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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | Sea fog detection based on unsupervised domain adaptation显示文摘Sea fog detection with remote sensing images is a challenging task. Driven by the different image characteristics between fog and other types of clouds, such as textures and colors, it can be achieved by using image processing methods. Currently, most of the available methods are datadriven and relying on manual annotations. However, because few meteorological observations and buoys over the sea can be realized, obtaining visibility information to help the annotations is difficult. Considering the feasibility of obtaining abundant visible information over the land and the similarity between land fog and sea fog, we propose an unsupervised domain adaptation method to bridge the abundant labeled land fog data and the unlabeled sea fog data to realize the sea fog detection. We used a seeded region growing module to obtain pixel-level masks from roughlabels generated by the unsupervised domain adaptation model. Experimental results demonstrate that our proposed method achieves an accuracy of sea fog recognition up to 99.17%, which is nearly 3% higher than those vanilla methods. | Mengqiu XU Ming WU Jun GUO Chuang ZHANG Yubo WANG Zhanyu MA | 2022 | Chinese Journal of Aeronautics2022，35，4： | 3 |
| 3 | Data scheme-based wireless channel modeling method: motivation, principle and performance显示文摘In recent years,data mining and machine learning technologies have made great progress driven by enormous volumes of data.Meanwhile,the wireless-channel measurement data appears large in volume because of the large-scale antenna numbers,increased bandwidth,and versatile application scenarios.With powerful data mining and machine learning methods and large volumes of data,we can extract valuable and hidden rules from the wireless channel.Motivated by this,we propose a channel-modeling method using PCA in this paper.Its principle is to utilize the features and structures extracted from the CIR data collected by measurements,and then model the wireless channel of the targeted measurement scenario.In addition,a noise removing method using a BP neural network is designed for the proposed model,which can recognize and remove the noise of the polluted CIR accurately.The performance of the proposed scheme is investigated with the actual measured CIR data,and its superiority is verified. | Xiaochuan Ma Jianhua Zhang Yuxiang Zhang Zhanyu Ma | 2017 | Journal of Communications and Information Networks2017，2，3： | 3 |
| 4 | Probabilistic mul- tiview depth image enhancement using variational inference 显示文摘 | Rana P K Taghia J Ma Zhanyu | 2015 | IEEE Journal of Elected Topics in Signal Processing2015，9，3： | 1 |
| 5 | Efficacy of methionine hydroxy analog and DL-methionine as methionine sources for growing pigs显示文摘 | Zhanyu Feng Shiyan Qiao Yongxi Ma | | 0，，02： | 1 |
| 6 | CMK-3 modified separator for ultra-high stability performance Cu_(1.8)Se aluminum batteries显示文摘Rechargeable aluminum batteries(RABs)are a popular energy storage device because of its safety and environmental protection.As cathode materials of RABs,transition metal oxide,sulfide,and selenide have become the research hotspot.In this work,we have successfully prepared CuO,Cu_(1.8)S,and Cu_(1.8)Se electrode materials.Among them,although Cu_(1.8)Se had a relatively higher initial discharge capacity,all of these products had severe capacity degradation in terms of cycling and rate performance.Furthermore,for solving the problem of capacity decline,CMK-3 modified separator was used to make the Cu_(1.8)Se cathode material more stable,thus improving cycling and rate performance.It can be confirmed by ex situ X-ray photoelectron spectroscopy(XPS)that both Cu and Se elements underwent reversible redox reactions during the charging/discharging process.Density functional theory was implemented to study the energy storage mechanism of CumX(X=O,S,Se).The results showed that Cu_(1.8)S and Cu_(1.8)Se mainly relied on AlCl4−for energy storage,and the intercalation/de-intercalation of Al3+occurred during the charge/discharge process in CuO material.Consequently,the optimized Cu_(1.8)Se/CMK-3@GF/C/Al revealed an outstanding rate capability(977.83 mAh·g^(−1)at 0.5 A·g^(−1))and long cyclic stability(retention of 478.77 mAh·g^(−1)after 500 cycles at 1.0 A·g^(−1)).Compared to previously reported cathode materials of RABs,this type of battery displays great superiority in terms of rate and cycling stability.This research also provides a novel approach to suppress the shuttle effect of active species for advanced clean energy devices. | Xiaoxiao Li Mingxiao Ma Wenrong Lv Gaohong Wu Ruqian Lian Wenming Zhang Zhanyu Li | 2022 | Nano Research2022，15，9： | 0 |
| 7 | Structural Connectivity Enhanced Anisotropic 3D Network for Brain Midline Delineation显示文摘Brain midline delineation can facilitate the clinical evaluation of brain midline shift,which has a pivotal role in the diagnosis and prognosis of various brain pathology.However,there are still challenges for brain midline delineation:1)the largely deformed midline is hard to localize if mixed with severe cerebral hemorrhage;2)the predicted midlines of recent methods are not smooth and continuous which violates the structural priority.To overcome these challenges,we propose an anisotropic three dimensional(3D)network with context-aware refinement(A3D-CAR)for brain midline modeling.The proposed network fuses 3D context from different two dimensional(2D)slices through asymmetric context fusion.To exploit the elongated structure of the midline,an anisotropic block is designed to balance the difference between the adjacent pixels in the horizontal and vertical directions.For maintaining the structural priority of a brain midline,we present a novel 3D connectivity regular loss(3D CRL)to penalize the disconnectivity between nearby coordinates.Extensive experiments on the CQ dataset and one in-house dataset show that the proposed method outperforms three state-of-the-art methods on four evaluation metrics without excessive computational burden. | Yufan Liu Kongming Liang Yinuo Jing Shen Wang Zhanyu Ma Yiming Li Yizhou Yu Yizhou Wang Jun Guo | 2023 | Journal of Beijing Institute of Technology2023，32，5： | 0 |
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