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| 1 | Source apportionment of VOCs in a typical medium-sized city in North China Plain and implications on control policy显示文摘Characteristics of atmospheric VOCs(volatile organic compounds) have been extensively studied in megacities in China, however, they are scarcely investigated in medium/smallsized cities in North China Plain(NCP).A comprehensive research on possible sources of VOCs was conducted in a medium-sized city of NCP, from May to September 2019.A total of 143 canister samples of 8 sites in Xuchang city were collected, and 57 VOC species were detected.The average VOC concentrations were 42.6 ± 31.6 μg/m3, with 53.7 ± 31.0 μg/m3 and 32.1 ± 27.8 μg/m^(3), in the morning and afternoon, respectively.Alkenes and aromatics contributed 80% of the total ozone formation potential(OFP).Aromatics accounted for more than 95% of secondary organic aerosol potential(SOAP).VOCs were dominated by the local emission with significant transport from the southeast direction.PMF analysis extracted 6 sources, which were combustion(33.1%), LPG usage(19.3%), vehicular exhaust & fuel evaporation(15.8%), solvent usage(15.2%), industrial(9.11%) and biogenic(7.51%), respectively and they contributed 33.4%, 17.6%, 12.9%, 18.6%, 9.28% and 8.22% to the OFP, respectively.Combustion and LPG usage were the dominant VOC sources;and combustion, solvent usage and LPG usage were the main sources of OFP in Xuchang city, which were different to megacities in China with a high contribution from vehicular exhaust, solvent usage and industry,suggesting specific control strategies on VOCs need to be implemented in medium-sized city such as Xuchang city. | Juanjuan Qin Xiaobo Wang Yanrong Yang Yuanyuan Qin Shaoxuan Shi Peihua Xu Rongzhi Chen Xueming Zhou Jihua Tan Xinming Wang | 2021 | Journal of Environmental Sciences2021，33，9： | 6 |
| 2 | Contents of soil organic carbon and nitrogen in water-stable aggregates in abandoned agricultural lands in an arid ecosystem of Northwest China显示文摘Soil organic matter content in water-stable aggregates(WSA) in the arid ecosystems(abandoned agricultural lands especially) of China is poorly understood. In this study, we examined the WSA sizes and stability, and soil organic carbon(OC) and nitrogen(N) contents in agricultural lands with abandonment ages of 0, 3, 12, 20, 30 and 40 years, respectively, in the Minqin Oasis of Northwest China. The total soil OC and N contents at depths of 0–20, 20–40 and 40–60 cm in abandoned agricultural lands were compared to those in cultivated land(the control). Agricultural land abandonment significantly(P<0.05) influenced the distribution of MWD(mean weight diameter), and OC and N contents. There were significant increases in MWD and the proportion of macroaggregates(sizes >0.25 mm) as the age of agricultural land abandonment increased. The effect of abandonment ages of agricultural lands on MWD was determined by the changes of OC and N accumulation in WSA sizes >2 mm. The total OC and N contents presented a stratification phenomenon across soil depths in this arid ecosystem. That is, both of them decreased significantly at depths of 0–20 and 40–60 cm while increased at the depth of 20–40 cm. The WSA sizes <0.053 mm had the highest soil OC and N contents(accounting for 51.41%–55.59% and 42.61%–48.94% of their total, respectively). Soil OC and N contents in microaggregates(sizes 0.053–0.25 mm) were the dominant factors that influenced the variations of total OC and N contents in abandoned agricultural lands. The results of this study suggested that agricultural land abandonment may result in the recovery of WSA stability and the shifting of soil organic matter from the silt+clay(<0.053 mm) and microaggregate fractions to the macroaggregate fractions. However, agricultural land abandonment did not increase total soil OC and N contents in the short-term. | WANG Junqiang LIU Lichao QIU Xiaoqing WEI Yujie LI Yanrong SHI Zhiguo | 2016 | Journal of Arid Land2016，8，3： | 6 |
| 3 | Bortezomib improves progression-free survival in multiple myeloma patients overexpressing preferentially expressed antigen of melanoma显示文摘 | Qin Yazhen Lu Jin Bao Li Zhu Honghu Li Jinlan Li Lingdi Lai Yueyun Shi Hongxia Wang Yazhe Liu Yanrong Jiang Bin Huang Xiaojun | 2014 | Chinese Medical Journal2014，，9： | 4 |
| 4 | Recoverable Mn~Ⅲ (salen) supported on diamine modified zirconium poly(styrene-isopropenyl phosphonate)-phosphate as an efficient catalyst for epoxidation of unfunctionalized olefins显示文摘Chiral Mn Ⅲ (salen) (Jacobsen's catalyst) was axially immobilized onto a new type of organic polymer-inorganic hybrid materialzirconium poly(styrene-isopropenyl phosphonate)-phosphate(ZPS-IPPA) with different linkage lengths and evaluated as catalysts for the epoxidation of unfunctionalized olefins. The results demonstrated that the prepared catalysts exhibited moderate to good activity and enantioselectivity in the asymmetric epoxidation of unfunctionalized olefins. Furthermore, the immobilized catalysts were relatively stable and could be conveniently separated from the reaction system by simple precipitation in hexane. Moreover, higher enantioselectivity was obtained with catalyst 2c than that of homogeneous counterpart catalyzed even after eight times. The excellent recycling of the catalyst was attributed to its structure feature of ZPS-IPPA which is different from either pure polystyrene or pure zirconium phosphates. | ZOU XiaoChuan CHEN ShaoCheng REN YanRong SHI KaiYun LI Jun FU XiangKai | 2012 | Science China Chemistry2012，55，11： | 3 |
| 5 | Improvement on the modeling of rate-dependent plasticity and cyclic hardening by Bodner-Partom model显示文摘 | SHI Duoqi YANG Xiaoguang WANG Yanrong | 2005 | Chinese Journal of Aeronautic2005，18，1： | 1 |
| 6 | Emerging phagocytosis checkpoints in cancer immunotherapy显示文摘Cancer immunotherapy,mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells,has revolutionized the oncology landscape as it utilizes patients’own immune systems in combating the cancer cells.Cancer cells escape immune surveillance by hijacking the corresponding inhibitory pathways via overexpressing checkpoint genes.Phagocytosis checkpoints,such as CD47,CD24,MHC-I,PD-L1,STC-1 and GD2,have emerged as essential checkpoints for cancer immunotherapy by functioning as“don’t eat me”signals or interacting with“eat me”signals to suppress immune responses.Phagocytosis checkpoints link innate immunity and adaptive immunity in cancer immunotherapy.Genetic ablation of these phagocytosis checkpoints,as well as blockade of their signaling pathways,robustly augments phagocytosis and reduces tumor size.Among all phagocytosis checkpoints,CD47 is the most thoroughly studied and has emerged as a rising star among targets for cancer treatment.CD47-targeting antibodies and inhibitors have been investigated in various preclinical and clinical trials.However,anemia and thrombocytopenia appear to be formidable challenges since CD47 is ubiquitously expressed on erythrocytes.Here,we review the reported phagocytosis checkpoints by discussing their mechanisms and functions in cancer immunotherapy,highlight clinical progress in targeting these checkpoints and discuss challenges and potential solutions to smooth the way for combination immunotherapeutic strategies that involve both innate and adaptive immune responses. | Yu’e Liu Yanjin Wang Yanrong Yang Linjun Weng Qi Wu Jin Zhang Pengcheng Zhao Lan Fang Yufeng Shi Ping Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 7 | A HighEfficiency Panchromatic Squaraine Sensitizer for Dye-Sensitized Solar Cells显示文摘 | Yanrong Shi Rebecca B M Hill Yum J H | | 0，，： | 1 |
| 8 | Changes of adrenomedullin and receptor activity modifying protein2(RAMP2)in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia显示文摘 | Qi Yongfen Shi Yanrong Bu Dingfang | 2003 | Peptides2003，24，3： | 1 |
| 9 | Synthesis, Structural Studies and Reactivity of Two cis-Bis(phosphine)bis(silyl) Palladium(ll) Complexes显示文摘 | Lizhong Wang Jinfei Guo Yajuan Li Yanrong Su Jiawei Liu Yonghua Li Shi Wang Shigeru Shimada Wei Huang | 2017 | Chinese Journal of Chemistry2017，35，4： | 1 |
| 10 | Potential factors and mechanism of particulate matters explosive increase induced by free radicals oxidation显示文摘Atmospheric particulate pollution in China has attracted much public attention.Occasionally, the particle number concentration increases sharply in a short time period,which is defined as a 'particulate matter explosive increase'. Heavy particulate matter pollution not only reduces visibility but also has an adverse effect on human health. Hence,there is an urgent need to discover the causes of particulate matter explosive increase.During this campaign, the particle number concentration and free radicals were measured at a tall building on the campus of Lanzhou University of Technology. Additionally, we examined a series of chemicals to reproduce the observed particulate matter explosive increase in a smog chamber to determine its potential factors. Then, we analyzed the mechanism of particulate matter explosive increase in the presence of free radicals. We found that, among the potential inorganic and organic sources analyzed, a mixture of organic and SO_2 in the research region had a major effect on particulate matter explosive increase. Moreover, free radical oxidation has a large effect, especially in the formation of organic particulates. | Guoying Wang Shiming Jia Xiuli Niu Haoqi Tian Yanrong Liu Zhong Xie Chao Liu Yucan Dong Ying Su Jianglei Yu Gaofeng Shi Xuefu Chen Lan Li Peng Zhang | 2019 | Journal of Environmental Sciences2019，31，7： | 0 |
| 11 | Urotensin Ⅱ increases endothelin production by vascular smooth muscle cells in rats显示文摘The aim of this study was to observe the effects of urotensin Ⅱ (UII) on production of endothelin (ET) in rat aortic vascular smooth muscle cells (VSMC). Cultured VSMCs incubated with various concentrations of UII were used to measure the YSMC 3H-TdR incorporation, the amount of ET mRNA and ET production in VSMCs. In this work we found that UII (10-10-10-8 mol/L) promoted VSMC 3H-TdR incorporation (47%-83%, P<0.01) and increased the amount of ET mRNA by 17.1% (P < 0.05) to 112.8% (P < 0.01), respectively, in a concentration dependent manner compared with control. After 4 and 8 h incubation, 10-10-10-8 mol/L of UII elevated the ET synthesis and release in a concentration dependent manner. After 4 h incubation, the content of ET in medium was 4.9, 5.36 and 7.12 pg/mL (P < 0.01). After 8 h incubation, the ET content released from VSMCs was 12.6, 12.07 and 17.17 pg/mL (P < 0.01). In addition, it was found that BQ123, a specific ETA receptor antagonist, obviously decreased the VSMC DNA synthesis induced by | Ql Yongfen, BU Dingfang, YANG Jun, ZHANG Zhaokang, NIU Dadi, SHI Yanrong, ZHANG Zhenghao, TANG Chaoshu & DU JunbaoInstitute of Cardiovascular Diseases, The First Hospital of Peking University, Beijing 100083, China Department of Physiology, Health Science | 2002 | Chinese Science Bulletin2002，47，12： | 0 |
| 12 | Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants显示文摘To the Editor:As of January 27,2022,there were 363,062,293 cases and 5,645,884deaths from the COVID-19 pandemic1.The prevalent mutated strains have aggravated the global pandemic2.SARS-Co V-2 is highly mutable,and the mutations on the spike(S)protein resulted in a high transmission of COVID-19 and vaccine breakthrough infection3.For example,there is a notable decrease in neutralizing ability of BNT162b2 vaccination-elicited antibodies against the Delta and other variants4,5,and attenuation of peak viral burden and vaccine effectiveness are reduced with Delta variant6. | Bin Tu Huiyuan Wang Xinran An Jingkun Qu Qianqian Li Yanrong Gao Mingjie Shi Hong Qiu Yongzhuo Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 0 |
| 13 | COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors显示文摘Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism.In this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases,and found new-onset in suli n resista nee,hyperglycemia,and decreased HDL-C in these patie nts.Mecha nistically,SARS-CoV-2 infecti on in creased the expression of RE1-silencing transcription factor(REST),which modulated the expression of secreted metabolic factors including myeloperoxidase,apelin,and myostatin at the transcriptional level,resulting in the perturbation of glucose and lipid metabolism.Furthermore,several lipids,including(±)5-HETE,(±)12-HETE,propionic acid,and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation,especially in insulin resistance.Taken together,our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19,and further illustrated the underlying mechanisms,providing potential therapeutic targets for COVID-19-induced metabolic complications. | Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 14 | Lateral Hypothalamus Calcium/Calmodulin-Dependent Protein Kinase IIα Neurons Encode Novelty-Seeking Signals to Promote Predatory Eating显示文摘Predatory hunting is an innate appetite-driven and evolutionarily conserved behavior essential for animal survival, integrating sequential behaviors including searching, pursuit, attack, retrieval, and ultimately consumption. Nevertheless, neural circuits underlying hunting behavior with different features remain largely unexplored. Here, we deciphered a novel function of lateral hypothalamus (LH) calcium/calmodulin-dependent protein kinase II α (CaMKIIα^(+)) neurons in hunting behavior and uncovered upstream/downstream circuit basis. LH CaMKIIα^(+) neurons bidirectionally modulate novelty-seeking behavior, predatory attack, and eating in hunting behavior. LH CaMKIIα^(+) neurons integrate hunting-related novelty-seeking information from the medial preoptic area (MPOA) and project to the ventral periaqueductal gray (vPAG) to promote predatory eating. Our results demonstrate that LH CaMKIIα^(+) neurons are the key hub that integrate MPOA-conveyed novelty-seeking signals and encode predatory eating in hunting behavior, which enriched the neuronal substrate of hunting behavior. | Na Tan Jiaying Shi Lingyu Xu Yanrong Zheng Xia Wang Nanxi Lai Zhuowen Fang Jialu Chen Yi Wang Zhong Chen | 2022 | Research2022，，4： | 0 |
| 15 | Adrenomedullin inhibits the endothelin production induced by urotensin Ⅱ in rat vascular smooth muscle cells显示文摘The aim of this study was to observe the effects of adrenomedullin (ADM) on endothelin (ET) production induced by urotensin Ⅱ (UⅡ) in rat vascular smooth muscle cells (VSMCs). Cultured VSMCs which were incubated with UⅡ (10-8 mol/L) and with various concentrations of ADM were used to measure the VSMCs 3H-TdR incorporation, the activity of extracellular signal-regulated kinase (ERK), the amount of ET mRNA and ET production in VSMCs. In this work we found that incubation with UⅡ (10-8 mol/L) increased obviously the amount of ET mRNA in VSMCs and ET production in medium, however, co-incubation with ADM (10-10-10-8 mol/L) and UⅡ(10-8 mol/L) reduced the amount of ET mRNA by 15%, 24% and 45% (P< 0.01) respectively, compared with UⅡ alone. The content of ET in medium was 14.13, 11.38 and 11.00 pg/mL. ADM alone (10-8 mol/L) had no effect on ET production in VSMCs. UⅡ (10-8 mol/L) promoted the 3H-TdR incorporation and activity of ERK in VSMCs. ADM inhibited VSMCs 3H-TdR incorporation and activation of | Ql Yongfen BU Dingfang YANG Jun ZHANG Zhaokang SHI Yanrong PANG Yongzheng TANG Chaoshu | 2002 | Chinese Science Bulletin2002，47，17： | 0 |
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