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94篇 您的检索式:作者名="Yizhou Wang"
    题名 作者 年代 出处 被引量
1A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo显示文摘Chao Jiang Miao Mei Bin Li Xiurui Zhu Wenhong Zu Yujie Tian Qiannan Wang Yong GUO Yizhou Dong Xu Tan 2017Cell Research2017,27,3:12
2MiR-29a/b/c regulate human circadian gene hPER1 expression by targeting its 3/UTR显示文摘在哺乳动物的几必要生物进步被生理节奏的节奏调整。不过分子的机制 ofoscillating 这些生理节奏的节奏被揭开了,生理节奏的基因的特定的功能不是很, clear.It 被报导了那由 microRNA 将生理节奏的基因击倒是有用策略探索 circadianrhythms 的功能。在这研究,通过屏蔽途径的前面的生物信息学,我们作为有势力 inhibitorsfor 识别了 miR-29a/b/c 人的生理节奏的基因 hPER1。我们进一步发现 miR-29a/b/c 能直接在人的 A549 房间在 mRNA 和蛋白质表示层次指向 hPER1 3untranslated 区域(UTR ) 和下面调整 hPER1。因此,我们的调查结果建议 hPER1 的表示被 miR-29a/b/c 调整,它可以也为 hPER1 的功能提供新线索。Xiyan Zhao Xueqiang Zhu Shuting Cheng Yizhou Xie Zhengrong Wang Yanyou Liu Zhou Jiang Jing Xiao Huiling Guo Yuhui Wang 2014Acta Biochimica et Biophysica Sinica2014,46,4:7
3Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury显示文摘Wallerian degeneration occurs after peripheral nerve injury and provides a beneficial microenvironment for nerve regeneration.Our previous study demonstrated that ascorbic acid promotes peripheral nerve regeneration,possibly through promoting Schwann cell proliferation and phagocytosis and enhancing macrophage proliferation,migration,and phagocytosis.Because Schwann cells and macrophages are the main cells involved in Wallerian degeneration,we speculated that ascorbic acid may accelerate this degenerative process.To test this hypothesis,400 mg/kg ascorbic acid was administered intragastrically immediately after sciatic nerve transection,and 200 mg/kg ascorbic acid was then administered intragastrically every day.In addition,rat sciatic nerve explants were treated with 200μM ascorbic acid.Ascorbic acid significantly accelerated the degradation of myelin basic protein-positive myelin and neurofilament 200-positive axons in both the transected nerves and nerve explants.Furthermore,ascorbic acid inhibited myelin-associated glycoprotein expression,increased c-Jun expression in Schwann cells,and increased both the number of macrophages and the amount of myelin fragments in the macrophages.These findings suggest that ascorbic acid accelerates Wallerian degeneration by accelerating the degeneration of axons and myelin in the injured nerve,promoting the dedifferentiation of Schwann cells,and enhancing macrophage recruitment and phagocytosis.The study was approved by the Southern Medical University Animal Care and Use Committee(approval No.SMU-L2015081)on October 15,2015.Lixia Li Yizhou Xu Xianghai Wang Jingmin Liu Xiaofang Hu Dandan Tan Zhenlin Li Jiasong Guo 2021Neural Regeneration Research2021,16,6:6
4Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression显示文摘Background:Cancer cells selectively promote the translation of oncogenic tran-scripts to stimulate cancer progression.Although growing evidence has revealed that tRNA modifications and related genes participate in this process,their roles in head and neck squamous cell carcinoma(HNSCC)remain largely unchar-acterized.Here,we sought to investigate the function and mechanisms of the transfer RNA(tRNA)N7-methylguanosine(m'G)modification in regulating the occurrence and development of HNSCC.Methods:Cell lost of-function and gain-of function assays,xenograft models,conditional knockout and knockin mouse models were used to study the physi-ological functions of tRNA m'G modification in HNSCC tumorigenesis.tRNA modification and expression profiling,mRNA translation profiling and res-cue assays were performed to uncover the underlying molecular mechanisms.Single-cell RNA sequencing(scRNA seq)was conducted to explore the tumor microenvironment changes.Results:The tRNA.m7G methyltransferase complex components Methyltransferase-like 1(METTL1)/WD repeat domain 4(WDR4)were upregulated in HNSCC and associated with a poor prognosis.Functionally,METTL1/WDR4 promoted HNSCC progression and metastasis in cell-based and transgenic mouse models.Mechanistically,ablation of METTL1 reduced the m'G levels of 16 tRNAS,inhibiting the translation of a subset of oncogenic transcripts,including genes related to the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)signaling pathway.In addition,chemical modulators of the PI3K/Akt/mTOR signaling pathway reversed the effects of Mettll in mouse HNSCC.Furthermore,scRNA-seq results revealed that Mettll knockout in mouse tumor cells altered the immune landscape and cell-cell interaction between the tumor and stromal compartment.Conclusions:The tRNA m?G methyltransferase METTLI was found to promote the development and malignancy of HNSCC through regulating global mRNA translation,including the PI3K/AKT/mTOR signaling pathway,and found to alter immune landscape.METTLI could be a promising treatment target for HNSCC patients.Jie Chen Kang Li Jianwen Chen Xiaochen Wang Rongsong Ling Maosheng Cheng Zhi Chen Fangfang Chen Qianting He Shuai Li Caihua Zhang Yizhou Jiang Qianming Chen Anxun Wang Demeng Chen 2022Cancer Communications2022,42,3:6
5Intensifying Electron Utilization by Surface-Anchored Rh Complex for Enhanced Nicotinamide Cofactor Regeneration and Photoenzymatic CO_(2)Reduction显示文摘Solar-driven photocatalytic regeneration of cofactors,including reduced nicotinamide adenine dinucleotide(NADH),reduced nicotinamide adenine dinucleotide phosphate(NADPH),and reduced flavin adenine dinucleotide(FADH_(2)),could ensure the sustainable energy supply of enzymatic reactions catalyzed by oxidoreductases for the efficient synthesis of chemicals.However,the elevation of cofactor regeneration efficiency is severely hindered by the inefficient utilization of electrons transferred on the surface of photocatalysts.Inspired by the phenomenon of ferredoxin-NADP+reductase(FNR)anchoring on thylakoid membrane,herein,a homogeneous catalyst of rhodium(Rh)complex,[Cp_(∗)Rh(bpy)H_(2)O]^(2+),was anchored on polymeric carbon nitride(PCN)mediated by a tannic acid/polyethyleneimine(TA/PEI)adhesive layer,acquiring PCN@TA/PEI-Rh core@shell photocatalyst.Illuminated by visible light,electrons were excited from the PCN core,then transferred through the TA/PEI shell,and finally captured by the surface-anchored Rh for instant utilization during the regeneration of NADH.The TA/PEI-Rh shell could facilitate the electron transfer from the PCN core and,more importantly,achieved~1.3-fold elevation of electron utilization efficiency compared with PCN.Accordingly,the PCN@TA/PEI-Rh afforded the NADH regeneration efficiency of 37.8%after 20 min reaction under LED light(405 nm)illumination,over 1.5 times higher than PCN with free Rh.Coupling of the NADH regeneration system with formate dehydrogenase achieved continuous production of formate from carbon dioxide(CO_(2)).Our study may provide a generic and effective strategy to elevate the catalytic efficiency of a photocatalyst through intensifying the electron utilization.Yuqing Cheng Jiafu Shi Yizhou Wu Xueying Wang Yiying Sun Ziyi Cai Yu Chen Zhongyi Jiang 2021Research2021,,1:5
6Effects of scanning speed on microstructure in laser surface-melted single crystal superalloy and theoretical analysis显示文摘Scanning speed is a critical parameter for laser process,which can play a key role in the microstructure evolution of laser melting.In the laser melting of single crystal superalloy,the effects of scanning speed were investigated by experimental analysis and computational simulation.The laser was scanning along710 direction on(001) surface in different speeds.Solidification microstructures of dendrites growth direction and the primary dendritic spacing were analyzed by metallograph.Besides,a planar interface during solidification was taken into attention.Experiment results indicated that the primary dendritic spacing and thickness of planar interface decrease with the increase of speed.Through simulation,distribution of dendrites growth velocity and thermal gradient along dendrite growth direction were calculated,and the simulation of dendrites growth direction agreed with the experiment results.Additionally,a constant value was acquired which can be used to predict the primary dendritic spacing.Moreover,according to curve-fitting method and inequality relation,a model was proposed to predict the thickness of planar interface.Guowei Wang Jingjing Liang Yanhong Yang Yu Shi Yizhou Zhou Tao Jin Xiaofeng Sun 2018Journal of Materials Science & Technology2018,34,8:5
7Multi-objective optimal preliminary planning of multi-debris active removal mission in LEO显示文摘The goal of this paper is to develop a preliminary plan for a multi-nanosatellite active debris removal platform(Mn ADRP) for low-Earth-orbit(LEO) missions. A dynamic multi-objective traveling salesman problem(TSP) scheme is proposed in which three optimization objectives, i.e., the debris removal priority,the Mn ADRP orbital transfer energy, and the number of required nanosatellites are modeled respectively. A modified genetic algorithm(GA) is also proposed to solve the dynamic multi-objective TSP. Finally, numerical experiments involving partially real-world the debris data set are conducted to verify the efficacy of the proposed models and the solution method.Yong LIU Jianan YANG Yizhou WANG Quan PAN Jianping YUAN 2017Science China(Information Sciences)2017,60,7:4
8Parentage Analysis of Dongfang No.2, a Hybrid of a Female Gametophyte Clone of Laminaria japonica (Laminariales, Phaeophyta) and a Male Clone of L. longissima显示文摘The cultivation of the first filial generation of monoploid gametophyte clones of different Laminaria species (hybrid Laminaria) is an effective way of utilizing heterozygous vigor (heterosis). A female gametophyte clone of L. japonica and a male gametophyte clone of L. longissima were hybridized, generating Dongfang No.2 hybrid Laminaria. The parentage of this hybrid Laminaria was determined using AFLP of total DNA, SNP of the ITS region of ribosomal RNA transcription unit and microsatellite DNA variation at two loci. In addition to 167 AFLP bands shared by Dongfang No.2, L. japonica and L. longissima, Dongfang No.2 hybrid Laminaria shared another 70 and 55 bands with L. japonica and L. longissima, respectively, which were obviously more than 11 bands shared by L. japonica and L. longissima. Dongfang No.2 held both ‘T’ and ‘C’ at position 847 of the ITS region, while ‘T’ at this position was specific for L. japonica and ‘C’ for L. longissima, respectively. Dongfang No.2 also held the microsatellite DNA alleles of two parents together at two microsatellite DNA marker loci. These observations clearly proved that Dongfang No.2 is a true hybrid of L. japonica and L. longissiuma. Unfortunately, the origin of the chloroplast of Dongfang No.2 was not determined based on the variation of RuBisCo spacer. More sequence variants of both ITS region and RuBisCo spacer were identified in Dongfang No.2 and most of them did not exist in either L. japonica or L. longissima. The unexpected variants may be due to the mutation of ga- metophyte clones occurring during their vegetative amplification.YANG Guanpin LIAO Meijie LI Xiaojie CONG Yizhou QU Shancun WANG Tongyong 2008Journal of Ocean University of China2008,7,2:4
9The interaction and migration of deformation twin in an eutectic high-entropy alloy AlCoCrFeNi2.1显示文摘An eutectic high-entropy alloy consisting Al, Co, Cr, Fe and Ni elements was prepared by vacuum directional solidification technology. The alloy exhibits excellent comprehensive mechanical performance during tension at temperature range of 600–700℃. The microstructure reveals the intersection of twintwin is the prevailing deformation mechanism and the twins play a dual role in strengthening and toughening the alloy in the thermomechanical process. The deformation twin variants I and were formed by the edge dislocation 112 and the mixed dislocation 211 on the {111} crystal planes, respectively. Besides, the dislocation jogs and kinks caused by twin intersection on the slip planes can strengthen the alloy, which may contribute to the high strength(the tensile strengths at the 600°and 700°tensile tests are respectively780 MPa and 630 MPa.). Moreover, the coherent twin boundary migration has the function of coordinating deformation and contributes to the high ductility of the alloy.Yaoli Zhang Jinguo Li Xinguang Wang Yiping Lu Yizhou Zhou Xiaofeng Sun 2019Journal of Materials Science & Technology2019,35,5:4
10Timing Advanced Estimation Algorithm of Low Complexity Based on DFT Spectrum Analysis for Satellite System显示文摘In satellite mobile communication system, relative movement of the satellite and the terminal will cause a large Doppler offset. Timing advanced estimation with Zadoff-Chu sequence is sensitive to the frequency offset. When the frequency offset is larger than one times subcarrier spacing, the value of peak cannot be detected at the receiving end. To suppress the larger Doppler frequency shift, this paper proposes a novel timing advanced estimation scheme(TAE-MCD) for satellite communication system. In this algorithm, t r a n s m i t t e d s i g n a l i s d i v i d e d i n t o Z C sequence and its conjugate sequence. Using multiplication and DFT operation to find the estimated peak at the receiving end, and make subtraction with the obtained sequences at last. The scheme can not only inhibit the adverse effects of large Doppler frequency shift in timing estimation effectively, but also reduce the computational complexity at the receiving end and improve the work efficiency of the hardware. Simulations results show that TAEMCD outperform the existing timing advanced estimation methods, on the condition of no additional time and frequency resource are needed.HE Yizhou CUI Gaofeng LI Pengxu CHANG Ruijun WANG Weidong 2015China Communications2015,12,4:4
11Effect of thermal exposure on the microstructure and creep properties of a fourth-generation Ni-based single crystal superalloy显示文摘The effect of thermal exposure on microstructure and creep properties of a fourth-generation nickelbased single crystal superalloy was investigated.The thermal exposure of samples after the full heat treatment was carried out at 1000℃,1100℃ and 1140℃ for 100 h and 200 h.The γ’ coarsening,γ’ rafting and γ channel widening were observed in samples after thermal exposure.When the thermal exposure time was constant,the morphology of γ’ phase in the alloy evolved significantly with increasing aging temperature.The interracial dislocation networks in aged samples after creep ruptured gradually became irregular and sparse with the increase of exposure temperature.When the higher exposure temperature was used,enla rgement of the defect pores was observed in samples,the microcracks were more likely to initiate and propagate at the corner of these pores.After aging at 1000℃ for 100 h,the creep life at 1140℃/137 MPa was slightly longer than that of heat-treated sample,which could be attributed to the slightly coarsened γ’ phase,homogenization of refractor elements.In contrast,the creep life of sample exposed at 1140℃ for 100 h was greatly decreased.The decrease of creep life was dominated by the rafting of γ’phase,the irregular interfacial dislocation networks as well as the enlargement of homogenization pores.Yeshun Huang Xinguang Wang Chuanyong Cui Zihao Tan Jinguo Li Yanhong Yang Jinlai Liu Yizhou Zhou Xiaofeng Sun 2021Journal of Materials Science & Technology2021,,10:4
12On the γ' precipitates of the normal and inverse Portevin-Le Chatelier effect in a wrought Ni-base superalloy显示文摘The Portevin-Le Chatelier(PLC) effects in a wrought Ni-base superalloy with different γ' precipitates contents have been investigated. Detailed analysis on the serration type of the tensile curves indicates that the γ' precipitates have a decisive influence on the transformation from normal to inverse PLC behavior, which is rarely proposed in other works. It is considered that the γ' precipitates play the same role in PLC effect as temperature and strain rate for the investigated wrought Ni-base superalloy.Xinguang Wang Guoming Han Chuanyong Cui Shuai Guan Jinguo Li Guichen Hou Yizhou Zhou Xiaofeng Sun 2019Journal of Materials Science & Technology2019,35,1:3
13Graphene as an intermediary for enhancing the electron transfer rate: A free-standing Ni3S2@graphene@CogSs electrocatalytic electrode for oxygen evolution reaction显示文摘Qiuchun Dong Yizhou Zhang Ziyang Dai Peng Wang Min Zhao Jinjun Shao Wei Huang Xiaochen Dong 2018Nano Research2018,11,3:3
14Amyloid precursor protein and growth-associated protein 43 expression in brain white matter and spinal cord tissues in a rat model of experimental autoimmune encephalomyelitis显示文摘Studies have demonstrated that amyloid precursor protein(APP)expression increases in multiple sclerosis tissues during acutely and chronically active stages.To determine the relationship between axonal injury and regeneration in multiple sclerosis,an animal model of experimental autoimmune encephalomyelitis was induced using different doses of myelin basic protein peptide.APP and growth-associated protein 43(GAP-43),which is considered a specific marker of neural regeneration,were assessed by western blot analysis.Expression of APP and GAP-43,as well as the correlation between these two proteins,in brain white matter and spinal cord tissues of experimental autoimmune encephalomyelitis rats at different pathological stages was analyzed.Results showed that APP and GAP-43 expression increased during the acute stage and decreased during remission,with a positive correlation between APP and GAP-43 expression in brain white matter and spinal cord tissues.These results suggest that APP and GAP-43 could provide nutritional and protective effects on damaged neurons.Yizhou Wang Shuang Kou Jingcheng Tang Ping Zhang Qiuxia Zhang Yan Liu Qi Zheng Hui Zhao Lei Wang 2011Neural Regeneration Research2011,6,2:3
15Recent advances on “ordered water monolayer that does not completely wet water” at room temperature显示文摘The molecular scales behavior of interfacial water at the solid/liquid interfaces is of a fundamental significance in a diverse set of technical and scientific contexts,ranging from the efficiency of oil mining to the activity of biological molecules.Recently,it has become recognized that,both the physical interactions and the surface morphology have significant impact on the behavior of interfacial water,including the water structures as well as the wetting properties of the surface.In this review,we summarize some of recent advances in the atom-level pictures of the interfacial water,which exhibits the ordered character on various solid surfaces at room or cryogenic temperature.Special focus has been devoted to the wetting phenomenon of'ordered water monolayer that does not completely wet water'and the underlying mechanism on model and some real solid surfaces at room temperature.The possible applications of this phenomenon are also discussed.WANG ChunLei YANG YiZhou FANG HaiPing 2014Science China(Physics,Mechanics & Astronomy)2014,57,5:3
16Heterojunction-Type Photocatalytic System Based on Inorganic Halide Perovskite CsPbBr3显示文摘of main observation and conclusion The heterojunction-type structure has shown significant merits in tuning the optical properties and carrier physics.Inspired by the excellent absorption capability of halide perovskite materials for visible light,a series of CsPbBr3/TiO2 heterojunction-type photocatalysts with various all-inorganic-perovskite/TiO2 ratios are successfully fabricated by the ligand-assisted reprecipitation(LARP)method.The heterojunction structure extends the light absorption of TiO2 with good chemical and structural stability.A Pb-O interaction at the CsPbBr3/TiO2 interface is observed by the XPS and confirmed by the TRPL showing improved interface carrier transport and stability.The heterojunction-type catalyst shows drastically enhanced photocatalytic activity towards the direct oxidation of toluene with 02 molecule,as an important reaction for organic chemical synthesis.The optimized sample shows an activity of 2356μmol·g^-1·h^-1 at 75℃,4 times of that of the naked CsPbBr3 nanocrystals,and 3 times of that of the bare TiO2.Based on the investigation with trapping agents,a reaction mechanism is hence proposed suggesting that the photo-generated hole may be involved in the rate-limiting step.This work demonstrates the potential of inorganic halide perovskite-based heterojunction structure for photocatalytic applications.Enbo Zhu Yizhou Zhao Yi Dai Qiuhe Wang Yuanyuan Dong Qi Chen Yujing Li 2020Chinese Journal of Chemistry2020,38,12:3
17Effect of solution cooling rate on the microstructure and creep deformation mechanism of a rhenium-free second-generation single crystal superalloy显示文摘Various cooling scenarios(water,oil,air and furnace)were employed to study the impacts of the solution cooling rate(SCR)on the microstructure and creep behavior of a novel single-crystal(SX)superalloy.The results showed that the cubic degree and size of theγphases were inversely proportional to the SCR.The creep life first increased and then dropped dramatically with a reduction in the SCR.The creep life of the sample cooled with air cooling(AC)was the highest,up to 144.90 h at 800℃/750 MPa and160.15 h at 1100℃/137 MPa.During creep at 800℃/750 MPa,the improved creep life of the AC sample was mainly attributed to the fine cubicγphases,which decreased the rate ofγ-phase coarsening and favoured plastic deformation by promoting the active movement of dislocations.The AC helped theγphases become rich in Al,Ti and Ta while depleted in Co and Cr,which enhanced its stacking fault energy,thus promoting the formation of dislocation locks.Meanwhile,the largest negative lattice misfit caused by AC induced denserγ/γinterface dislocation networks at 1100℃/137 MPa,which efficiently reduced the minimum creep rate.The calculated average dislocation spacing results indicated that the smallest density of excess dislocations corresponded to the AC sample,proving its greatest creep resistance.Interestingly,the size of the secondaryγphases first decreased and then increased sharply with decreasing SCR during creep at 1100℃/137 MPa,when fine secondaryγphases had a positive role in the blockage of dislocation movement in the matrix.Eventually,the comprehensive SCR effect was explored to provide more guidance in the design of Re-free SX superalloys.Xipeng Tao Yunling Du Xinguang Wang Jie Meng Yizhou Zhou Jinguo Li Xiaofeng Sun 2022Journal of Materials Science & Technology2022,,36:3
18Variation of crystal orientation during epitaxial growth of dendrites by laser deposition显示文摘A nickel-based superalloy was deposited onto a single crystal substrate based on epitaxial laser metal forming(E-LMF). The microstructure development in two depositions has been researched. For the first time, the crystal orientation of dendrites varying beyond 20° was found when the dendrites deflected in deposition. In addition, a new grain boundary was found between different orientation dendrites in a grain, and the detected grain boundary angle was 23°. The result shows that flowing field in laser pool is responsible for this phenomenon.Guowei Wang Jingjing Liang Yizhou Zhou Libin Zhao Tao Jin Xiaofeng Sun 2018Journal of Materials Science & Technology2018,34,4:3
19Compact 517 MHz soliton mode-locked Er-doped fiber ring laser显示文摘We report on a compact passive mode-locked Er:fiber ring laser operated at the fundamental repetition rate of 517 MHz, which we believe is the highest fundamental repetition rate ever reported in a ring cavity fiber laser.The key technique is the employment of two innovative high-power wavelength domain multiplexer collimators with all gain fiber cavity suited for the high power(up to 2 W) pumping. The laser is featured with a direct chirpfree output pulse, which is 97 fs without extracavity compression at an average output power of 90 mW.Jian Zhang Ziyun Kong Yizhou Liu Aimin Wang Zhigang Zhang 2016Photonics Research2016,4,1:2
20Construction and Application of a Climate Risk Index for China显示文摘In the context of global warming,China is facing with increasing climate risks.It is imperative to develop quantitative indices to reflect the climate risks caused by extreme weather/climate events and adverse climatic conditions in association with different industries.Based on the observations at 2288 meteorological stations in China and the meteorological disasters data,a set of indices are developed to measure climate risks due to water-logging,drought,high temperature,cryogenic freezing,and typhoon.A statistical method is then used to construct an overall climate risk index(CRI)for China from these individual indices.There is a good correspondence between these indices and historical climatic conditions.The CRI,the index of water-logging by rain,and the high temperature index increase at a rate of 0.28,0.37,and 0.65 per decade,respectively,from 1961 to 2016.The cryogenic freezing index is closely related to changes in the consumer price index for food.The high temperature index is correlated with the consumption of energy and electricity.The correlation between the yearly growth in claims on household property insurance and the sum of the water-logging index and the typhoon index in the same year is as high as 0.70.Both the growth rate of claims on agricultural insurance and the annual growth rate of hospital inpatients are positively correlated with the CRI.The year-on-year growth in the number of domestic tourists is significantly negatively correlated with the CRI in the same year.More efforts are needed to develop regional CRIs.Yujie WANG Lianchun SONG Dianxiu YE Zhe WANG Rong GAO Xiucang LI Yizhou YIN Zunya WANG Yaoming LIAO 2018Journal of Meteorological Research2018,32,6:2
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