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| 1 | Ultrasonically activated scalpel versus monopolar electrocautery shovel in laparoscopic total mesorectal excision for rectal cancer显示文摘AIM: To investigate the feasibility and safety of monopolar electrocautery shovel (ES) in laparoscopic total mesorectal excision (TME) with anal sphincter preservation for rectal cancer in order to reduce the cost of the laparoscopic operation, and to compare ES with the ultrasonically activated scalpel (US). METHODS: Forty patients with rectal cancer, who underwent laparoscopic TME with anal sphincter preservation from June 2005 to June 2007, were randomly divided into ultrasonic scalpel group and monopolar ES group, prospectively. White blood cells (WBC) were measured before and after operation, operative time, blood loss, pelvic volume of drainage, time of anal exhaust, visual analogue scales (VAS) and surgery-related complications were recorded. RESULTS: All the operations were successful; no one was converted to open procedure. No significant differences were observed in terms of preoperative and postoperative d 1 and d 3 WBC counts (P = 0.493, P = 0.375, P = 0.559), operation time (P = 0.235), blood loss (P = 0.296), anal exhaust time (P = 0.431), pelvicdrainage volume and VAS in postoperative d 1 (P = 0.431, P = 0.426) and d 3 (P = 0.844, P = 0.617) between ES group and US group. The occurrence of surgery-related complications such as anastomotic leakage and wound infection was the same in the two groups. CONCLUSION: ES is a safe and feasible tool as same as US used in laparoscopic TME with anal sphincter preservation for rectal cancer on the basis of the skillful laparoscopic technique and the complete understanding of laparoscopic pelvic anatomy. Application of ES can not only reduce the operation costs but also benef it the popularization of laparoscopic operation for rectal cancer patients. | Bao-Jun Zhou, Wei-Qing Song, Qing-Hui Yan, Jian-Hui Cai, Feng-An Wang, Jin Liu, Guo-Jian Zhang, Guo-Qiang Duan, Zhan-Xue Zhang, Department of Gastrointestinal Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China Author contributions: Zhou BJ, Song WQ, Yan QH, Cai JH, Wang FA, Liu J, Zhang GJ, Duan GQ and Zhang ZX contributed equally to this work Zhou BJ, Song WQ, Yan QH, Cai JH and Wang FA designed the research Zhou BJ, Liu J and Zhang GJ performed the research Duan GQ and Zhang ZX analyzed the data and Zhou BJ, Song WQ and Yan QH wrote the paper. | 2008 | World Journal of Gastroenterology2008，14，25： | 25 |
| 2 | Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi显示文摘BACKGROUND:Many Chinese herbs,especially herbal injections,have been shown to have anti-tumor effects in recent years.However,since most reports focus on the clinical effectiveness of these herbs,their mechanisms of action are not well understood.In this study,we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis,SC),and monitored the expression of Bcl-2 and caspase-8.METHODS:Injectable SC was applied to HepG2 cells at different concentrations and the cells were collected 12,24 and 48 hours later.5-fluorouracil was used as a positive control group,and fluorescence-activated cell-sorting cytometry was used to measure the apoptosis rate of HepG2 cells and the expression of Bcl-2 and caspase-8 proteins.RESULTS:SC induced apoptosis in HepG2 cells in a concentration and time-dependent manner,and the expression of caspase-8 was elevated and prolonged.However,it did not significantly influence the expression of Bcl-2.CONCLUSION:Injectable SC may induce apoptosis in HCC cells by regulating the expression of caspase-8. | Department of General Surgery (Lu Y and Zhang BY),Department of Bio-Information (Jia ZX),Affiliated Medical College Hospital,Qingdao University,Qingdao 266003,China Shanghai Jiaotong University School of Medicine,Shanghai 200025,China (Wu WJ) Department of Medicine,Heze Medical College,Heze 274000,China (Lu ZQ) | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 17 |
| 3 | Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai.显示文摘 | Zhang ZX Roman GC Hong Z Wu CB Qu QM Huang JB Zhou B Geng ZP Wu JX Wen HB Zhao H Zahner GE | 2006 | 中国生物学文摘2006，20，8： | 9 |
| 4 | The compression of IR spectra by using wavelet neural network显示文摘IR spectra play an important role in determining the structure of compounds qualitatively andquantitatively.In general a great number of data are required to exactly show the features ofthe compounds.Regarding various compounds,there are massive IR spectra.With the basicfeatures of IR spectra being reserved,it is important to compress IR spectra for improving thestorage,index and process of IR spectra.The wavelet neural network(WNN)is a newneural network model based on wavelet analysis.However,its introduction and applica-tion in chemistry have not been reported.In this note,WNN is applied to the compression ofthe IR spectra of polystyrene.The results show that the original spectra can be | Liu, W Li, JP Xiong, JH Pan, ZX Zhang, MS | 1997 | Chinese Science Bulletin1997，42，10： | 8 |
| 5 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 6 | Expression of gap junctions and inhibition of cell growth in communication-defected cells after transfection with gap junction gene Cx43 cDNA显示文摘Gap junctions form intercellular channels for direct exchange of metabolites and second messengers between adjacent cells. The existence of a multi-gene family encoding gap junction proteins, i. e. the connexins (Cx), has been recently demonstrated. Despite the overall sequence homologies and a similar predicted structural motif, their functional properties differ in various tissues. Because of coexpression of two or more connexin proteins in one tissue, determination of properties specific for each connexin is complicated. The regulation of expression of gap junctions and their roles in cellular activities remain mostly unelucidative. Controlled manipulation of connexin molecules in Xenopus oocyte expression system has been use- | Zhang, ZQ Lin, ZX Wang, NQ Han, YL | 1997 | Chinese Science Bulletin1997，42，5： | 3 |
| 7 | A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUM显示文摘A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUMFangShengWANG;HuiCAI;ZaiXinJING(UniversityofAgricultureandAnimalScience.P... | Wang, FS Cai, H Jing, ZX Yang, JS Zhang, YM | 1995 | Chinese Chemical Letters1995，6，12： | 2 |
| 8 | Effect of HSP70 antisense RNA on normal sorghum pollen formation显示文摘IT has been found that heat shock proteins (hsp) exist universally in animals, plants, microbesand human beings. Some of hsps possess functions of molecular chaperons, such as hsp60,hsp70 and hsp90, which participate in folding and assembling polypeptides to functional struc-tures and transferring them into suitable sites. They also undertake repairing damaged cellularDNA and nucleolus. Therefore, they are house-keeping proteins and play an importantrole in maintaining normal cellular life and functions and in cellular response to environmentalstresses. There exists high homology in DNA sequence among the hsp of the same molecularweight across species. We have first reported the close relationship between hsps | Chen, JN Fu, HY Lu, ZX Qin, HY Zhang, L Guo, ZB | 1997 | Chinese Science Bulletin1997，42，23： | 2 |
| 9 | Identification of a pre2 viously unknown antigen2specific regulatory T cell a nd its mechanism of suppression显示文摘 | Zhang ZX Yang L Young K J | 2000 | Nat Med2000，6，7： | 1 |
| 10 | Prevalence of Parkinson's disease and related disorders in the elderly population of greater Beijing, China 显示文摘 | Zhang ZX Anderson DW Huang JB | 2003 | Movement Disorders2003，18，7： | 1 |
| 11 | Ly-6A is critical for the function of double negative regulatory T cells显示文摘 | Stanford WL Zhang L | 2002 | Eur J Immunol2002，32，6： | 1 |
| 12 | 5-aminolevulinic acid-based photodynamic therapy in leukemia cell HL60显示文摘 | Zhang SJ Zhang ZX | 2004 | Photochem Photobiol2004，79，： | 1 |
| 13 | Anti- IL-2 receptor antibody decreases cytokine- induced apoptosis of human renal tubular epithelial cells(TEC )显示文摘 | WANG S ZHANG ZX YIN Z | 2011 | Nephrol Dial Transplant2011，26，7： | 1 |
| 14 | Low birth weight is associated with components of the metabolic syndrome 显示文摘 | Xiao X Zhang ZX Li WH | 2010 | Metabolism2010，59，： | 1 |
| 15 | Dementia Subtypes in China: Prevalencl in Beijing, Xi'an, Shanghai and chengdu 显示文摘 | Zhang ZX Zahner GE P Roman GC | 2005 | ArchNeurol2005，62，： | 1 |
| 16 | Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu显示文摘 | Zhang ZX Zahner GE | 2005 | Arch Neurol2005，62，3： | 1 |
| 17 | Relationship between birth head circumference and adulthood quality of life in Chinese people 显示文摘 | Xu T Zhang ZX Han SM | 2010 | J Paediatr Child Health2010，46，11： | 1 |
| 18 | The current status of occupational health in China 显示文摘 | Zhang XY Wang ZX Li T | 2010 | Environ Health Prev Med2010，15，5： | 1 |
| 19 | Serum antitoxin antibodies mediate systemic and mucosal protection from Clostridium difficile disease in hamsters显示文摘 | Paul JG Zhang ZX Lei WD | 1999 | Infect Immun1999，67，： | 1 |
| 20 | Parkinson's disease in China:prevalence in Beijing,Xian,and Shanghai显示文摘 | Zhang ZX Roman GC Hong Z | 2005 | Lancet2005，365，9459： | 1 |
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