm the oncologic safety of laparoscopic treatment in selected GBC patients, and favor measurement of preoperative CA19-9 in the selection of GBCs suitable for laparoscopic treatment. | Lingfu Zhang Chunsheng Hou Zhi Xu Lixin Wang Xiaofeng Ling Dianrong Xiu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 6 |
| 4 | Application of hydrophobic ionic liquid [Bmmim][PF6] in solvent extraction for oily sludge显示文摘In this study, an ionic liquid(IL), 1-butyl-2,3-dimmmethylimidazolium hexafluorophosphate([Bmmim][PF6]),was used in combination with a composite solvent of methyl acetate and n-heptane to enhance the oil extraction from oily sludge. The oil recovery increased by approximately 15% compared with that of solvent extraction without [Bmmim][PF6] at the optimal ratios of IL to sludge and solvents to sludge, which were at 2:5(M/M) and 4:1(V/M), respectively. The saturate, aromatic, resin and asphaltene(SARA) analysis revealed that the recovery of resins and asphaltenes was increased by 14% and 38%, respectively, in the solvent extraction with the addition of [Bmmim][PF6]. [Bmmim][PF6] maintained a good performance after its reuse four times. The addition of[Bmmim][PF6] changed the adhesion forces between oil and soil. The IL-assisted solvent extraction procedure followed the pseudo second-order kinetic model, while the unassisted solvent extraction procedure followed the pseudo first-order kinetic model. The results also demonstrated that [Bmmim][PF6] decreased the solvent consumption by approximately 60% each time. Additionally, [Bmmim][PF6] can be easily separated. The results suggested that enhancing the solvent extraction with this IL is a promising way to recover oil from oily sludge with a higher oil recovery rate and lower organic solvent consumption than those with the unassisted solvent extraction method. | Lingfu Zhu Zuhong Lin Jie Tan Liyang Hu Tingting Zhang | 2020 | Chinese Journal of Chemical Engineering2020，28，9： | 3 |
| 5 | Characterization of oil component and solid particle of oily sludge treated by surfactant-assisted ultrasonication显示文摘The ultrasonic technique has been demonstrated to be a promising method for the disposal of hazardous oily sludge.However,the separation of oil from the surfaces of the solid particles is still difficult due to the strong interaction between the oil and solid particle.In this study,three types of surfactants were used to assist the ultrasonic treatment of oily sludge.The oil component,surface composition,and structure of the solid particle were determined.The results showed that different surfactants had different oil removal abilities.In the three surfactant-assisted sonication systems,the oil removal rate increased during the starting reaction period and then decreased with longer sonication time.The results of four components analysis suggested that surfactant easy to be ionized in water posed a better removal effect on resins,while the amphiphilic surfactant preferred saturates,aromatics and asphaltenes.The morphology analysis indicated that particle size was shattered into smaller ones by the ultrasonic process,and the wettability of the solid surface also changed during this treatment.The characterization of the oil component and solid particle during surfactant-assisted ultrasonication treatment will help to better understand the separation of oil from oily sludge and improve the oil recovery efficiency from oily sludge. | Zuhong Lin Fushuai Xu Lili Wang Liyang Hu Lingfu Zhu Jie Tan Zhifeng Li Tingting Zhang | 2021 | Chinese Journal of Chemical Engineering2021，34，6： | 2 |
| 6 | System of Grid Resource Monitoring Service显示文摘 | Lingfu Kong Jing Jin Jing Chen Xiaoyan Zhang | 2006 | 通讯和计算机(中英文版)2006，3，1： | 1 |
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