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| 1 | SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion显示文摘Bone marrow mesenchymal stem cells(MSCs)are considered as a promising cell source to treat the acute myocardial infarction.However,over 90%of the stem cells usually die in the first three days of transplantation.Survival potential,migration ability and paracrine capacity have been considered as the most important three factors for cell transplantation in the ischemic cardiac treatment.We hypothesized that stromal-derived factor-1(SDF-1)/CXCR4 axis plays a critical role in the regulation of these processes.In this study,apoptosis was induced by exposure of MSCs to H2O2 for 2 h.After re-oxygenation,the SDF-1 pretreated MSCs demonstrated a significant increase in survival and proliferation.SDF-1 pretreatment also enhanced the migration and increased the secretion of pro-survival and angiogenic cytokines including basic fibroblast growth factor and vascular endothelial growth factor.Western blot and RT-PCR demonstrated that SDF-1 pretreatment significantly activated the pro-survival Akt and Erk signaling pathways and up-regulated Bcl-2/Bax ratio.These protective effects were partially inhibited by AMD3100,an antagonist of CXCR4.We conclude that the SDF-1/CXCR4 axis is critical for MSC survival,migration and cytokine secretion. | Xiaolei Liu Biyan Duan Zhaokang Cheng Xiaohua Jia Lina Mao Hao Fu Yongzhe Che Lailiang Ou Lin Liu Deling Kong | 2011 | Protein & Cell2011，2，10： | 53 |
| 2 | Effects of rare earth elements on telomerase activity and apoptosis of human peripheral blood mononuclear cells显示文摘 | Li Yu Yucheng Dai Zhaokang Yuan Jie Li | 2007 | Biological Trace Element Research2007，，1： | 1 |
| 3 | Lung funetion after deep hypothrmic cardiopulmonary bypass in infants显示文摘 | Su Zhaokang Sun Yong Yanmin | 2003 | Asian Cardivasc Thorae Ann2003，11，4： | 1 |
| 4 | Lung function after deep hypothermic cardiopulmonary bypass in infants 显示文摘 | Su Zhaokang Sun Yong Yang Yanmin | 2003 | Asian Cardlovasc Thorac Ann2003，11，4： | 1 |
| 5 | Lung function after deep hypothermic cardiopulmonary bypass in infants显示文摘 | Su Zhaokang Sun Yong Yan Min | 2003 | Asian CardiovasThorae Ann2003，11，4： | 1 |
| 6 | Size -Controlled Synthesis and Growth Mechanism of Monodisperse Tellurium Nanorods by a Surfactant - Assisted Method 显示文摘 | Zhaoping Liu Zhaokang Hu Jianbo Liang | 2004 | Langmuir2004，，20： | 1 |
| 7 | Better Protection of Pulmonary Surfactant Integrity With Deep Hypothermia and Circulatory Arrest显示文摘 | Yanmin Yang Jiming Cai Shunming Wang Haibo Zhang Jinfen Liu Zhiwei Xu Zhaokang Su | 2006 | The Annals of Thoracic Surgery2006，，1： | 1 |
| 8 | Lung function after deep hypothermic cardiopulmonary bypass in infants显示文摘 | Su Zhaokang Sun Yong Yang Yanmin | 2003 | Asian Cardivasc Thorae Ann2003，11，4： | 1 |
| 9 | Chip-scale spontaneous quasi-phase matched second harmonic generation in a micro-racetrack resonator显示文摘In this paper,we demonstrate efficient spontaneous quasi-phase matched(SQPM)second harmonic generation(SHG)in a microracetrack resonator on X-cut thin film lithium niobate.Our approach does not involve poling,but exploits the anisotropy of the crystals to allow the phase-matching condition to be fulfilled spontaneously as the TE-polarized light circulates in a specifically designed racetrack resonator.In experiment,normalized on-chip conversion efficiencies of 1.01×10-4/W and 0.43×10-4/W are achieved by 37th-order and 111th-order SQPM,respectively.The configurable SQPM will benefit the application of nonlinear frequency conversion and quantum source generation in chip-scale integrated photonics compatible with standard CMOS fabrication processes. | Tingge Yuan Jiangwei Wu Yi'an Liu Xiongshuo Yan Haowei Jiang Hao Li Zhaokang Liang Qiang Lin Yuping Chen Xianfeng Chen | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 1 |
| 10 | TNF-α and IL-1β increase Ca 2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes显示文摘 | David J. Duncan Zhaokang Yang Philip M. Hopkins Derek S. Steele Simon M. Harrison | 2010 | Cell Calcium2010，，4： | 1 |
| 11 | Lung function after deep hypothermic cardiopulmonary bypass in infants显示文摘 | Sun Yong Yang Yanmin | 2003 | Asian cardiovasc thorac ann2003，11，4： | 1 |
| 12 | PropertyandmicrostructureofVO2filmbyinorganicsolGgelmethod显示文摘 | ZhaoKang WeiJianfeng SunJun etal | 2002 | JournalofFunctionalMaterials2002，33，1： | 1 |
| 13 | Lung function after deep hypothermic cardiopulmonary bypass in infants 显示文摘 | Zhaokang S Yong S Yanmin Y | 2003 | A- sian Cardivasc Thorae Ann2003，11，4： | 1 |
| 14 | Monitoring of Cerebral Oxygenation by Near-infrared Spectroscopy during Cardiopulmonary Bypass in Infants显示文摘Objective: To evaluate the use of near-infrared spectroscopy for monitoring cerebral oxygenation under different cardiopulmonary bypass models. Method: Twenty-four patients with ventricular septal defect and pulmonary hypertension undergoing open-heart surgery were assigned eight each to three groups, with respect to different cardiopulmonary bypass models: moderate hypothermia cardiopulmonary bypass, deep hypothermia low flow and deep hypothermia circulatory arrest. For each patient, cerebral oxygenation with near-infrared spectroscopy were monitored and the relative concentration changes in cerebral oxygenated hemoglobin, deoxygenated hemoglobin and oxidized cytochrome aa3 were calculated. Electroencephalography, biochemical indicators such as neuron-specific enolase and lactate, and performed correlation analyses for near-infrared spectroscopy data and biochemical indicators were also measured. Results: Near-infrared spectroscopy data and biochemical indicators for moderate hypothermia cardiopulmonary bypass and deep hypothermia low flow group showed no correlation. For deep hypothermia circulatory arrest group, oxygenated hemoglobin signal declined to a plateau (nadir) during the circulatory arrest period. The duration from reaching nadir until reperfusion “oxygenated hemoglobin signal nadir-time', and the minimum values of oxygenated hemoglobin, and oxidized cytochrome aa3 were closely correlated with increasing neuron-specific enolase and lactate. And, all patients whose oxygenated hemoglobin signal nadir-time was less than 35 min were free from behavioral evidence of brain injury. Conclusion: Near-infrared spectroscopy data including oxygenated hemoglobin signal nadir-time and the minimum of oxygenated hemoglobin and oxidized cytochrome aa3 showed strong correlation with other cerebral function assessment for deep hypothermia circulatory arrest. Oxygenated hemoglobin signal nadir-time determined by near-infrared spectroscopy can be useful in predicting the safe duration of circulatory arrest. | Su Zhaokang Huang Jihong Wang Shunmin | 2006 | 工程科学(英文版)2006，4，3： | 0 |
| 15 | Urotensin Ⅱ increases endothelin production by vascular smooth muscle cells in rats显示文摘The aim of this study was to observe the effects of urotensin Ⅱ (UII) on production of endothelin (ET) in rat aortic vascular smooth muscle cells (VSMC). Cultured VSMCs incubated with various concentrations of UII were used to measure the YSMC 3H-TdR incorporation, the amount of ET mRNA and ET production in VSMCs. In this work we found that UII (10-10-10-8 mol/L) promoted VSMC 3H-TdR incorporation (47%-83%, P<0.01) and increased the amount of ET mRNA by 17.1% (P < 0.05) to 112.8% (P < 0.01), respectively, in a concentration dependent manner compared with control. After 4 and 8 h incubation, 10-10-10-8 mol/L of UII elevated the ET synthesis and release in a concentration dependent manner. After 4 h incubation, the content of ET in medium was 4.9, 5.36 and 7.12 pg/mL (P < 0.01). After 8 h incubation, the ET content released from VSMCs was 12.6, 12.07 and 17.17 pg/mL (P < 0.01). In addition, it was found that BQ123, a specific ETA receptor antagonist, obviously decreased the VSMC DNA synthesis induced by | Ql Yongfen, BU Dingfang, YANG Jun, ZHANG Zhaokang, NIU Dadi, SHI Yanrong, ZHANG Zhenghao, TANG Chaoshu & DU JunbaoInstitute of Cardiovascular Diseases, The First Hospital of Peking University, Beijing 100083, China Department of Physiology, Health Science | 2002 | Chinese Science Bulletin2002，47，12： | 0 |
| 16 | Fabrication of Foamed Aluminum by New Vesicant-Mixed Rare Earths Hydride显示文摘The preparation and foaming mechanism of a new vesicant-mixed rare earths hydride were investigated. The closed cell aluminum by foaming method of molten aluminum was produced. The result obtained isas follows: compared with Till2, REH, a higher decomposition temperature is exhibited and the mechanical properties especially the compressive strength of foam aluminum are increased significantly. | YanFuxue ZhaoKang GuChenging | 2005 | Journal of Rare Earths2005，23，2： | 0 |
| 17 | Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes显示文摘Dear Editor,Postovulatory aging would occur to impair the oocyte quality in a timedependent manner if ovulated oocytes are not fertilized within the optimal timing in the oviduct or in the dishes(Trapphoff et al.,2016),which might result in the early pregnancy failure in vivo and adverse outcome of assisted reproductive technology(ART)in vitro(Nagy et al.,1993;Wilcox et al.,1998).However,the effective approaches to preventing the postovulatory aging-induced oocyte deterioration are still underexplored.We recently reported that supplementation of nicotinamide mononucleotide(NMN),a synthetic precursor of NAD+,which is an essential cofactorfor enzymes'functioning in almost all critical cellularmetabolic reactions(Imai and Guarente,2014;Canto et al.,2015),reverses the declining quality of maternally aged mouse oocytes(Miao et al.,2020). | Yilong Miao Zhaokang Cui Xiaotong Zhu Qian Gao Bo xiong | 2022 | Journal of Molecular Cell Biology2022，14，4： | 0 |
| 18 | Cultural Protection and Inheritance of Red Buildings from the Perspective of Rural Revitalization:A Case Study of the Former Site of'Third Line'Military Factory in Pengfang,Jiangxi Province显示文摘This paper makes an investigation and analysis of the existing red buildings in Pengfang Township,and puts forward the circular development model of'Red Building+Rural Tourism'after systematic arrangement.And through the dialectical perspective of the protection,inheritance,development and utilization of architectural culture under rural revitalization,this paper observes how the villages with red buildings help to boost the rural economy by integrating its own internal and external resources under the background of the great revival of the national rural traditional culture,so as to realize the protective development of rural red buildings. | Jianjian HE Xidi YANG Yuanmin NING Jie GAO Zhaokang RAO | 2022 | Asian Agricultural Research2022，14，5： | 0 |
| 19 | Adrenomedullin inhibits the endothelin production induced by urotensin Ⅱ in rat vascular smooth muscle cells显示文摘The aim of this study was to observe the effects of adrenomedullin (ADM) on endothelin (ET) production induced by urotensin Ⅱ (UⅡ) in rat vascular smooth muscle cells (VSMCs). Cultured VSMCs which were incubated with UⅡ (10-8 mol/L) and with various concentrations of ADM were used to measure the VSMCs 3H-TdR incorporation, the activity of extracellular signal-regulated kinase (ERK), the amount of ET mRNA and ET production in VSMCs. In this work we found that incubation with UⅡ (10-8 mol/L) increased obviously the amount of ET mRNA in VSMCs and ET production in medium, however, co-incubation with ADM (10-10-10-8 mol/L) and UⅡ(10-8 mol/L) reduced the amount of ET mRNA by 15%, 24% and 45% (P< 0.01) respectively, compared with UⅡ alone. The content of ET in medium was 14.13, 11.38 and 11.00 pg/mL. ADM alone (10-8 mol/L) had no effect on ET production in VSMCs. UⅡ (10-8 mol/L) promoted the 3H-TdR incorporation and activity of ERK in VSMCs. ADM inhibited VSMCs 3H-TdR incorporation and activation of | Ql Yongfen BU Dingfang YANG Jun ZHANG Zhaokang SHI Yanrong PANG Yongzheng TANG Chaoshu | 2002 | Chinese Science Bulletin2002，47，17： | 0 |
| 20 | Liver HMGCS2 is critical in the maintenance of liver lipid homeostasis during fasting显示文摘Fasting induces mammalian metabolic switch from glucose to fatty acid-derived ketones,resulting in a marked change in blood glucose,triglyceride,free fatty acid andβ-hydroxybutyrate levels and a phenotype of transient hepatic steatosis.However,the underlying mechanism remains incompletely understood. | Yunfeng Zhou Tingting Gu Shuyuan Hu Zhaokang Luo Ling Huang Cong Yu Jie Wang Baohua Liu Xiaoyan Zhang Youfei Guan | 2023 | Genes & Diseases2023，10，3： | 0 |
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