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| 1 | Identification and estimation of the biomass burning contribution to Beijing aerosol using levoglucosan as a molecular marker显示文摘 | Ting Zhang Magda Claeys Hélène Cachier Shuping Dong Wan Wang Willy Maenhaut Xiande Liu | 2008 | Atmospheric Environment2008，，29： | 2 |
| 2 | Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases显示文摘AIM: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer(CRC) predisposing genes in early-onset or familial CRC cases.METHODS: We performed whole-exome sequencing in 23 Chinese patients from 21 families with nonpolyposis CRC diagnosed at ≤ 40 years of age, or from multiple affected CRC families with at least 1 firstdegree relative diagnosed with CRC at ≤ 55 years of age.Genomic DNA from blood was enriched for exome sequences using the Sure Select Human All Exon Kit, version 2(Agilent Technologies) and sequencing was performed on an Illumina Hi Seq 2000 platform.Data were processed through an analytical pipeline to search for rare germline variants in known or novel CRC predisposing genes.RESULTS: In total, 32 germline variants in 23 genes were identified and confirmed by Sanger sequencing.In 6 of the 21 families(29%), we identified 7 mutations in 3 known CRC predisposing genes including MLH1(5 patients), MSH2(1 patient), and MUTYH(biallelic, 1 patient), five of which were reported as pathogenic.Inthe remaining 15 families, we identified 20 rare and novel potentially deleterious variants in 19 genes, six of which were truncating mutations.One previously unreported variant identified in a conserved region of EIF2AK4(p.Glu738_Asp739insA rgA rg) was found to represent a local Chinese variant, which was significantly enriched in our early-onset CRC patient cohort compared to a control cohort of 100 healthy Chinese individuals scored negative by colonoscopy(33.3% vs 7%, P < 0.001).CONCLUSION: Whole-exome sequencing of early-onset or familial CRC cases serves as an efficient method to identify known and potential pathogenic variants in established and novel candidate CRC predisposing genes. | Jun-Xiao Zhang Lei Fu Richarda M de Voer Marc-Manuel Hahn Peng Jin Chen-Xi Lv Eugène TP Verwiel Marjolijn JL Ligtenberg Nicoline Hoogerbrugge Roland P Kuiper Jian-Qiu Sheng Ad Geurts van Kessel | 2015 | World Journal of Gastroenterology2015，21，14： | 1 |
| 3 | GC/ATcontent spikes as genomic punctuation marks显示文摘 | Zhang LG Kasif S Cantor CR Broude NE | | 0，，： | 1 |
| 4 | Anticancer effects of Chinese red yeast rice versus Monaco link alone on colon cancer cells显示文摘 | Hong MY Seeram NE Zhang Y | 2008 | J Nutr Biochem2008，19，7： | 1 |
| 5 | 查看详情显示文摘 | K?nig M Wiedmann S Brüne C Roth A Buhmann H Molenkamp L W Qi X L Zhang S C | | 0，，： | 1 |
| 6 | Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer 显示文摘 | Zhang Q Bhola NE Lui VW | 2007 | Mol Cancer Ther2007，6，4： | 1 |
| 7 | A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults 显示文摘 | Oxman MN Levin MJ Johnson GR Schmader KE Straus SE Gelb LD Arbeit RD Simberkoff MS Gershon AA Davis LE Weinberg A Boardman KD Williams HM Zhang JH Peduzzi PN Beisel CE Morrison VA Guatelli JC Brooks PA Kauffman CA Pachucki CT Neuzil KM Betts RF Wright PF Griffin MR Brunell P Soto NE Marques AR Keay SK Goodman RP Cotton DJ Gnann JW Jr Loutit J Holodniy M Keitel WA Crawford GE Yeh SS Lobo Z Toney JF Greenberg RN Keller PM Harbecke R Hayward AR Irwin MR Kyriakides TC Chan CY Chan IS Wang WW Annunziato PW Silber JL Shingles Prevention Study Group | 2005 | New Engl J Med2005，352，22： | 1 |
| 8 | Vaccine preventable community-acquired pneumonia in hospitalized children in Northwest China显示文摘 | Zhang Q Guo Z Mac Donald NE | 2011 | Pediatr Infect Dis J2011，30，1： | 1 |
| 9 | Rapid large-scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry 显示文摘 | Seeram NE Henning SM Zhang Y | 2005 | Sep Purif Technol2005，41，2： | 1 |
| 10 | Exclusive Low-Molecular-Weight Heparin as Bridging Anticoagulant After Mechanical Valve Replacement显示文摘 | Michel Kindo Sébastien Gerelli Tam Hoang Minh Min Zhang Nicolas Meyer Tarek Announe Jonathan Bentz Ziad Mansour Arnaud Mommerot Hélène Petit-Eisenmann Hélène Kremer Olivier Collange Julien Pottecher Mircea Cristinar Jean-Claude Thiranos Philippe Billaud J | 2013 | The Annals of Thoracic Surgery2013，，： | 1 |
| 11 | Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin显示文摘 | Song L Zhang Y Yun NE | | 0，，42： | 1 |
| 12 | { alpha}2 { beta } 1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor - cell specific manner 显示文摘 | Zhang Z Ramirez NE Yankeelov TE | 2008 | Blood2008，111，4： | 1 |
| 13 | Efficient genome engineering in human pluripotent stem ceils using Cas9 from Neisseria meningi- tides 显示文摘 | Hou Z Zhang Y Propson NE | 2013 | Proceedings of the National Academy of Sciences2013，110，15： | 1 |
| 14 | Improvement of bacterial blight resistance of hybrid rice in China using the Xa23 gene derived from wild rice ( Oryza rufipogon) 显示文摘 | Zhou Y L NE Uzokwe V Zhang C H Cheng L R Wang L Chert K GaoX Q SunY Chen J J Zhu LH Zhang Q AliJ XuJL Li Z K | 2011 | Crop Protection2011，30，： | 1 |
| 15 | Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer 显示文摘 | Zhang Q Bhola NE Lui VW ct al | 2007 | Mol Cancer Ther2007，，4： | 1 |
| 16 | alpha2betal integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner显示文摘 | Zhang Z Ramirez NE Yankeelov TE et at | 2008 | Blood2008，111，4： | 1 |
| 17 | Identifying Canadian freshwater fishes through DNA barcodes显示文摘 | Hubert N Hanner R Holm E Mandrak NE Taylor E Burridge M Watkinson D Dumont P Curry A Bentzen P Zhang J April J Bernatchez L | | 0，，： | 1 |
| 18 | Linking sister chromatid cohesion and apoptosis:role of RAD2显示文摘 | Pati D Zhang NE Plon S | 2002 | Molecular and Cellular Biology2002，22，23： | 1 |
| 19 | Focused evolution of HIV-1 neu- tralizing antibodies revealed by structures and deep sequen- cing显示文摘 | Wu X Zhou T Zhu J Zhang B Georgiev I Wang C Chen X Longo NS Louder M MeKee K O'Dell S Perfet- to S Schmidt SD Shi W Wu L Yang Y Yang ZY Yang Z Zhang Z Bonsignori M Crump JA Kapiga SH Sam NE Haynes BF Simek M Burton DR Koff WC Doria- Rose NA Connors M NISC Comparative Sequencing Pro- gram Mullikin JC Nabel GJ Roederer M Shapiro L Kwong PD Mascola JR | 2011 | Science2011，333，6049： | 1 |
| 20 | Normocalcemic hyperparathyroidism and hypoparathyroidism in two community-based non-referral populations显示文摘 | Cusano NE Maalouf NM Wang PY Zhang C Cremers SC Haney EM Bauer DC Orwoll ES Bilezikian JP | | 0，，： | 1 |
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