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| 1 | Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer显示文摘 | Jiang Kewei Lyu Liang Shen Zhanlong Zhang Jizhun Zhang Hui Dong Jianqiang Yan Yichao Liu Fangfang Wang Shan | 2014 | Chinese Medical Journal2014，，11： | 5 |
| 2 | Vasohibin-1 and vasohibin-2 expression in gastric cancer cells and TAMs显示文摘 | Zhanlong Shen Tuuli Kauttu Hanna Sepp?nen Sanna Vainionp?? Yingjiang Ye Shan Wang Harri Mustonen Pauli Puolakkainen | 2012 | Medical Oncology2012，，4： | 2 |
| 3 | 对比经肛全直肠系膜切除术与腹腔镜全直肠系膜切除术:一项多中心III期随机临床试验(TaLaR试验)方案显示文摘背景:全直肠系膜切除术是直肠癌治疗的标准手术方法。经肛全直肠系膜切除术(taTME)是治疗低位直肠癌的新术式。既往研究表明,与腹腔镜全直肠系膜切除术(lapTME)相比,taTME应用于低位直肠癌患者可提供更高质量的手术标本,但其长期肿瘤学结果仍需进一步观察。因此,我们设计了这个非劣效性临床试验(TaLaR试验),比较taTME与lapTME治疗直肠癌的短期和长期结果。方法/设计:TaLaR试验是一项多中心III期随机对照试验。研究对象为经磁共振成像、直肠指检或结肠镜检查被诊断为位于腹膜反折以下的直肠癌,若肿瘤分期≤cT3N2直接手术,若>cT3N2则先行新辅助治疗。通过计算,本研究需纳入1,114例患者(每组557例)。纳入病例随机分配到taTME或lapTME组。本研究的主要终点是3年无病生存率(DFS)和5年总生存率(OS)。次要终点包括手术标本质量、围手术期结果、骨盆和肛门功能以及生活质量。讨论:我们认为,TaLaR试验将阐明taTME是否可以达到与lapTME相似的肿瘤学结果,以及是否可改善直肠癌患者的手术标本质量及恢复情况。 | Liang Kang Ziwei Zeng Shuangling Luo Hong Zhang Quan Wang Mingyang Ren Miao Wu Weidong Tong Qing Xu Yi Xiao Aiwen Wu Yuan-Guang Chen Bo Feng Zhanlong Shen Liang Huang Xingwei Zhang Minhua Zheng Jian-Ping Wang | 2021 | Gastroenterology Report2021，9，1： | 2 |
| 4 | Cancer Ig G, a potential prognostic marker, promotes colorectal cancer progression显示文摘Objective: Currently, no satisfactory targets for colorectal cancer or markers for immunotherapy and diagnosis and prognosis are available. Immunoglobulin G(Ig G) is widely expressed in many cancers, and it promotes cancer progression. This study explored the role of cancer-derived Ig G(CIg G) in colorectal cancer.Methods: First, using a monoclonal antibody to CIg G, we examined the expression levels of CIg G in colorectal cancer cell lines by western blot and immunofluorescence analyses and in tissue specimens by immunohistochemistry. Second, the variable region gene was amplified by nested polymerase chain reaction(PCR), and PCR products were sequenced and analyzed. Third, we investigated the effect of CIg G on colorectal cancer cells by cell proliferation, wound healing, migration and invasion assays, and colony formation assay. Fourth, we performed in vivo tumorigenicity experiments to explore the effect of CIg G on tumorigenicity. Finally, we used RNA-seq analysis and co-immunoprecipitation experiments to further clarify possible mechanisms of CIg G.Results: We found that CIg G is widely expressed in colorectal cancer cells, and the overexpression of CIg G indicates significantly poor colorectal cancer prognosis. Furthermore, CIg G knockdown significantly inhibits the proliferation, migration and invasion ability of cells, and tumor growth in vivo. RNA-seq analysis indicated that CIg G knockdown results primarily in changes in expression of apical junction and epithelial-mesenchymal transition-related genes. CIg G may be involved in colorectal cancer invasion and metastasis through interacting with E-cadherin.Conclusions: CIg G is a potential human oncogene in colorectal cancer and that it has potential for application as a novel target in targeted therapy and a marker for prognostic evaluation. | Hongpeng Jiang Boxi Kang Xinmei Huang Yichao Yan Shan Wang Yingjiang Ye Zhanlong Shen | 2019 | Chinese Journal of Cancer Research2019，31，3： | 2 |
| 5 | A novel molecu- lar marker of prognosis in colorectal cancer: Vasohibin - 1 显示文摘 | Yichao Yan Zhanlong Shen Yingjiang Ye | 2014 | Med Oncol2014，31，： | 1 |
| 6 | Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis显示文摘 | Zhanlong Shen Yingjiang Ye Liang Bin Mujun Yin Xiaodong Yang Kewei Jiang Shan Wang | 2010 | The American Journal of Surgery2010，，1： | 1 |
| 7 | Macrophage coculture enhanced invasion of gastric cancer cells via TGF-β and BMP pathways显示文摘 | Zhanlong Shen Tuuli Kauttu Jian Cao Hanna Sepp?nen Sanna Vainionp?? Yingjiang Ye Shan Wang Harri Mustonen Pauli Puolakkainen | 2013 | Scandinavian Journal of Gastroenterology2013，，4： | 1 |
| 8 | The novel focal adhesion gene kindlin-2 promotes the invasion of gastriccancer cells mediated by tumor-associated macrophages显示文摘 | Zhanlong Shen Yingjiang Ye Tuuli Kauttu Hanna Sepp?nen Sanna Vainionp?? Shan Wang Harri Mustonen Pauli Puolakkainen | 2013 | Oncology Reports2013，，2： | 1 |
| 9 | Metabolic syn- drome is an important factor for the evolution of prognosis of colo- rectal cancer : Survival, recurrence, and liver metastasis 显示文摘 | Zhanlong Shen Yingjiang Ye Liang Bin | 2010 | Am J Sur2010，200，1： | 1 |
| 10 | Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing显示文摘Objective:The goal of this study was to get preliminary insight on the intra-tumor heterogeneity in colitisassociated cancer(CAC)and to reveal a potential evolutionary trajectory from ulcerative colitis(UC)to CAC at the single-cell level.Methods:Fresh samples of tumor tissues and adjacent UC tissues from a CAC patient with pT3N1M0 stage cancer were examined by single-cell RNA sequencing(scRNA-seq).Data from The Cancer Genome Atlas(TCGA)and The Human Protein Atlas were used to confirm the different expression levels in normal and tumor tissues and to determine their relationships with patient prognosis.Results:Ultimately,4,777 single-cell transcriptomes(1,220 genes per cell)were examined,of which 2,250(47%)and 2,527(53%)originated from tumor and adjacent UC tissues,respectively.We defined the composition of cancer-associated stromal cells and identified six cell clusters,including myeloid,T and B cells,fibroblasts,endothelial and epithelial cells.Notable pathways and transcription factors involved in these cell clusters were analyzed and described.Moreover,the precise cellular composition and developmental trajectory from UC to UCassociated colon cancer were graphed,and it was predicted that CD74,CLCA1,and DPEP1 played a potential role in disease progression.Conclusions:scRNA-seq technology revealed intra-tumor cell heterogeneity in UC-associated colon cancer,and might provide a promising direction to identify novel potential therapeutic targets in the evolution from UC to CAC. | Quan Wang Zhu Wang Zhen Zhang Wei Zhang Mengmeng Zhang Zhanlong Shen Yingjiang Ye Kewei Jiang Shan Wang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 1 |
| 11 | Evaluation of the seventh AJCC TNM staging system for gastric cancer: a meta-analysis of cohort studies显示文摘 | Jizhun Zhang Yangbing Zhou Kewei Jiang Zhanlong Shen Yingjiang Ye Shan Wang | 2014 | Tumor Biology2014，，9： | 1 |
| 12 | Establishment of organoid models based on a nested array chip for fast and reproducible drug testing in colorectal cancer therapy显示文摘The conventional microwell-based platform for construction of organoid models exhibits limitations in precision oncology applications because of low-speed growth and high variability. Here, we established organoid models on a nested array chip for fast and reproducible drug testing using 50% matrigel. First, we constructed mouse small intestinal and colonic organoid models. Compared with the conventional microwell-based platform, the mouse organoids on the chip showed accelerated growth and improved reproducibility due to the nested design of the chip. The design of the chip provides miniaturized and uniform shaping of the matrigel that allows the organoid to grow in a concentrated and controlled manner. Next, a patient-derived organoid(PDO) model from colorectal cancer tissues was successfully generated and characterized on the chip. Finally, the PDO models on the chip, from three patients, were implemented for high-throughput drug screening using nine treatment regimens. The drug sensitivity testing on the PDO models showed good quality control with a coefficient of variation under 10% and a Z’ factor of more than 0.7. More importantly, the drug responses on the chip recapitulate the heterogeneous response of individual patients, as well as showing a potential correlation with clinical outcomes. Therefore,the organoid model coupled with the nested array chip platform provides a fast and reproducible means for predicting drug responses to accelerate precise oncology. | Yancheng Cui Rongrong Xiao Yushi Zhou Jianchuang Liu Yi Wang Xiaodong Yang Zhanlong Shen Bin Liang Kai Shen Yi Li Geng Xiong Yingjiang Ye Xiaoni Ai | 2022 | Bio-Design and Manufacturing2022，5，4： | 0 |
| 13 | Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer显示文摘Dear Editor,Early diagnosis is critical for successful treatment of gastric adenocarcinoma(GA).However,the sensitivities of tumor markers carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9)and CA72-4 for GA detection are approximately 20%[1],and the sensitivities of all markers combined for early gastric cancer detection is still very low[2].DNA methylation plays a major role in tumorigenesis and therefore has obvious potential as a non-invasive biomarker for cancer detection[3].Through genome-wide methylation analysis and histological verification,we previously identified ring finger protein 180(RNF180)as a novel preferentially methylated gene in GA[4,5]. | Yongzhan Nie Xianchun Gao Xiqiang Cai Zhen Wu Qiaoyi Liang Guobing Xu Na Liu Peng Gao Jingyu Deng Hongzhi Xu Zhanlong Shen Changqi Cao Fenrong Chen Nannan Zhang Yongxi Song Mingjun Sun Chengyin Liu Guangpeng Zhou Weili Han Jianhua Dou Huahong Xie Liping Yao Zhiguo Liu Gang Ji Xin Wang Qingchuan Zhao Lei Shang Daiming Fan Xiaoliang Han Jianlin Ren Han Liang Zhenning Wang Jinhai Wang Qi Wu Jun Yu Kaichun Wu the MAGIS Study Group | 2023 | Cancer Communications2023，43，11： | 0 |
| 14 | Biomarkers for immune checkpoint inhibitors in colorectal cancer:recent advances and future perspectives显示文摘Colorectal cancer(CRC)has become a major threat to human health.Recent years,improvements have been seen in the treatment of advanced CRC with immune checkpoint inhibitors(ICIs).Nonetheless,sensitivity to ICIs notably varies among patients,thus greatly limiting clinical applications of ICIs in CRC.Hence,the identification of biomarkers that can accurately distinguish between ICI-sensitive and drug-resistant patients is of utmost importance.Such biomarkers are essential for selecting appropriate treatment regimens and achieving precision therapy(Figure 1).The biomarkers discussed below provide insights into the advancements made in this field(Table 1). | Changjiang Yang Long Zhao Yilin Lin Shan Wang Yingjiang Ye Zhanlong Shen | 2023 | Cancer Biology & Medicine2023，20，9： | 0 |
| 15 | Examined lymph node numbers influence prognosis in rectal cancer treated with neoadjuvant therapy显示文摘Background:The number of lymph nodes examined(LNe)is often insufficient in patients with rectal cancer(RC)treated with neoadjuvant therapy;however,its prognostic value remains controversial.Thus,we retrospectively explored whether LNe had an influence on staging and prognosis and investigated whether there was a cut-off value for better prognosis in patients with RC treated with neoadjuvant therapy.Methods:Data were collected from seven prospective hospital databases in China from July 2002 to May 2018.Binary logistic regression models were used to predict lymph node metastasis.The cut-off value for LNe was determined using X-tile 3.6.1.Survival outcomes and risk factors were analyzed using the log-rank test and Cox regression model.Results:A total of 482 patients were included,of whom 459 had complete overall survival(OS)information.Using the percentile method,the total number of lymph nodes examined(TLNe)was 14-16(40th-60th percentile),and the proportion of patients with lymph node metastasis reached a maximum of 48.1%.Cox multivariate analysis showed that the odds ratio(OR)remained the highest when TLNe was 14-16(OR=3.379,P=0.003).The 3-year and 5-year OS were 85.4% and 77.8%,respectively.Negative lymph nodes examined(NLNe)of≤6 was an independent risk factor for 3-year and 5-year OS(3-year OS 71.1%vs.85.9%,P=0.004;5-year OS 66.3%vs.74.3%,P=0.035).Subgroup analysis for patients with ypN+showed that higher 3-year and 5-year OS were achieved when the TLNe was>10,78.8%vs.54.0%(P=0.005),and 60.8%vs.36.0%(P=0.012),respectively.Patients with ypN0M0 had a higher 5-year OS when the TLNe was>19(P=0.055).Conclusion:The TLNe and NLNe influenced the staging accuracy and demonstrated prognostic value in patients with RC treated with neoadjuvant therapy. | Liyu Zhu Lin Wang Zhidong Gao Yujian Zeng Kaixiong Tao Quan Wang Xinming Li Huanhu Zhang Zhanlong Shen Jing Zhou Kai Shen Yingjiang Ye Aiwen Wu | 2023 | Cancer Pathogenesis and Therapy2023，1，3： | 0 |
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