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| 1 | High-entropy ceramics:Present status,challenges,and a look forward显示文摘High-entropy ceramics (HECs) are solid solutions of inorganic compounds with one or more Wyckoff sites shared by equal or near-equal atomic ratios of multi-principal elements.Although in the infant stage,the emerging of this new family of materials has brought new opportunities for material design and property tailoring.Distinct from metals,the diversity in crystal structure and electronic structure of ceramics provides huge space for properties tuning through band structure engineering and phonon engineering.Aside from strengthening,hardening,and low thermal conductivity that have already been found in high-entropy alloys,new properties like colossal dielectric constant,super ionic conductivity,severe anisotropic thermal expansion coefficient,strong electromagnetic wave absorption,etc.,have been discovered in HECs.As a response to the rapid development in this nascent field,this article gives a comprehensive review on the structure features,theoretical methods for stability and property prediction,processing routes,novel properties,and prospective applications of HECs.The challenges on processing,characterization,and property predictions are also emphasized.Finally,future directions for new material exploration,novel processing,fundamental understanding,in-depth characterization,and database assessments are given. | Huimin XIANG Yan XING Fu-zhi DAI Hongjie WANG Lei SU Lei MIAO Guojun ZHANG Yiguang WANG Xiwei QI Lei YAO Hailong WANG Biao ZHAO Jianqiang LI Yanchun ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 28 |
| 2 | Temporo-spatial Coordinates of Evolution of the Ordos Basin and Its Mineralization Responses显示文摘摘要:Ordos 盆被开发从中间迟了对早白垩纪三叠纪,然后自从迟了的白垩纪,进入了它的以后的改革时期。它的主要身体忍受 intra-cratonic 盆的特征。盆也属于在大规模盆上重叠了的多迭加的盆早并且晚古生代。当前, Ordos 盆成为了剩余盆各种各样的式样的富有经验的改革自从迟了的白垩纪。它建议了有在盆的进化期间存在的构造变丑的至少四个明显的阶段,把进化和沉积划分成四个阶段。优先二个阶段具有最繁荣,在哪个期间湖盆是宽广的,免职范围多于比当前的剩余盆两次大,导致主要含有石油、忍受煤的阶层。二个阶段被分开由地区性高举在区域的变化。在 Yan'an 阶段的结束, depositional 打断和侵蚀正在持续时间的一个短时期。第三是中间 -- 侏罗记并且 Zhiluo 舞台,沉积程度仍然在是宽广的但是湖区域显然被减少。在迟了的侏罗记构造变丑是集中的。当不同厚度的集团企业在东方方面的 foredeep 以内被积累时,一条戳越过水坝落下的水带在盆的西方的边缘上被形成。盆的中央、东方的部分服从于侵蚀和改革。一个地区性的框架与在西方在东方和消沉高举黄河向西在区域形成了。在早白垩纪,沉积广泛地被散布, unconformably 重叠北、南部的边阶上的以前的西方的边缘戳带和山脉。象在 Ordos 盆形成的油,天然气,煤和铀存款那样有丰富的精力资源。产生的主要阶段,矿化作用并且资源有明显的反应的多重精力放在 Ordos 中生代和新生代进化和改革与那些联合关系的连接和结束盆。 | LIU Chiyang ZHAO Hongge ZHAO Junfeng WANG Jianqiang ZHANG Dongdong YANG Minghui | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 20 |
| 3 | A point mutation resulting in a 13 bp deletion in the coding sequence of Cldf leads to a GA-deficient dwarf phenotype in watermelon显示文摘The dwarf architecture is an important and valuable agronomic trait in watermelon breeding and has the potential to increase fruit yield and reduce labor cost in crop cultivation.However,the molecular basis for dwarfism in watermelon remains largely unknown.In this study,a recessive dwarf allele(designated as Cldf(Citrullus lanatus dwarfism))was fine mapped in a 32.88 kb region on chromosome 09 using F2 segregation populations derived from reciprocal crossing of a normal line M08 and a dwarf line N21.Gene annotation of the corresponding region revealed that the Cla015407 gene encoding a gibberellin 3β-hydroxylase functions as the best possible candidate gene for Cldf.Sequence analysis showed that the fourth polymorphism site(a G to A point mutation)at the 3′AG splice receptor site of the intron leads to a 13 bp deletion in the coding sequence of Cldf in dwarf line N21 and thus results in a truncated protein lacking the conserved domain for binding 2-oxoglutarate.In addition,the dwarf phenotype of Cldf could be rescued by exogenous GA3 application.Phylogenetic analysis suggested that the small multigene family GA3ox(GA3 oxidase)in cucurbit species may originate from three ancient lineages in Cucurbitaceae.All these data support the conclusion that Cldf is a GA-deficient mutant,which together with the cosegregated marker can be used for breeding new dwarf cultivars. | Chunhua Wei Chunyu Zhu Liping Yang Wei Zhao Rongxue Ma Hao Li Yong Zhang Jianxiang Ma Jianqiang Yang Xian Zhang | 2019 | Horticulture Research2019，6，1： | 12 |
| 4 | Association of serum levels of perfluoroalkyl substances with gestational diabetes mellitus and postpartum blood glucose显示文摘This study was conducted to examine the association of perfluoroalkyl substance(PFAS)exposure with gestational diabetes mellitus(GDM) risk and postpartum fasting blood glucose.We used a 1:2 matched case–control study with 84 GDM subjects and 168 healthy pregnant women from Beijing, China. The maternal blood was collected at 1–2 days before delivery, and eight linear isomers and fourteen branched isomers were determined in maternal serum.Logistic regression analyses were performed to evaluate the associations after adjusting for potential confounders. The median of the sum of levels of total PFASs was 4.24 ng/m L with a interquartile range(IQR) of 2.82–6.54 ng/m L. Although maternal PFAS exposure was not associated with risk of GDM, significant positive associations were observed between evaluated exposure to specific PFAS congeners and increasing blood glucose. The odds ratio(ORs) of the highest category of postpartum fasting blood glucose for perfluoro-1-metylheptylsulfonat(1 m-PFOS), perfluoro-3/4-metylheptylsulfonat(3 m+4 m-PFOS), perfluoro-5-metylheptylsulfonat(5 m-PFOS), and perfluorohexane sulfonate(PFHx S) were 2.03(95% CI: 1.09–3.77), 1.93(95% CI:1.04–3.58), 2.48(95% CI: 1.33–4.65), and 2.26(95% CI: 1.21–4.21), respectively, suggesting negative effects of maternal exposure to specific PFAS compounds on glucose metabolism. | Yuxin Wang Lei Zhang Yue Teng Jiayu Zhang Lin Yang Jingguang Li Jianqiang Lai Yunfeng Zhao Yongning Wu | 2018 | Journal of Environmental Sciences2018，30，7： | 8 |
| 5 | Uplift and evolution of Helan Mountain显示文摘The Helan Mountain lies in the northwest margin of Ordos Basin and its uplift periods have close relations with the tectonic feature and evolution of the basin. There are many views on the uplift time of Helan Mountain, which is Late Triassic and Late Jurassic. It is concluded by the present strata, magmatic rock and hot fluid distribution that the Helan Mountain does not uplift in Late Triassic to Middle Jurassic but after Middle Jurassic. Through the research of the sedimentary strata and deposit rate in Yinchuan Graben which is near to the Helan Mountain, it is proved that the Helan Mountain uplifts in Eocene with a huge scale and in Pliocene with a rapid speed. The fission track analysis of apatite and zircon can be used to determine the precise uplift time of Helan Mountain, which shows that four stages of uplifting or cooling: Late Jurassic to the early stage of Early Cretaceous, mid-late stage of Early Cretaceous, Late Cretaceous and since Eocene. During the later two stages the uplift is most apparent and the mid-late stage of Early Cretaceous is a regional cooling course. Together with several analysis ways, it is considered that the earliest time of Helan Mountain uplift is Late Jurassic with a limited scale and that Late Cretaceous uplift is corresponding to the whole uplift of Ordos Basin, extensive uplift happened in Eocene and rapid uplift in Pliocene. | ZHAO HongGe LIU ChiYang WANG Feng WANG JianQiang LI Qiong YAO YaMing | 2007 | Science China Earth Sciences2007，50，z2： | 7 |
| 6 | Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases显示文摘Objective: The safety of the simultaneous resection of synchronous colorectal cancer liver metastases(SCRLM) is still being debated.However, this simultaneous operative approach is more commonly adopted at present than in the past.Therefore, we compared simultaneous hepatic resection with delayed hepatic resection in this study.Methods: All patients with SCRLM diagnosed before initial treatment between January 2009 and September 2013 were retrospectively included in our study.Short-term and long-term outcomes were compared in patients who underwent simultaneous colorectal and hepatic resection and those treated by delayed hepatectomy.Results: Among the 73 patients diagnosed with SCRLM, simultaneous colorectal and hepatic resection was performed in 60 patients(82.2%), while delayed hepatic resection was performed in 13 patients(17.8%).The mortality rate was zero.The postoperative complication rate after delayed resection was higher than, but not significantly different from, that after simultaneous resection(46% vs.23%, P=0.166).The duration of operating time(240 vs.420 min, P<0.05) and postoperative hospital stay time(11 vs.18 days, P<0.05) were shorter in the simultaneous resection group.After the initial treatments were given, the 1-, 2-, and 3-year survival rates in the simultaneous resection group were 77%, 59%, and 53%, respectively, whereas those in the delayed resection group were 67%, 42%, and 10%, respectively.The 5-year survival rate in the simultaneous resection group was 23%; overall survival differed significantly between the two groups(P=0.037).Median disease-free survival(DFS) times were 19.1 months in the simultaneous resection group and 8.8 months in the delayed resection group.DFS differed significantly between the two groups.Conclusions: Simultaneous colorectal and hepatic resection is safe and exhibits advantages in the longtime survival of patients. | Yuan Li Xinyu Bi Jianjun Zhao Zhen Huang Jianguo Zhou Zhiyu Li Yefan Zhang Hong Zhao Jianqiang Cai | 2016 | Chinese Journal of Cancer Research2016，28，5： | 7 |
| 7 | Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma显示文摘Objective:This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical features.Methods:The clinicopathological data of 114 patients who were diagnosed with histologically proven four subtypes:clear cell carcinoma(CCC),giant cell carcinoma(GCC),sarcomatoid carcinoma(SC),and combined hepatocellular-cholangiocarcinoma(CHC)between October 1998 and August 2015 were reviewed.Their survival data were compared with those of 908 patients with histologically proven common hepatocellular carcinoma(HCC)(early-and advanced-stage HCC)during the same period.Results:The outcome of the CCC group was better than that of the other three subgroups,and was similar to that of the early-stage HCC group.Also,the smallest tumor size and the highest incidence of pseudocapsule formation were observed in the CCC group.The SC group had the worst outcome among these four subgroups;the prognosis was much poorer than that of any other subgroups,even poorer than that of the advanced-stage common HCC group.No statistical difference was observed between the GCC,CHC and advanced-stage HCC groups on survival analysis.The incidences of tumor vascular emboli,TNM staging and non-radical resection were three risk factors of the prognosis.Conclusions:CCC is a low-degree malignancy and relatively favorably prognostic subtype of HCC.However,GCC,SC,and CHC are three rare high-degree malignancy subtypes of HCC with poor prognosis. | Zhiyu Li Xiaolong Wu Xinyu Bi Yefan Zhang Zhen Huang Haizhen Lu Hong Zhao Jianjun Zhao Jianguo Zhou Muxing Li Jianming Ying Jianqiang Cai | 2018 | Chinese Journal of Cancer Research2018，30，3： | 6 |
| 8 | Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice显示文摘Oxysophoridine, a new alkaloid extracted from Sophora alopecuroides L., has been shown to have a protective effect against ischemic brain damage. In this study, a focal cerebral ischemia/reperfusion injury model was established using middle cerebral artery occlusion in mice. Both 62.5, 125, and 250 mg/kg oxysophoridine, via intraperitoneal injection, and 6 mg/kg nimodipine, via intragastric administration, were administered daily for 7 days before modeling. After 24 hours of reperfusion, mice were tested for neurological deficit, cerebral infarct size was assessed and brain tissue was collected. Results showed that oxysophoridine at 125, 250 mg/kg and 6 mg/kg nimodipine could reduce neurological deficit scores, cerebral infarct size and brain water content in mice. These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. In addition, oxysophoridine at 62.5, 125, and 250 mg/kg and 6 mg/kg nimodipine increased adenosine-triphosphate content, and decreased malondialdehyde and nitric oxide content. These compounds enhanced the activities of glutathione-peroxidase, superoxide dismutase, catalase, and lactate dehydrogenase, and decreased the activity of nitric oxide synthase. Protein and mRNA expression levels of N-methyl-D-aspartate receptor subunit NR1 were markedly inhibited in the presence of 250 mg/kg oxysophoridine and 6 mg/kg nimodipine. Our experimental findings indicated that oxysophoridine has a neuroprotective effect against cerebral ischemia/reperfusion injury in mice, and that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1. | Hongbo Wang Yuxiang Li Ning Jiang Xiaoping Chen Yi Zhang Kuai Zhang Tengfei Wang Yinju Hao Lin Ma Chengjun Zhao Yanrong Wang Tao Sun Jianqiang Yu | 2013 | Neural Regeneration Research2013，8，15： | 5 |
| 9 | Neoadjuvant radiotherapy for resectable hepatocellular carcinoma with portal vein tumor thrombus:a systematic review显示文摘Background:The prognosis of hepatocellular carcinoma(HCC)with portal vein tumor thrombus(PVTT)is extremely poor.The clinical outcome of preoperative radiotherapy(RT)is still controversial.This study aimed to compare the clinical outcomes of combined neoadjuvant RT and hepatectomy with hepatectomy alone for HCC with PVTT.Methods:Comprehensive database searches were performed in PubMed,the Cochrane Library,EMBASE,and the Web of Science to retrieve studies published from the database creation to July 1,2020.Only comparative studies that measured survival between neoadjuvant RT followed by hepatectomy and hepatectomy alone were included.The characteristics of the included studies and patients were extracted,and the included data are presented as relative ratio(RR)estimates with 95%confidence intervals(CIs)for all outcomes.The RRs of each study were pooled using a fixed or random effects model with Review Manager(the Cochrane Collaboration,Oxford,UK)version 5.3.The response rate to RT and the overall survival(OS)rate in neoadjuvant RT followed by hepatectomy and hepatectomy alone were measured.Results:One randomized and two non-randomized controlled trials with 302 patients were included.Most patients were classified as Child-Pugh A,and Type II and III PVTT were the most common types.After RT,29(22.8%)patients were evaluated as partial response(PR)and had a positive RT response,but nine(7.1%)had progressive disease(PD).Neoadjuvant RT followed by hepatectomy was received by 127(42.1%)patients after excluding 15(5.0%)patients with severe complications or PD after RT,and 160(53.0%)patients received hepatectomy alone.In the randomized controlled trial(RCT),the 1-year OS rate in the neoadjuvant RT group and the surgery alone group was 75.2%and 43.1%,respectively(P<0.001).In the two non-randomized studies,a meta-analysis with a fixed effects model showed a longer OS in patients undergoing neoadjuvant RT followed by hepatectomy compared with hepatectomy alone at 1-year follow-up(RR=2.02;95%CI:1.45-2.80;P<0.0001).Conclusions:This systematic review showed that neoadjuvant RT followed by hepatectomy in patients with resectable HCC and PVTT was associated with a longer OS than patients who received hepatectomy alone. | Zhewen Wei Jianjun Zhao Xinyu Bi Yefan Zhang Jianguo Zhou Zhiyu Li Zhen Huang Hong Zhao Jianqiang Cai | 2022 | Hepatobiliary Surgery and Nutrition2022，11，5： | 4 |
| 10 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 11 | Petrology, Geochemistry and Zircon U-Pb Geochronology of the Xiangshan Group in the Eastern Hexi Corridor Belt: Implications for Provenance and Tectonic Evolution显示文摘The eastern Hexi Corridor Belt(HCB) is located in the transitional belt among the Alxa Block,the Qilian Orogenic Belt and the North China Block. Because of its unique tectonic location, the tectonic setting, provenance, and even the age of the sedimentary strata in the eastern HCB during the Early Paleozoic remain controversial. This study analyzes the provenance of the poorly studied Xiangshan Group, discusses its age of development and tectonic setting in the eastern HCB using a combination of petrological, geochemical and LA-ICP-MS U-Pb zircon dating methods. Based on the youngest age peaks and the fossil evidence, we suggest that the Xiangshan Group is Middle Cambrian to Late Ordovician in age. The complexity of the geochemical characteristics and associated diagrams suggests that the early stage of the Xiangshan Group developed in a passive continental margin environment, late in the backarc basin of the eastern HCB. Based on the sandstone detrital composition, whole-rock geochemistry and detrital zircon ages, we conclude that the Xiangshan Group had an early provenance that was mainly from the Qilian Block and a late provenance from the Qilian Block and the western Alxa Block. The eastern HCB and its northern and southern blocks have similar palaeontology, lithology and basement age characteristics to the South China Block. This indicates that the eastern HCB might not have formed in the intra-continental aulacogen of the North China Block during the Early Paleozoic but has a close affinity to eastern Gondwana. | ZHAO Xiaochen LIU Chiyang WANG Jianqiang DUAN Liang ZHAO Yan ZHANG Qihang LUO Wei | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 4 |
| 12 | Provenance Analyses of Lower Cretaceous Strata in the Liupanshan Basin: From Paleocurrents Indicators, Conglomerate Clast Compositions, and Zircon U-Pb Geochronology显示文摘The Liupanshan Basin constitutes a major portion of the northern North-South tectonic belt. The Lower Cretaceous strata in the Liupanshan Basin recorded the tectono-sedimentary evolution processes of this area and are pivotal for understanding the original sedimentary appearance of the Liupanshan Basin. In this work, we present a study of provenance and tectono-sedimentary evolution of the Liupanshan Basin during the Early Cretaceous. Integrated-paleocurrent directions, gravel clast compositions, and detrital zircon U-Pb isotopic analysis of the Lower Cretaceous Sanqiao and Heshangpu formations were applied to determine the provenance. The gravel clast compositions of Sanqiao Formation conglomerates(mainly including magmatic rocks, metamorphic rocks and limestones) display various features in different places, revealing different rock components of source areas. The paleocurrent directions of the Sanqiao and Heshangpu formations suggest that the sediments were transported from the basin margin to the center. Detrital zircons of two samples from the Huoshizhai Section(northwestern Liupanshan Basin) yield a dominant unimodal distribution from 420 to 500 Ma, suggesting a single-sourced provenance. Based on the above analyses, comparing to the magmatic records in the Qilian-Qinling orogenic belt, the detritus of the Sanqiao and Heshangpu formations were mainly from the proximal metamorphic and magmatic rocks of the Qilian-Qinling orogenic belt and the limestones of the archaic uplift. Combined with sedimentary characteristics, we concluded that the Liupanshan Basin experienced multi-stage evolution history:(1) the early rifting extension stage(Sanqiao Period),(2) the middle spanning and depression stage(Heshangpu–Early Naijiahe Period), and(3) the late extinction stage(Late Naijiahe Period). The evolution of Liupanshan Basin is closely related to that of Ordos Basin and it is further associated with tectonic transition of the northern North-South tectonic belt. | Xiaochen Zhao Chiyang Liu Jianqiang Wang Wei Luo Fangpeng Du Li Ma | 2020 | Journal of Earth Science2020，31，4： | 3 |
| 13 | Wetting behavior and interfacial characteristic of Sn-Ag-Cu solder alloy on Cu substrate显示文摘Wettability of molten Sn-Ag-Cu alloy on Cu substrate has been determined by sessile drop method, as well as its dependence on time and temperature. It was found that the evolution of contact angle at the alloy’s melting point experienced four different stages. Especially, the contact angle was unstable and fluctuant in stage II, and gradually decreased in stage III mainly due to a chemical reaction between Sn-Ag-Cu alloy and Cu substrate. The contact angle decreased with increasing temperature, but increased slightly at 629 K, for another chemical reaction occurred. Interfacial characteristic has been further investigated by examining the sample’s cross section. Intermetallic compounds of Cu6Sn5 and β-Sn phase were found at the interface of Sn-Ag-Cu/Cu. | ZHANG XiaoRui YUAN ZhangFu ZHAO HongXin ZANG LiKun LI JianQiang | 2010 | Chinese Science Bulletin2010，55，9： | 3 |
| 14 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 15 | Au nanowires with high aspect ratio and atomic shell of Pt-Ru alloy for enhanced methanol oxidation reaction显示文摘The methanol oxidation reaction(MOR)is the limiting half-reaction in direct methanol fuel cell(DMFC).Although Pt is the most active single-metal electrocatalyst for MOR,it is hampered by high cost and CO poisoning.Constructing a Pt or Ru monolayer on a second metal substrate by means of galvanic replacement of underpotentially deposited(UPD)Cu monolayer has been shown as an efficient catalyst design strategy for the electrocatalysis of MOR because of the presumed 100%utilization of atoms and resistance to CO poisoning.Herein,we prepared one-dimensional surface-alloyed electrocatalyst from predominantly(111)faceted Au nanowires with high aspect ratio as the substrate of under-potential deposition.The electrocatalyst comprises a core of the Au nanowire and a shell of catalytically active Pt coated by Ru.Coverage-dependent electro-catalytic activity and stability is demonstrated on the Pt/Ru submonolayers on Au wires for MOR.Among all these catalysts,Au@Pt_(ML)@Ru_(ML)exhibits the best electrocatalytic activity and poisoning tolerance to CO.This presents a viable method for the rational catalyst design for achieving high noble-metal utilization efficiency and high catalytic performance. | Xiran Zhu Zheng Hu Ming Huang Yuxin Zhao Jianqiang Qu Shi Hu | 2021 | Chinese Chemical Letters2021，32，6： | 3 |
| 16 | Absolute instability modes due to rescattering of stimulated Raman scattering in a large nonuniform plasma显示文摘Absolute instability modes due to secondary scattering of stimulated Raman scattering (SRS) in a large nonuniform plasma are studied theoretically and numerically. The backscattered light of convective SRS can be considered as a pump light with a finite bandwidth. The different frequency components of the backscattered light can be coupled to develop absolute SRS instability near their quarter-critical densities via rescattering process. The absolute SRS mode develops a Langmuir wave with a high phase velocity of about c/■ with c the light speed in vacuum. Given that most electrons are at low velocities in the linear stage, the absolute SRS mode grows with very weak Landau damping. When the interaction evolves into the nonlinear regime, the Langmuir wave can heat abundant electrons up to a few hundred ke V via the SRS rescattering. Our theoretical model is validated by particle-in-cell simulations. The absolute instabilities may play a considerable role in the experiments of inertial confinement fusion. | Yao Zhao Zhengming Sheng Suming Weng Shengzhe Ji Jianqiang Zhu | 2019 | High Power Laser Science and Engineering2019，7，1： | 2 |
| 17 | Yield gap and resource utilization efficiency of three major food crops in the world——A review显示文摘Yield gap analysis could provide management suggestions to increase crop yields,while the understandings of resource utilization efficiency could help judge the rationality of the management.Based on more than 110 published papers and data from Food and Agriculture Organization (FAO,www.fao.org/faostat) and the Global Yield Gap and Water Productivity Atlas (www.yieldgap.org),this study summarized the concept,quantitative method of yield gap,yield-limiting factors,and resource utilization efficiency of the three major food crops (wheat,maize and rice).Currently,global potential yields of wheat,maize and rice were 7.7,10.4 and 8.5 t ha^(–1),respectively.However,actual yields of wheat,maize and rice were just 4.1,5.5 and 4.0 t ha^(–1),respectively.Climate,nutrients,moisture,crop varieties,planting dates,and socioeconomic conditions are the most mentioned yield-limiting factors.In terms of resource utilization,nitrogen utilization,water utilization,and radiation utilization efficiencies are still not optimal,and this review has summarized the main improvement measures.The current research focuses on quantitative potential yield and yield gap,with a rough explanation of yield-limiting factors.Subsequent research should use remote sensing data to improve the accuracy of the regional scale and use machine learning to quantify the role of yield-limiting factors in yield gaps and the impact of change crop management on resource utilization efficiency,so as to propose reasonable and effective measures to close yield gaps. | RONG Liang-bing GONG Kai-yuan DUAN Feng-ying LI Shao-kun ZHAO Ming HE Jianqiang ZHOU Wen-bin YU Qiang | 2021 | Journal of Integrative Agriculture2021，20，2： | 2 |
| 18 | Assessment and improvement of k-ω-γ model for separation-induced transition prediction显示文摘The purpose of this work is to improve the k-ω-γtransition model for separationinduced transition prediction.The fundamental cause of the excessively small separation bubble predicted by k-ω-γmodel is scrutinized from the perspective of model construction.On the basis,three rectifications are conducted to improve the k-ω-γmodel for separation-induced transition.Firstly,a damping function is established via comparing the molecular diffusion timescale with the rapid pressure-strain timescale.The damping function is applied to prevent the effective length scale from incorrect distribution near the leading edge of the separation bubble.Secondly,the pressure gradient parameterλζ,is proposed as an indicator for local susceptibility to the separation instability.Additionally,λζ,-based separation intermittencyγsep is constructed to accelerate the substantial growth of turbulent kinetic energy after flow separation.The improved model appropriate for both low-and high-speed flow has been calibrated against a variety of diverse and challenging experiments,including the subsonic T3L plate,Aerospatial A airfoil,transonic NLR-7301 airfoil and deformed hypersonic inflatable aerodynamic decelerator aeroshell.The improved model is strictly based on local variables and Galilean invariance.Besides,the proposed improvement for k-ω-γmodel can be fairly convenient to incorporate into other existing intermittency-based transition models. | Yatian ZHAO Jianqiang CHEN Rui ZHAO Hongkang LIU | 2022 | Chinese Journal of Aeronautics2022，35，11： | 2 |
| 19 | Genetic causes of oil-rich and oil-poor reservoirs: Implications from two Cenozoic basins in the eastern North China Craton显示文摘The Bohai Bay and Hehuai(southern North China) rift basins in the eastern part of the North China Craton are southnorth-adjacent. They have shown synchronous evolutionary processes, and possess generally identical superficial and shallow structural characteristics as well as similar basin areas. However, there is a large difference in the richness of oil resources between the two basins. The Bohai Bay Basin has extremely abundant oil reserves, while commercial oil reserves have not been found in the Hehuai Basin. The deep tectonic structures, magmatic activities, and modern and paleo-geothermal fields of the two basins are significantly different. Compared with the Hehuai Basin, the Bohai Bay Basin has a thinner crust and more complex structure with multiple low-velocity layers. It is also characterized by intense magmatic activity, high modern and paleogeothermal fields, frequent seismic activity, and active deep interactions, small effective elastic thickness of the isotropic lithosphere, and shorter balanced transformation wavelength of the lithosphere with a high likelihood of local compensation. The Hehuai Basin has a simple deep structure and homogeneous crustal composition, with a high likelihood of regional compensation. The characteristics of the deep structures mentioned above are generally similar to those of the southern part of the stable Ordos Basin, except for the smaller crust thickness. This indicates the presence of differences in Mesozoic destruction between the southern and northern zones in the eastern part of the North China Craton. The northern zone was subjected to significant destruction, while the southern zone was subjected to modifications, primarily in the form of local changes in the structures and/or properties of the crust or lithospheric mantle, with the overall structure and stability of the craton kept intact. The formation of high-quality source rock is primarily influenced by the abnormal flourishment of organisms in water bodies during the syndepositional period, and is also strongly associated with the high geothermal setting of basins and nutrients from hydrothermal solutions and volcanoes. In other words, it is mainly controlled by deep processes and deep-major fault activity. The differences in the deep structures and modern and paleo geothermal fields of the two basins correspond to the difference in richness of oil resources, suggesting that there is an important internal or causal relationship between the two aspects. This viewpoint coincides with the conditions and environments required for the development of high-quality source rock in hydrocarbon-rich basins(sags)in China and other countries, and is evidenced by the modern lake basin of the East African Rift. A new hydrocarbon generation model is proposed in this work: petroleum is a comprehensive product of the integration of bioenergy, thermal energy, and other related energies(such as chemical and kinetic energy) and their interactions; the degree of richness of petroleum is generally controlled by the regional tectonic structure, thermal environment, and deep processes; nonmarine basins or depressions with abundant resources are closely related to active deep processes, intense exchange of material between the deep and shallow layers, participation of external hydrocarbons, and energy integration and conversion. | Chiyang LIU Lei HUANG Dongdong ZHANG Junfeng ZHAO Yu DENG Pei GUO Yijian HUANG &Jianqiang WANG | 2018 | Science China Earth Sciences2018，61，12： | 2 |
| 20 | Partial removal of the pulmonary artery in video-assisted thoracic surgery for non-small cell lung cancer显示文摘Lobectomy with partial removal of the pulmonary artery in video-assisted thoracic surgery (VATS) currently remains a challenge for thoracic surgeons. We were interested in introducing pulmonary vessel blocking techniques in open thoracic surgery into video-assisted thoracic surgery (VATS) procedures. In this study, we reported a surgical technique simultaneously blocking the pulmonary artery and the pulmonary vein for partial removal of the pulmonary artery under VATS. Seven patients with non-small-cell lung cancer (NSCLC) received lobectomy with partial removal of the pulmonary artery using the technique between December 2007 and March 2012. Briefly, rather than using a small clamp on the distal pulmonary artery to the area of invading cancer, we replaced a vascular clamp with a ribbon and Hem-o-lock clip to block the preserved pulmonary veins so as to prevent back bleeding and yield a better view for surgeons. The mean occlusion time of the pulmonary artery and pulmonary veins were 44.0±10.0 and 41.3±9.7 minutes, respectively. The mean repair time of the pulmonary artery was 25.3±13.7 minutes. No complications occurred. No patients showed abnormal blood flow through the reconstructed vessel. There were no local recurrences on the pulmonary artery. In conclusion, the technique for blocking the pulmonary artery and veins is feasible and safe in VATS and reduces the risk of abrupt intraoperative bleeding and the chance of converting to open thoracotomy, and extends the indications of VATS lobectomy. | Keping Xu Zhi Zhang Jianqiang Zhao Jianfeng Huang Rong Yin Lin Xu | 2013 | The Journal of Biomedical Research2013，27，4： | 2 |
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